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1.再颁专利Polymerizable biodegradable polymers including carbonate or dioxanone linkages 有权可聚合的可生物降解聚合物，包括碳酸盐或二氧杂环己酮键公开(公告)号：USRE39713E1
公开(公告)日：2007-07-03
申请号：US10351930
申请日：2003-01-23
申请人： Amarpreet S. Sawhney , Peter K. Jarrett , Arthur J. Coury , Ronald S. Rudowsky , Michelle D. Lyman , Luis Z. Avila , David J. Enscore , Stephen D. Goodrich , William C. Nason , Fei Yao , Douglas Weaver , Shikha P. Barman
发明人： Amarpreet S. Sawhney , Peter K. Jarrett , Arthur J. Coury , Ronald S. Rudowsky , Michelle D. Lyman , Luis Z. Avila , David J. Enscore , Stephen D. Goodrich , William C. Nason , Fei Yao , Douglas Weaver , Shikha P. Barman
IPC分类号： A61F2/02
CPC分类号： C08G63/64 , A61K9/1635 , A61L24/0042 , A61L24/046 , A61L26/0019 , A61L31/06 , A61L31/148 , C08L67/04
摘要： Water-soluble macromers including at least one hydrolysable linkage formed from carbonate or dioxanone groups, at least one water-soluble polymeric block, and at least one polymerizable group, and methods of preparation and use thereof are described. The macromers are preferably polymerized using free radical initiators under the influence of long wavelength ultraviolet light or visible light excitation. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. The macromers can be used to encapsulate cells, deliver prophylactic, therapeutic or diagnostic agents in a controlled manner, plug leaks in tissue, prevent adhesion formation after surgical procedures, temporarily protect or separate tissue surfaces, and adhere or seal tissues together.
摘要翻译： 描述了包括由碳酸酯或二恶烷酮基团形成的至少一种可水解键，至少一种水溶性聚合物嵌段和至少一种可聚合基团的水溶性大分子单体及其制备和使用方法。 大分子单体优选在长波长紫外光或可见光激发的影响下使用自由基引发剂进行聚合。 生物降解发生在延伸低聚物内的连接处，并导致无毒且容易从体内去除的碎片。 大分子单体可用于包封细胞，以受控的方式递送预防性，治疗性或诊断性药物，堵塞组织中的渗漏，防止外科手术后的粘连形成，暂时保护或分离组织表面，以及将组织粘附或密封在一起。
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公开(公告)号：US07238364B2
公开(公告)日：2007-07-03
申请号：US10338933
申请日：2003-01-07
CPC分类号： A61L31/06 , A61K9/1635 , A61K9/1647 , A61L24/0042 , A61L24/046 , A61L26/0019 , A61L31/10 , A61L31/148 , C08G63/64 , C08G63/676 , C08L67/04
摘要： An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming to the three dimensional structure of a tissue surface as the tissue bends and deforms during healing processes. The barrier or drug delivery systems is formed as a polymeric coating on tissue surfaces by applied a polymerizable monomer to the surface, and then polymerizing the monomer. The polymerized compliant coating preferably is biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications.
摘要翻译： 公开了与施加的表面高度附着的改进的屏障或药物递送系统，以及用于制造屏障的方法。 在优选实施例中，该系统是符合的，因为当组织在愈合过程中弯曲并变形时，其能够符合组织表面的三维结构。 通过将可聚合单体施加到表面上，然后聚合单体，将屏障或药物递送系统形成为组织表面上的聚合物涂层。 聚合的柔顺涂层优选是可生物降解和生物相容的，并且可以设计成具有选择的适应性和弹性性质，用于不同的手术和治疗应用。
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3.发明授权Polymerizable biodegradable polymers including carbonate or dioxanone linkages 有权可聚合的可生物降解聚合物，包括碳酸盐或二氧杂环己酮键公开(公告)号：US06177095B1
公开(公告)日：2001-01-23
申请号：US09479520
申请日：2000-01-07
申请人： Amarpreet S. Sawhney , Peter K. Jarrett , Arthur J. Coury , Ronald S. Rudowsky , Michelle D. Powell , Luis Z. Avila , David J. Enscore , Stephen D. Goodrich , William C. Nason , Fei Yao , Douglas Weaver , Shikha P. Barman
发明人： Amarpreet S. Sawhney , Peter K. Jarrett , Arthur J. Coury , Ronald S. Rudowsky , Michelle D. Powell , Luis Z. Avila , David J. Enscore , Stephen D. Goodrich , William C. Nason , Fei Yao , Douglas Weaver , Shikha P. Barman
IPC分类号： A61F202
CPC分类号： C08G63/64 , A61K9/1635 , A61L24/0042 , A61L24/046 , A61L26/0019 , A61L31/06 , A61L31/148 , C08L67/04
摘要： Water-soluble macromers including at least one hydrolysable linkage formed from carbonate or dioxanone groups, at least one water-soluble polymeric block, and at least one polymerizable group, and methods of preparation and use thereof are described. The macromers are preferably polymerized using free radical initiators under the influence of long wavelength ultraviolet light or visible light excitation. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. The macromers can be used to encapsulate cells, deliver prophylactic, therapeutic or diagnostic agents in a controlled manner, plug leaks in tissue, prevent adhesion formation after surgical procedures, temporarily protect or separate tissue surfaces, and adhere or seal tissues together.
摘要翻译： 描述了包括由碳酸酯或二恶烷酮基团形成的至少一种可水解键，至少一种水溶性聚合物嵌段和至少一种可聚合基团的水溶性大分子单体及其制备方法和用途。 大分子单体优选在长波长紫外光或可见光激发的影响下使用自由基引发剂进行聚合。 生物降解发生在延伸低聚物内的连接处，并导致无毒且容易从体内去除的碎片。 大分子单体可用于包封细胞，以受控的方式递送预防性，治疗性或诊断性药物，堵塞组织中的渗漏，防止外科手术后的粘连形成，暂时保护或分离组织表面，以及将组织粘附或密封在一起。
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4.发明授权Polymerizable biodegradable polymers including carbonate or dioxanone linkages 失效可聚合的可生物降解聚合物，包括碳酸盐或二氧杂环己酮键
公开(公告)号：US6083524A
公开(公告)日：2000-07-04
申请号：US944739
申请日：1997-10-06
申请人： Amarpreet S. Sawhney , David J. Enscore , Stephen D. Goodrich , William C. Nason , Fei Yao , Douglas Weaver , Peter K. Jarrett , Arthur J. Coury , Ronald S. Rudowsky , Michelle D. Powell , Luis Z. Avila , Shikha P. Barman
发明人： Amarpreet S. Sawhney , David J. Enscore , Stephen D. Goodrich , William C. Nason , Fei Yao , Douglas Weaver , Peter K. Jarrett , Arthur J. Coury , Ronald S. Rudowsky , Michelle D. Powell , Luis Z. Avila , Shikha P. Barman
IPC分类号： A61K9/16 , A61L24/00 , A61L24/04 , A61L26/00 , A61L31/06 , A61L31/14 , C08G63/64 , A61R2/02 , A61K31/74
CPC分类号： C08G63/64 , A61L24/0042 , A61L24/046 , A61L26/0019 , A61L31/06 , A61L31/148 , A61K9/1635
摘要： Water-soluble macromers including at least one hydrolysable linkage formed from carbonate or dioxanone groups, at least one water-soluble polymeric block, and at least one polymerizable group, and methods of preparation and use thereof are described. The macromers are preferably polymerized using free radical initiators under the influence of long wavelength ultraviolet light or visible light excitation. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. The macromers can be used to encapsulate cells, deliver prophylactic, therapeutic or diagnostic agents in a controlled manner, plug leaks in tissue, prevent adhesion formation after surgical procedures, temporarily protect or separate tissue surfaces, and adhere or seal tissues together.
摘要翻译： 描述了包括由碳酸酯或二恶烷酮基团形成的至少一种可水解键，至少一种水溶性聚合物嵌段和至少一种可聚合基团的水溶性大分子单体及其制备方法和用途。 大分子单体优选在长波长紫外光或可见光激发的影响下使用自由基引发剂进行聚合。 生物降解发生在延伸低聚物内的连接处，并导致无毒且容易从体内去除的碎片。 大分子单体可用于包封细胞，以受控的方式递送预防性，治疗性或诊断性药物，堵塞组织中的渗漏，防止外科手术后的粘连形成，暂时保护或分离组织表面，以及将组织粘附或密封在一起。
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公开(公告)号：US06531147B2
公开(公告)日：2003-03-11
申请号：US10053356
申请日：2001-11-07
IPC分类号： C09D400
CPC分类号： A61L31/06 , A61K9/1635 , A61K9/1647 , A61L24/0042 , A61L24/046 , A61L26/0019 , A61L31/10 , A61L31/148 , C08G63/64 , C08G63/676 , C08L67/04
摘要： An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming to the three dimensional structure of a tissue surface as the tissue bends and deforms during healing processes. The barrier or drug delivery systems is formed as a polymeric coating on tissue surfaces by applied a polymerizable monomer to the surface, and then polymerizing the monomer. The polymerized compliant coating preferably is biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications.
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公开(公告)号：US6051248A
公开(公告)日：2000-04-18
申请号：US288207
申请日：1999-04-08
IPC分类号： A61K9/16 , A61L24/00 , A61L24/04 , A61L26/00 , A61L31/06 , A61L31/10 , A61L31/14 , C08G63/64 , C08G63/676 , C09D4/00 , A61L27/00 , A61L29/00 , A61L25/00
CPC分类号： A61L31/06 , A61K9/1647 , A61L24/0042 , A61L24/046 , A61L26/0019 , A61L31/10 , A61L31/148 , C08G63/64 , C08G63/676 , A61K9/1635
摘要： An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming to the three dimensional structure of a tissue surface as the tissue bends and deforms during healing processes. The barrier or drug delivery systems is formed as a polymeric coating on tissue surfaces by applied a polymerizable monomer to the surface, and then polymerizing the monomer. The polymerized compliant coating preferably is biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications.
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公开(公告)号：US5900245A
公开(公告)日：1999-05-04
申请号：US710689
申请日：1996-09-23
IPC分类号： A61K9/16 , A61L24/00 , A61L24/04 , A61L26/00 , A61L31/06 , A61L31/10 , A61L31/14 , C08G63/64 , C08G63/676 , C09D4/00 , A61L25/00 , A61L27/00 , A61L29/00
CPC分类号： A61L31/06 , A61K9/1647 , A61L24/0042 , A61L24/046 , A61L26/0019 , A61L31/10 , A61L31/148 , C08G63/64 , C08G63/676 , A61K9/1635
摘要： An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming to the three dimensional structure of a tissue surface as the tissue bends and deforms during healing processes. The barrier or drug delivery systems is formed as a polymeric coating on tissue surfaces by applied a polymerizable monomer to the surface, and then polymerizing the monomer. The polymerized compliant coating preferably is biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications.
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公开(公告)号：US06352710B2
公开(公告)日：2002-03-05
申请号：US09732419
申请日：2000-12-07
IPC分类号： C09D400
CPC分类号： A61L31/06 , A61K9/1635 , A61K9/1647 , A61L24/0042 , A61L24/046 , A61L26/0019 , A61L31/10 , A61L31/148 , C08G63/64 , C08G63/676 , C08L67/04
摘要： An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming to the three dimensional structure of a tissue surface as the tissue bends and deforms during healing processes. The barrier or drug delivery systems is formed as a polymeric coating on tissue surfaces by applied a polymerizable monomer to the surface, and then polymerizing the monomer. The polymerized compliant coating preferably is biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications.
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公开(公告)号：US06217894B1
公开(公告)日：2001-04-17
申请号：US09477162
申请日：2000-01-04
IPC分类号： C09D400
CPC分类号： A61L31/06 , A61K9/1635 , A61K9/1647 , A61L24/0042 , A61L24/046 , A61L26/0019 , A61L31/10 , A61L31/148 , C08G63/64 , C08G63/676 , C08L67/04
摘要： An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming to the three dimensional structure of a tissue surface as the tissue bends and deforms during healing processes. The barrier or drug delivery systems is formed as a polymeric coating on tissue surfaces by applied a polymerizable monomer to the surface, and then polymerizing the monomer. The polymerized compliant coating preferably is biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications.
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公开(公告)号：US5849035A
公开(公告)日：1998-12-15
申请号：US448572
申请日：1995-10-30
申请人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
发明人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
IPC分类号： A61L27/00 , A61B17/22 , A61F2/00 , A61F2/02 , A61F2/82 , A61F2/945 , A61F2/95 , A61L31/14 , B29C35/08 , B29C49/00 , B29C55/24 , B29C70/74 , A61F2/06
CPC分类号： A61F2/82 , A61F2/945 , A61F2/95 , A61L31/14 , B29C35/08 , B29C49/00 , B29C55/24 , B29C70/74 , A61B2017/22001 , A61F2210/0047 , A61F2220/0008 , A61F2250/0098 , B29C2035/0822 , B29C2035/0827 , B29C2035/0833 , B29C49/0042 , B29K2995/006 , B29L2023/00 , B29L2031/7542 , Y10S623/901
摘要： A method and apparatus for molding polymeric structures in vivo is disclosed. The structures comprise polymers that may be heated to their molding temperature by absorption of visible or near-visible wavelengths of light. By providing a light source that produces radiation of the wavelength absorbed by the polymeric material, the material may be selectively heated and shaped in vivo without a corresponding heating of adjacent tissues or fluids to unacceptable levels. The apparatus comprises a catheter having a shaping element positioned near its distal end. An emitter provided with light from at least one optical fiber is positioned within the shaping element. The emitter serves to provide a moldable polymeric article positioned on the shaping element with a substantially uniform light field, thereby allowing the article to be heated and molded at a desired treatment site in a body lumen.
摘要翻译： PCT No.PCT / US94 / 04824 Sec。 371 1995年10月30日第 102（e）日期1995年10月30日PCT 1994年4月28日PCT PCT。 第WO94 / 24962号公报 日期：1994年11月10日公开了一种用于在体内模制聚合物结构的方法和装置。 该结构包括可以通过吸收可见光或近似可见波长的光而被加热到它们的模制温度的聚合物。 通过提供产生由聚合物材料吸收的波长的辐射的光源，该材料可以在体内被选择性地加热和成形，而相邻组织或液体的相应加热不能接受。 该装置包括具有定位在其远端附近的成形元件的导管。 设置有来自至少一个光纤的光的发射器被定位在成形元件内。 发射器用于提供具有基本上均匀的光场的位于成形元件上的可成型的聚合物制品，从而允许制品在体腔内的期望的治疗部位被加热和模制。
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