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    NOGO RECEPTOR FUNCTIONAL MOTIFS, PEPTIDE MIMETICS, AND MUTATED FUNCTIONAL MOTIFS RELATED THERETO, AND METHODS OF USING THE SAME
    1.
    发明申请
    NOGO RECEPTOR FUNCTIONAL MOTIFS, PEPTIDE MIMETICS, AND MUTATED FUNCTIONAL MOTIFS RELATED THERETO, AND METHODS OF USING THE SAME 审中-公开
    NOGO受体功能运动，肽类物质及其相关的功能性运动物质及其使用方法

    公开(公告)号：US20080027001A1

    公开(公告)日：2008-01-31

    申请号：US11774940

    申请日：2007-07-09

    申请人： Andrew Wood ,  Alan Katz ,  Ying Gao ,  Brian Bates ,  Patrick Doherty ,  Gareth Williams

    发明人： Andrew Wood ,  Alan Katz ,  Ying Gao ,  Brian Bates ,  Patrick Doherty ,  Gareth Williams

    IPC分类号： A61K38/00 ,  C07D211/06 ,  C07D211/72 ,  C07D215/00 ,  C07D277/62 ,  C07D401/00 ,  C07K14/00 ,  C07K16/18 ,  C07K7/00 ,  C12N5/06 ,  C40B30/04 ,  G01N33/566

    CPC分类号： C07K14/705 ,  A61K38/00 ,  G01N33/6872 ,  G01N2500/04

    摘要： The present invention provides novel isolated and purified polynucleotides and polypeptides related to functional motifs of the Nogo receptor 1 (NgR1) (e.g., the binding pocket on the side surface of NgR1, functional motifs comprising the amino acid sequence of FRG, etc.) and use of peptides mimicking these functional motifs as antagonists to NgR1 ligands, e.g., myelin-associated glycoprotein, oligodendrocyte myelin glycoprotein, Nogo-A, Nogo-66, GT1b, an antibody to Nogo receptor, an antibody to GT1b, an antibody to p75 neurotrophin receptor, and an antibody to Lingo-1, etc. The invention also provides antibodies to the mimetic peptide antagonists. The present invention is further directed to novel therapeutics and therapeutic targets and to methods of screening and assessing test compounds for treatments requiring axonal regeneration, i.e., reversal of the effects of NgR1 ligand binding to the NgR1 (i.e., producing inhibition of axonal growth). The present invention also is directed to novel methods for treating disorders arising from inhibition of axonal growth mediated by the binding of NgR1 ligands to the NgR1. Further, the invention is directed to methods of treating a subject with a neurodegenerative disorder, including, but not limited to, Parkinson's disease, Alzheimer's disease, progressive supranuclear palsy, multiple sclerosis, multiple system atrophy, corticobasal degeneration, Huntington's disease, dementia with Lewy bodies, spinocerebellar ataxia, stroke, spinal cord trauma, traumatic brain injury, multiinfarct dementia, epilepsy, and senile dementia, comprising, e.g., antagonizing NgR1.

    摘要翻译： 本发明提供了与Nogo受体1（NgR1）的功能基序相关的新型分离和纯化的多核苷酸和多肽（例如，NgR1侧表面的结合口袋，包含FRG的氨基酸序列的功能基序等）和 使用模仿这些功能基序的肽作为NgR1配体的拮抗剂，例如髓鞘相关糖蛋白，少突胶质细胞髓鞘糖蛋白，Nogo-A，Nogo-66，GT1b，Nogo受体的抗体，GT1b的抗体，p75神经营养蛋白的抗体 受体和针对Lingo-1的抗体等。本发明还提供了针对模拟肽拮抗剂的抗体。 本发明还涉及新的治疗学和治疗靶标，以及筛选和评估需要轴突再生的治疗的试验化合物的方法，即逆转NgR1配体结合NgR1的作用（即产生轴突生长的抑制）。 本发明还涉及用于治疗由NgR1配体与NgR1结合介导的轴突生长抑制引起的疾病的新方法。 此外，本发明涉及用神经退行性疾病治疗受试者的方法，包括但不限于帕金森病，阿尔茨海默病，进行性核上性麻痹，多发性硬化，多系统萎缩，皮质基底变性，亨廷顿病，路易氏痴呆 身体，脊髓小脑性共济失调，中风，脊髓创伤，创伤性脑损伤，多发性痴呆，癫痫和老年性痴呆，包括例如拮抗NgR1。

    Concentric passive knotless suture terminator
    4.
    发明授权
    Concentric passive knotless suture terminator 有权
    同心无源无缝缝合终止子

    公开(公告)号：US06716243B1

    公开(公告)日：2004-04-06

    申请号：US09660745

    申请日：2000-09-13

    申请人： Stephen B. Colvin ,  Eugene Grossi ,  Alan Katz

    发明人： Stephen B. Colvin ,  Eugene Grossi ,  Alan Katz

    IPC分类号： A61F224

    CPC分类号： A61F2/2409 ,  A61B17/0487 ,  A61B2017/00243 ,  A61B2017/00783 ,  A61B2017/0454 ,  A61B2017/0464 ,  A61B2017/0488 ,  A61F2/2427 ,  A61F2250/006

    摘要： The present invention provides a suture-terminating device comprising a central body having at least one surface, a plurality of flanges extending radially from the surface and defining at least one grove therebetween, each flange having at least one aperture axially aligned and spaced away from the base wall, at least one removable member disposed within each aperture, and at least one spring disposed adjacently to the surface and maintained in its activated state by contact with a removable member disposed within the aperture. The grove has a base wall and at least one sidewall. The spring, while in its active state, is positioned adjacent to and spaced from the base wall, defining a gap of sufficient size to permit the passage of at least one suture therethrough. The surgeon actuates the device by withdrawing the removable member from the aperture, thus permitting the spring to return to its resting state within the grove. The spring and the base and side walls cooperate to restrict the suture's movement through the gap.

    摘要翻译： 本发明提供了一种缝合线终止装置，其包括具有至少一个表面的中心体，多个凸缘从表面径向延伸并且在其间限定至少一个凹槽，每个凸缘具有至少一个轴向对准并与之隔开的孔 底壁，设置在每个孔内的至少一个可拆卸构件以及与该表面相邻设置并通过与布置在孔内的可移除构件的接触而保持在其激活状态的至少一个弹簧。 树丛有一个底壁和至少一个侧壁。 该弹簧在其活动状态下定位成与基壁相邻并且与基壁间隔开，从而限定足够尺寸的间隙以允许至少一条缝合线通过。 外科医生通过从孔中取出可移除构件来致动装置，从而允许弹簧返回到树丛内的静止状态。 弹簧和基部和侧壁配合以限制缝合线通过间隙的移动。

    Auction system and method for pricing and allocation during capital formation
    5.
    发明授权
    Auction system and method for pricing and allocation during capital formation 有权
    资本形成期间的定价和分配的拍卖制度和方法

    公开(公告)号：US06629082B1

    公开(公告)日：2003-09-30

    申请号：US09347949

    申请日：1999-07-06

    申请人： William R. Hambrecht ,  Othar Hansson ,  Jordan Hayes ,  Alan Katz ,  Charles Ocheret ,  Matt Regan

    发明人： William R. Hambrecht ,  Othar Hansson ,  Jordan Hayes ,  Alan Katz ,  Charles Ocheret ,  Matt Regan

    IPC分类号： G06F1760

    CPC分类号： G06Q30/08 ,  G06Q40/00 ,  G06Q40/04 ,  G06Q40/06

    摘要： Techniques are provided for an auction system that is used for pricing and allocating equity securities. Information about an offering to accept bids for equity shares is provided to qualified potential purchasers and non-qualified potential purchasers. Bids front potential purchasers for equity shares are received through a communication network. Bids are accepted and offered to be accepted only from qualified potential purchasers. A non-qualified potential purchaser submits a bid through a qualified potential purchaser. A clearing price for the offered shares is determined based on the received bids. Prospective investors who bid a price above the clearing price are allocated all of the shares for which they bid. Prospective investors who bid a price equal to the clearing price are allocated a pro-rata allocation of the shares for which they bid. No shares are allocated to prospective investors who bid a price below the clearing price.

    摘要翻译： 为用于定价和分配股本证券的拍卖系统提供技术。 向合格的潜在购买者和非合格潜在购买者提供关于接受股权投标的发售的信息。 通过通信网络收到前股权股份的潜在买家。 投标被接受，只能由合格的潜在购买者接受。 非合格潜在购买者通过合格的潜在购买者提交投标书。 所发行股票的清算价格根据收到的出价确定。 投标价格高于清算价的潜在投资者将分配所有投标的股份。 投标价格等于清算价的投资者按比例分配其投标股份。 没有分配给投标价低于清算价的潜在投资者的股票。

    Event Timing Mechanisms for Dutch Auction of Securities
    10.
    发明申请
    Event Timing Mechanisms for Dutch Auction of Securities 审中-公开
    荷兰拍卖证券活动时间机制

    公开(公告)号：US20080306854A1

    公开(公告)日：2008-12-11

    申请号：US11758148

    申请日：2007-06-05

    申请人： Alan Katz ,  Whitney White

    发明人： Alan Katz ,  Whitney White

    IPC分类号： G06Q40/00

    CPC分类号： G06Q30/08 ,  G06Q40/04

    摘要： A method for auctioning securities defines an auction start time and an auction end time. The time therebetween is defined by time bucket intervals and transparency intervals. At the auction start time, a real-time auction of securities over a communications network begins. During each time bucket interval bids are received from prospective purchasers, and assigned a time bucket stamp such that bids with the same time stamp are treated as having occurred at the same time. At the end of each transparency interval public bid information related to the auction is updated and made available to the prospective purchasers. After the auction end time, a final auction price for the securities is established based upon the bids made during the auction, and the securities are allocated to the prospective purchasers at the final auction price.

    摘要翻译： 拍卖证券的方法定义拍卖开始时间和拍卖结束时间。 它们之间的时间由时间段间隔和透明度间隔定义。 在拍卖开始时间，通过通信网络实时拍卖证券开始。 在每次从潜在购买者收到桶间距出价时，分配了一个时间桶标记，使得具有相同时间戳的出价被视为已经同时发生。 在每个透明度间隔结束时，与拍卖相关的公开投标信息被更新并提供给潜在购买者。 拍卖结束时间后，根据拍卖期间的出价确定证券的最终拍卖价格，并以最终拍卖价格向潜在买家分配证券。