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公开(公告)号：US20100179213A1
公开(公告)日：2010-07-15
申请号：US12616616
申请日：2009-11-11
申请人： Lubna Patrawala , Dean G. Tang , Kevin Kelnar , Jason Wiggins , Stephanie Volz , Jeffrey Shelton , Can Liu , Andreas G. Bader , David Brown
发明人： Lubna Patrawala , Dean G. Tang , Kevin Kelnar , Jason Wiggins , Stephanie Volz , Jeffrey Shelton , Can Liu , Andreas G. Bader , David Brown
IPC分类号： A61K31/7088 , A61P35/04 , C12Q1/68
CPC分类号： C12N15/113 , C12N15/1131 , C12N2310/14 , C12N2310/141
摘要： The present invention concerns methods and compositions for treating a patient having, suspected of having, or at risk of developing cancer by targeting cancer stem cells.
摘要翻译： 本发明涉及通过靶向癌症干细胞来治疗患有怀疑具有或具有发展癌症风险的患者的方法和组合物。
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公开(公告)号：US08597892B2
公开(公告)日：2013-12-03
申请号：US12785216
申请日：2010-05-21
申请人： Jeffrey Shelton , Kevin Kelnar , Stephanie Volz , Alex Adai , David Brown
发明人： Jeffrey Shelton , Kevin Kelnar , Stephanie Volz , Alex Adai , David Brown
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/16 , C12Q2600/178
摘要： This application describes miRNAs that may be used as serum or plasma biomarkers for characterizing prostate disease in a patient. These miRNA biomarkers may be used alone or in combination with other markers for the diagnosis, prognosis, or monitoring of diseases such as prostate cancer.
摘要翻译： 该应用描述了可用作血清或血浆生物标志物的miRNA，用于表征患者中的前列腺疾病。 这些miRNA生物标志物可以单独使用或与其它标志物组合使用，用于诊断，预后或监测前列腺癌等疾病。
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公开(公告)号：US20100297652A1
公开(公告)日：2010-11-25
申请号：US12785216
申请日：2010-05-21
申请人： Jeffrey Shelton , Kevin Kelnar , Stephanie Volz , Alex Adai , David Brown
发明人： Jeffrey Shelton , Kevin Kelnar , Stephanie Volz , Alex Adai , David Brown
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/16 , C12Q2600/178
摘要： This application describes miRNAs that may be used as serum or plasma biomarkers for characterizing prostate disease in a patient. These miRNA biomarkers may be used alone or in combination with other markers for the diagnosis, prognosis, or monitoring of diseases such as prostate cancer.
摘要翻译： 该应用描述了可用作血清或血浆生物标志物的miRNA，用于表征患者中的前列腺疾病。 这些miRNA生物标志物可以单独使用或与其它标志物组合使用，用于诊断，预后或监测前列腺癌等疾病。
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4.发明申请COMPOSITIONS AND METHODS RELATED TO MIRNA MODULATION OF NEOVASCULARIZATION OR ANGIOGENESIS 有权与微血管调节或血管生成调节相关的组合物和方法公开(公告)号：US20090281167A1
公开(公告)日：2009-11-12
申请号：US12437899
申请日：2009-05-08
申请人： Jikui Shen , Kevin Kelnar , Jeffrey Shelton , David Brown , Peter Campochiaro
发明人： Jikui Shen , Kevin Kelnar , Jeffrey Shelton , David Brown , Peter Campochiaro
IPC分类号： A61K31/7052 , A61P9/00 , C12N15/85 , C12Q1/68
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/141 , C12N2310/32 , C12N2310/351 , C12N2310/531 , C12N2320/30 , C12N2320/32 , C12Q1/6809 , C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178 , C12Q2525/207
摘要： The present invention concerns methods and compositions for diagnosing and/or treating vascular diseases including cancer, cardiac diseases, vascular diseases of the eye, and inflammatory diseases. The methods involve measuring the levels of one or multiple miRNAs in patient samples and using the test results to diagnose and/or predict an optimal treatment regimen for the patient. Compositions described in the invention include nucleic acids that function as miRNAs or miRNA inhibitors that can be introduced to a patient to reduce or increase vascularization as needed.
摘要翻译： 本发明涉及用于诊断和/或治疗包括癌症，心脏疾病，眼睛血管疾病和炎性疾病的血管疾病的方法和组合物。 该方法包括测量患者样品中一种或多种miRNA的水平，并使用测试结果诊断和/或预测患者的最佳治疗方案。 在本发明中描述的组合物包括起到miRNA或miRNA抑制剂的功能，可以根据需要引入患者以减少或增加血管形成。
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公开(公告)号：US20090092974A1
公开(公告)日：2009-04-09
申请号：US11953606
申请日：2007-12-10
申请人： Tim Davison , Dmitriy Ovcharenko , Jeffrey Shelton , Kevin Kelnar , David Brown
发明人： Tim Davison , Dmitriy Ovcharenko , Jeffrey Shelton , Kevin Kelnar , David Brown
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6809 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/178 , C12Q2525/207
摘要： The present invention concerns methods and compositions for identifying a miRNA profile for acute myeloid leukemia (AML), and using the profile in assessing the condition of a patient.
摘要翻译： 本发明涉及用于鉴定急性骨髓性白血病（AML）的miRNA谱的方法和组合物，并且在评估患者状况时使用该分布。
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6.发明申请公开(公告)号：US20130065951A1
公开(公告)日：2013-03-14
申请号：US13602933
申请日：2012-09-04
申请人： Jikui Shen , Kevin Kelnar , Jeffrey Shelton , David Brown , Peter Campochiaro
发明人： Jikui Shen , Kevin Kelnar , Jeffrey Shelton , David Brown , Peter Campochiaro
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/141 , C12N2310/32 , C12N2310/351 , C12N2310/531 , C12N2320/30 , C12N2320/32 , C12Q1/6809 , C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178 , C12Q2525/207
摘要： The present invention concerns methods and compositions for diagnosing and/or treating vascular diseases including cancer, cardiac diseases, vascular diseases of the eye, and inflammatory diseases. The methods involve measuring the levels of one or multiple miRNAs in patient samples and using the test results to diagnose and/or predict an optimal treatment regimen for the patient. Compositions described in the invention include nucleic acids that function as miRNAs or miRNA inhibitors that can be introduced to a patient to reduce or increase vascularization as needed.
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7.发明授权Compositions and methods related to miRNA modulation of neovascularization or angiogenesis 有权与新生血管形成或血管生成miRNA调控相关的组成和方法公开(公告)号：US08258111B2
公开(公告)日：2012-09-04
申请号：US12437899
申请日：2009-05-08
申请人： Jikui Shen , Kevin Kelnar , Jeffrey Shelton , David Brown , Peter Campochiaro
发明人： Jikui Shen , Kevin Kelnar , Jeffrey Shelton , David Brown , Peter Campochiaro
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/141 , C12N2310/32 , C12N2310/351 , C12N2310/531 , C12N2320/30 , C12N2320/32 , C12Q1/6809 , C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178 , C12Q2525/207
摘要： The present invention concerns methods and compositions for diagnosing and/or treating vascular diseases including cancer, cardiac diseases, vascular diseases of the eye, and inflammatory diseases. The methods involve measuring the levels of one or multiple miRNAs in patient samples and using the test results to diagnose and/or predict an optimal treatment regimen for the patient. Compositions described in the invention include nucleic acids that function as miRNAs or miRNA inhibitors that can be introduced to a patient to reduce or increase vascularization as needed.
摘要翻译： 本发明涉及用于诊断和/或治疗包括癌症，心脏疾病，眼睛血管疾病和炎性疾病的血管疾病的方法和组合物。 该方法包括测量患者样品中一种或多种miRNA的水平，并使用测试结果诊断和/或预测患者的最佳治疗方案。 在本发明中描述的组合物包括起到miRNA或miRNA抑制剂的功能，可以根据需要引入患者以减少或增加血管形成。
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公开(公告)号：US08465914B2
公开(公告)日：2013-06-18
申请号：US13540413
申请日：2012-07-02
申请人： David Brown , Rick Conrad , Eric Devroe , Marianna Goldrick , Kerri Keiger , Emmanuel Labourier , Ivonne Moon , Patricia Powers , Jeffrey Shelton , Jaclyn Shingara
发明人： David Brown , Rick Conrad , Eric Devroe , Marianna Goldrick , Kerri Keiger , Emmanuel Labourier , Ivonne Moon , Patricia Powers , Jeffrey Shelton , Jaclyn Shingara
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12N15/111 , C12N2310/14 , C12N2310/3517 , C12N2310/3519 , C12N2320/10 , C12P19/34 , C12Q1/6809 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178 , C12Q2565/501 , C12Q2525/207
摘要： The present invention concerns methods and compositions for isolating, enriching, and/or labeling miRNA molecules and for preparing and using arrays or other detection techniques for miRNA analysis. Moreover, the present invention concerns methods and compositions for generating miRNA profiles and employing such profiles for therapeutic, diagnostic, and prognostic applications.
摘要翻译： 本发明涉及用于分离，富集和/或标记miRNA分子以及制备和使用阵列或其他用于miRNA分析的检测技术的方法和组合物。 此外，本发明涉及用于产生miRNA谱并用于治疗，诊断和预后应用的这种分布的方法和组合物。
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公开(公告)号：US20080026951A1
公开(公告)日：2008-01-31
申请号：US11837495
申请日：2007-08-11
申请人： David Brown , Rick Conrad , Eric Devroe , Marianna Goldrick , Kerri Keiger , Emmanuel Labourier , Ivonne Moon , Patricia Powers , Jeffrey Shelton , Jaclyn Shingara
发明人： David Brown , Rick Conrad , Eric Devroe , Marianna Goldrick , Kerri Keiger , Emmanuel Labourier , Ivonne Moon , Patricia Powers , Jeffrey Shelton , Jaclyn Shingara
IPC分类号： C40B30/04
CPC分类号： C12Q1/6806 , C12N15/111 , C12N2310/14 , C12N2310/3517 , C12N2310/3519 , C12N2320/10 , C12P19/34 , C12Q1/6809 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178 , C12Q2565/501 , C12Q2525/207
摘要： The present invention concerns methods and compositions for isolating, enriching, and/or labeling miRNA molecules and for preparing and using arrays or other detection techniques for miRNA analysis. Moreover, the present invention concerns methods and compositions for generating miRNA profiles and employing such profiles for therapeutic, diagnostic, and prognostic applications.
摘要翻译： 本发明涉及用于分离，富集和/或标记miRNA分子以及制备和使用阵列或其他用于miRNA分析的检测技术的方法和组合物。 此外，本发明涉及用于产生miRNA谱并用于治疗，诊断和预后应用的这种分布的方法和组合物。
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公开(公告)号：US08003320B2
公开(公告)日：2011-08-23
申请号：US11837494
申请日：2007-08-11
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12N15/111 , C12N2310/14 , C12N2310/3517 , C12N2310/3519 , C12N2320/10 , C12P19/34 , C12Q1/6809 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178 , C12Q2565/501 , C12Q2525/207
摘要： The present invention concerns methods and compositions for isolating, enriching, and/or labeling miRNA molecules and for preparing and using arrays or other detection techniques for miRNA analysis. Moreover, the present invention concerns methods and compositions for generating miRNA profiles and employing such profiles for therapeutic, diagnostic, and prognostic applications.
摘要翻译： 本发明涉及用于分离，富集和/或标记miRNA分子以及制备和使用阵列或其他用于miRNA分析的检测技术的方法和组合物。 此外，本发明涉及用于产生miRNA谱并用于治疗，诊断和预后应用的这种分布的方法和组合物。
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