公开(公告)号：US08354569B2

公开(公告)日：2013-01-15

申请号：US12844938

申请日：2010-07-28

申请人： Andreas Renz ,  Jörg Bauer ,  Margit Frentzen ,  Nursen Sözer ,  Stobart Keith ,  Thomas Fraser ,  Colin M. Lazarus ,  Baoxiu Qi ,  Amine Abbadi ,  Ernst Heinz

发明人： Andreas Renz ,  Jörg Bauer ,  Margit Frentzen ,  Nursen Sözer ,  Stobart Keith ,  Thomas Fraser ,  Colin M. Lazarus ,  Baoxiu Qi ,  Amine Abbadi ,  Ernst Heinz

IPC分类号： A01H5/00 ,  C12N15/82 ,  C12N1/20 ,  C07H21/04

CPC分类号： C12P7/6427 ,  C12N9/1029 ,  C12N15/8247 ,  C12P7/6472

摘要： The invention relates to a process for the production of long-chain polyunsaturated fatty acids in an organism by introducing, into the organism, nucleic acids coding for polypeptides with acyltransferase activity. These nucleic acid sequences, if appropriate together with further nucleic acid sequences coding for polypeptides of the fatty acid or lipid metabolism biosynthesis, can advantageously be expressed in the organism. Furthermore, the invention relates to a method for the production of oils and/or triacylglycerides with an elevated content of long-chain polyunsaturated fatty acids. The invention furthermore relates to the nucleic acid sequences, and constructs, vectors and organisms comprising the nucleic acid sequences. A further part of the invention relates to oils, lipids and/or fatty acids produced by the process according to the invention and to their use.

摘要翻译： 本发明涉及通过向生物体中引入编码具有酰基转移酶活性的多肽的核酸来生产生物体中长链多不饱和脂肪酸的方法。 如果合适，这些核酸序列与编码脂肪酸或脂质代谢生物合成的多肽的其它核酸序列一起可以有利地在生物体中表达。 此外，本发明涉及一种具有升高的多链多不饱和脂肪酸含量的油和/或三酰基甘油酯的生产方法。 本发明还涉及包含核酸序列的核酸序列和构建体，载体和生物体。 本发明的另一部分涉及通过根据本发明的方法生产的油，脂质和/或脂肪酸及其用途。

公开(公告)号：US07855321B2

公开(公告)日：2010-12-21

申请号：US10552013

申请日：2004-03-26

申请人： Andreas Renz ,  Jörg Bauer ,  Margit Frentzen ,  Nursen Sözer ,  Stobart Keith ,  Thomas Fraser ,  Colin M. Lazarus ,  Baoxiu Qi ,  Amine Abbadi ,  Ernst Heinz

发明人： Andreas Renz ,  Jörg Bauer ,  Margit Frentzen ,  Nursen Sözer ,  Stobart Keith ,  Thomas Fraser ,  Colin M. Lazarus ,  Baoxiu Qi ,  Amine Abbadi ,  Ernst Heinz

IPC分类号： A01H5/00 ,  C12N15/82 ,  C12N1/20 ,  C07H21/04

CPC分类号： C12P7/6427 ,  C12N9/1029 ,  C12N15/8247 ,  C12P7/6472

摘要： The present invention relates to a process for the production of long-chain polyunsaturated fatty acids in an organism by introducing, into the organism, nucleic acids which code for polypeptides with acyl transferase activity. These nucleic acid sequences, if appropriate together with further nucleic acid sequences which code for polypeptides of the fatty acid or lipid metabolism biosynthesis, can advantageously be expressed in the organism. Furthermore, the invention relates to a method for the production of oils and/or triacylglycerides with an elevated content of long-chain polyunsaturated fatty acids.The invention furthermore relates to the nucleic acid sequences, nucleic acid constructs, vectors and organisms comprising the nucleic acid sequences according to the invention, vectors comprising the nucleic acid sequences and/or the nucleic acid constructs and to transgenic organisms comprising the abovementioned nucleic acid sequences, nucleic acid constructs and/or vectors.A further part of the invention relates to oils, lipids and/or fatty acids produced by the process according to the invention and to their use.

摘要翻译： 本发明涉及通过向生物体中引入编码具有酰基转移酶活性的多肽的核酸来生产生物体中长链多不饱和脂肪酸的方法。 如果合适的话，这些核酸序列与编码脂肪酸或脂质代谢生物合成的多肽的其它核酸序列一起可以有利地在生物体中表达。 此外，本发明涉及一种具有升高的多链多不饱和脂肪酸含量的油和/或三酰基甘油酯的生产方法。 本发明还涉及包含本发明的核酸序列的核酸序列，核酸构建体，载体和生物，包含核酸序列和/或核酸构建体的载体以及包含上述核酸序列的转基因生物 ，核酸构建体和/或载体。 本发明的另一部分涉及通过根据本发明的方法生产的油，脂质和/或脂肪酸及其用途。

公开(公告)号：US20060174376A1

公开(公告)日：2006-08-03

申请号：US10552013

申请日：2004-03-26

申请人： Andreas Renz ,  Jorg Bauer ,  Margit Frentzen ,  Nursen Sozer ,  Stobart Keith

发明人： Andreas Renz ,  Jorg Bauer ,  Margit Frentzen ,  Nursen Sozer ,  Stobart Keith

IPC分类号： A01H1/00 ,  C07H21/04 ,  C12P7/64 ,  C12N15/82 ,  C12N5/04

CPC分类号： C12P7/6427 ,  C12N9/1029 ,  C12N15/8247 ,  C12P7/6472

摘要： The present invention relates to a process for the production of long-chain polyunsaturated fatty acids in an organism by introducing, into the organism, nucleic acids which code for polypeptides with acyl transferase activity. These nucleic acid sequences, if appropriate together with further nucleic acid sequences which code for polypeptides of the fatty acid or lipid metabolism biosynthesis, can advantageously be expressed in the organism. Furthermore, the invention relates to a method for the production of oils and/or triacylglycerides with an elevated content of long-chain polyunsaturated fatty acids. The invention furthermore relates to the nucleic acid sequences, nucleic acid constructs, vectors and organisms comprising the nucleic acid sequences according to the invention, vectors comprising the nucleic acid sequences and/or the nucleic acid constructs and to transgenic organisms comprising the abovementioned nucleic acid sequences, nucleic acid constructs and/or vectors. A further part of the invention relates to oils, lipids and/or fatty acids produced by the process according to the invention and to their use.

摘要翻译： 本发明涉及通过向生物体中引入编码具有酰基转移酶活性的多肽的核酸来生产生物体中长链多不饱和脂肪酸的方法。 如果合适的话，这些核酸序列与编码脂肪酸或脂质代谢生物合成的多肽的其它核酸序列一起可以有利地在生物体中表达。 此外，本发明涉及一种具有升高的多链多不饱和脂肪酸含量的油和/或三酰基甘油酯的生产方法。 本发明还涉及包含本发明的核酸序列的核酸序列，核酸构建体，载体和生物，包含核酸序列和/或核酸构建体的载体以及包含上述核酸序列的转基因生物 ，核酸构建体和/或载体。 本发明的另一部分涉及通过根据本发明的方法生产的油，脂质和/或脂肪酸及其用途。