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1.发明申请Transdermal Therapeutic System for Administering Lipophilic and/or Sparingly Skin- Permeable Active Substances 有权用于管理亲脂性和/或微量透皮活性物质的透皮治疗系统公开(公告)号：US20090169601A1
公开(公告)日：2009-07-02
申请号：US12083888
申请日：2006-10-04
申请人： Andreas Koch , Christoph Schmitz , Rolf Pracht , Mohammad Sameti
发明人： Andreas Koch , Christoph Schmitz , Rolf Pracht , Mohammad Sameti
IPC分类号： A61K9/70 , A61K31/4375 , A61K31/506 , A61K31/437
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7084
摘要： A transdermal therapeutic system for administering lipophilic, poorly water-soluble and/or sparingly skin-permeable pharmaceutical active substances. The active substance is present in a multi-component enhancer system consisting of 4 components and each component of the multi-component enhancer system is selected from a different one of the substance groups: a) terpenes, b) cyclic glucitol ethers, c) medium-chain triglycerides of capric and caprylic acid and/or of linoleic acid; and d) longer-chain alcohols having a chain length of 8 or more carbon atoms.
摘要翻译： 一种用于施用亲脂性，水溶性差和/或微量透皮的药物活性物质的透皮治疗系统。 活性物质存在于由4种组分组成的多组分增强剂体系中，多组分增强子系统的每种组分选自不同的物质组：a）萜烯，b）环状糖醇醚，c）中等 癸酸和辛酸和/或亚油酸的链状甘油三酸酯; 和d）链长为8个或更多个碳原子的长链醇。
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2.发明授权Transdermal therapeutic system for administering lipophilic and/or sparingly skin-permeable active substances 有权用于施用亲脂性和/或微量透皮活性物质的透皮治疗系统公开(公告)号：US09486417B2
公开(公告)日：2016-11-08
申请号：US13592066
申请日：2012-08-22
申请人： Andreas Koch , Christoph Schmitz , Rolf Pracht , Mohammad Sameti
发明人： Andreas Koch , Christoph Schmitz , Rolf Pracht , Mohammad Sameti
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7084
摘要： A transdermal therapeutic system for administering lipophilic, poorly water-soluble and/or sparingly skin-permeable pharmaceutical active substances. The active substance is present in a multi-component enhancer system consisting of 4 components and each component of the multi-component enhancer system is selected from a different one of the substance groups: a) terpenes, b) cyclic glucitol ethers, c) medium-chain triglycerides of capric and caprylic acid and/or of linoleic acid; and d) longer-chain alcohols having a chain length of 8 or more carbon atoms.
摘要翻译： 一种用于施用亲脂性，水溶性差和/或微量透皮的药物活性物质的透皮治疗系统。 活性物质存在于由4种组分组成的多组分增强剂体系中，多组分增强子系统的每种组分选自不同的物质组：a）萜烯，b）环状糖醇醚，c）中等 癸酸和辛酸和/或亚油酸的链状甘油三酸酯; 和d）链长为8个或更多个碳原子的长链醇。
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3.发明授权Transdermal therapeutic system for administering lipophilic and/or sparingly skin- permeable active substances 有权用于施用亲脂性和/或微量皮肤可渗透活性物质的透皮治疗系统公开(公告)号：US08309120B2
公开(公告)日：2012-11-13
申请号：US12083888
申请日：2006-10-04
申请人： Andreas Koch , Christoph Schmitz , Rolf Pracht , Mohammad Sameti
发明人： Andreas Koch , Christoph Schmitz , Rolf Pracht , Mohammad Sameti
IPC分类号： A61L15/44
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7084
摘要： A transdermal therapeutic system for administering lipophilic, poorly water-soluble and/or sparingly skin-permeable pharmaceutical active substances. The active substance is present in a multi-component enhancer system consisting of 4 components and each component of the multi-component enhancer system is selected from a different one of the substance groups: a) terpenes, b) cyclic glucitol ethers, c) medium-chain triglycerides of capric and caprylic acid and/or of linoleic acid; and d) longer-chain alcohols having a chain length of 8 or more carbon atoms.
摘要翻译： 一种用于施用亲脂性，水溶性差和/或微量透皮的药物活性物质的透皮治疗系统。 活性物质存在于由4种组分组成的多组分增强剂体系中，多组分增强子系统的每种组分选自不同的物质组：a）萜烯，b）环状糖醇醚，c）中等 癸酸和辛酸和/或亚油酸的链状甘油三酸酯; 和d）链长为8个或更多个碳原子的长链醇。
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4.发明申请TRANSDERMAL THERAPEUTIC SYSTEM FOR ADMINISTERING LIPOPHILIC AND/OR SPARINGLY SKIN-PERMEABLE ACTIVE SUBSTANCES 有权用于治疗嗜酸性和/或微量渗透性活性物质的透皮治疗系统公开(公告)号：US20120316520A1
公开(公告)日：2012-12-13
申请号：US13592066
申请日：2012-08-22
申请人： Andreas Koch , Christoph Schmitz , Rolf Pracht , Mohammad Sameti
发明人： Andreas Koch , Christoph Schmitz , Rolf Pracht , Mohammad Sameti
IPC分类号： A61K47/14 , A61K31/506 , A61M35/00 , A61K47/32 , A61K47/40 , A61K47/38 , A61K31/4375 , A61K31/48
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7084
摘要： A transdermal therapeutic system for administering lipophilic, poorly water-soluble and/or sparingly skin-permeable pharmaceutical active substances. The active substance is present in a multi-component enhancer system consisting of 4 components and each component of the multi-component enhancer system is selected from a different one of the substance groups: a) terpenes, b) cyclic glucitol ethers, c) medium-chain triglycerides of capric and caprylic acid and/or of linoleic acid; and d) longer-chain alcohols having a chain length of 8 or more carbon atoms.
摘要翻译： 一种用于施用亲脂性，水溶性差和/或微量透皮的药物活性物质的透皮治疗系统。 活性物质存在于由4种组分组成的多组分增强剂体系中，多组分增强子系统的每种组分选自不同的物质组：a）萜烯，b）环状糖醇醚，c）中等 癸酸和辛酸和/或亚油酸的链状甘油三酸酯; 和d）链长为8个或更多个碳原子的长链醇。
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公开(公告)号：US11612571B2
公开(公告)日：2023-03-28
申请号：US12525888
申请日：2008-01-19
申请人： Bodo Asmussen , Michael Horstmann , Christoph Schmitz , Mohammad Sameti , Yves-Thorsten Przybylla , Rolf Pracht
发明人： Bodo Asmussen , Michael Horstmann , Christoph Schmitz , Mohammad Sameti , Yves-Thorsten Przybylla , Rolf Pracht
IPC分类号： A61K9/70 , A61K31/135
摘要： The invention relates to a transdermal therapeutic system for the controlled release of water-soluble pharmaceutical active ingredients from an aqueous phase, comprising an occlusive back layer, a central device facing the skin for releasing the agent, an adhesive layer concentrically surrounding the dispensing device and a removable protective film. Said device is made from a stationary solid phase and a liquid phase containing the active ingredient in aqueous solution, the solid phase being formed from a solid with a fleecy or spongy structure.
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6.发明申请TRANSDERMAL THERAPEUTIC SYSTEM FOR ADMINISTERING WATER-SOLUABLE ACTIVE INGREDIENTS 审中-公开用于管理水溶性活性成分的超导治疗系统公开(公告)号：US20100028412A1
公开(公告)日：2010-02-04
申请号：US12525888
申请日：2008-01-19
申请人： Bodo Asmussen , Michael Horstmann , Christoph Schmitz , Mohammad Sameti , Yves-Thorsten Przybylla , Rolf Pracht
发明人： Bodo Asmussen , Michael Horstmann , Christoph Schmitz , Mohammad Sameti , Yves-Thorsten Przybylla , Rolf Pracht
CPC分类号： A61K9/7084 , A61K31/135
摘要： The invention relates to a transdermal therapeutic system for the controlled release of water-soluble pharmaceutical active ingredients from an aqueous phase, comprising an occlusive back layer, a central device facing the skin for releasing the agent, an adhesive layer concentrically surrounding the dispensing device and a removable protective film. Said device is made from a stationary solid phase and a liquid phase containing the active ingredient in aqueous solution, the solid phase being formed from a solid with a fleecy or spongy structure.
摘要翻译： 本发明涉及一种用于从水相控制释放水溶性药物活性成分的透皮治疗系统，其包括闭合背层，面向皮肤以释放药剂的中心装置，同心地围绕分配装置的粘合剂层，以及 一个可拆卸的保护膜。 所述装置由静态固相和在水溶液中含有活性成分的液相制成，固相由具有绒毛或海绵结构的固体形成。
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公开(公告)号：US10881606B2
公开(公告)日：2021-01-05
申请号：US12737209
申请日：2009-06-16
摘要： A composition for transdermal delivery, particularly iontophoretic transdermal delivery, having at least one cationic active agent or a salt thereof. The composition comprises at least one cationic active agent or a salt thereof, at least one polyamine and/or polyamine salt, water or an aqueous solvent mixture, and optionally one or more additives. Use of the composition as a component of a transdermal patch or of an iontophoretic transdermal patch is also provided, as well as the use of the composition in a method for transdermally or iontophoretically administering cationic active agents. A method for determining the in vitro skin permeation properties of an active agent-containing iontophoretic composition is also provided.
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公开(公告)号：US20110111029A1
公开(公告)日：2011-05-12
申请号：US12737209
申请日：2009-06-16
IPC分类号： A61K9/00 , A61K31/4045 , A61K38/02 , A61K31/485 , A61K31/439 , A61K31/4178 , A61K38/22 , A61K38/36 , A61K31/55 , A61K31/167 , A61P25/04 , A61P7/00 , A61P25/00 , A61P9/00 , A61K31/65 , A61P31/00 , G01N27/447
摘要： A composition for transdermal delivery, particularly iontophoretic transdermal delivery, having at least one cationic active agent or a salt thereof. The composition comprises at least one cationic active agent or a salt thereof, at least one polyamine and/or polyamine salt, water or an aqueous solvent mixture, and optionally one or more additives. Use of the composition as a component of a transdermal patch or of an iontophoretic transdermal patch is also provided, as well as the use of the composition in a method for transdermally or iontophoretically administering cationic active agents. A method for determining the in vitro skin permeation properties of an active agent-containing iontophoretic composition is also provided.
摘要翻译： 用于透皮递送，特别是离子电渗透皮递送的组合物，其具有至少一种阳离子活性剂或其盐。 组合物包含至少一种阳离子活性剂或其盐，至少一种多胺和/或多胺盐，水或水性溶剂混合物，以及任选的一种或多种添加剂。 还提供了组合物作为透皮贴片或离子电渗透皮贴剂的组分的用途，以及组合物在透皮或离子电渗治疗阳离子活性剂的方法中的用途。 还提供了用于测定含活性剂的离子电渗疗法组合物的体外皮肤渗透性质的方法。
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9.发明申请Monitoring System For Collecting And/Or Transdermally Rediffusing Air Containing Environmental Contaminants, And Corresponding Method 失效用于收集和/或经皮再循环使用含有环境污染物的空气监测系统及相应方法公开(公告)号：US20070289360A1
公开(公告)日：2007-12-20
申请号：US11659072
申请日：2005-08-06
申请人： Michael Horstmann , Christina Schutz , Mohammad Sameti , Yves-Thorsten Przybylla , Christoph Schmitz
发明人： Michael Horstmann , Christina Schutz , Mohammad Sameti , Yves-Thorsten Przybylla , Christoph Schmitz
CPC分类号： A61B5/6833 , A61B5/00 , G01N1/2273 , G01N2001/2223 , G01N2001/2276 , G01N2001/2833 , G01N2013/003
摘要： Disclosed is a monitoring system for collecting and/or transdermally rediffusing air containing environmental contaminants. The inventive monitoring system generally includes at least one diffusion collector and/or an equilibrium diffuser. The diffusion collector is provided with at least three layers, i.e. an adhesive layer that is in direct contact with the skin of a living being, a barrier layer, and a collecting layer on the exterior face of the monitoring system. The equilibrium diffuser includes an adhesive layer and a collecting layer. The collecting layers and the adhesive layers of the two components of the monitoring system are preferably made of the same material and have the same dimensions.
摘要翻译： 公开了一种用于收集和/或透皮地重新分配含有环境污染物的空气的监测系统。 本发明的监测系统通常包括至少一个扩散收集器和/或平衡扩散器。 扩散收集器设置有至少三层，即与监视系统的外表面上的活体皮肤，阻挡层和收集层直接接触的粘合剂层。 平衡扩散器包括粘合剂层和收集层。 监测系统的两个部件的收集层和粘合剂层优选由相同的材料制成并且具有相同的尺寸。
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10.发明申请公开(公告)号：US20070062548A1
公开(公告)日：2007-03-22
申请号：US10581867
申请日：2004-11-16
申请人： Michael Horstmann , Christoph Schmitz , Karin Ludwig , Mohammad Sameti , Yves-Thorsten Pryzbylla
发明人： Michael Horstmann , Christoph Schmitz , Karin Ludwig , Mohammad Sameti , Yves-Thorsten Pryzbylla
IPC分类号： A24F47/00
CPC分类号： A61K9/007 , A24F47/002 , A61M15/0003 , A61M15/06
摘要： A device for the administration of basic active agents, such as nicotine, to the human or animal body. The active agents are administered by inhalation. The device comprises a first preparation containing a nicotine base or/and a further basic active agent and, a second or further preparations. At least one preparation contains at least one volatile acid suitable for inhalation.
摘要翻译： 用于向人体或动物体内施用碱性活性剂如尼古丁的装置。 活性剂通过吸入给药。 该装置包括含有尼古丁碱或/和另一种碱性活性剂的第一制剂，和第二种或其它制剂。 至少一种制剂含有至少一种适用于吸入的挥发性酸。
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