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1.发明授权MiR-124 regulated genes and pathways as targets for therapeutic intervention 有权MiR-124调控基因和途径作为治疗干预的目标公开(公告)号：US08071562B2
公开(公告)日：2011-12-06
申请号：US12325917
申请日：2008-12-01
申请人： Andreas G. Bader , Jason F. Wiggins , Lubna Patrawala , Kevin Kelnar , Mike Byrom , David Brown
发明人： Andreas G. Bader , Jason F. Wiggins , Lubna Patrawala , Kevin Kelnar , Mike Byrom , David Brown
CPC分类号： C12N15/1135 , C12N15/113 , C12N2310/141 , C12N2330/10
摘要： The present invention concerns methods and compositions for identifying genes or genetic pathways modulated by miR-124, using miR-124 to modulate a gene or gene pathway, using this profile in assessing the condition of a patient and/or treating the patient with an appropriate miRNA.
摘要翻译： 本发明涉及用于鉴定miR-124调节的基因或遗传途径的方法和组合物，其使用miR-124调节基因或基因途径，使用该分布在评估患者的状况和/或以适当的方式治疗患者时 miRNA。
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2.发明申请miR-124 Regulated Genes and Pathways as Targets for Therapeutic Intervention 有权miR-124调控基因和途径作为治疗干预的目标公开(公告)号：US20090192111A1
公开(公告)日：2009-07-30
申请号：US12325917
申请日：2008-12-01
申请人： Andreas G. Bader , Jason F. Wiggins , Lubna Patrawala , Kevin Kelnar , Mike Byrom , David Brown
发明人： Andreas G. Bader , Jason F. Wiggins , Lubna Patrawala , Kevin Kelnar , Mike Byrom , David Brown
IPC分类号： A61K31/7088 , C12Q1/68 , A61P35/00
CPC分类号： C12N15/1135 , C12N15/113 , C12N2310/141 , C12N2330/10
摘要： The present invention concerns methods and compositions for identifying genes or genetic pathways modulated by miR-124, using miR-124 to modulate a gene or gene pathway, using this profile in assessing the condition of a patient and/or treating the patient with an appropriate miRNA.
摘要翻译： 本发明涉及用于鉴定miR-124调节的基因或遗传途径的方法和组合物，其使用miR-124调节基因或基因途径，使用该分布在评估患者的状况和/或以适当的方式治疗患者时 miRNA。
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3.发明申请miR-34 Regulated Genes and Pathways as Targets for Therapeutic Intervention 审中-公开miR-34调节基因和途径作为治疗干预的目标公开(公告)号：US20090227533A1
公开(公告)日：2009-09-10
申请号：US12134932
申请日：2008-06-06
申请人： Andreas G. Bader , Lubna Patrawala , Jason F. Wiggins , Mike W. Byrom , Charles D. Johnson , David Brown
发明人： Andreas G. Bader , Lubna Patrawala , Jason F. Wiggins , Mike W. Byrom , Charles D. Johnson , David Brown
IPC分类号： A61K31/7105 , C12N5/06 , G01N33/50 , C12Q1/68 , A61P35/00
CPC分类号： G01N33/574 , C12N15/113 , C12N2310/141 , C12N2320/12 , C12N2320/31 , C12N2330/31 , G01N2800/52 , Y10T436/143333
摘要： The present invention concerns methods and compositions for identifying genes or genetic pathways modulated by miR-34, using miR-34 to modulate a gene or gene pathway, using this profile in assessing the condition of a patient and/or treating the patient with an appropriate miRNA.
摘要翻译： 本发明涉及用于鉴定miR-34调节的基因或遗传途径的方法和组合物，其使用miR-34调节基因或基因途径，在评估患者状况和/或用合适的患者治疗患者时使用该分布 miRNA。
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公开(公告)号：US20100179213A1
公开(公告)日：2010-07-15
申请号：US12616616
申请日：2009-11-11
申请人： Lubna Patrawala , Dean G. Tang , Kevin Kelnar , Jason Wiggins , Stephanie Volz , Jeffrey Shelton , Can Liu , Andreas G. Bader , David Brown
发明人： Lubna Patrawala , Dean G. Tang , Kevin Kelnar , Jason Wiggins , Stephanie Volz , Jeffrey Shelton , Can Liu , Andreas G. Bader , David Brown
IPC分类号： A61K31/7088 , A61P35/04 , C12Q1/68
CPC分类号： C12N15/113 , C12N15/1131 , C12N2310/14 , C12N2310/141
摘要： The present invention concerns methods and compositions for treating a patient having, suspected of having, or at risk of developing cancer by targeting cancer stem cells.
摘要翻译： 本发明涉及通过靶向癌症干细胞来治疗患有怀疑具有或具有发展癌症风险的患者的方法和组合物。
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5.发明申请miR-126 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION 审中-公开miR-126调节基因和途径作为治疗性干预的目标公开(公告)号：US20090131354A1
公开(公告)日：2009-05-21
申请号：US12125675
申请日：2008-05-22
IPC分类号： A61K31/7105 , C12N5/06 , C12Q1/68
CPC分类号： A61K31/7105 , C12Q1/6886 , C12Q2600/106 , C12Q2600/178
摘要： The present invention concerns methods and compositions for identifying genes or genetic pathways modulated by miR-126, using miR-126 to modulate a gene or gene pathway, using this profile in assessing the condition of a patient and/or treating the patient with an appropriate miRNA.
摘要翻译： 本发明涉及用于鉴定miR-126调节的基因或遗传途径的方法和组合物，其使用miR-126调节基因或基因途径，在评估患者状况和/或用合适的患者治疗患者时使用该分布 miRNA。
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6.发明申请miR-16 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION 审中-公开miR-16调控基因和途径作为治疗性干预的目标公开(公告)号：US20090175827A1
公开(公告)日：2009-07-09
申请号：US11967663
申请日：2007-12-31
IPC分类号： A61K35/76 , C12N5/06 , A61K31/7088 , C12Q1/68 , A61P31/00 , A61K31/7105 , A61K31/711
CPC分类号： C12Q1/6886 , A61K31/7088 , A61K31/7105 , A61K31/711 , C12Q2600/158 , C12Q2600/178
摘要： The present invention concerns methods and compositions for identifying genes or genetic pathways modulated by miR-16, using miR-16 to modulate a gene or gene pathway, using this profile in assessing the condition of a patient and/or treating the patient with an appropriate miRNA.
摘要翻译： 本发明涉及用于鉴定miR-16调节的基因或遗传途径的方法和组合物，其使用miR-16调节基因或基因途径，使用该分布在评估患者的状况和/或以适当的方式治疗患者时 miRNA。
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7.发明申请miR-15, miR-26, miR-31, miR-145, miR-147, miR-188, miR-215, miR-216, miR-331, mmu-miR-292-3P REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION 审中-公开miR-15，miR-26，miR-31，miR-145，miR-147，miR-188，miR-215，miR-216，miR-331，mmu-miR-292-3P调节基因和途径作为目标 治疗干预公开(公告)号：US20090131356A1
公开(公告)日：2009-05-21
申请号：US12167492
申请日：2008-07-03
IPC分类号： A61K31/7105 , C12N5/06 , C12Q1/68
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/111 , C12N2310/141 , C12N2320/12
摘要： The present invention concerns methods and compositions for identifying genes or genetic pathways modulated by miR-15, miR-26, miR-31, miR-145, miR-147, miR-188, miR-215, miR-216, miR-331, mmu-miR-292-3p, and using nucleic acid comprising all or part of the miR-15, miR-26, miR-31, miR-145, miR-147, miR-188, miR-215, miR-216, miR-331, mmu-miR-292-3p sequences to modulate a gene or gene pathway, using this profile in assessing the condition of a patient and/or treating the patient with an appropriate miRNA.
摘要翻译： 本发明涉及用于鉴定由miR-15，miR-26，miR-31，miR-145，miR-147，miR-188，miR-215，miR-216，miR-331调节的基因或遗传途径的方法和组合物 ，并使用包含全部或部分miR-15，miR-26，miR-31，miR-145，miR-147，miR-188，miR-215，miR-216的核酸 ，miR-331，mmu-miR-292-3p序列以调节基因或基因途径，使用该概况评估患者的状况和/或用合适的miRNA治疗患者。
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8.发明授权公开(公告)号：US08173611B2
公开(公告)日：2012-05-08
申请号：US11273640
申请日：2005-11-14
申请人： David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
发明人： David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
IPC分类号： C12N15/11
CPC分类号： C12N15/113 , A61K9/127 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , A61N5/10 , C12N15/111 , C12N15/1136 , C12N2310/14 , C12N2310/141 , C12N2310/312 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/344 , C12N2310/35 , C12N2310/351 , C12N2310/3527 , C12N2310/3535 , C12N2310/533 , C12N2320/12 , C12N2320/30 , C12N2320/50 , C12N2330/10 , C12Q1/68 , C12Q1/6876 , C12Q2600/158 , C12Q2600/178 , C12N2310/3521
摘要： The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
摘要翻译： 本发明涉及使用合成核酸分子将miRNA活性或功能引入细胞的方法和组合物。 此外，本发明涉及用于鉴定具有与治疗，诊断和预后应用相关的特定细胞功能的miRNA的方法和组合物，其中在文库筛选测定中使用合成的miRNA和/或miRNA抑制剂。
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9.发明申请miR-21 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION 审中-公开miR-21调控基因和途径作为治疗性干预的目标公开(公告)号：US20090192102A1
公开(公告)日：2009-07-30
申请号：US12120388
申请日：2008-05-14
申请人： Andreas G. Bader , Mike Byrom , Charles D. Johnson , David Brown
发明人： Andreas G. Bader , Mike Byrom , Charles D. Johnson , David Brown
IPC分类号： A61K31/7088 , C12N5/06 , A61P35/00 , C12Q1/68
CPC分类号： C12N15/113 , C12N2310/14
摘要： The present invention concerns methods and compositions for identifying genes or genetic pathways modulated by miR-21, using miR-21 to modulate a gene or gene pathway, using this profile in assessing the condition of a patient and/or treating the patient with an appropriate miRNA.
摘要翻译： 本发明涉及用于鉴定miR-21调节的基因或遗传途径的方法和组合物，其使用miR-21调节基因或基因途径，使用该分布在评估患者的状况和/或以适当的方式治疗患者时 miRNA。
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公开(公告)号：US08563708B2
公开(公告)日：2013-10-22
申请号：US11837487
申请日：2007-08-10
申请人： David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
发明人： David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
IPC分类号： C07H21/04
CPC分类号： C12N15/113 , A61K9/127 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , A61N5/10 , C12N15/111 , C12N15/1136 , C12N2310/14 , C12N2310/141 , C12N2310/312 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/344 , C12N2310/35 , C12N2310/351 , C12N2310/3527 , C12N2310/3535 , C12N2310/533 , C12N2320/12 , C12N2320/30 , C12N2320/50 , C12N2330/10 , C12Q1/68 , C12Q1/6876 , C12Q2600/158 , C12Q2600/178 , C12N2310/3521
摘要： The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
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