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1.发明申请Novel plant acyltransferases specific for long-chained, multiply unsaturated fatty acids 有权新型植物酰基转移酶特异于长链，多不饱和脂肪酸公开(公告)号：US20060174376A1
公开(公告)日：2006-08-03
申请号：US10552013
申请日：2004-03-26
申请人： Andreas Renz , Jorg Bauer , Margit Frentzen , Nursen Sozer , Stobart Keith
发明人： Andreas Renz , Jorg Bauer , Margit Frentzen , Nursen Sozer , Stobart Keith
CPC分类号： C12P7/6427 , C12N9/1029 , C12N15/8247 , C12P7/6472
摘要： The present invention relates to a process for the production of long-chain polyunsaturated fatty acids in an organism by introducing, into the organism, nucleic acids which code for polypeptides with acyl transferase activity. These nucleic acid sequences, if appropriate together with further nucleic acid sequences which code for polypeptides of the fatty acid or lipid metabolism biosynthesis, can advantageously be expressed in the organism. Furthermore, the invention relates to a method for the production of oils and/or triacylglycerides with an elevated content of long-chain polyunsaturated fatty acids. The invention furthermore relates to the nucleic acid sequences, nucleic acid constructs, vectors and organisms comprising the nucleic acid sequences according to the invention, vectors comprising the nucleic acid sequences and/or the nucleic acid constructs and to transgenic organisms comprising the abovementioned nucleic acid sequences, nucleic acid constructs and/or vectors. A further part of the invention relates to oils, lipids and/or fatty acids produced by the process according to the invention and to their use.
摘要翻译： 本发明涉及通过向生物体中引入编码具有酰基转移酶活性的多肽的核酸来生产生物体中长链多不饱和脂肪酸的方法。 如果合适的话，这些核酸序列与编码脂肪酸或脂质代谢生物合成的多肽的其它核酸序列一起可以有利地在生物体中表达。 此外，本发明涉及一种具有升高的多链多不饱和脂肪酸含量的油和/或三酰基甘油酯的生产方法。 本发明还涉及包含本发明的核酸序列的核酸序列，核酸构建体，载体和生物，包含核酸序列和/或核酸构建体的载体以及包含上述核酸序列的转基因生物 ，核酸构建体和/或载体。 本发明的另一部分涉及通过根据本发明的方法生产的油，脂质和/或脂肪酸及其用途。
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2.发明授权Plant acyltransferases specific for long-chained, multiply unsaturated fatty acids 有权植物酰基转移酶特异于长链，多不饱和脂肪酸公开(公告)号：US08354569B2
公开(公告)日：2013-01-15
申请号：US12844938
申请日：2010-07-28
申请人： Andreas Renz , Jörg Bauer , Margit Frentzen , Nursen Sözer , Stobart Keith , Thomas Fraser , Colin M. Lazarus , Baoxiu Qi , Amine Abbadi , Ernst Heinz
发明人： Andreas Renz , Jörg Bauer , Margit Frentzen , Nursen Sözer , Stobart Keith , Thomas Fraser , Colin M. Lazarus , Baoxiu Qi , Amine Abbadi , Ernst Heinz
CPC分类号： C12P7/6427 , C12N9/1029 , C12N15/8247 , C12P7/6472
摘要： The invention relates to a process for the production of long-chain polyunsaturated fatty acids in an organism by introducing, into the organism, nucleic acids coding for polypeptides with acyltransferase activity. These nucleic acid sequences, if appropriate together with further nucleic acid sequences coding for polypeptides of the fatty acid or lipid metabolism biosynthesis, can advantageously be expressed in the organism. Furthermore, the invention relates to a method for the production of oils and/or triacylglycerides with an elevated content of long-chain polyunsaturated fatty acids. The invention furthermore relates to the nucleic acid sequences, and constructs, vectors and organisms comprising the nucleic acid sequences. A further part of the invention relates to oils, lipids and/or fatty acids produced by the process according to the invention and to their use.
摘要翻译： 本发明涉及通过向生物体中引入编码具有酰基转移酶活性的多肽的核酸来生产生物体中长链多不饱和脂肪酸的方法。 如果合适，这些核酸序列与编码脂肪酸或脂质代谢生物合成的多肽的其它核酸序列一起可以有利地在生物体中表达。 此外，本发明涉及一种具有升高的多链多不饱和脂肪酸含量的油和/或三酰基甘油酯的生产方法。 本发明还涉及包含核酸序列的核酸序列和构建体，载体和生物体。 本发明的另一部分涉及通过根据本发明的方法生产的油，脂质和/或脂肪酸及其用途。
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3.发明授权Plant acyltransferases specific for long-chained, multiply unsaturated fatty acids 有权植物酰基转移酶特异于长链，多不饱和脂肪酸公开(公告)号：US07855321B2
公开(公告)日：2010-12-21
申请号：US10552013
申请日：2004-03-26
申请人： Andreas Renz , Jörg Bauer , Margit Frentzen , Nursen Sözer , Stobart Keith , Thomas Fraser , Colin M. Lazarus , Baoxiu Qi , Amine Abbadi , Ernst Heinz
发明人： Andreas Renz , Jörg Bauer , Margit Frentzen , Nursen Sözer , Stobart Keith , Thomas Fraser , Colin M. Lazarus , Baoxiu Qi , Amine Abbadi , Ernst Heinz
CPC分类号： C12P7/6427 , C12N9/1029 , C12N15/8247 , C12P7/6472
摘要： The present invention relates to a process for the production of long-chain polyunsaturated fatty acids in an organism by introducing, into the organism, nucleic acids which code for polypeptides with acyl transferase activity. These nucleic acid sequences, if appropriate together with further nucleic acid sequences which code for polypeptides of the fatty acid or lipid metabolism biosynthesis, can advantageously be expressed in the organism. Furthermore, the invention relates to a method for the production of oils and/or triacylglycerides with an elevated content of long-chain polyunsaturated fatty acids.The invention furthermore relates to the nucleic acid sequences, nucleic acid constructs, vectors and organisms comprising the nucleic acid sequences according to the invention, vectors comprising the nucleic acid sequences and/or the nucleic acid constructs and to transgenic organisms comprising the abovementioned nucleic acid sequences, nucleic acid constructs and/or vectors.A further part of the invention relates to oils, lipids and/or fatty acids produced by the process according to the invention and to their use.
摘要翻译： 本发明涉及通过向生物体中引入编码具有酰基转移酶活性的多肽的核酸来生产生物体中长链多不饱和脂肪酸的方法。 如果合适的话，这些核酸序列与编码脂肪酸或脂质代谢生物合成的多肽的其它核酸序列一起可以有利地在生物体中表达。 此外，本发明涉及一种具有升高的多链多不饱和脂肪酸含量的油和/或三酰基甘油酯的生产方法。 本发明还涉及包含本发明的核酸序列的核酸序列，核酸构建体，载体和生物，包含核酸序列和/或核酸构建体的载体以及包含上述核酸序列的转基因生物 ，核酸构建体和/或载体。 本发明的另一部分涉及通过根据本发明的方法生产的油，脂质和/或脂肪酸及其用途。
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公开(公告)号：US20060168684A1
公开(公告)日：2006-07-27
申请号：US10513412
申请日：2003-05-06
申请人： Andreas Renz , Jorg Bauer , Marc Nigel , Rita Zrenner , Peter Geigenberger , Helene Vigeolas
发明人： Andreas Renz , Jorg Bauer , Marc Nigel , Rita Zrenner , Peter Geigenberger , Helene Vigeolas
CPC分类号： C12N9/0006 , C12N15/8247
摘要： The invention relates to methods for increasing the oil content in plants, preferably in the seeds of plants, by expression of glycerol-3-phosphatdehydrogenases (G3PDH) from yeast, preferably from Saccharomyces cerevisiae. The invention also relates to expression constructs for the expression of G3PDH yeast in plants, preferably in the seeds of plants, transgenic plants expressing G3PDH, and to the use of said transgenic plants in the production of foodstuffs, feed, seeds, pharmaceuticals or fine chemicals, especially in the production of oils.
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公开(公告)号：US08486671B2
公开(公告)日：2013-07-16
申请号：US12417171
申请日：2009-04-02
申请人： Andreas Renz , Ernst Heinz , Amine Abbadi , Frederic Domergue , Thorsten Zank
发明人： Andreas Renz , Ernst Heinz , Amine Abbadi , Frederic Domergue , Thorsten Zank
CPC分类号： C12N15/8247 , C12N9/1029 , C12P7/6427 , C12P7/6472
摘要： The present invention relates to a process for producing polyunsaturated fatty acids in an organism by introducing nucleic acids into the organism which code for polypeptides having acyl-CoA:lysophospholipid a cyltransferase activity. Advantageously, these nucleic acid sequences may, if appropriate together with further nucleic acid sequences coding for biosynthesis polypeptides of the fatty acid or lipid metabolism, be expressed in the transgenic organism. The invention furthermore relates to the nucleic acid sequences, to nucleic acid constructs comprising the nucleic acid sequences of the invention, to vectors comprising the nucleic acid sequences and/or the nucleic acid constructs and to transgenic organisms comprising the abovementioned nucleic acid sequences, nucleic acid constructs and/or vectors. A further part of the invention relates to oils, lipids and/or fatty acids produced by the process of the invention and to their use.
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公开(公告)号：US09457159B2
公开(公告)日：2016-10-04
申请号：US13521946
申请日：2010-12-23
申请人： Wilfried Weber , Andreas Renz , Dariusz Petry
发明人： Wilfried Weber , Andreas Renz , Dariusz Petry
摘要： An injection device including a carrier housing in which an injection unit having at least one injection liquid container that can be pressed out can be inserted, and an actuating device which can be driven along an injection direction (R) to activate the injection unit. The actuating device includes a piercing carriage a receptacle for the injection unit, and an injection carriage which can be displaced relative to the piercing carriage. The injection carriage has an actuating plunger for acting on a plunger of the injection unit. The piercing carriage and the injection carriage can be actuated by a force application means at least in order to carry out a piercing stroke and an injection stroke, and a piercing depth (tE) of the injection unit can be set. For this purpose, the receptacle is mounted on the piercing carriage adjustably in the injection direction (R).
摘要翻译： 一种注射装置，其包括载体壳体，其中可以插入具有可以被挤出的至少一个注射液体容器的注射单元，以及可以沿着注射方向（R）驱动以致动注射单元的致动装置。 致动装置包括穿孔托架用于注射单元的容器，以及可相对于穿孔托架移位的注射托架。 注射支架具有用于作用在注射单元的柱塞上的致动柱塞。 刺穿托架和注射托架可以由施力装置致动，至少为了执行穿刺行程和注射行程，并且可以设定注射单元的刺穿深度（tE）。 为此，插座可以在注射方向（R）上可调节地安装在穿孔架上。
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7.发明授权公开(公告)号：US07544859B2
公开(公告)日：2009-06-09
申请号：US10182634
申请日：2001-02-08
申请人： Ernst Heinz , Thorsten Zank , Ulrich Zähringer , Jens Lerchl , Andreas Renz
发明人： Ernst Heinz , Thorsten Zank , Ulrich Zähringer , Jens Lerchl , Andreas Renz
CPC分类号： C12N9/1029 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： The invention relates to novel elongase genes with the sequences stated in sequence SEQ ID NO:1, SEQ ID NO: 3, SEQ ID NO: 5 and SEQ ID NO: 7 or their homologs, derivatives or analogs, to a gene construct comprising this gene or its homologs, derivatives and analogs, and to its use. The invention also relates to vectors or transgenic organisms comprising an elongase gene with the sequence SEQ ID NO:1, SEQ ID NO: 3, SEQ ID NO: 5 and SEQ ID NO: 7 or its homologs, derivatives and analogs. The invention furthermore relates to the use of the elongase gene sequences alone or in combination with further elongases and/or further fatty acid biosynthesis genes. The present invention relates to a novel elongase gene with the sequence SEQ ID NO:1 or its homologs, derivatives and analogs. Furthermore, the invention relates to a process for the preparation of polyunsaturated fatty acids and to a process for introducing DNA into organisms which produce large amounts of oils and, in particular, oils with a high content of unsaturated fatty acids. Moreover, the invention relates to an oil and/or a fatty acid preparation with a higher content of polyunsaturated fatty acids with at least two double bonds and/or a triacylglycerol preparation with a higher content of polyunsaturated fatty acids with at least two double bonds.
摘要翻译： 本发明涉及具有序列SEQ ID NO：1，SEQ ID NO：3，SEQ ID NO：5和SEQ ID NO：7所示序列的新型延伸酶基因或其同源物，衍生物或类似物，其包含该基因构建体 基因或其同系物，衍生物和类似物及其用途。 本发明还涉及包含具有序列SEQ ID NO：1，SEQ ID NO：3，SEQ ID NO：5和SEQ ID NO：7的延伸酶基因或其同源物，衍生物和类似物的载体或转基因生物。 本发明还涉及单独使用延伸酶基因序列或与其它延伸酶和/或其它脂肪酸生物合成基因组合的用途。 本发明涉及具有序列SEQ ID NO：1或其同系物，衍生物和类似物的新型延伸酶基因。 此外，本发明涉及一种制备多不饱和脂肪酸的方法，以及将DNA引入生产大量油，特别是具有高含量不饱和脂肪酸的油的生物体中的方法。 此外，本发明涉及具有较高含量的具有至少两个双键的多不饱和脂肪酸的油和/或脂肪酸制剂和/或具有至少两个双键的具有较高含量的多不饱和脂肪酸的三酰基甘油制剂。
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公开(公告)号：US08641669B2
公开(公告)日：2014-02-04
申请号：US13201578
申请日：2010-01-22
申请人： Andreas Renz , Wilfried Weber
发明人： Andreas Renz , Wilfried Weber
CPC分类号： A61M5/2066 , A61M5/20 , A61M5/2033 , A61M5/2448 , A61M5/326 , A61M5/46 , A61M5/482 , A61M2005/206
摘要： An injection apparatus (2) has a carrier housing (4), into which an injection device (8) having at least one injection fluid container (10) that can be pressed out can be inserted, and an actuating apparatus (12) which can be driven along an injection direction (R) in order to activate the injection device (8) and which can be acted on for performing at least one pricking stroke and one injection stroke by a mechanical energy storage unit (20) and an electrical transport unit (26). The invention provides for the actuating apparatus (12) to be driven in the injection direction (R) by the driving force of a mechanical energy storage unit (20) and for the electrical transport unit (26) to form a speed limiter which acts counter to the driving force during an injection, in order to limit a stroke speed attained via the energy storage unit.
摘要翻译： 注射装置（2）具有载体壳体（4），可以插入具有至少一个能够挤出的注射流体容器（10）的注射装置（8），以及能够插入的致动装置（12） 沿着注射方向（R）被驱动以便启动注射装置（8），并且可以通过机械能量存储单元（20）和电气输送单元（20）进行至少一次穿刺冲程和一次注射冲程 （26）。 本发明通过机械能量存储单元（20）的驱动力和电气传输单元（26）提供致动装置（12）以喷射方向（R）驱动以形成速度限制器 以限制通过能量存储单元获得的行程速度。
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公开(公告)号：US20130150787A1
公开(公告)日：2013-06-13
申请号：US13521946
申请日：2010-12-23
申请人： Wilfried Weber , Andreas Renz , Dariusz Petry
发明人： Wilfried Weber , Andreas Renz , Dariusz Petry
IPC分类号： A61M5/46
摘要： The invention relates to an injection device (2) comprising a carrier housing (4), in which an injection unit (8) having at least one injection liquid container (10) that can be pressed out can be inserted, and an actuating device (12), which can be driven along an injection direction (R) to activate the injection unit (8), wherein said actuating device comprises a piercing carriage (14), a receptacle (18) for the injection unit (8) and an injection carriage (16), which can be displaced relative to the piercing carriage (14), said injection carriage having an actuating plunger (48) for acting on a plunger (50) of the injection unit (8), wherein the piercing carriage (14) and the injection carriage (16) can be actuated by a force application means at least in order to carry out a piercing stroke and an injection stroke, and a piercing depth (tE) of the injection unit (8) can be set. For this purpose, the receptacle (18) is mounted on the piercing carriage (14) adjustably in the injection direction (R).
摘要翻译： 本发明涉及一种包括载体壳体（4）的注射装置（2），其中可以插入具有可压出的至少一个注射液体容器（10）的注射单元（8）和致动装置 12），其可以沿喷射方向（R）驱动以启动喷射单元（8），其中所述致动装置包括刺穿滑架（14），用于喷射单元（8）的容器（18）和喷射单元 滑架（16）可以相对于穿孔滑架（14）移动，所述注射滑架具有用于作用在喷射单元（8）的柱塞（50）上的致动柱塞（48），其中穿孔滑架（14） ）和喷射托架（16）可以由施力装置致动，以至少执行穿刺冲程和喷射冲程，并且可以设定喷射单元（8）的刺穿深度（tE）。 为此，容器（18）在喷射方向（R）上可调节地安装在穿孔滑架（14）上。
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公开(公告)号：US20120056019A1
公开(公告)日：2012-03-08
申请号：US13254919
申请日：2010-01-22
申请人： Andreas Renz , Wilfried Weber
发明人： Andreas Renz , Wilfried Weber
IPC分类号： B05B1/30
CPC分类号： A61M5/2033 , A61M5/24 , A61M5/31546 , A61M5/31553 , A61M5/31563 , A61M5/31573 , A61M5/31591 , A61M5/46 , A61M2005/2006 , A61M2005/206 , A61M2005/2414
摘要： An injection device (2) comprises a housing (4) in which a receiving chamber (6) is provided for an injection mechanism (8) having an injection fluid container (10) that can be pressed out by means of an injection plunger (12). The injection device (2) further comprises an actuating device (18) that can be driven for automatically pressing out the injection fluid container (10), wherein said actuating device can be displaced between an insertion/removal position outside of the receiving chamber (6) and an injection position within the receiving chamber (6), wherein the actuating device (18) is spaced by a release distance (d) from the receiving chamber (6) in the insertion/removal position. A contact mechanism (22) is provided, by means of which the actuating device (18) can be brought into a stop position in which an actuating stop (26) of the actuating device (18) contacts the injection plunger (12) and in which an injection volume adjustment (28) is automatically actuated.
摘要翻译： 注射装置（2）包括壳体（4），其中设置有用于注射机构（8）的接收室（6），该注射机构具有可以通过注射柱塞（12）压出的注射流体容器（10） ）。 注射装置（2）还包括致动装置（18），其可被驱动以自动挤出注射流体容器（10），其中所述致动装置可以在接收室（6）外部的插入/取出位置之间移位 ）和所述接收室（6）内的注射位置，其中所述致动装置（18）在所述插入/取出位置处与所述容纳室（6）间隔开释放距离（d）。 提供接触机构（22），通过该接触机构，致动装置（18）能够进入停止位置，致动装置（18）的致动止动件（26）接触到注射柱塞（12） 自动启动进样量调节（28）。
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