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    Silicon photonic wire waveguide biosensor
    4.
    发明授权
    Silicon photonic wire waveguide biosensor 有权
    硅光子线波导生物传感器

    公开(公告)号：US07778499B2

    公开(公告)日：2010-08-17

    申请号：US11898660

    申请日：2007-09-13

    申请人： Siegfried Janz ,  Pavel Cheben ,  Andre Delage ,  Adam Densmore ,  Dan-Xia Xu

    发明人： Siegfried Janz ,  Pavel Cheben ,  Andre Delage ,  Adam Densmore ,  Dan-Xia Xu

    IPC分类号： G02B6/00

    CPC分类号： G02B6/12007 ,  G01N21/7703 ,  G01N21/7746 ,  G01N2021/7779 ,  G01N2021/7783 ,  G02B6/2813

    摘要： Methods and devices relating to a sensor for use in detecting and monitoring molecular interactions. A silicon waveguide sensing element is provided along with a layer of silicon. A silicon oxide layer is also provided between the waveguide element and the layer of silicon. The sensing element is adjacent to an aqueous solution in which the molecular interactions are occurring. A light beam travelling in the silicon waveguide creates an evanescent optical field on the surface of the sensing element adjacent to the boundary between the sensing element and the aqueous medium. Molecular interactions occurring on this surface affect the intensity or the phase of the light beam travelling through the waveguide by changing the effective refractive index of the medium. By measuring the effect on the intensity, phase, or speed of the light beam, the molecular interactions can be detected and monitored in real time.

    摘要翻译： 与用于检测和监测分子相互作用的传感器相关的方法和装置。 硅波导传感元件与硅层一起提供。 在波导元件和硅层之间还提供氧化硅层。 传感元件与发生分子相互作用的水溶液相邻。 在硅波导中行进的光束在感测元件的表面上邻近感测元件和水性介质之间的边界产生消逝的光场。 通过改变介质的有效折射率，在该表面上发生的分子相互作用影响穿过波导的光束的强度或相位。 通过测量对光束的强度，相位或速度的影响，可以实时检测和监测分子相互作用。

    PRISM COUPLED SILICON ON INSULATOR SENSOR
    5.
    发明申请
    PRISM COUPLED SILICON ON INSULATOR SENSOR 审中-公开
    绝缘子传感器上的PRISM耦合硅

    公开(公告)号：US20100290037A1

    公开(公告)日：2010-11-18

    申请号：US12671234

    申请日：2007-08-15

    申请人： Dan-xia Xu ,  Adam Densmore ,  Andre Delage ,  Pavel Cheben ,  Siegfried Janz

    发明人： Dan-xia Xu ,  Adam Densmore ,  Andre Delage ,  Pavel Cheben ,  Siegfried Janz

    IPC分类号： G01N21/41

    CPC分类号： G01N21/552

    摘要： Methods and devices related to a sensor element for use in the detection and monitoring of molecular interactions. The sensor element uses a silicon-on-insulator wafer optically coupled to a silicon prism. The wafer has a thin silicon film top layer, a silicon substrate layer, and a buried silicon dioxide layer sandwiched between the silicon film and substrate layers. The wafer is coupled to the prism on the wafer's substrate side while the interactions to be monitored are placed on the wafer's silicon film side. An incident beam is directed at the prism and the incident angle is adjusted until the beam optically couples to the silicon film's optical waveguide mode. When this occurs, a decrease in the intensity of the reflected beam can be detected. The molecular interactions affect the phase velocity or wave vector of the propagating mode. Similarly, instead of measuring the incident angle at which optical coupling occurs, the phase of the reflected beam may be measured.

    摘要翻译： 与用于检测和监测分子相互作用的传感器元件相关的方法和装置。 传感器元件使用与硅棱镜光学耦合的绝缘体上硅晶片。 晶片具有薄的硅膜顶层，硅衬底层和夹在硅膜和衬底层之间的掩埋的二氧化硅层。 晶片在晶片的衬底侧与棱镜耦合，同时要监测的相互作用被放置在晶片的硅膜侧。 入射光束被引导到棱镜，并且调整入射角直到光束光耦合到硅膜的光波导模式。 当发生这种情况时，可以检测到反射光束的强度的降低。 分子相互作用影响传播模式的相速度或波矢量。 类似地，不是测量发生光耦合的入射角，而是可以测量反射光束的相位。

    SILICON PHOTONIC WAVEGUIDE BIOSENSOR CONFIGURATIONS
    6.
    发明申请
    SILICON PHOTONIC WAVEGUIDE BIOSENSOR CONFIGURATIONS 审中-公开
    硅光电波导生物传感器配置

    公开(公告)号：US20100165351A1

    公开(公告)日：2010-07-01

    申请号：US12451608

    申请日：2008-04-09

    申请人： Dan-Xia Xu ,  Adam Densmore ,  Andre Delage ,  Pavel Cheben ,  Siegfried Janz

    发明人： Dan-Xia Xu ,  Adam Densmore ,  Andre Delage ,  Pavel Cheben ,  Siegfried Janz

    IPC分类号： G01B9/02 ,  G02B6/00

    CPC分类号： G02B6/12007 ,  G01N21/7703 ,  G01N21/7746 ,  G01N2021/7779 ,  G01N2021/7783 ,  G02B6/2813

    摘要： Methods and devices relating to sensors and sensor blocks for use in detecting and monitoring molecular interactions. A silicon waveguide sensing element is provided along with a layer of silicon. A silicon oxide layer is also provided between the waveguide element and the layer of silicon. The sensing element is adjacent to an aqueous solution in which the molecular interactions are occurring. A light beam travelling in the silicon waveguide creates an evanescent optical field on the surface of the sensing element adjacent to the boundary between the sensing element and the aqueous medium. Molecular interactions occurring on this surface affect the intensity or the phase of the light beam travelling through the waveguide by changing the effective refractive index of the medium. By measuring the effect on the intensity, phase, or speed of the light beam, the molecular interactions can be detected and monitored in real time. Various configurations using this sensor technology is also disclosed.

    摘要翻译： 与用于检测和监测分子相互作用的传感器和传感器块有关的方法和设备。 硅波导传感元件与硅层一起提供。 在波导元件和硅层之间还提供氧化硅层。 传感元件与发生分子相互作用的水溶液相邻。 在硅波导中行进的光束在感测元件的表面上邻近感测元件和水性介质之间的边界产生消逝的光场。 通过改变介质的有效折射率，在该表面上发生的分子相互作用影响穿过波导的光束的强度或相位。 通过测量对光束的强度，相位或速度的影响，可以实时检测和监测分子相互作用。 还公开了使用该传感器技术的各种配置。

    Silicon photonic wire waveguide biosensor
    7.
    发明申请
    Silicon photonic wire waveguide biosensor 有权
    硅光子线波导生物传感器

    公开(公告)号：US20080292236A1

    公开(公告)日：2008-11-27

    申请号：US11898660

    申请日：2007-09-13

    申请人： Siegfried Janz ,  Pavel Cheben ,  Andre Delage ,  Adam Densmore

    发明人： Siegfried Janz ,  Pavel Cheben ,  Andre Delage ,  Adam Densmore

    IPC分类号： G02B6/00

    CPC分类号： G02B6/12007 ,  G01N21/7703 ,  G01N21/7746 ,  G01N2021/7779 ,  G01N2021/7783 ,  G02B6/2813

    摘要： Methods and devices relating to a sensor for use in detecting and monitoring molecular interactions. A silicon waveguide sensing element is provided along with a layer of silicon. A silicon oxide layer is also provided between the waveguide element and the layer of silicon. The sensing element is adjacent to an aqueous solution in which the molecular interactions are occurring. A light beam travelling in the silicon waveguide creates an evanescent optical field on the surface of the sensing element adjacent to the boundary between the sensing element and the aqueous medium. Molecular interactions occurring on this surface affect the intensity or the phase of the light beam travelling through the waveguide by changing the effective refractive index of the medium. By measuring the effect on the intensity, phase, or speed of the light beam, the molecular interactions can be detected and monitored in real time.

    摘要翻译： 与用于检测和监测分子相互作用的传感器相关的方法和装置。 硅波导传感元件与硅层一起提供。 在波导元件和硅层之间还提供氧化硅层。 传感元件与发生分子相互作用的水溶液相邻。 在硅波导中行进的光束在感测元件的表面上邻近感测元件和水性介质之间的边界产生消逝的光场。 通过改变介质的有效折射率，在该表面上发生的分子相互作用影响穿过波导的光束的强度或相位。 通过测量对光束的强度，相位或速度的影响，可以实时检测和监测分子相互作用。

    Planar waveguide echelle grating device with astigmatic grating facets
    9.
    发明授权
    Planar waveguide echelle grating device with astigmatic grating facets 有权
    具有散光光栅面的平面波导组件光栅装置

    公开(公告)号：US06766077B2

    公开(公告)日：2004-07-20

    申请号：US09986828

    申请日：2001-11-13

    申请人： Muthukumaran Packirisamy ,  Andre Delage

    发明人： Muthukumaran Packirisamy ,  Andre Delage

    IPC分类号： G02B634

    CPC分类号： G02B6/124 ,  G02B6/29328

    摘要： A planar waveguide grating device has a slab waveguide defining an input channel and a plurality of output channels. An echelle grating has a multitude of facets, each of the facets being blazed with respect to a preselected output channel. Each facet has an elliptical curvature so as to be astigmatic with respect to the input channel and the preselected output channel. The echelle grating is preferably based on a Rowland circle design. The astigmatic design of the facets reduces aberrations at high orders.

    摘要翻译： 平面波导光栅器件具有限定输入通道和多个输出通道的平板波导。 一个梯形光栅具有许多小平面，每个小面相对于预选的输出通道闪耀。 每个小面具有椭圆曲率，以便相对于输入通道和预选输出通道是散光的。 梯形光栅优选地基于罗兰圆设计。 小平面的散光设计降低了高阶下的像差。