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    Terephthalamide peptidomimetic compounds and methods
    1.
    发明申请
    Terephthalamide peptidomimetic compounds and methods 审中-公开
    对苯二甲酰胺拟肽化合物和方法

    公开(公告)号：US20070123592A1

    公开(公告)日：2007-05-31

    申请号：US10588478

    申请日：2005-02-22

    申请人： Andrew Hamilton ,  Hang Yin

    发明人： Andrew Hamilton ,  Hang Yin

    IPC分类号： A61K31/195

    CPC分类号： C07C235/60 ,  C07C233/83 ,  C07C235/52 ,  C07C237/36

    摘要： The present invention relates to compounds and pharmaceutical compositions based upon terephthalamide which are proteomimetic and to methods for inhibiting the interaction of an alpha-helical protein with another protein or binding site. Methods for treating diseases or conditions which are modulated through interactions between alpha helical proteins and their binding sites are other aspects of the invention. Methods of inhibiting the binding of proteins to their binding sites are other aspects of the present invention.

    摘要翻译： 本发明涉及基于对苯二甲酰胺的化合物和药物组合物，其为蛋白质组学的，以及用于抑制α-螺旋蛋白与另一蛋白质或结合位点相互作用的方法。 用于治疗通过α螺旋蛋白及其结合位点之间的相互作用调节的疾病或病症的方法是本发明的其它方面。 抑制蛋白质与其结合位点结合的方法是本发明的其它方面。

    Enhanced occlusive effect photodynamic therapy
    3.
    发明申请
    Enhanced occlusive effect photodynamic therapy 审中-公开
    增强闭塞效应光动力疗法

    公开(公告)号：US20060229284A1

    公开(公告)日：2006-10-12

    申请号：US11301743

    申请日：2005-12-13

    申请人： Paula Mahoney ,  Louise Culham ,  Brian McIlroy ,  Gregory Heacock ,  Andrew Hamilton ,  John Marshall

    发明人： Paula Mahoney ,  Louise Culham ,  Brian McIlroy ,  Gregory Heacock ,  Andrew Hamilton ,  John Marshall

    IPC分类号： A61K31/409 ,  A61K31/555 ,  A61H33/00

    CPC分类号： A61K31/295 ,  A61K31/409 ,  A61K31/555

    摘要： This invention discloses methods of treating neovasculature diseases of the eye through the administration of a photosensitizing agent and subsequent exposure to light of specific wavelength sufficient to photoactivate the photosensitizing agent to occlude one or more vessels in the neovasculature for an extended period of time. Diseases treatable under this invention, include, for example: diabetic retinopathy; macular degeneration; subfoveal choroidal neovascularization, malignant uveal melanomas and other maladies of the human or animal eye or body.

    摘要翻译： 本发明公开了通过施用光敏剂和随后暴露于足以使光敏剂光敏化以特定波长的光以长时间封闭新血管中的一个或多个血管的方法来治疗眼睛新生血管疾病的方法。 本发明可治疗的疾病包括，例如：糖尿病性视网膜病变; 黄斑变性; 中心凹下脉络膜新生血管形成，恶性葡萄膜黑素瘤和人或动物眼睛或身体的其他疾病。

    Growth factor binding molecules
    4.
    发明申请
    Growth factor binding molecules 有权

    公开(公告)号：US20060084596A1

    公开(公告)日：2006-04-20

    申请号：US11226112

    申请日：2005-09-14

    申请人： Said Sebti ,  Andrew Hamilton

    发明人： Said Sebti ,  Andrew Hamilton

    IPC分类号： A61K38/12 ,  C07K5/12

    CPC分类号： C07K7/56 ,  A61K38/00 ,  C07K14/001

    摘要： Growth factor binding molecules having a plurality of peptide loops attached to a non-peptide organic scaffold, preferably having pseudo-six amino acid peptide loops with four amino acid sidechains. The growth factor binding molecules specifically bind various growth factors and are suitable for treating a subject having tumors or restinosis. In one embodiment a platelet-derived growth factor binding molecule is disclosed that is used to inhibit tumor growth and angiogenesis in solid tumors.

    RNA molecules and vectors for gene silencing
    5.
    发明申请
    RNA molecules and vectors for gene silencing 有权
    RNA分子和载体用于基因沉默

    公开(公告)号：US20050102709A1

    公开(公告)日：2005-05-12

    申请号：US11013315

    申请日：2004-12-17

    申请人： David Baulcombe ,  Andrew Hamilton

    发明人： David Baulcombe ,  Andrew Hamilton

    IPC分类号： C12N15/82 ,  C12Q1/68 ,  A01H1/00 ,  A01K67/033

    CPC分类号： C12N15/113 ,  A01N57/16 ,  C12N15/8218

    摘要： Provided are methods of screening for the occurrence of gene silencing (e.g. post transcriptional gene silencing) in an organism (e.g. a plant or animal), which method comprises the steps of; (i) obtaining a sample of material from said organism, (ii) producing a nucleic acid extract from said sample, (iii) analysing said extract such as to determine the presence or absence of short RNA molecules which are approximately 25 nucleotides in length (SRMs) in said nucleic extract, (iv) correlating the presence of said SRMs in the extract with the occurrence of gene silencing in said organism. The SRMs are preferably short anti-sense RNA molecules (SARMs). Also provided are associated methods for detecting the silencing of a target gene in an organism. Processes for isolating one or more RNA molecules, such as SARMs, which may be advantageously employed in the method, may include a purification step selected from (i) filtration; (ii) differential precipitation (iii) ion exchange chromatography, followed by separation the purified RNA molecules according to size by electrophoresis through 15% polyacrylamide gel containing 7M urea as a denaturant and TBE (0.5×) as a buffer, and blotting by electrophoresis. Also provided are processes for isolating silencing agents comprising SRMs; methods of selecting target regions of target genes for directed silencing; and methods of silencing target genes in organisms based on these. Silencing in a first organism may be achieved by generating in a second organism, SRMs which are introduced into the first organism such as to silence a target gene therein. Also provided are DNA constructs, host cells, plants and non-human mammals which comprise target genes which have been silenced in accordance with the methods herein.

    摘要翻译： 提供了筛选生物体（例如植物或动物）中基因沉默（例如转录后基因沉默）的发生的方法，该方法包括以下步骤： （i）从所述生物体获得材料样品，（ii）从所述样品中产生核酸提取物，（iii）分析所述提取物，以确定长度为约25个核苷酸的短RNA分子的存在或不存在 SRM），（iv）将所述提取物中所述SRM的存在与所述生物体中基因沉默的发生相关联。 SRM优选为短反义RNA分子（SARM）。 还提供了用于检测生物体中靶基因沉默的相关方法。 用于分离一种或多种RNA分子（例如SARM）的方法，其可以有利地用于该方法中，可以包括纯化步骤，其选自（i）过滤; （ii）差示沉淀（iii）离子交换层析，然后根据大小通过电泳，通过含有7M尿素作为变性剂和TBE（0.5x）作为缓冲液的15％聚丙烯酰胺凝胶分离纯化的RNA分子，并通过电泳印迹。 还提供了用于分离包含SRM的沉默剂的方法; 选择目标基因靶向定向沉默的方法; 以及基于这些沉默生物体中靶基因的方法。 在第一生物体中的沉默可以通过在第二生物体中产生被引入第一生物体的SRM来实现，以使其中的靶基因沉默。 还提供了包括根据本文方法已经沉默的靶基因的DNA构建体，宿主细胞，植物和非人哺乳动物。

    Proteomimetic compounds as inhibitors of the interaction of nuclear receptor with coactivator peptides
    6.
    发明授权
    Proteomimetic compounds as inhibitors of the interaction of nuclear receptor with coactivator peptides 有权
    蛋白质组学化合物作为核受体与共激活肽相互作用的抑制剂

    公开(公告)号：US08084471B2

    公开(公告)日：2011-12-27

    申请号：US12226369

    申请日：2007-09-04

    申请人： Andrew Hamilton ,  Jorge Becerril

    发明人： Andrew Hamilton ,  Jorge Becerril

    IPC分类号： A01N43/40 ,  A61K31/44 ,  C07D213/22

    CPC分类号： C07D213/69

    摘要： The present invention relates to compounds, pharmaceutical compositions and methods which inhibit the binding of coactivator proteins in nuclear receptors, including estrogen receptors (alpha and/or beta), androgen receptors, thyroid receptors and peroxisome proliferators-activated receptors, among others. Compounds according to the present invention may be useful in the treatment of a variety of disease states or conditions which are mediated through nuclear receptors.

    摘要翻译： 本发明涉及抑制核受体（包括雌激素受体（α和/或β）），雄激素受体，甲状腺受体和过氧化物酶体增殖物激活的受体等共激活因子结合的化合物，药物组合物和方法。 根据本发明的化合物可用于治疗通过核受体介导的各种疾病状态或病症。

    Method and system for error detection in an automated teller machine
    8.
    发明申请
    Method and system for error detection in an automated teller machine 审中-公开
    自动取款机中错误检测的方法和系统

    公开(公告)号：US20070131757A1

    公开(公告)日：2007-06-14

    申请号：US11297212

    申请日：2005-12-08

    申请人： Andrew Hamilton ,  Stephen MacPhail ,  Wolf-Dieter Rossmann

    发明人： Andrew Hamilton ,  Stephen MacPhail ,  Wolf-Dieter Rossmann

    IPC分类号： G07F19/00 ,  G06Q40/00

    CPC分类号： G07F19/211 ,  G06Q20/1085 ,  G07F19/20 ,  G07F19/206

    摘要： The invention features a method for administering an ATM. One or more transactions are conducted at the ATM and the ATM generates one or more logs corresponding to the transactions. A communications link is established between the ATM and a computer. The logs are represented in an XML-based format and are transmitted over the communications link in that format. XML stands for extensible Markup Language.

    摘要翻译： 本发明的特征在于一种用于管理ATM的方法。 一个或多个交易在ATM处进行，并且ATM生成对应于交易的一个或多个日志。 在ATM和计算机之间建立通信链路。 日志以基于XML的格式表示，并通过该格式的通信链路进行传输。 XML代表可扩展标记语言。

    Fractionated light PDT therapy for posterior eye disease
    9.
    发明申请
    Fractionated light PDT therapy for posterior eye disease 有权
    分光光PDT治疗后眼病

    公开(公告)号：US20050240247A1

    公开(公告)日：2005-10-27

    申请号：US11089944

    申请日：2005-03-25

    申请人： Brian McIlroy ,  Gregory Heacock ,  Paula Mahoney ,  Andrew Hamilton

    发明人： Brian McIlroy ,  Gregory Heacock ,  Paula Mahoney ,  Andrew Hamilton

    IPC分类号： A61N5/06

    CPC分类号： A61N5/062 ,  A61N2005/0651

    摘要： A method and system directs therapeutic light of a first wavelength to a patient's eye to excite a photosensitizing agent for PDT during a series of discrete periods of time that are separated by non-therapeutic intervals. Diagnostic light of a second wavelength can be directed to the eye during at least a portion of one or more of the non-therapeutic intervals to allow a physician to see the affect of the therapy.

    摘要翻译： 方法和系统将第一波长的治疗光引导到患者的眼睛，以在由非治疗间隔分开的一系列离散时间段内激发用于PDT的光敏剂。 第二波长的诊断光可以在一个或多个非治疗间隔的至少一部分期间被引导到眼睛，以允许医师看到治疗的影响。

    Gene silencing
    10.
    发明申请
    Gene silencing 审中-公开
    基因沉默

    公开(公告)号：US20050158758A1

    公开(公告)日：2005-07-21

    申请号：US11013469

    申请日：2004-12-17

    申请人： David Baulcombe ,  Andrew Hamilton

    发明人： David Baulcombe ,  Andrew Hamilton

    IPC分类号： C12N15/82 ,  A01K67/00 ,  A01H1/00 ,  C12Q1/68

    CPC分类号： C12N15/113 ,  A01N57/16 ,  C12N15/8218

    摘要： Provided are methods of screening for the occurrence of gene silencing (e.g. post transcriptional gene silencing) in an organism (e.g. a plant or animal), which method comprises the steps of; (i) obtaining a sample of material from said organism, (ii) producing a nucleic acid extract from said sample, (iii) analysing said extract such as to determine the presence or absence of short RNA molecules which are approximately 25 nucleotides in length (SRMs) in said nucleic extract, (iv) correlating the presence of said SRMs in the extract with the occurrence of gene silencing in said organism. The SRMs are preferably short anti-sense RNA molecules (SARMs). Also provided are associated methods for detecting the silencing of a target gene in an organism. Processes for isolating one or more RNA molecules, such as SARMs, which may be advantageously employed in the method, may include a purification step selected from (i) filtration; (ii) differential precipitation (iii) ion exchange chromatography, followed by separation the purified RNA molecules according to size by electrophoresis through 15% polyacrylamide gel containing 7M urea as a denaturant and TBE (0.5×) as a buffer, and blotting by electrophoresis. Also provided are processes for isolating silencing agents comprising SRMs; methods of selecting target regions of target genes for directed silencing; and methods of silencing target genes in organisms based on these. Silencing in a first organism may be achieved by generating in a second organism, SRMs which are introduced into the first organism such as to silence a target gene therein. Also provided are DNA constructs, host cells, plants and non-human mammals which comprise target genes which have been silenced in accordance with the methods herein.

    摘要翻译： 提供了筛选生物体（例如植物或动物）中基因沉默（例如转录后基因沉默）的发生的方法，该方法包括以下步骤： （i）从所述生物体获得材料样品，（ii）从所述样品中产生核酸提取物，（iii）分析所述提取物，以确定长度为约25个核苷酸的短RNA分子的存在或不存在 SRM），（iv）将所述提取物中所述SRM的存在与所述生物体中基因沉默的发生相关联。 SRM优选为短反义RNA分子（SARM）。 还提供了用于检测生物体中靶基因沉默的相关方法。 用于分离一种或多种RNA分子（例如SARM）的方法，其可以有利地用于该方法中，可以包括纯化步骤，其选自（i）过滤; （ii）差示沉淀（iii）离子交换层析，然后根据大小通过电泳，通过含有7M尿素作为变性剂和TBE（0.5x）作为缓冲液的15％聚丙烯酰胺凝胶分离纯化的RNA分子，并通过电泳印迹。 还提供了用于分离包含SRM的沉默剂的方法; 选择目标基因靶向定向沉默的方法; 以及基于这些沉默生物体中靶基因的方法。 在第一生物体中的沉默可以通过在第二生物体中产生被引入第一生物体的SRM来实现，以使其中的靶基因沉默。 还提供了包括根据本文方法已经沉默的靶基因的DNA构建体，宿主细胞，植物和非人哺乳动物。