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公开(公告)号:US07858626B2
公开(公告)日:2010-12-28
申请号:US11830024
申请日:2007-07-30
申请人: Amogh Boloor , Mui Cheung , Ronda Gayle Davis-Ward , Philip Anthony Harris , Kevin Hinkle , Christopher P. Lauderman , Robert Anthony Mook, Jr. , Jeffery Alan Stafford , James Marvin Veal
发明人: Amogh Boloor , Mui Cheung , Ronda Gayle Davis-Ward , Philip Anthony Harris , Kevin Hinkle , Christopher P. Lauderman , Robert Anthony Mook, Jr. , Jeffery Alan Stafford , James Marvin Veal
IPC分类号: C07D403/04 , A61K31/53 , A61P35/00
CPC分类号: C07D239/30 , C07D231/56 , C07D235/08 , C07D403/12 , C07D413/14
摘要: Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译: 本文描述了可用作VEGFR2抑制剂的嘧啶衍生物。 所述的发明还包括制备此类嘧啶衍生物的方法以及使用该嘧啶衍生物的方法来治疗过度增殖性疾病。
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公开(公告)号:US07262203B2
公开(公告)日:2007-08-28
申请号:US11383229
申请日:2006-05-15
申请人: Amogh Boloor , Mui Cheung , Ronda Davis , Philip Anthony Harris , Kevin Hinkle , Robert Anthony Mook, Jr. , Jeffery Alan Stafford , James Marvin Veal
发明人: Amogh Boloor , Mui Cheung , Ronda Davis , Philip Anthony Harris , Kevin Hinkle , Robert Anthony Mook, Jr. , Jeffery Alan Stafford , James Marvin Veal
IPC分类号: C07D239/48 , C07D403/04 , A61K31/506 , A61P27/02
CPC分类号: C07D239/30 , C07D231/56 , C07D235/08 , C07D403/12 , C07D413/14
摘要: Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译: 本文描述了可用作VEGFR2抑制剂的嘧啶衍生物。 所述的发明还包括制备此类嘧啶衍生物的方法以及使用该嘧啶衍生物的方法来治疗过度增殖性疾病。
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公开(公告)号:US07105530B2
公开(公告)日:2006-09-12
申请号:US10451305
申请日:2001-12-19
申请人: Amogh Boloor , Mui Cheung , Ronda Davis , Philip Anthony Harris , Kevin Hinkle , Robert Anthony Mook, Jr. , Jeffery Alan Stafford , James Marvin Veal
发明人: Amogh Boloor , Mui Cheung , Ronda Davis , Philip Anthony Harris , Kevin Hinkle , Robert Anthony Mook, Jr. , Jeffery Alan Stafford , James Marvin Veal
IPC分类号: C07D239/48 , A61K31/506 , A61P27/02
CPC分类号: C07D239/30 , C07D231/56 , C07D235/08 , C07D403/12 , C07D413/14
摘要: Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also Includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译: 本文描述了可用作VEGFR2抑制剂的嘧啶衍生物。 所述的发明还包括制备此类嘧啶衍生物的方法以及使用该嘧啶衍生物的方法来治疗过度增殖性疾病。
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公开(公告)号:US07462614B2
公开(公告)日:2008-12-09
申请号:US10550434
申请日:2004-03-29
申请人: Mui Cheung , Nigel Paul King , Kevin Wayne Kuntz , Robert Anthony Mook, Jr. , Mark Andrew Pobanz , James Michael Salovich , Brian John Wilson
发明人: Mui Cheung , Nigel Paul King , Kevin Wayne Kuntz , Robert Anthony Mook, Jr. , Mark Andrew Pobanz , James Michael Salovich , Brian John Wilson
IPC分类号: C07D487/04 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/14 , A61K31/53 , A61P35/00
CPC分类号: C07D487/04
摘要: The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
摘要翻译: 本发明提供式(I)化合物:其中所有变量如本文所定义,含有该化合物的药物组合物,其制备方法及其作为药剂的用途。
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5.
公开(公告)号:US06187789B1
公开(公告)日:2001-02-13
申请号:US09381719
申请日:2000-01-19
申请人: Eric Cleveland Bigham , Grady Evan Boswell , John Joseph Savarese , Roy Archibald Swaringen, Jr. , Sanjay Shashikant Patel , Eric Eugene Boros , Robert Anthony Mook, Jr. , Vincente Samano
发明人: Eric Cleveland Bigham , Grady Evan Boswell , John Joseph Savarese , Roy Archibald Swaringen, Jr. , Sanjay Shashikant Patel , Eric Eugene Boros , Robert Anthony Mook, Jr. , Vincente Samano
IPC分类号: A61K3147
CPC分类号: C07D217/16 , C07D217/20
摘要: Ultrashort acting neuromuscular blocking agents of Formula (I) which are useful as skeletal muscle relaxants during emergency intubation procedures, routine surgery and post-operative settings are disclosed, wherein: X is a halogen; h is from 1 to 2; Y is hydrogen or methoxy; Z1 and Z2 are methyl; W1 and W2 are carbon; and A is a pharmaceutically acceptable anion.
摘要翻译: 公开了在紧急插管程序,常规手术和术后设置中可用作骨骼肌松弛剂的式(I)的超短促作用神经肌肉阻滞剂,其中:X为卤素; h为1〜2; Y是氢或甲氧基; Z1和Z2是甲基; W1和W2是碳; A是药学上可接受的阴离子。
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公开(公告)号:US07514446B2
公开(公告)日:2009-04-07
申请号:US10545352
申请日:2004-02-11
IPC分类号: A61K31/505 , C07D239/24
CPC分类号: C07D239/42 , C07D239/48 , C07D403/12 , C07D405/12 , C07D413/12
摘要: The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
摘要翻译: 本发明提供式(I)化合物:其中所有变量如本文所定义,含有该化合物的药物组合物,其制备方法及其作为药剂的用途。
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7.
公开(公告)号:US06177445B1
公开(公告)日:2001-01-23
申请号:US09381721
申请日:1999-12-22
申请人: Eric Cleveland Bigham , Grady Evan Boswell , John Joseph Savarese , Roy Archibald Swaringen, Jr. , Sanjay Shashikant Patel , Eric Eugene Boros , Robert Anthony Mook, Jr. , Vincente Samano
发明人: Eric Cleveland Bigham , Grady Evan Boswell , John Joseph Savarese , Roy Archibald Swaringen, Jr. , Sanjay Shashikant Patel , Eric Eugene Boros , Robert Anthony Mook, Jr. , Vincente Samano
IPC分类号: A61K3147
CPC分类号: C07D217/16 , C07D217/20
摘要: Ultra short acting neuromuscular blocking agents of Formula (I) which are useful as skeletal muscle relaxants during emergency intubation procedures, routine surgery and post-operative settings are disclosed, wherein q and t are independently from 0 to 4; X1 and X2 are independently halogen; ha and hb are independenity from 0 to 2; Z1 and Z2 are indepentdently hydrogen, C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl with the proviso that Z1 and Z2 are not both hydrogen; Y1, Y2, and Y3 and Y4 are independently hydrogen, halogen or C1-3 alkoxy; m and p are independently 1 to 6; n and r are independently 0 to 4; with the proviso the if ha and hb are both 0, then r is 0 and n is 0 to 2; R1 to R14 are independently hydrogen, halogen, C1-3 alkoxy, or R2 and R3 together with the carbon atoms to which they are bonded, R5 and R6 together with the carbon atoms to which they are bonded, R9 and R10 together with the carbon atoms to which they are bonded, R12 and R13 together with the carbon atoms to which they are bonded, may independently form a methylenedioxy or ethylenedioxy moiety contained in five- or six-membered ring; W1 and W2 are carbon; and A is a pharmaceutically acceptable anion.
摘要翻译: 公开了在紧急插管程序,常规手术和术后设置中可用作骨骼肌松弛剂的式(I)的超短效神经肌肉阻滞剂,其中q和t独立地为0至4; X1和X2独立地为卤素; ha和hb是从0到2的独立性; Z1和Z2独立地为氢,C1-6烷基,C2-6烯基或C2-6炔基,条件是Z1和Z2不同时为氢; Y1,Y2和Y3和Y4独立地是氢,卤素或C1-3烷氧基; m和p独立地为1至6; n和r分别为0〜4; 条件是如果ha和hb均为0,则r为0且n为0至2; R 1至R 14独立地为氢,卤素,C 1-3烷氧基或R 2和R 3与它们所键合的碳原子一起,R 5和R 6与它们所键合的碳原子一起,R 9和R 10与碳 R12和R13与它们所键合的碳原子一起可以独立地形成五元或六元环中所含的亚甲二氧基或亚乙二氧基部分; W1和W2是碳; A是药学上可接受的阴离子。
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