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1.发明授权15-valent pneumococcal polysaccharide-protein conjugate vaccine composition 有权15价肺炎球菌多糖 - 蛋白质结合疫苗组合物公开(公告)号：US08192746B2
公开(公告)日：2012-06-05
申请号：US13020402
申请日：2011-02-03
IPC分类号： A61K39/385
CPC分类号： A61K39/092 , A61K2039/55505 , A61K2039/6037
摘要： The present invention provides a multivalent immunogenic composition having 15 distinct polysaccharide-protein conjugates. Each conjugate consists of a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, 22F, 23F or 33F) conjugated to a carrier protein, preferably CRM197. The immunogenic composition, preferably formulated as a vaccine on an aluminum -based adjuvant, provides broad coverage against pneumococcal disease, particularly in infants and young children.
摘要翻译： 本发明提供具有15种不同的多糖 - 蛋白质缀合物的多价免疫原性组合物。 每个缀合物由与载体结合的不同血清型肺炎链球菌（1,3,4,5,6A，6B，7F，9V，14,18C，19A，19F，22F，23F或33F）制备的荚膜多糖组成。 蛋白质，优选CRM197。 免疫原性组合物，优选配制为基于铝的佐剂上的疫苗，提供对肺炎球菌疾病的广泛覆盖，特别是在婴儿和幼儿中。
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2.发明授权Pharmaceutical compositions containing interdigitation-fusion liposomes and gels 失效含有交叉指导 - 融合脂质体和凝胶的药物组合物
公开(公告)号：US6086851A
公开(公告)日：2000-07-11
申请号：US881651
申请日：1997-06-24
申请人： Lawrence T. Boni , Andrew S. Janoff , Sharma R. Minchey , Walter R. Perkins , Christine E. Swenson , Patrick L. Ahl , Thomas S. Davis
发明人： Lawrence T. Boni , Andrew S. Janoff , Sharma R. Minchey , Walter R. Perkins , Christine E. Swenson , Patrick L. Ahl , Thomas S. Davis
CPC分类号： A61K9/1277 , A61L2/0011 , Y10S436/829 , Y10T428/2984 , Y10T428/2989
摘要： This invention provides a composition containing a sized liposome comprising a lipid and an inducer; the sized liposome has a diameter of at most about 1 micron and the inducer is present in an amount effective to induce interdigitation-fusion of the sized liposome. Also provided herein are interdigitation-fusion liposomes and gels, and methods of making the same.
摘要翻译： 本发明提供含有脂质体和脂质体的组合物，其包含脂质和诱导剂; 大小的脂质体具有至多约1微米的直径，并且诱导剂以有效诱导大小的脂质体的交叉指向融合的量存在。 本文还提供了交叉指导 - 融合脂质体和凝胶，以及制备它们的方法。
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3.发明授权Methods of preparing interdigitation-fusion liposomes and gels which encapsulate a bioactive agent 失效制备交联融合脂质体和封装生物活性剂的凝胶的方法
公开(公告)号：US5820848A
公开(公告)日：1998-10-13
申请号：US315988
申请日：1994-09-30
申请人： Lawrence T. Boni , Andrew S. Janoff , Sharma R. Minchey , Walter R. Perkins , Christine E. Swenson , Patrick L. Ahl , Thomas S. Davis
发明人： Lawrence T. Boni , Andrew S. Janoff , Sharma R. Minchey , Walter R. Perkins , Christine E. Swenson , Patrick L. Ahl , Thomas S. Davis
CPC分类号： A61K9/1277 , A61L2/0011 , Y10S436/829 , Y10T428/2984 , Y10T428/2989
摘要： This invention provides a composition containing a sized liposome comprising a lipid and an induce; the sized liposome has a diameter of at most about 1 micoron and the induces is present in an amount effective to induce interdigitation-fusion of the sized liposome. Also provided herein are interdigitation-fusion liposomes and gels, and methods of making the same.
摘要翻译： 本发明提供含有脂质体和脂质体的组合物，其包含脂质和诱导物; 大小的脂质体具有至多约1微米的直径，并且诱导物以有效诱导大小的脂质体的交叉指向融合的量存在。 本文还提供了交叉指导 - 融合脂质体和凝胶，以及制备它们的方法。
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公开(公告)号：US20140314653A1
公开(公告)日：2014-10-23
申请号：US14359840
申请日：2012-11-19
CPC分类号： C01B25/36 , A61K39/39 , A61K2039/55505
摘要： The present invention relates to methods for preparing amorphous aluminum hydroxyphosphate. An aluminum salt and a phosphate solution are co-mixed at a constant ratio in the presence of a buffer. Preferably, an excess of the phosphate solution is used to act as a buffer. Due to the presence of a buffer, the pH is maintained constant during reaction (after initial rapid equilibration) without active adjustment. The methods are particularly applicable for the large scale manufacturing of aluminum phosphate adjuvant. Aluminum phosphate is used as an adjuvant in vaccine formulations, particularly those including a protein or saccharide antigen.
摘要翻译： 本发明涉及制备无定形羟基磷酸铝的方法。 在缓冲液存在下，以一定的比例将铝盐和磷酸盐溶液共混。 优选地，过量的磷酸盐溶液用作缓冲剂。 由于存在缓冲液，pH在反应期间（初始快速平衡后）保持恒定，无需主动调整。 该方法特别适用于大规模生产磷酸铝佐剂。 磷酸铝被用作疫苗制剂中的佐剂，特别是包括蛋白质或糖抗原的那些。
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公开(公告)号：US5614214A
公开(公告)日：1997-03-25
申请号：US247053
申请日：1994-05-20
CPC分类号： A61K9/1271 , Y10T428/2984
摘要： Provided herein is a method of administering a liposome composition to an animal, the method involving adminstering to the animal a liposome composition containing an adverse physiological reaction-reducing effective amount of a liposome which has, in addition to a bioactive agent, a lipid bilayer containing a lipid and a surface agent-modified molecule. An adverse physiological reaction which may be experienced by the animal upon administration of a liposome composition is reduced by way of the presence of the surface agent-modified molecule in the liposome's lipid bilayer.
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公开(公告)号：US06339069B1
公开(公告)日：2002-01-15
申请号：US09343650
申请日：1999-06-29
申请人： Paul R. Meers , Charles Pak , Shaukat Ali , Andrew Janoff , J. Craig Franklin , Ravi K. Erukulla , Donna Cabral-Lilly , Patrick L. Ahl
发明人： Paul R. Meers , Charles Pak , Shaukat Ali , Andrew Janoff , J. Craig Franklin , Ravi K. Erukulla , Donna Cabral-Lilly , Patrick L. Ahl
IPC分类号： A61K4800
CPC分类号： A61K9/127 , A61K9/1271 , A61K9/1272 , A61K9/1275 , A61K38/00 , A61K47/543 , A61K47/544 , A61K47/6911 , C07K1/1077 , C07K5/06026 , C07K5/06191 , C07K5/0806 , C07K5/0808 , C07K5/0819 , C07K5/0823 , C07K5/0827 , C07K5/1008 , C07K5/1013 , C07K5/1027 , C07K7/06 , C07K9/001
摘要： Peptide-lipid conjugates are incorporated into liposomes so as to selectively destabilize the liposomes in the vicinity of target peptidase-secreting cells, and hence, to deliver the liposomes to the vicinity of the target cells, or directly into the cells. The liposomes can thus be used to treat mammals for diseases, disorders or conditions, e.g., tumors, microbial infection and inflammations, characterized by the occurrence of peptidase-secreting cells.
摘要翻译： 将肽 - 脂质缀合物掺入脂质体中，以选择性地使目标肽酶分泌细胞附近的脂质体不稳定，从而将脂质体递送至靶细胞附近或直接进入细胞。 因此，脂质体可用于治疗哺乳动物疾病，病症或病症，例如肿瘤，微生物感染和炎症，其特征在于发生肽酶分泌细胞。
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7.发明申请15-VALENT PNEUMOCOCCAL POLYSACCHARIDE-PROTEIN CONJUGATE VACCINE COMPOSITION 有权15多种气球蛋白多糖 - 蛋白质结合疫苗组合物公开(公告)号：US20110195086A1
公开(公告)日：2011-08-11
申请号：US13020402
申请日：2011-02-03
IPC分类号： A61K39/385 , A61P37/04 , A61P31/04
CPC分类号： A61K39/092 , A61K2039/55505 , A61K2039/6037
摘要： The present invention provides a multivalent immunogenic composition having 15 distinct polysaccharide-protein conjugates. Each conjugate consists of a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, 22F, 23F or 33F) conjugated to a carrier protein, preferably CRM197. The immunogenic composition, preferably formulated as a vaccine on an aluminum-based adjuvant, provides broad coverage against pneumococcal disease, particularly in infants and young children.
摘要翻译： 本发明提供具有15种不同的多糖 - 蛋白质缀合物的多价免疫原性组合物。 每个缀合物由与载体结合的不同血清型肺炎链球菌（1,3,4,5,6A，6B，7F，9V，14,18C，19A，19F，22F，23F或33F）制备的荚膜多糖组成。 蛋白质，优选CRM197。 免疫原性组合物，优选配制成基于铝的佐剂上的疫苗，提供对肺炎球菌疾病的广泛覆盖，特别是在婴儿和幼儿中。
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公开(公告)号：US5662930A
公开(公告)日：1997-09-02
申请号：US433665
申请日：1995-05-04
CPC分类号： A61K9/1271 , Y10T428/2984
摘要： Provided herein is a method of administering a liposome composition to an animal, the method involving adminstering to the animal a liposome composition containing an adverse physiological reaction-reducing effective amount of a liposome which has, in addition to a bioactive agent, a lipid bilayer containing a lipid and a surface agent-modified molecule. An adverse physiological reaction which may be experienced by the animal upon administration of a liposome composition is reduced by way of the presence of the surface agent-modified molecule in the liposome's lipid bilayer.
摘要翻译： 本文提供了向动物施用脂质体组合物的方法，该方法涉及向动物施用含有不利的生理学降低反应的有效量的脂质体的脂质体组合物，该有效量除了生物活性剂外还含有含有 脂质和表面活性剂改性分子。 通过在脂质体脂质双层中存在表面活性剂修饰的分子，减少了在施用脂质体组合物时可能经历的不良生理反应。
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