公开(公告)号：US06694171B1

公开(公告)日：2004-02-17

申请号：US09445977

申请日：2000-03-06

申请人： Amos Breskin ,  Rachel Chechik ,  Zvi Paltiel ,  Bilha Schechter ,  Abraham Warshawsky ,  Abraham Shanzer ,  Michal Neeman

发明人： Amos Breskin ,  Rachel Chechik ,  Zvi Paltiel ,  Bilha Schechter ,  Abraham Warshawsky ,  Abraham Shanzer ,  Michal Neeman

IPC分类号： A61B500

CPC分类号： A61K49/04

摘要： A delivery system and method for targeting a contrast agent to tissues and organs for improved diagnosis of tumors and for prognosis and follow-up of cancer therapy by X-ray imaging. The delivery system includes a conjugate or complex of a macromolecular carrier and a contrast agent selected from the group consisting of: (a) a compound having a heavy element with an atomic number in the range of 75 to 92, and (b) a compound having an element with a property of an abrupt change in its X-ray attenuation coefficient within the energy range used for radiography, said macromolecular carrier of said conjugate or complex being optionally linked to a specific tissue marker molecule.

摘要翻译： 用于将造影剂靶向组织和器官的递送系统和方法，用于改善肿瘤的诊断以及通过X射线成像进行癌症治疗的预后和随访。 递送系统包括大分子载体和造影剂的共轭物或复合物，其选自：（a）原子序数在75至92范围内的重元素的化合物，和（b）化合物 具有在用于放射照相的能量范围内其X射线衰减系数突然变化的性质的元件，所述缀合物或复合物的所述大分子载体任选地连接到特定的组织标记分子。

公开(公告)号：US4717877A

公开(公告)日：1988-01-05

申请号：US911576

申请日：1986-09-25

申请人： Zvi Taicher ,  Shmuel Shtrikman ,  Zvi Paltiel ,  Mordechai Shporer

发明人： Zvi Taicher ,  Shmuel Shtrikman ,  Zvi Paltiel ,  Mordechai Shporer

IPC分类号： G01R33/383 ,  G01V3/32 ,  G01R33/20

CPC分类号： G01V3/32 ,  G01R33/383

摘要： Nuclear magnetic resonance sensing apparatus includingone or more magnets operative to generate a static magnetic field in a region remote therefrom containing materials sought to be analyzed, the one or more magnets defining a longitudinal axis, the static magnetic field having a static field direction substantially perpendicular to the longitudinal axis and having generally uniform amplitude along the azimuth with respect to the longitudinal axis in the remote region;apparatus for generating a variable magnetic field in said remote region in a direction substantially parallel to the static magnetic field;apparatus for generating a radio frequency magnetic field in the remote region for exciting nuclei of the materials sought to e analyzed and having a radio frequency magnetic field direction substantially perpendicular to both the longitudinal axis and to the static field direction; andapparatus for receiving nuclear magnetic resonance signals from the excited nuclei and for providing an output indication of the properties of the materials sought to be analyzed.Methods for nuclear magnetic resonance sensing are also described and claimed.

摘要翻译： 核磁共振传感装置包括一个或多个磁体，其操作以在远离其的区域中产生静态磁场，其中包含寻求分析的材料，所述一个或多个磁体限定纵向轴线，该静磁场具有基本垂直的静态场方向 沿着纵向轴线并且沿着相对于远程区域中的纵向轴线的方位角具有大致均匀的振幅; 用于在所述远程区域中沿与所述静磁场大致平行的方向产生可变磁场的装置; 用于在所述远程区域中产生用于激发被分析的材料的核的并具有基本上垂直于所述纵向轴线和静态磁场方向的射频磁场方向的射频磁场的装置; 以及用于从激发的核接收核磁共振信号并提供寻求分析的材料的性质的输出指示的装置。 还描述和要求保护核磁共振感测的方法。

公开(公告)号：US5966196A

公开(公告)日：1999-10-12

申请号：US20397

申请日：1998-02-09

申请人： Eduardo Svetliza ,  Dov Freiman ,  Zvi Paltiel

发明人： Eduardo Svetliza ,  Dov Freiman ,  Zvi Paltiel

IPC分类号： A61B3/125 ,  A61B3/10

CPC分类号： A61B3/125

摘要： Apparatus for wide angle examination of the eye fundus is provided. The apparatus includes an optical module providing a wide angle view image of the eye fundus and an image capturing unit connected to the optical module for capturing the wide angle view image. According to one aspect of the invention, the optical module includes a front lens complex for providing a primary large scale image of the fundus and an optical relay, connected to the front lens complex, for transforming the primary large scale image into a small scale image.

摘要翻译： 提供了用于眼底广角检查的装置。 该装置包括提供眼底广角图像的光学模块和连接到用于捕获广角视图图像的光学模块的图像捕获单元。 根据本发明的一个方面，光学模块包括用于提供眼底的初级大规模图像的前透镜复合体和连接到前透镜复合体的光继电器，用于将初级大尺度图像变换成小尺度图像 。

公开(公告)号：US4714885A

公开(公告)日：1987-12-22

申请号：US892105

申请日：1986-08-04

申请人： Zvi Paltiel ,  Amir Ban

发明人： Zvi Paltiel ,  Amir Ban

IPC分类号： G01R33/485 ,  G01R33/54 ,  G01R33/565 ,  G01R33/20

CPC分类号： G01R33/4828 ,  G01R33/485 ,  G01R33/56563

摘要： A method of obtaining a separate data contribution from first and second spectral components during a single magnetic resonance scan. The method uses a scan sequence causing the data from the first and second spectral components to be 90 degrees out of phase. This shift of the data along with a measurement of the inhomegeneities of the field initiates two output signals which are used to provide all of the data required for imaging the two spectral components and/or correcting images for chemical shifts.

摘要翻译： 一种在单个磁共振扫描期间从第一和第二光谱分量获得单独的数据贡献的方法。 该方法使用导致来自第一和第二光谱分量的数据相位为90度的扫描序列。 数据的这种移动以及场的不均匀性的测量启动了两个输出信号，这两个输出信号用于提供成像两个光谱分量所需的全部数据和/或用于化学位移的校正图像。

公开(公告)号：US4644280A

公开(公告)日：1987-02-17

申请号：US652462

申请日：1984-09-20

申请人： Zvi Paltiel

发明人： Zvi Paltiel

IPC分类号： G01R33/56 ,  G01R33/20

CPC分类号： G01R33/5604

摘要： A slice selection arrangement for MRI systems uses a psuedo-spin echo procedure by applying a 90 degree RF pulse in the presence of gradient pulse, applied in the direction of the encoding pulses; applying the 180 degree RF pulse in the presence of a gradient in another orthogonal direction and reading out the echo in the presence of the third orthogonal gradient pulse. Aliasing artifacts are avoided even though the section imaged is smaller than the object size, allowing zooming and/or a reduced number of encoding cycles for single slice imaging.

摘要翻译： 用于MRI系统的切片选择装置使用伪自旋回波程序，通过在存在梯度脉冲的情况下施加90度RF脉冲，施加在编码脉冲的方向上; 在另一个正交方向存在梯度的情况下应用180度RF脉冲，并在存在第三正交梯度脉冲的情况下读出回波。 即使所成像的部分小于对象尺寸，允许缩放和/或减少数量的编码周期用于单片成像也避免了别名假象。

公开(公告)号：US5212447A

公开(公告)日：1993-05-18

申请号：US624975

申请日：1990-12-03

申请人： Zvi Paltiel

发明人： Zvi Paltiel

IPC分类号： G01R33/20 ,  G01N24/08 ,  G01R33/44 ,  G01R33/563 ,  G01V3/14 ,  G01V3/32

CPC分类号： G01V3/32 ,  G01R33/56341

摘要： A method for conducting borehole NMR measurements comprising the steps of:providing a magnetic field and a magnetic field gradient at a desired location along a borehole;carrying out at least one NMR experiment in the presence of the magnetic field gradient;sensing the diffusion effect on the decay of at least the first echo; anddetermining therefrom the diffusion coefficient.Apparatus for carrying out the method is also described.