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    Benzopyran derivatives
    3.
    发明授权
    Benzopyran derivatives 失效
    苯并吡喃衍生物

    公开(公告)号：US06403594B1

    公开(公告)日：2002-06-11

    申请号：US09691770

    申请日：2000-10-18

    申请人： Amedeo Leonardi ,  Gianni Motta ,  Carlo Riva ,  Giorgio Sironi

    发明人： Amedeo Leonardi ,  Gianni Motta ,  Carlo Riva ,  Giorgio Sironi

    IPC分类号： A61K31496

    CPC分类号： C07D311/30 ,  C07D311/24

    摘要： The invention relates to novel benzopyran derivatives of formula I, their N-oxides and pharmaceutically acceptable salts thereof. The compounds are endowed with enhanced selectivity for alpha1-adrenergic receptors and a low activity in lowering blood pressure. The compounds are useful in the treatment of obstructive syndromes of the lower urinary tract, including benign prostatic hyperplasia (BPH), and in the treatment of lower urinary tract symptoms (LUTS), neurogenic lower urinary tract dysfunction (NLUTD), and other conditions.

    摘要翻译： 本发明涉及式I的新型苯并吡喃衍生物，其N-氧化物及其药学上可接受的盐。 该化合物具有增强的α1-肾上腺素能受体的选择性和降低血压的低活性。 该化合物可用于治疗下尿路阻塞性综合征，包括良性前列腺增生（BPH），以及治疗下尿路症状（LUTS），神经源性下尿路功能障碍（NLUTD）等情况。

    Thienopyranecarboxamide derivatives
    9.
    发明授权
    Thienopyranecarboxamide derivatives 失效
    噻吩甲酰胺衍生物

    公开(公告)号：US06486163B1

    公开(公告)日：2002-11-26

    申请号：US09931153

    申请日：2001-08-16

    申请人： Amedeo Leonardi ,  Gianni Motta ,  Carlo Riva ,  Rodolfo Testa

    发明人： Amedeo Leonardi ,  Gianni Motta ,  Carlo Riva ,  Rodolfo Testa

    IPC分类号： A61K31497

    CPC分类号： C07D495/04

    摘要： The invention relates to novel N-(substituted phenyl)-N′-[&ohgr;-(5-substituted-7-oxo-7H-thieno[3,2-b]pyran-3-carbonylamino)alkyl]piperazines their N-oxides and pharmaceutically acceptable salts thereof. The compounds are endowed with enhanced selectivity for alpha1-adrenergic receptors and a low activity in lowering blood pressure. The compounds are useful in the treatment of obstructive syndromes of the lower urinary tract, including benign prostatic hyperplasia (BPH), and in the treatment of lower urinary tract symptoms (LUTS) and neutogenic lower urinary tract dysfunction (NLUTD), and other conditions. The compounds may be administered alone or in combination with an anticholinergic compound.

    摘要翻译： 本发明涉及新的N-（取代苯基）-N' - （5-取代-7-氧代-7H-噻吩并[3,2-b]吡喃-3-羰基氨基）烷基]哌嗪的N-氧化物 及其药学上可接受的盐。 该化合物具有增强的α1-肾上腺素能受体的选择性和降低血压的低活性。 该化合物可用于治疗下尿路阻塞性综合征，包括良性前列腺增生（BPH），以及治疗下尿路症状（LUTS）和神经生长性下尿路功能障碍（NLUTD）等情况。 化合物可以单独施用或与抗胆碱能化合物组合施用。

    Thienopyranecarboxamide derivatives
    10.
    发明授权
    Thienopyranecarboxamide derivatives 失效
    噻吩甲酰胺衍生物

    公开(公告)号：US06387909B1

    公开(公告)日：2002-05-14

    申请号：US09627767

    申请日：2000-07-28

    申请人： Amedeo Leonardi ,  Gianni Motta ,  Carlo Riva ,  Rodolfo Testa

    发明人： Amedeo Leonardi ,  Gianni Motta ,  Carlo Riva ,  Rodolfo Testa

    IPC分类号： C07D49504

    CPC分类号： C07D495/04

    摘要： The invention relates to novel N-(substituted phenyl)-N′-[&ohgr;-(5-substituted-7-oxo-7H-thieno[3,2-b]pyran-3-carbonylamino)alkyl]piperazines their N-oxides and pharmaceutically acceptable salts thereof. The compounds are endowed with enhanced selectivity for alpha1-adrenergic receptors and a low activity in lowering blood pressure. The compounds are useful in the treatment of obstructive syndromes of the lower urinary tract, including benign prostatic hyperplasia (BPH), and in the treatment of lower urinary tract symptoms (LUTS) and neurogenic lower urinary tract dysfunction (NLUTD). The compounds are also useful in the treatment of excessive intraocular pressure, cardiac arrhythmia, erectile dysfunction, sexual dysfunction, and for inhibiting cholesterol synthesis or reducing sympathetically mediated pain.

    摘要翻译： 本发明涉及新的N-（取代苯基）-N' - （5-取代-7-氧代-7H-噻吩并[3,2-b]吡喃-3-羰基氨基）烷基]哌嗪的N-氧化物 及其药学上可接受的盐。 该化合物具有增强的α1-肾上腺素能受体的选择性和降低血压的低活性。 该化合物可用于治疗下尿路阻塞性综合征，包括良性前列腺增生（BPH）和治疗下尿路症状（LUTS）和神经源性下尿路功能障碍（NLUTD）。 该化合物还可用于治疗过度的眼内压，心律失常，勃起功能障碍，性功能障碍，以及抑制胆固醇合成或减少交感神经介导的疼痛。