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    Pyrazolopyrimidinone antianginal agents
    1.
    发明授权
    Pyrazolopyrimidinone antianginal agents 失效
    吡唑嘧啶酮抗心绞痛药

    公开(公告)号：US5346901A

    公开(公告)日：1994-09-13

    申请号：US84827

    申请日：1993-06-29

    申请人： Andrew S. Bell ,  David Brown ,  Nicholas K. Terrett

    发明人： Andrew S. Bell ,  David Brown ,  Nicholas K. Terrett

    IPC分类号： C07D487/04 ,  A61K31/505

    CPC分类号： C07D487/04

    摘要： Compounds of the formula: ##STR1## wherein R.sup.1 is H, C.sub.1 -C.sub.3 alkyl, C.sub.3 -C.sub.5 cycloalkyl or C.sub.1 -C.sub.3 perfluoroalkyl; R.sup.2 is H, C.sub.1 -C.sub.6 alkyl optionally substituted by OH, C.sub.1 -C.sub.3 alkoxy or C.sub.3 -C.sub.6 cycloalkyl, or C.sub.1 -C.sub.3 perfluoroalkyl; R.sup.3 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 alkynyl, C.sub.3 -C.sub.6 alkynyl, C.sub.3 -C.sub.7 cycloalkyl, C.sub.1 -C.sub.6 perfluoroalkyl or (C.sub.3 -C.sub.6 cycloalky)C.sub.1 -C.sub.6 alkyl; R.sup.4 taken together with the nitrogen atom to which it is attached completes a pyrrolidinyl, piperidino, morpholino, or 4-N-(R.sup.6)-piperazinyl group; R.sup.5 is H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.3 alkoxy, NR.sup.7 R.sup.8, or CONR.sup.7 R.sup.8 ; R.sup.6 is H, C.sub.1 -C.sub.6 alkyl, (C.sub.1 -C.sub.3 alkoxy) C.sub.2 -C.sub.6 alkyl, hydroxy C.sub.2 -C.sub.6 alkyl, (R.sup.7 R.sup.8 N)C.sub.2 -C.sub.6 alkyl, (R.sup.7 R.sup.8 NCO)C.sub.1 -C.sub.6 alkyl, CONR.sup.7 R.sup.8, CSNR.sup.7 R.sup.8 or C(NH)NR.sup.7 R.sup.8 ; R.sup.7 and R.sup.8 are each independently H, C.sub.1 -C.sub.4 alkyl, (C.sub.1 -C.sub.3 alkoxy)C.sub.2 -C.sub.4 alkyl or hydroxy C.sub.2 -C.sub.4 alkyl; and pharmaceutically acceptable salts thereof, are selective cGMP PDE inhibitors useful in the treatment of cardiovascular disorders such as angina, hypertension, heart failure and atherosclerosis.

    摘要翻译： 下式的化合物：其中R 1是H，C 1 -C 3烷基，C 3 -C 5环烷基或C 1 -C 3全氟烷基; R2是H，任选被OH，C1-C3烷氧基或C3-C6环烷基取代的C1-C6烷基，或C1-C3全氟烷基; R3是C1-C6烷基，C3-C6炔基，C3-C6炔基，C3-C7环烷基，C1-C6全氟烷基或（C3-C6环烷基）C1-C6烷基; R4与其所连接的氮原子一起形成吡咯烷基，哌啶子基，吗啉代或4-N-（R6） - 哌嗪基; R5是H，C1-C4烷基，C1-C3烷氧基，NR7R8或CONR7R8; R6是H，C1-C6烷基，（C1-C3烷氧基）C2-C6烷基，羟基C2-C6烷基，（R7R8N）C2-C6烷基，（R7R8NCO）C1-C6烷基，CONR7R8，CSNR7R8或C（NH） NR7R8; R 7和R 8各自独立地为H，C 1 -C 4烷基，（C 1 -C 3烷氧基）C 2 -C 4烷基或羟基C 2 -C 4烷基; 及其药学上可接受的盐是用于治疗心血管疾病如心绞痛，高血压，心力衰竭和动脉粥样硬化的选择性cGMP PDE抑制剂。

    Pyrazolopyrimidinone antianginal agents
    2.
    发明授权
    Pyrazolopyrimidinone antianginal agents 失效
    吡唑嘧啶酮抗心绞痛药

    公开(公告)号：US5250534A

    公开(公告)日：1993-10-05

    申请号：US882988

    申请日：1992-05-14

    申请人： Andrew S. Bell ,  David Brown ,  Nicholas K. Terrett

    发明人： Andrew S. Bell ,  David Brown ,  Nicholas K. Terrett

    IPC分类号： C07D487/04 ,  A61K31/505

    CPC分类号： C07D487/04

    摘要： Compounds of the formula: ##STR1## wherein R.sup.1 is H, C.sub.1 -C.sub.3 alkyl, C.sub.3 -C.sub.5 cycloalkyl or C.sub.1 -C.sub.3 perfluoroalkyl; R.sup.2 is H, C.sub.1 -C.sub.6 alkyl optionally substituted by OH, C.sub.1 -C.sub.3 alkoxy or C.sub.3 -C.sub.6 cycloalkyl, or C.sub.1 -C.sub.3 perfluoroalkyl; R.sup.3 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 alkenyl, C.sub.3 -C.sub.6 alkynyl, C.sub.3 -C.sub.7 cycloalkyl, C.sub.1 -C.sub.6 perfluoroalkyl or (C.sub.3 -C.sub.6 cycloalkyl)C.sub.1 -C.sub.6 alkyl; R.sup.4 taken together with the nitrogen atom to which it is attached completes a pyrrolidinyl, piperidino, morpholino, or 4-N-(R.sup.6)-piperazinyl group; R.sup.5 is H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.3 alkoxy, NR.sup.7 R.sup.8, or CONR.sup.7 R.sup.8 ; R.sup.6 is H, C.sub.1 -C.sub.6 alkyl, (C.sub.1 -C.sub.3 alkoxy) C.sub.2 - C.sub.6 alkyl, hydroxy C.sub.2 -C.sub.6 alkyl, (R.sup.7 R.sup.8 N)C.sub.2 -C.sub.6 alkyl, (R.sup.7 R.sup.8 NCO)C.sub.1 -C.sub.6 alkyl, CONR.sup.7 R.sup.8, CSNR.sup.7 R.sup.8 or C(NH)NR.sup.7 R.sup.8 ; R.sup.7 and R.sup.8 are each independently H, C.sub.1 -C.sub.4 alkyl, (C.sub.1 -C.sub.3 alkoxy)C.sub.2 -C.sub.4 alkyl or hydroxy C.sub.2 -C.sub.4 alkyl; and pharmaceutically acceptable salts thereof, are selective cGMP PDE inhibitors useful in the treatment of cardiovascular disorders such as angina, hypertension, heart failure and atherosclerosis.

    摘要翻译： 下式的化合物：其中R 1是H，C 1 -C 3烷基，C 3 -C 5环烷基或C 1 -C 3全氟烷基; R2是H，任选被OH，C1-C3烷氧基或C3-C6环烷基取代的C1-C6烷基，或C1-C3全氟烷基; R3是C1-C6烷基，C3-C6烯基，C3-C6炔基，C3-C7环烷基，C1-C6全氟烷基或（C3-C6环烷基）C1-C6烷基; R4与其所连接的氮原子一起形成吡咯烷基，哌啶子基，吗啉代或4-N-（R6） - 哌嗪基; R5是H，C1-C4烷基，C1-C3烷氧基，NR7R8或CONR7R8; R6是H，C1-C6烷基，（C1-C3烷氧基）C2-C6烷基，羟基C2-C6烷基，（R7R8N）C2-C6烷基，（R7R8NCO）C1-C6烷基，CONR7R8，CSNR7R8或C（NH） NR7R8; R 7和R 8各自独立地为H，C 1 -C 4烷基，（C 1 -C 3烷氧基）C 2 -C 4烷基或羟基C 2 -C 4烷基; 及其药学上可接受的盐是用于治疗心血管疾病如心绞痛，高血压，心力衰竭和动脉粥样硬化的选择性cGMP PDE抑制剂。

    Deposition particles and a method and apparatus for producing the same
    5.
    发明授权
    Deposition particles and a method and apparatus for producing the same 有权

    公开(公告)号：US11345606B2

    公开(公告)日：2022-05-31

    申请号：US15435318

    申请日：2017-02-17

    申请人： David Brown

    发明人： David Brown

    IPC分类号： G02B6/02 ,  C01G23/053 ,  C01G49/06 ,  C01B33/18

    摘要： Disclosed is a method for producing deposition particles or intermediate particles, characterized in that the method comprises: forming a solution comprising a solvent and one or more deposit sources, aerosolizing the formed solution to produce an aerosol of precursor particles comprising the deposit source, conditioning the precursor particles to produce deposition particles or intermediate particles from the deposit source and collecting said particles. The particles may be collected as a deposit or precursor deposit on a substrate. The particles may include a matrix material and a dopant. The conditioning may be quenched to produce a desired substructure. The matrix material may be essentially optically clear. The substrate may comprise an optical fiber or an optical fiber preform or mandrel.

    ADJUSTABLE CUT BLOCK AND SIZER INSTRUMENT FOR ARTHROPLASTY PLANNING
    7.
    发明申请
    ADJUSTABLE CUT BLOCK AND SIZER INSTRUMENT FOR ARTHROPLASTY PLANNING 审中-公开

    公开(公告)号：US20170128079A1

    公开(公告)日：2017-05-11

    申请号：US15343765

    申请日：2016-11-04

    申请人： David Brown

    发明人： David Brown

    IPC分类号： A61B17/15

    CPC分类号： A61B17/155

    摘要： An integrated instrument for arthroplasty planning comprises a cutting block having an adjustable distance between an anterior cut guide and a posterior cut guide, and a sizer mounted to the cutting block, the sizer comprising medial and lateral posterior feet having an adjustable distance from one of the cut guides and an adjustable angular position relative to the one of the cut guides.

    COLLAPSIBLE BEVERAGE CONTAINMENT DEVICE
    9.
    发明申请
    COLLAPSIBLE BEVERAGE CONTAINMENT DEVICE 审中-公开
    不可饮用的饮料包装设备

    公开(公告)号：US20160130026A1

    公开(公告)日：2016-05-12

    申请号：US14534692

    申请日：2014-11-06

    申请人： David Brown ,  Sheletia Brown

    发明人： David Brown ,  Sheletia Brown

    IPC分类号： B65D1/02 ,  B65D41/04 ,  B65D47/06 ,  B65D1/40

    CPC分类号： B65D1/0292 ,  B65D1/0284 ,  B65D1/40 ,  B65D2501/0036

    摘要： A collapsible beverage containment assembly includes a bottle. The bottle has an outer wall extending between a top end and a bottom end of the bottle to contain a carbonated fluid. The outer wall is structured such that the bottle is collapsible. A sleeve is coupled to the bottom end. The sleeve is positioned within an interior of the bottle. A lid is movably coupled to the top end so the lid may be rotated. A screw is coupled to the lid such that the screw extends downwardly into the bottle. The screw engages the sleeve. Thus, the outer wall is collapsed when the lid is rotated to reduce a volume of the bottle, preserving the carbonation in the carbonated beverage.

    摘要翻译： 可折叠的饮料容纳组件包括瓶子。 瓶子具有在瓶的顶端和底端之间延伸以容纳碳酸液体的外壁。 外壁的结构使得瓶子可折叠。 套筒连接到底端。 套筒位于瓶子的内部。 盖子可移动地联接到顶端，因此盖子可以旋转。 螺钉联接到盖上，使得螺钉向下延伸到瓶中。 螺钉接合套筒。 因此，当盖旋转以减小瓶的体积时，外壁被折叠，从而保持碳酸饮料中的碳酸化。