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公开(公告)号：US06958239B2
公开(公告)日：2005-10-25
申请号：US09211794
申请日：1998-12-15
IPC分类号： C12N15/113 , C12N5/00 , C07H21/04
CPC分类号： C12N15/113 , C12N2310/311 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/346 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527
摘要： This invention relates to antisense oligonucleotides that target mRNAs in cells as substrates for the cellular enzyme RNase H and thereby cause specific degradation of the targeted mRNA. The oligonucleotides have three components: an RNase H activating region, a complementary region and 3′ and 5′ ends. The invention optimizes each of the components to resist intracellular nucleases, to increase hybridization to target mRNA, to specifically inactivate target mRNA in cells, and to decrease cytotoxicity.
摘要翻译： 本发明涉及靶细胞中的mRNA作为细胞酶RNase H底物的反义寡核苷酸，从而导致目标mRNA的特异性降解。 寡核苷酸具有三个组分：RNA酶H活化区，互补区和3'和5'末端。 本发明优化每种组分以抵抗细胞内核酸酶，增加与靶mRNA的杂交，以特异性地灭活细胞中的靶mRNA，并降低细胞毒性。
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公开(公告)号：US5989912A
公开(公告)日：1999-11-23
申请号：US211795
申请日：1998-12-15
IPC分类号： C12N15/113 , C07H21/04 , C12N15/00 , C12Q1/68
CPC分类号： C12N15/113 , C12N2310/311 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/346
摘要： This invention relates to antisense oligonucleotides that target mRNAs in cells as substrates for the cellular enzyme RNase H and thereby cause specific degradation of the targeted mRNA. The oligonucleotides have three components: a RNase H activating region, a complementarity region and 3' and 5' ends. The invention optimizes each of the components to resist intracellular nucleases, to increase hybridization to target mRNA, to specifically inactivate target mRNA in cells, and to decrease cytotoxicity.
摘要翻译： 本发明涉及靶细胞中的mRNA作为细胞酶RNase H底物的反义寡核苷酸，从而导致目标mRNA的特异性降解。 寡核苷酸具有三个组分：RNase H激活区，互补区和3'和5'末端。 本发明优化每种组分以抵抗细胞内核酸酶，增加与靶mRNA的杂交，以特异性地灭活细胞中的靶mRNA，并降低细胞毒性。
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公开(公告)号：US07691996B2
公开(公告)日：2010-04-06
申请号：US11035693
申请日：2005-01-14
CPC分类号： C12N15/113 , C12N2310/311 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/346 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527
摘要： This invention relates to antisense oligonucleotides that target mRNAs in cells as substrates for the cellular enzyme RNase H and thereby cause specific degradation of the targeted mRNA. The oligonucleotides have three components: an RNase H activating region, a complementary region and 3′ and 5′ ends. The invention optimizes each of the components to resist intracellular nucleases, to increase hybridization to target mRNA, to specifically inactivate target mRNA in cells, and to decrease cytotoxicity.
摘要翻译： 本发明涉及靶细胞中的mRNA作为细胞酶RNase H底物的反义寡核苷酸，从而导致目标mRNA的特异性降解。 寡核苷酸具有三个组分：RNA酶H活化区，互补区和3'和5'末端。 本发明优化每种组分以抵抗细胞内核酸酶，增加与靶mRNA的杂交，以特异性地灭活细胞中的靶mRNA，并降低细胞毒性。
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公开(公告)号：US5849902A
公开(公告)日：1998-12-15
申请号：US754580
申请日：1996-11-21
申请人： Amy Arrow , Roderic M.K. Dale , Tod Mitchell Woolf
发明人： Amy Arrow , Roderic M.K. Dale , Tod Mitchell Woolf
IPC分类号： C12N15/09 , A61K31/7125 , A61K48/00 , C07H21/00 , C12N15/113 , C02Q1/68 , C07H21/04
CPC分类号： C12N15/113 , C12N2310/311 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/346
摘要： This invention relates to antisense oligonucleotides that target mRNAs in cells as substrates for the cellular enzyme RNase H and thereby cause specific degradation of the targeted mRNA. The oligonucleotides have three components: a RNase H activating region, a complementarity region and 3' and 5' ends. The invention optimizes each of the components to resist intracellular nucleases, to increase hybridization to target mRNA, to specifically inactivate target mRNA in cells, and to decrease cytotoxicity.
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5.发明授权Compositions and methods of treatment of androgen-associated baldness using antisense oligomers 失效使用反义寡聚体治疗雄激素相关秃发的组合物和方法
公开(公告)号：US5877160A
公开(公告)日：1999-03-02
申请号：US483464
申请日：1995-06-07
CPC分类号： A61K31/70 , A61K47/48 , A61K8/606 , A61Q7/00 , C07H21/00 , C12N15/113 , C12N15/1137 , C12N15/1138 , C12Y103/99005 , C12N2310/15 , C12N2310/152 , C12N2310/3125
摘要： Compositions and methods of treating androgen-associated hair loss, in particular decreasing the progression of male pattern baldness using a nucleoside Oligomer or Oligomers useful in the described methods are provided.
摘要翻译： 提供治疗雄激素相关脱发的组合物和方法，特别是使用核苷降低男性型秃发的进展在所述方法中有用的低聚物或低聚物。
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