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    Interdigitation-fusion liposomes containing arachidonic acid metabolites
    1.
    发明授权
    Interdigitation-fusion liposomes containing arachidonic acid metabolites 失效
    含有花生四烯酸代谢物的交叉指导融合脂质体

    公开(公告)号：US5882678A

    公开(公告)日：1999-03-16

    申请号：US339964

    申请日：1994-11-15

    申请人： Andrew S. Janoff ,  Sharma R. Minchey

    发明人： Andrew S. Janoff ,  Sharma R. Minchey

    IPC分类号： A61K9/127 ,  A61K31/557 ,  A61L2/00

    CPC分类号： A61K31/557 ,  A61K9/127 ,  A61K9/1277 ,  A61L2/0011 ,  Y10S514/825 ,  Y10S514/866

    摘要： This invention provides an interdigitation-fusion liposome comprising an arachidonic acid metabolite, a lipid bilayer comprising a lipid and an aqueous compartment comprising a release-inhibiting buffer. Preferred arachidonic acid metabolites are the prostaglandins, particularly PGE.sub.1. The liposomal formulations can be used to treat animals, particularly humans, for diseases, disorders or conditions which can be ameliorated by prostaglandins, e.g., cell activation/adhesion disorders and inflammatory disorders.

    摘要翻译： 本发明提供了一种包含花生四烯酸代谢物的交叉指导 - 融合脂质体，包含脂质的脂质双层和包含释放抑制缓冲液的水性隔室。 优选的花生四烯酸代谢物是前列腺素，特别是PGE1。 脂质体制剂可用于治疗可由前列腺素改善的疾病，病症或病症的动物，特别是人，例如细胞活化/粘附障碍和炎症性疾病。

    Reduction of liposome-induced adverse physiological reactions
    2.
    发明授权
    Reduction of liposome-induced adverse physiological reactions 失效
    减少脂质体诱导的不良生理反应

    公开(公告)号：US5662930A

    公开(公告)日：1997-09-02

    申请号：US433665

    申请日：1995-05-04

    申请人： Patrick L. Ahl ,  Suresh K. Bhatia ,  Sharma R. Minchey ,  Andrew S. Janoff

    发明人： Patrick L. Ahl ,  Suresh K. Bhatia ,  Sharma R. Minchey ,  Andrew S. Janoff

    IPC分类号： A61K9/127 ,  A61P9/02 ,  A61K9/133

    CPC分类号： A61K9/1271 ,  Y10T428/2984

    摘要： Provided herein is a method of administering a liposome composition to an animal, the method involving adminstering to the animal a liposome composition containing an adverse physiological reaction-reducing effective amount of a liposome which has, in addition to a bioactive agent, a lipid bilayer containing a lipid and a surface agent-modified molecule. An adverse physiological reaction which may be experienced by the animal upon administration of a liposome composition is reduced by way of the presence of the surface agent-modified molecule in the liposome's lipid bilayer.

    摘要翻译： 本文提供了向动物施用脂质体组合物的方法，该方法涉及向动物施用含有不利的生理学降低反应的有效量的脂质体的脂质体组合物，该有效量除了生物活性剂外还含有含有 脂质和表面活性剂改性分子。 通过在脂质体脂质双层中存在表面活性剂修饰的分子，减少了在施用脂质体组合物时可能经历的不良生理反应。

    Tocopherol-based pharmaceutical systems
    4.
    发明授权
    Tocopherol-based pharmaceutical systems 失效
    基于生育酚的制药系统

    公开(公告)号：US5364631A

    公开(公告)日：1994-11-15

    申请号：US18913

    申请日：1993-02-17

    申请人： Andrew S. Janoff ,  Lawrence Boni ,  Sharma R. Minchey ,  Lois E. Bolcsak ,  Steven J. Weiss

    发明人： Andrew S. Janoff ,  Lawrence Boni ,  Sharma R. Minchey ,  Lois E. Bolcsak ,  Steven J. Weiss

    IPC分类号： A61K9/127 ,  A61K31/415

    CPC分类号： A61K31/415 ,  A61K9/1272 ,  Y10T428/2984

    摘要： A method for making a pharmaceutical composition is described. The composition is comprised of an organic acid derivative of alpha tocopherol, and may additionally comprise other lipids. The composition may be in the form of liposomes, and as such are associated with or entrap a bioactive agent. Particularly suited for such systems are drugs stable at acidic pH, for example drugs having imidazole groups, such as pilocarpine. The composition requires a stabilizer to maintain the bilayer phase of the organic acid derivative of alpha tocopherol in a low pH environment. Such a stabilizer is for example a detergent. Upon in vivo administration of the system and concomitant increase of pH, viscosity of the preparation increases.

    摘要翻译： 描述制备药物组合物的方法。 组合物由α-生育酚的有机酸衍生物组成，并且还可以包含其它脂质。 组合物可以是脂质体的形式，因此与生物活性剂相关联或截留生物活性剂。 特别适用于这种系统是在酸性pH下稳定的药物，例如具有咪唑基团的药物，如毛果芸香碱。 该组合物需要稳定剂以在低pH环境中维持α-生育酚的有机酸衍生物的双相。 这种稳定剂是例如洗涤剂。 在系统的体内给药和伴随pH的增加时，制剂的粘度增加。

    High ratio active agent: lipid complex
    5.
    发明授权
    High ratio active agent: lipid complex 失效
    高比例活性剂：脂质复合物

    公开(公告)号：US5415867A

    公开(公告)日：1995-05-16

    申请号：US105764

    申请日：1993-08-11

    申请人： Sharma R. Minchey ,  Christine E. Swenson ,  Andrew S. Janoff ,  Lawrence Boni ,  Kathy A. Stewart ,  Walter Perkins

    发明人： Sharma R. Minchey ,  Christine E. Swenson ,  Andrew S. Janoff ,  Lawrence Boni ,  Kathy A. Stewart ,  Walter Perkins

    IPC分类号： A61K9/127 ,  A61K31/545 ,  A61K49/04

    CPC分类号： A61K49/0466 ,  A61K31/545 ,  A61K47/48053 ,  A61K9/127

    摘要： High ratio active agent:lipid complexes, their preparation and use are disclosed. Particular reference is made to cephalosporin:lipid complex and iodinated contrast agent:lipid complex. Use of high ratio cephalosporin:lipid complex in bacterial prophylaxis, and particularly bacteremia prophylaxis, including a method of preventing bacterial infection in an animal over an extended period comprising the step of administering to said animal a high ratio cephalosporin:lipid complex is further disclosed as is the use of high ratio iodinated contrast agent:lipid complex in X-ray applications.

    摘要翻译： 高比例的活性剂：脂质复合物，其制备和用途被公开。 特别提到头孢菌素：脂质复合物和碘化造影剂：脂质复合物。 在细菌预防中使用高比例头孢菌素：脂质复合物，特别是菌血症预防，包括在长时间内预防动物细菌感染的方法，包括向所述动物施用高比例头孢菌素：脂质复合物的步骤进一步公开为 是使用高比例碘化造影剂：X射线应用中的脂质复合物。