SYNTHETIC MIMICS OF MIR-34
    6.
    发明申请
    SYNTHETIC MIMICS OF MIR-34 有权
    MIR-34的合成纤维

    公开(公告)号:US20140107182A1

    公开(公告)日:2014-04-17

    申请号:US14081295

    申请日:2013-11-15

    IPC分类号: C12N15/113

    摘要: Embodiments concern methods and compositions involving miR-34 mimics, including miR-34a and miR-34c mimics. In some embodiments, there are double-stranded RNA molecules with modified nucleotides having an active strand with a miR-34a sequence and a complementary passenger strand. In additional embodiments, there are double-stranded RNA molecules with modified nucleotides having an active strand with a miR-34c sequence and a complementary passenger strand.

    摘要翻译: 实施方案涉及涉及miR-34模拟物的方法和组合物,包括miR-34a和miR-34c模拟物。 在一些实施方案中,存在具有经修饰的核苷酸的双链RNA分子,其具有miR-34a序列和补体乘客链的活性链。 在另外的实施方案中,存在具有经修饰的核苷酸的双链RNA分子,其具有与miR-34c序列和补体乘客链的活性链。