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公开(公告)号：US4215219A
公开(公告)日：1980-07-29
申请号：US802897
申请日：1977-06-02
IPC分类号： B01J45/00 , C07C45/68 , C07C205/22 , C07D213/06 , C07D213/16 , C07D215/24 , C07D215/26 , C08F8/00 , C08F8/24 , C08F8/30 , C08F212/00 , C22B3/26 , C07D215/14 , C07C119/00
CPC分类号： C07D213/16 , B01J45/00 , C07C205/22 , C07C205/45 , C07C45/68 , C07D213/06 , C07D215/24 , C07D215/26 , C08F8/24 , C08F8/30 , C22B3/0097 , C22B3/42 , Y02P10/234
摘要： A process for producing reagents useful in organic synthesis, for removing metal values from solutions thereof, for the capture of aldehydes, of the general formula ##STR1## wherein Z designates a recurring part (CH.sub.2 --CH--CH.sub.2) of a polymeric backbone of a polymer like polystyrene, of a copolymer comprising polystyrene and divinylbenzene, and butadiene, or other copolymers comprising styrene moieties; or wherein Z is the aliphatic moiety of a long-chain aralkyl compound having a terminal aryl group; or wherein Z designates alkyl; corresponding compounds wherein instead of the optionally substituted phenyl group there is present an optionally substituted naphthyl group; wherein n is an integer of from 1 to 15, and wherein Q designates a group selected from: ##STR2## wherein R designates --H, lower alkyl, aryl, which may be substituted and wherein R" designates --H, alkyl, aryl, halogen, nitro or carboxy, or ##STR3## wherein R is --H, lower alkyl, aryl (which may be substituted), R.sub.1 is --H, alkyl, aryl (which may be substituted), R.sub.2 is --H, alkyl, aryl or substituted aryl, and wherein Y is --H or a non-interferring substituent, which comprises chemically binding an activated chemical moiety to a group ##STR4## or a corresponding naphthyl-containing group, wherein Z is as defined above, according to the reaction scheme: ##STR5## wherein Q is as defined above, or a functional group which can be converted to such group after the chemical bonding; and X is --Cl or --Br.
摘要翻译： 一种制备用于有机合成的试剂的方法，用于从其溶液中除去金属，用于捕获醛，通式为：其中Z表示聚合物主链的重复部分（CH 2 -CH-CH 2） 聚苯乙烯，包含聚苯乙烯和二乙烯基苯的共聚物，丁二烯，或包含苯乙烯部分的其它共聚物; 或其中Z是具有末端芳基的长链芳烷基化合物的脂族部分; 或其中Z表示烷基; 相应的化合物，其中代替任选取代的苯基存在任选取代的萘基; 其中n是1至15的整数，并且其中Q表示选自以下的基团：其中R表示-H，低级烷基，可被取代的芳基，其中R' 表示-H，烷基，芳基，卤素，硝基或羧基，或其中R是-H，低级烷基，芳基（其可被取代的），R 1是-H，烷基，芳基（ 其可以被取代），R2是-H，烷基，芳基或取代的芳基，并且其中Y是-H或非干扰性取代基，其包括将活化的化学部分与基团或相应的萘基 - 其中Z如上所定义，根据反应方案：其中Q如上所定义，或在化学键合后可以转化为这种基团的官能团; X是-Cl或-Br。
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公开(公告)号：US4154674A
公开(公告)日：1979-05-15
申请号：US817808
申请日：1977-07-21
摘要： The present process causes selective removal of a predetermined anionic or cationic constituent from a mixture containing a plurality of constituents by contacting the mixture with an extraction agent so as to remove the desired constituent from the mixture, and if desired eluting the constituent from the extraction agent, thus recovering the extracting agent for further use. The extraction agent has the general formulaRY [(XO).sub.n --X] YR'wherein X is a group (CH.sub.2 --CH.sub.2) or (CH.sub.2 --CHR.sup.1) where R.sup.1 is alkyl, aryl or a non-interfering functional substituent, n is an integer between 2 and 100 which defines the molecular weight of the glycol or glycol derivative, and wherein R and R', which may be identical or different, each designates:(a) R and R' are hydrocarbon groups selected from alkyl, aryl and aralkyl;(b) R and R' are as defined in (a), one at least of R and R' being a group ##STR1## WHEREIN R.sub.a is a non-interfering substitutent; R.sub.b is --H, --OH, --COR.sub.d, CR.sub.d NOH, --NO.sub.2 m --COOH, halogen or a non-interfering substituent,R.sub.c is --OH or --SH,R.sub.d is --H, alkyl, aralkyl(c) R and R' are [X'], X' being a group ##STR2## (D) R and R' designate a polymeric backbone or a group as defined under (a), (b) or (c), above at least one of R and R' being a polymeric backbone, and Y is O or --NH.
摘要翻译： 本发明方法通过使混合物与提取剂接触，从含有多种成分的混合物中选择性除去预定的阴离子或阳离子成分，从混合物中除去所需的成分，如果需要，则从提取剂 ，从而回收提取剂进一步使用。 提取剂具有通式RY [（XO）nX] YR'其中X是基团（CH 2 -CH 2）或（CH 2 -CHR），其中R 1是烷基，芳基或不干扰官能取代基，n是整数 在2和100之间，其限定了二醇或二醇衍生物的分子量，并且其中R和R'可以相同或不同，各自表示：
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公开(公告)号：US4317887A
公开(公告)日：1982-03-02
申请号：US65751
申请日：1979-08-10
IPC分类号： C01G3/00 , C07D215/26 , C07F9/09 , C07F9/165 , C07F9/20 , C07F9/53 , C08F8/00 , C22B3/26 , C22B3/30 , C22B3/36 , C22B3/38 , B01J45/00
CPC分类号： C07F9/09 , C01G3/003 , C07D215/26 , C07F9/165 , C07F9/20 , C07F9/53 , C08F8/02 , C08F8/26 , C08F8/30 , C08F8/32 , C08F8/34 , C08F8/38 , C08F8/44 , C22B3/0017 , C22B3/0036 , C22B3/0052 , C22B3/0066 , C22B3/0067 , C22B3/007 , C22B3/0097 , C08F2810/20 , Y02P10/234
摘要： Novel polyfunctional compounds and polymers are disclosed of the general formula ##STR1## wherein Q designates -X' or -X-.epsilon.-R; where X' designates ##STR2## where .alpha. is --OH, or --SH;.beta. is --OH, --SH, --NH.sub.2, --NO.sub.2, --CO--R.sub.2, --R.sub.2 C.dbd.N--OH, --COOH, -hal, alkyl, aryl, or aralkyl; halogen being chlorine or bromine;.gamma. is a non-interfering substituent;where .beta. and .gamma. may form together a hydrocarbyl ring system;where .delta. is --(CH.sub.2).sub.n -- or --SO.sub.2 --;where X is --O--, --S--, --NH--, --N.sup.+ R.sub.2 R.sub.3 Cl.sup.- or --P--;where.epsilon. is --(CH.sub.2).sub.n --, --SO.sub.2 --, --NH-- or --CH.sub.2 (O-CH.sub.2 --CH.sub.2).sub.n --; ##STR3## wherein the upwardly directed bonds are connected to the R polymer molecule and the downwardly directed bonds are connected to .delta. groups;n is an integer of from 1 to 15 or zero;R is a polymeric backbone, alkyl or aralkyl; andR.sub.2, R.sub.3 and R.sub.4 which may be identical or different, each designates hydrogen, alkyl, aryl or aralkyl. These compounds are useful as ion-exchange agents, extractants, biocides, flameproofing agents, fire retardants, metal polishing agents and rust inhibitors. Metals may be selectively extracted from solution thereof by means of these compounds and polymers.
摘要翻译： 公开了通式“IMAGE”的新型多官能化合物和聚合物，其中Q表示-X'或-X-ε-R; 其中X'表示
SP（S）（OR2）2; NH2; NHR2; NR2R3; N + R2R3R4Cl- 其中α是-OH或-SH; β是-OH，-SH，-NH 2，-NO 2，-CO-R 2，-R 2 C = N-OH，-COOH， - 卤素，烷基，芳基或芳烷基; 卤素是氯或溴; γ是非干扰取代基; 其中β和γ可以一起形成烃基环体系; 其中δ是 - （CH 2）n - 或-SO 2 - ; 其中X是-O - ， - S - ， - NH - ， - N + R2R3Cl-或-P-; 其中ε是 - （CH 2）n - ， - SO 2 - ， - NH-或-CH 2（O-CH 2 -CH 2）n - 其中向上指向的键连接到R聚合物分子并且向下指向的键连接到δ基团; n为1至15的整数或零; R是聚合物主链，烷基或芳烷基; 和R 2，R 3和R 4可以相同或不同，各自表示氢，烷基，芳基或芳烷基。 这些化合物可用作离子交换剂，萃取剂，杀生物剂，防火剂，阻燃剂，金属抛光剂和防锈剂。 金属可以通过这些化合物和聚合物从其溶液中选择性提取。 -
公开(公告)号：US4085261A
公开(公告)日：1978-04-18
申请号：US545220
申请日：1975-01-29
IPC分类号： B01J45/00 , C07C45/68 , C07C205/22 , C07D213/06 , C07D213/16 , C07D215/24 , C07D215/26 , C08F8/00 , C08F8/24 , C08F8/30 , C08F212/00 , C22B3/26 , B01D11/00 , C08C19/00 , C08F232/00
CPC分类号： C07D213/16 , B01J45/00 , C07C205/22 , C07C205/45 , C07C45/68 , C07D213/06 , C07D215/24 , C07D215/26 , C08F8/24 , C08F8/30 , C22B3/0097 , C22B3/42 , Y02P10/234
摘要： A process for producing reagents useful in organic synthesis, for removing metal values from solutions thereof, for the capture of aldehydes, of the general formula ##STR1## wherein Z designates a recurring part (CH.sub.2 --CH--CH.sub.2 -- of a polymeric backbone of a polymer like polystyrene, of a copolymer comprising polystyrene and divinylbenzene, and butadiene, or other copolymers comprising styrene moieties; or wherein Z is the aliphatic moiety of a long-chain aralkyl compound having a terminal aryl group; or wherein Z designates alkyl; corresponding compounds wherein instead of the optionally substituted phenyl group there is present an optionally substituted naphthyl group; wherein n is an integer of from 1 to 15, and wherein Q designates a group selected from: ##STR2## wherein R designates --H, lower alkyl, aryl, which may be substituted and wherein R" designates --H, alkyl, aryl, halogen, nitro or carboxy, or ##STR3## wherein R is --H, lower alkyl, aryl (which may be substituted), R.sub.1 is --H, alkyl, aryl (which may be substituted), R.sub.2 is --H, alkyl, aryl or substituted aryl, and wherein Y is --H or a non-interfering substituent;which comprises chemically binding an activated chemical moiety to a group Z- -, or a corresponding naphthyl-containing group, wherein Z is as defined above, according to the reaction scheme: ##STR4## wherein Q is as defined above, or a functional group which can be converted to such group after the chemical bonding; and X is --Cl or --Br.
摘要翻译： 用于生产有机合成中的试剂的方法，用于从其溶液中除去金属，用于捕获醛，通式为“IMAGE”，其中Z表示重复部分（CH2-CH-CH2- 聚苯乙烯，包含聚苯乙烯和二乙烯基苯的共聚物，丁二烯或包含苯乙烯部分的其它共聚物;或其中Z是具有末端芳基的长链芳烷基化合物的脂族部分;或其中Z表示烷基;相应的化合物 其中代替任选取代的苯基，存在任选取代的萘基;其中n为1至15的整数，并且其中Q表示选自以下的基团：
其中R表示-H，可以被取代的低级烷基，芳基，其中R“表示-H，烷基，芳基，卤素，硝基或羧基，或者” IMAGE> wherei n为低级烷基，芳基（其可被取代），R 1为-H，烷基，芳基（其可被取代），R 2为-H，烷基，芳基或取代的芳基，并且其中Y为-H 或非干扰性取代基; 其包括根据反应方案将活化的化学部分与基团Z-或相应的含萘基团（其中Z如上所定义）化学结合：其中Q如上所定义 或在化学键合后可以转化为这种基团的官能团; X是-Cl或-Br。 -
5.发明授权Neuroprotective iron chelators and pharmaceutical compositions comprising them 有权神经保护性铁螯合剂和包含它们的药物组合物公开(公告)号：US08058442B2
公开(公告)日：2011-11-15
申请号：US10534357
申请日：2003-11-07
申请人： Moussa Youdim , Matitiyahu Fridkin , Hailin Zheng , Abraham Warshawsky , Rivka Warshawsky, legal representative
IPC分类号： C07D215/38
CPC分类号： C07D295/15 , A61K38/00 , A61K45/06 , A61K47/547 , C07D213/69 , C07D215/26 , C07D295/205 , C07K7/06 , C07K7/22 , C07K7/23 , C07K14/57563 , C07K14/70 , Y02A50/411
摘要： Novel iron chelators exhibiting neuroprotective and good transport properties are useful in iron chelation therapy for treatment of a disease, disorder or condition associated with iron overload and oxidative stress, eg. a neurodegenerative or cerebrovascular disease or disorder, a neoplastic disease, hemochromatosis, thalassemia, a cardiovascular disease, diabetes, a inflammatory disorder, anthracycline cardiotoxicity, a viral infection, a protozoal infection, a yeast infection, retarding ageing, and prevention and/or treatment of skin ageing and skin protection against sunlight and/or UV light. The iron chelator function is provided by a 8-hydroxyquinoline, a hydroxypyridinone or a hydroxamate moiety, the neuroprotective function is imparted to the compound e.g. by a neuroprotective peptide, and a combined antiapoptotic and neuroprotective function by a propargyl group.
摘要翻译： 显示出神经保护和良好转运性质的新型铁螯合剂可用于铁螯合治疗用于治疗与铁过载和氧化应激相关的疾病，病症或病症，例如， 神经变性或脑血管疾病或病症，肿瘤性疾病，血色素沉着病，地中海贫血，心血管疾病，糖尿病，炎症性疾病，蒽环类心脏毒性，病毒感染，原生动物感染，酵母感染，延迟衰老以及预防和/或治疗 的皮肤老化和皮肤防晒防晒和/或紫外线。 铁螯合剂功能由8-羟基喹啉，羟基吡啶酮或异羟肟酸盐部分提供，神经保护功能被赋予化合物例如 通过神经保护肽，以及由炔丙基组合的抗细胞凋亡和神经保护功能。
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公开(公告)号：US06694171B1
公开(公告)日：2004-02-17
申请号：US09445977
申请日：2000-03-06
申请人： Amos Breskin , Rachel Chechik , Zvi Paltiel , Bilha Schechter , Abraham Warshawsky , Abraham Shanzer , Michal Neeman
发明人： Amos Breskin , Rachel Chechik , Zvi Paltiel , Bilha Schechter , Abraham Warshawsky , Abraham Shanzer , Michal Neeman
IPC分类号： A61B500
CPC分类号： A61K49/04
摘要： A delivery system and method for targeting a contrast agent to tissues and organs for improved diagnosis of tumors and for prognosis and follow-up of cancer therapy by X-ray imaging. The delivery system includes a conjugate or complex of a macromolecular carrier and a contrast agent selected from the group consisting of: (a) a compound having a heavy element with an atomic number in the range of 75 to 92, and (b) a compound having an element with a property of an abrupt change in its X-ray attenuation coefficient within the energy range used for radiography, said macromolecular carrier of said conjugate or complex being optionally linked to a specific tissue marker molecule.
摘要翻译： 用于将造影剂靶向组织和器官的递送系统和方法，用于改善肿瘤的诊断以及通过X射线成像进行癌症治疗的预后和随访。 递送系统包括大分子载体和造影剂的共轭物或复合物，其选自：（a）原子序数在75至92范围内的重元素的化合物，和（b）化合物 具有在用于放射照相的能量范围内其X射线衰减系数突然变化的性质的元件，所述缀合物或复合物的所述大分子载体任选地连接到特定的组织标记分子。
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7.发明授权Process for the production of halomethylating agents which are of low volatility 失效制备挥发性低的卤代甲基化剂的方法
公开(公告)号：US4568700A
公开(公告)日：1986-02-04
申请号：US525619
申请日：1983-08-22
申请人： Abraham Warshawsky , Abraham Deshe
发明人： Abraham Warshawsky , Abraham Deshe
IPC分类号： C08F8/24
CPC分类号： C08F8/24
摘要： There is provided a process for the production of halomethylating agents which are of low volatility; and a process for the halomethylation of aromatic substrates and aromatic polymeric substances. Among products produced from the halomethylaryl polymers there are anion exchange resins.
摘要翻译： 提供了一种制备低挥发性的卤代甲基化剂的方法; 以及芳族底物和芳族聚合物质的卤甲基化方法。 在由卤代甲基芳基聚合物生产的产品中有阴离子交换树脂。
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8.发明授权Impregnated resins for extraction of metals and processes of production and use thereof 失效用于金属萃取的浸渍树脂及其生产和使用方法
公开(公告)号：US4220726A
公开(公告)日：1980-09-02
申请号：US817807
申请日：1977-07-21
申请人： Abraham Warshawsky
发明人： Abraham Warshawsky
IPC分类号： B01J31/06 , C01G3/00 , C01G9/00 , C01G53/00 , C08J5/20 , C22B3/00 , C22B15/00 , C22B60/02 , B01D15/08 , B01J8/06 , C08J9/40
CPC分类号： B01J20/28097 , C01G3/003 , C01G53/003 , C01G9/003 , C22B15/0089 , C22B3/24 , C22B3/42 , C22B60/0265 , Y02P10/234 , Y02P10/236
摘要： Extraction agents for the extraction of copper, zinc, uranium and nickel, or any of these, from aqueous solutions containing same, comprise a macroporous polymer supporting a specific extractant for such metal, the polymer being rendered hydrophilic by the method of impregnation or by attachment thereon of suitable functional groups, or by attaching such functional groups to the extraction agent, or by coabsorbing on said polymer an agent adapted to render the polymer hydrophilic. Such extraction agents may be produced by impregnating a macroporous polystyrene with a specific metal extraction agent in the presence of a diluent for the extraction agent, removing external diluent, contacting the product with a solution of the metal to be extracted, and removing the metal from the extraction agent by a suitable eluting agent. Alternatively, a macroporous polymer may be impregnated with a selective extraction agent complexed with the metal to be extracted in the presence of a diluent, the external diluent removed and the metal eluted with a suitable eluent. Furthermore, macroporous polymers containing finely dispersed metal powders may be prepared, which polymers can be used as catalyst in organic synthesis.
摘要翻译： 用于从含有它们的水溶液中提取铜，锌，铀和镍或其中任何一种的提取剂包括支持用于这种金属的特定提取剂的大孔聚合物，所述聚合物通过浸渍或附着方法使其亲水 或通过将这些官能团连接到萃取剂上，或通过在所述聚合物上共吸附适于使聚合物亲水的试剂。 这样的提取剂可以通过在用于萃取剂的稀释剂存在下用特定金属萃取剂浸渍大孔聚苯乙烯来制备，除去外部稀释剂，使产物与待萃取的金属溶液接触，并将金属从 萃取剂通过合适的洗脱剂。 或者，可以在稀释剂存在下用选择性提取剂与待萃取的金属一起浸渍大孔聚合物，除去外部稀释剂并用合适的洗脱剂洗脱金属。 此外，可以制备含有细分散金属粉末的大孔聚合物，该聚合物可用作有机合成中的催化剂。
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公开(公告)号：US4898734A
公开(公告)日：1990-02-06
申请号：US162161
申请日：1988-02-29
CPC分类号： A01N25/34 , A61K9/1641 , A61K9/1647 , A61K9/2077 , A61K9/2081 , A61K9/7023 , B01J13/025
摘要： The present invention is a method to produce novel composites based on microcapsules or microspheres embedded in contiuous polymeric matrices. Both non-bioerodible and erodible polymers can be used. Material can be incorporated into the microcapsules or microspheres for subsequent release. In one embodiment of the present invention, spheres are homogeneously dispersed in a polymer matrix and then forced to release their contents by exposure to temperature, light or ultrasound. Alternatively, polymers which degrade as a function of time or hydrolysis can be used for controlled releases. The polymer composites have completely different properties from either a continuous polymer matrix or microcapsules or microspheres and are therefore useful for a wide variety of applications. When carbon tetrachloride is the incorporated material, the film is useful as a flame retarding device. When foaming agents are used, especially UV or heat sensitive materials, gas can be evolved inside each capsulThe Government has rights in this invention pursuant to Grant Number 5-R01-GM26698 awarded by the Department of Health and Human Services.
摘要翻译： 本发明是一种基于嵌入在连续聚合物基质中的微胶囊或微球体生产新型复合材料的方法。 可以使用非生物可腐蚀和可侵蚀的聚合物。 可以将材料并入微胶囊或微球体中用于随后的释放。 在本发明的一个实施方案中，球体均匀地分散在聚合物基质中，然后通过暴露于温度，光或超声波被迫释放其内容物。 或者，作为时间或水解的函数降解的聚合物可用于受控释放。 聚合物复合材料与连续聚合物基质或微胶囊或微球具有完全不同的性质，因此可用于各种应用。 当四氯化碳是引入的材料时，该膜可用作阻燃装置。 当使用发泡剂，特别是UV或热敏材料时，可在每个胶囊内放出气体，以在聚合物中形成气泡。 当药物或其他生物活性剂掺入球体并用聚合物包封时，仅通过侵蚀或破裂的球体释放。 与从包封的微胶囊的释放相反，从聚合物复合材料的释放大约是随时间线性的。 聚合物球体的侵蚀也可用于产生多孔聚合物结构。 这种装置可用于透皮药物递送，血管移植物，伤口愈合膜或作为聚合物多孔膜。
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10.发明申请NEUROPROTECTIVE IRON CHELATORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM 有权神经保护性铁器和包含它们的药物组合物公开(公告)号：US20120058945A1
公开(公告)日：2012-03-08
申请号：US13296061
申请日：2011-11-14
IPC分类号： A61K38/09 , A61K38/00 , A61P25/28 , A61K31/497 , A61P25/00 , A61K31/4412 , C07K5/10 , C07K7/06 , A61P25/16 , A61K38/22 , A61K31/47
CPC分类号： C07D295/15 , A61K38/00 , A61K45/06 , A61K47/547 , C07D213/69 , C07D215/26 , C07D295/205 , C07K7/06 , C07K7/22 , C07K7/23 , C07K14/57563 , C07K14/70 , Y02A50/411
摘要： Novel iron chelators exhibiting neuroprotective and good transport properties are useful in iron chelation therapy for treatment of a disease, disorder or condition associated with iron overload and oxidative stress, e.g., a neurodegenerative or cerebrovascular disease or disorder, a neoplastic disease, hemochromatosis, thalassemia, a cardiovascular disease, diabetes, an inflammatory disorder, anthracycline cardiotoxicity, a viral infection, a protozoal infection, a yeast infection, retarding aging, and prevention and/or treatment of skin aging and skin protection against sunlight and/or UV light. The iron chelator function is provided by a 8-hydroxyquinoline, a hydroxypyridinone or a hydroxamate moiety. The neuroprotective function is imparted to the compound, e.g., by a neuroprotective peptide. A combined antiapoptotic and neuroprotective function is provided by a propargyl group.
摘要翻译： 表现出神经保护和良好转运性质的新型铁螯合剂可用于铁螯合治疗用于治疗与铁超载和氧化应激相关的疾病，病症或病状，例如神经变性或脑血管疾病或病症，肿瘤性疾病，血色素沉着症，地中海贫血症， 心血管疾病，糖尿病，炎性疾病，蒽环类心脏毒性，病毒感染，原生动物感染，酵母感染，延迟衰老，以及防止和/或治疗针对阳光和/或紫外光的皮肤老化和皮肤保护。 铁螯合剂功能由8-羟基喹啉，羟基吡啶酮或异羟肟基部分提供。 神经保护功能被赋予化合物，例如通过神经保护肽。 由炔丙基提供组合的抗细胞凋亡和神经保护功能。
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