公开(公告)号：US10344041B2

公开(公告)日：2019-07-09

申请号：US15966157

申请日：2018-04-30

申请人： AMGEN, INC.

发明人： David Bauer ,  Matthew Bio ,  Melanie Cooke ,  Katrina W. Copeland ,  Matthew Peterson ,  Michele Potashman ,  Roman Shimanovich ,  Helming Tan

IPC分类号： C07D519/00 ,  A61K31/52 ,  C07C55/10 ,  C07C55/12 ,  C07C57/10 ,  C07C57/145 ,  C07C275/02

摘要： Provided herein are novel polymorphic forms and co-crystals of a compound useful in the treatment, prevention, or amelioration of cancer. In particular, the invention provides polymorphs and co-crystals of 6-{(1R)-1-[8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl}-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one, which is an inhibitor of c-Met.

公开(公告)号：US09981988B2

公开(公告)日：2018-05-29

申请号：US15293511

申请日：2016-10-14

申请人： AMGEN, INC.

发明人： David Bauer ,  Matthew Bio ,  Melanie Cooke ,  Katrina W. Copeland ,  Matthew Peterson ,  Michele Potashman ,  Roman Shimanovich ,  Helming Tan

IPC分类号： C07D519/00 ,  A61K31/52 ,  C07C55/10 ,  C07C55/12 ,  C07C57/10 ,  C07C57/145 ,  C07C275/02

CPC分类号： C07D519/00 ,  A61K31/52 ,  C07B2200/13 ,  C07C55/10 ,  C07C55/12 ,  C07C57/10 ,  C07C57/145 ,  C07C275/02

摘要： Provided herein are novel polymorphic forms and co-crystals of a compound useful in the treatment, prevention, or amelioration of cancer. In particular, the invention provides polymorphs and co-crystals of 6-{(1R)-1-[8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl}-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one, which is an inhibitor of c-Met.

公开(公告)号：US20130303529A1

公开(公告)日：2013-11-14

申请号：US13916984

申请日：2013-06-13

申请人： Amgen Inc.

发明人： Brian K. ALBRECHT ,  David Bauer ,  Steven Bellon ,  Christiane M. Bode ,  Shon Booker ,  Alessandro Boezio ,  Deborah Choquette ,  Derin D'Amico ,  Jean-Christophe Harmange ,  Satoko Hirai ,  Randall W. Hungate ,  Tae-Seong Kim ,  Richard T. Lewis ,  Longbin Liu ,  Julia W. Lohman ,  Mark H. Norman ,  Michele Potashman ,  Aaron C. Siegmund ,  Stephanie K. Springer ,  Markian Stec ,  Ning Xi ,  Kevin Yang ,  Karina Romero ,  Katrina Woodin Copeland ,  Emily A. Peterson

IPC分类号： C07D487/04 ,  A61K31/5377 ,  A61K31/5025 ,  A61K31/497 ,  A61K31/52 ,  A61K31/437 ,  A61K45/06 ,  C07D473/34 ,  C07D471/04 ,  A61K31/538 ,  A61K31/506

CPC分类号： A61K31/538 ,  A61K31/437 ,  A61K31/497 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/52 ,  A61K31/5377 ,  A61K45/06 ,  C07D403/12 ,  C07D471/04 ,  C07D473/34 ,  C07D487/04 ,  C07D493/04 ,  C07D495/04 ,  C07D498/04 ,  C07D519/00

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

公开(公告)号：US09066954B2

公开(公告)日：2015-06-30

申请号：US13916984

申请日：2013-06-13

申请人： Amgen Inc.

发明人： Brian K. Albrecht ,  David Bauer ,  Steven Bellon ,  Christiane M. Bode ,  Shon Booker ,  Alessandro Boezio ,  Deborah Choquette ,  Derin D'Amico ,  Jean-Christophe Harmange ,  Satoko Hirai ,  Randall W. Hungate ,  Tae-Seong Kim ,  Richard T. Lewis ,  Longbin Liu ,  Julia W. Lohman ,  Mark H. Norman ,  Michele Potashman ,  Aaron C. Siegmund ,  Stephanie K. Springer ,  Markian Stec ,  Ning Xi ,  Kevin Yang

IPC分类号： C07D487/04 ,  C07D403/12 ,  A61K31/4192 ,  A61K31/4353 ,  A61K31/4709 ,  A61P35/00 ,  A61K31/538 ,  C07D471/04 ,  C07D493/04 ,  C07D495/04 ,  C07D498/04 ,  C07D519/00 ,  A61K31/437 ,  A61K31/497 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/52 ,  A61K31/5377 ,  A61K45/06 ,  C07D473/34

CPC分类号： A61K31/538 ,  A61K31/437 ,  A61K31/497 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/52 ,  A61K31/5377 ,  A61K45/06 ,  C07D403/12 ,  C07D471/04 ,  C07D473/34 ,  C07D487/04 ,  C07D493/04 ,  C07D495/04 ,  C07D498/04 ,  C07D519/00

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.