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28 条记录 (耗时 0.033 秒)

    Composite head-electrical conditioner assembly
    1.
    发明授权
    Composite head-electrical conditioner assembly 有权
    复合头电器组装

    公开(公告)号：US07450342B2

    公开(公告)日：2008-11-11

    申请号：US11079052

    申请日：2005-03-14

    申请人： Andrew David White ,  Roger Lee Hipwell, Jr. ,  John R. Pendray ,  Bradley Jay VerMeer

    发明人： Andrew David White ,  Roger Lee Hipwell, Jr. ,  John R. Pendray ,  Bradley Jay VerMeer

    IPC分类号： G11B5/48 ,  G11B5/60

    CPC分类号： G11B5/4853 ,  G11B5/484

    摘要： A composite head-electrical conditioner assembly that includes a slider with a transducer head and transducer bond pads. The transducer bond pads communicate a transducer level electrical signal with the transducer head. An integrated circuit substrate has a conditioning circuit and first substrate bond pads electrically connected to the transducer bond pads. The integrated circuit substrate has second substrate bond pads with a conditioned electrical signal that is transmittable over a circuit. The slider is rigidly mounted to the integrated circuit substrate to form an assembly that is flexibly mountable. A thermal isolation space is provided between the transducer and the conditioning circuit. The integrated circuit can be in the form of a cap that provides windage reduction.

    摘要翻译： 一种复合头 - 电调节器组件，其包括具有换能器头和换能器接合垫的滑块。 传感器接合焊盘将传感器电平信号与换能器头通信。 集成电路基板具有调节电路和电连接到换能器接合焊盘的第一基板接合焊盘。 集成电路衬底具有第二衬底接合焊盘，其具有可通过电路传输的经调节的电信号。 滑块刚性地安装到集成电路基板上以形成可灵活安装的组件。 在换能器和调节电路之间设有隔热空间。 集成电路可以是提供减少风量的帽子的形式。

    Matrix metalloproteinase inhibitors and their therapeutic uses
    3.
    发明授权
    Matrix metalloproteinase inhibitors and their therapeutic uses 失效
    基质金属蛋白酶抑制剂及其治疗用途

    公开(公告)号：US06624177B1

    公开(公告)日：2003-09-23

    申请号：US09254384

    申请日：1999-03-02

    申请人： Patrick Michael O'Brien ,  Joseph Armand Picard ,  Drago Robert Sliskovic ,  Andrew David White

    发明人： Patrick Michael O'Brien ,  Joseph Armand Picard ,  Drago Robert Sliskovic ,  Andrew David White

    IPC分类号： C07D20982

    CPC分类号： C07D307/91 ,  A61K31/343 ,  A61K31/381 ,  C07C311/19 ,  C07C2603/18 ,  C07D333/76

    摘要： The present invention relates to a method of inhibiting matrix metalloproteinases using compounds that are dibenzofuran sulfonamide derivatives having the Formula I More particularly, the present invention relates to a method of treating diseases in which matrix melatoproteinases are involved such as multiple sclerosis, atherosclerotic plaque rupture, restenosis, aortic aneurism, heart failure, periodontal disease, corneal ulceration, burns, decubital ulcers, chronic ulcers or wounds, cancer metastasis, tumor angiogenesis, arthritis, or other autoimmune or inflammatory diseases dependent upon tissue invasion by leukocytes.

    摘要翻译： 本发明涉及使用具有式IIIO的二苯并呋喃磺酰胺衍生物的化合物抑制基质金属蛋白酶的方法，本发明涉及一种治疗涉及多发性硬化症，动脉粥样硬化斑块破裂，再狭窄的基质蛋白酶的疾病的方法 ，主动脉瘤，心力衰竭，牙周病，角膜溃疡，烧伤，褥疮性溃疡，慢性溃疡或创伤，癌症转移，肿瘤血管生成，关节炎或依赖于白细胞组织侵袭的其他自身免疫性或炎性疾病。

    Benzene butyric acids and their derivatives as inhibitors of matrix metalloproteinases
    4.
    发明授权
    Benzene butyric acids and their derivatives as inhibitors of matrix metalloproteinases 失效
    苯丁酸及其衍生物作为基质金属蛋白酶的抑制剂

    公开(公告)号：US06541521B1

    公开(公告)日：2003-04-01

    申请号：US09351549

    申请日：1999-07-12

    申请人： Claude Forsey Purchase, Jr. ,  Bruce David Roth ,  Andrew David White

    发明人： Claude Forsey Purchase, Jr. ,  Bruce David Roth ,  Andrew David White

    IPC分类号： A61K31195

    CPC分类号： C07D213/82 ,  C07C233/54 ,  C07C233/55 ,  C07C233/63 ,  C07C233/81 ,  C07C235/56 ,  C07C251/48 ,  C07C2601/14 ,  C07D333/38

    摘要： Benzene butyric acid compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A, collagenase-3, and stromelysin-1 and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurysm, heart failure, left ventricular dilation, restenosis, periodontal disease, corneal ulceration, treatment of burns, decubital ulcers, wound healing, cancer, inflammation, pain, arthritis, osteoporosis, renal disease, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes or other activated migrating cells, acute and chronic neurodegenerative disorders including stroke, head trauma, spinal cord injury, Alzheimer's disease, amyotrophic lateral sclerosis, cerebral amyloid angiopathy, AIDS, Parkinson's disease, Huntington's disease, prion diseases, myasthenia gravis, and Duchenne's muscular dystrophy.

    摘要翻译： 苯丁酸化合物和衍生物以及其制备方法及其药物组合物的描述，其可用作基质金属蛋白酶抑制剂，特别是明胶酶A，胶原酶-3和溶基质溶解素-1以及用于治疗多发性硬化， 动脉粥样硬化斑块破裂，主动脉瘤，心力衰竭，左心室扩张，再狭窄，牙周病，角膜溃疡，烧伤治疗，褥疮溃疡，伤口愈合，癌症，炎症，疼痛，关节炎，骨质疏松症，肾脏疾病或其他自身免疫或炎症 依赖于白细胞或其他激活的迁移细胞的组织侵袭的疾病，急性和慢性神经变性疾病，包括中风，头部创伤，脊髓损伤，阿尔茨海默病，肌萎缩性侧索硬化，脑淀粉样血管病，艾滋病，帕金森病，亨廷顿病，朊病毒疾病， 重症肌无力和Duchenne肌营养不良症。

    Detectable components and detection apparatus for detecting such components
    6.
    发明授权
    Detectable components and detection apparatus for detecting such components 有权
    用于检测这些部件的可检测部件和检测装置

    公开(公告)号：US07469838B2

    公开(公告)日：2008-12-30

    申请号：US10863513

    申请日：2004-06-09

    申请人： Colin Philip Brooks ,  David Bernard Mapleston ,  Peter Robert Symons ,  Andrew David White

    发明人： Colin Philip Brooks ,  David Bernard Mapleston ,  Peter Robert Symons ,  Andrew David White

    IPC分类号： G06K19/06 ,  G06K7/08

    CPC分类号： G06K7/10128 ,  G01R33/02 ,  G01V3/081 ,  G01V15/00 ,  G06K7/0008 ,  G06K19/0723 ,  G07D7/04

    摘要： A detectable component has a first inductive coupler (L;M) adapted to couple inductively to a second inductive coupler (L1) of a detection apparatus when the detectable component is in range of or coupled to the detection apparatus. The first inductive coupler has a resistive component (M) with a resistance that varies with magnetic field to cause modulation of a carrier signal supplied to the second inductive coupler of the detection apparatus, the detectable component having a characteristic signature that enables the detectable component to be distinguished by the detection apparatus from other such detectable components having different characteristic signatures.

    摘要翻译： 当可检测组件在检测装置的范围内或耦合到检测装置时，可检测组件具有适于将感应耦合到检测装置的第二电感耦合器（L1）的第一感应耦合器（L; M）。 第一电感耦合器具有电阻分量（M），其电阻随磁场而变化，从而调制提供给检测装置的第二感应耦合器的载波信号，该可检测部件具有使得可检测部件能够 通过检测装置与具有不同特性特征的其它这种可检测组件区分开来。

    Electrical devices
    7.
    发明授权
    Electrical devices 有权
    电气设备

    公开(公告)号：US07248892B2

    公开(公告)日：2007-07-24

    申请号：US10477733

    申请日：2002-05-14

    申请人： Andrew David White ,  Marc Adrian Borrett ,  David Bernard Mapleston

    发明人： Andrew David White ,  Marc Adrian Borrett ,  David Bernard Mapleston

    IPC分类号： H04M1/00 ,  H04B1/38

    CPC分类号： H04M1/0256 ,  B23Q1/0009 ,  H04M1/0283 ,  H04M1/72525 ,  H04M1/72544 ,  H04M1/72561 ,  H04M1/72575 ,  H04M2250/22

    摘要： An electrical device such as a portable communications device, domestic or personal care appliance has a main body adapted to couple to an accessory which may be in the form of a tool attachable to the main body or a housing portion. The accessory carries a passive data storage device having a memory (59) storing control data for controlling an operation or affecting a function of the device. The passive data storage device is arranged to derive a power supply from the main body when a first coupler carried by the main body is placed in proximity to a second coupler carried by the accessory (3). Where the electrical device is a portable communications device, then the accessory may be, for example, a fascia. The coupling between the first and second couplers may be inductive or capacitive.

    摘要翻译： 诸如便携式通信设备，家用或个人护理用具的电气设备具有适于联接到可附接到主体或壳体部分的工具形式的附件的主体。 该附件携带具有存储器（59）的无源数据存储设备，存储器（59）存储用于控制操作或影响设备功能的控制数据。 无源数据存储装置被布置成当由主体承载的第一耦合器放置在由附件（3）承载的第二耦合器附近时从主体导出电力供应。 在电气设备是便携式通信设备的情况下，附件可以是例如面板。 第一和第二耦合器之间的耦合可以是电感的或电容的。

    Method of inhibiting matrix metalloproteinases
    9.
    发明授权
    Method of inhibiting matrix metalloproteinases 失效
    抑制基质金属蛋白酶的方法

    公开(公告)号：US06620835B2

    公开(公告)日：2003-09-16

    申请号：US10162518

    申请日：2002-06-04

    申请人： Patrick Michael O'Brien ,  Joseph Armand Picard ,  Drago Robert Sliskovic ,  Andrew David White

    发明人： Patrick Michael O'Brien ,  Joseph Armand Picard ,  Drago Robert Sliskovic ,  Andrew David White

    IPC分类号： A61K31381

    CPC分类号： C07D307/91 ,  A61K31/343 ,  A61K31/381 ,  C07C311/19 ,  C07C2603/18 ,  C07D333/76

    摘要： The present invention relates to a method of inhibiting matrix metalloproteinases using compounds that are dibenzofuran sulfonamide derivatives having the Formula I More particularly, the present invention relates to a method of treating diseases in which matrix metalloproteinases are involved such as multiple sclerosis, atherosclerotic plaque rupture, restenosis, aortic aneurism, heart failure, periodontal disease, corneal ulceration, burns, decubital ulcers, chronic ulcers or wounds, cancer metastasis, tumor angiogenesis, arthritis, or other autoimmune or inflammatory diseases dependent upon tissue invasion by leukocytes.

    摘要翻译： 本发明涉及使用具有式IIIO的二苯并呋喃磺酰胺衍生物的化合物抑制基质金属蛋白酶的方法，本发明涉及治疗涉及基质金属蛋白酶的疾病的方法，例如多发性硬化，动脉粥样硬化斑块破裂，再狭窄 ，主动脉瘤，心力衰竭，牙周病，角膜溃疡，烧伤，褥疮性溃疡，慢性溃疡或创伤，癌症转移，肿瘤血管生成，关节炎或依赖于白细胞组织侵袭的其他自身免疫性或炎性疾病。