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公开(公告)号：US20220280496A1
公开(公告)日：2022-09-08
申请号：US17500039
申请日：2021-10-13
Applicant: AMGEN INC.
Inventor： Matthew BIO , Sebastien CAILLE , Brian COCHRAN , Yuanqing FANG , Brian M. FOX , Brian S. LUCAS , Lawrence R. MCGEE , Filisaty VOUNATSOS , Sean H. WIEDEMANN , Sarah WORTMAN
IPC: A61K31/451 , C07D211/94 , C07D491/048 , C07C309/25 , C07C309/04 , C07C313/02 , C07C309/35 , C07D498/04 , C07D211/76
Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
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公开(公告)号：US20160289190A1
公开(公告)日：2016-10-06
申请号：US15175824
申请日：2016-06-07
Applicant: AMGEN INC.
Inventor： Matthew BIO , Sebastien CAILLE , Brian COCHRAN , Yuanqing FANG , Brian M. FOX , Brian S. LUCAS , Lawrence R. McGEE , Filisaty VOUNATSOS , Sean H. WIEDEMANN , Sarah WORTMAN
IPC: C07D211/76
CPC classification number: A61K31/451 , C07B2200/13 , C07C309/04 , C07C309/25 , C07C309/35 , C07C313/02 , C07D211/76 , C07D211/94 , C07D491/048 , C07D498/04
Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
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公开(公告)号：US20160287570A1
公开(公告)日：2016-10-06
申请号：US15175798
申请日：2016-06-07
Applicant: AMGEN INC.
Inventor： Matthew BIO , Sebastien CAILLE , Brian COCHRAN , Yuanqing FANG , Filisaty VOUNATSOS , Sarah WORTMAN
IPC: A61K31/451
CPC classification number: A61K31/451 , C07B2200/13 , C07C309/04 , C07C309/25 , C07C309/35 , C07C313/02 , C07D211/76 , C07D211/94 , C07D491/048 , C07D498/04
Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
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公开(公告)号：US20250163023A1
公开(公告)日：2025-05-22
申请号：US19029945
申请日：2025-01-17
Applicant: Amgen Inc.
Inventor： Sebastien CAILLE , Kyle QUASDORF , Philipp C. ROOSEN , Xianqing SHI , Andrew COSBIE , Fang WANG , Zufan WU , Archana NEERGUNDA , Bin Peter QUAN , Lianxiu GUAN
IPC: C07D401/12 , C07D241/04
Abstract: Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates.
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公开(公告)号：US20160264526A1
公开(公告)日：2016-09-15
申请号：US15163186
申请日：2016-05-24
Applicant: AMGEN INC.
Inventor： Matthew BIO , Sebastien CAILLE , Brian COCHRAN , Yuanqing FANG , Filisaty VOUNATSOS , Sarah WORTMAN
IPC: C07D211/76
CPC classification number: A61K31/451 , C07B2200/13 , C07C309/04 , C07C309/25 , C07C309/35 , C07C313/02 , C07D211/76 , C07D211/94 , C07D491/048 , C07D498/04
Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
Abstract translation: 本发明提供了制备2 - （（3R，5R，6S）-5-（3-氯苯基）-6-（4-氯苯基）-1 - （（S）-1-（异丙基磺酰基）-3-甲基丁基 -2-基）-3-甲基-2-氧代哌啶-3-基）乙酸，以及制备中间体的中间体和方法。 还提供了化合物和中间体的晶型。
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Patent Agency Ranking
公开(公告)号：US20240199550A1
公开(公告)日：2024-06-20
申请号：US18416741
申请日：2024-01-18
Applicant: Amgen Inc. , Cytokinetics, Inc.
Inventor： Henry MORRISON , Sheng CUI , Kyle QUASDORF , Evelyn YANEZ , Bin Peter QUAN , Ron C. KELLY , Sebastien CAILLE , Lingyun XIAO , David PEARSON , Jaclyn RAEBURN , Alisa GOLIGHTLY , Bradley MORGAN , Matthew PETERSON , Alex EBERLIN , Alexander OBLEZOV
IPC: C07D213/75
CPC classification number: C07D213/75 , C07B2200/13
Abstract: Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.
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公开(公告)号：US20230373955A1
公开(公告)日：2023-11-23
申请号：US18359467
申请日：2023-07-26
Applicant: Amgen Inc.
Inventor： Sebastien CAILLE , Kyle QUASDORF , Philipp C. ROOSEN , Xianqing SHI , Andrew COSBIE , Fang WANG , Zufan WU , Archana NEERGUNDA , Bin Peter QUAN , Lianxiu GUAN
IPC: C07D401/12 , C07D241/04
CPC classification number: C07D401/12 , C07D241/04
Abstract: Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates. (1)
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公开(公告)号：US20230301974A1
公开(公告)日：2023-09-28
申请号：US18313428
申请日：2023-05-08
Applicant: AMGEN INC.
Inventor： Matthew BIO , Sebastien CAILLE , Brian COCHRAN , Yuanqing FANG , Brian M. FOX , Brian S. LUCAS , Lawrence R. MCGEE , Filisaty VOUNATSOS , Sean H. WIEDEMANN , Sarah WORTMAN
IPC: A61K31/451 , C07D211/94 , C07D491/048 , C07C309/25 , C07C309/04 , C07C313/02 , C07C309/35 , C07D498/04 , C07D211/76
CPC classification number: A61K31/451 , C07D211/94 , C07D491/048 , C07C309/25 , C07C309/04 , C07C313/02 , C07C309/35 , C07D498/04 , C07D211/76 , C07B2200/13
Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
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公开(公告)号：US20230192682A1
公开(公告)日：2023-06-22
申请号：US17776950
申请日：2020-11-13
Applicant: AMGEN INC.
Inventor： Michael Thomas CORBETT , Sebastien CAILLE
IPC: C07D471/04 , C07D213/73
CPC classification number: C07D471/04 , C07D213/73
Abstract: The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.
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公开(公告)号：US20180092898A1
公开(公告)日：2018-04-05
申请号：US15820830
申请日：2017-11-22
Applicant: AMGEN INC.
Inventor： Matthew BIO , Sebastien CAILLE , Brian COCHRAN , Yuanqing FANG , Brian M. FOX , Brian S. LUCAS , Lawrence R. MCGEE , Filisaty VOUNATSOS , Sean H. WIEDEMANN , Sarah WORTMAN
IPC: A61K31/451 , C07C309/35 , C07C309/25 , C07C309/04 , C07C313/02 , C07D211/76 , C07D211/94 , C07D491/048 , C07D498/04
CPC classification number: A61K31/451 , C07B2200/13 , C07C309/04 , C07C309/25 , C07C309/35 , C07C313/02 , C07D211/76 , C07D211/94 , C07D491/048 , C07D498/04
Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
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