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    NOGO RECEPTOR FUNCTIONAL MOTIFS, PEPTIDE MIMETICS, AND MUTATED FUNCTIONAL MOTIFS RELATED THERETO, AND METHODS OF USING THE SAME
    1.
    发明申请
    NOGO RECEPTOR FUNCTIONAL MOTIFS, PEPTIDE MIMETICS, AND MUTATED FUNCTIONAL MOTIFS RELATED THERETO, AND METHODS OF USING THE SAME 审中-公开
    NOGO受体功能运动，肽类物质及其相关的功能性运动物质及其使用方法

    公开(公告)号：US20080027001A1

    公开(公告)日：2008-01-31

    申请号：US11774940

    申请日：2007-07-09

    申请人： Andrew Wood ,  Alan Katz ,  Ying Gao ,  Brian Bates ,  Patrick Doherty ,  Gareth Williams

    发明人： Andrew Wood ,  Alan Katz ,  Ying Gao ,  Brian Bates ,  Patrick Doherty ,  Gareth Williams

    IPC分类号： A61K38/00 ,  C07D211/06 ,  C07D211/72 ,  C07D215/00 ,  C07D277/62 ,  C07D401/00 ,  C07K14/00 ,  C07K16/18 ,  C07K7/00 ,  C12N5/06 ,  C40B30/04 ,  G01N33/566

    CPC分类号： C07K14/705 ,  A61K38/00 ,  G01N33/6872 ,  G01N2500/04

    摘要： The present invention provides novel isolated and purified polynucleotides and polypeptides related to functional motifs of the Nogo receptor 1 (NgR1) (e.g., the binding pocket on the side surface of NgR1, functional motifs comprising the amino acid sequence of FRG, etc.) and use of peptides mimicking these functional motifs as antagonists to NgR1 ligands, e.g., myelin-associated glycoprotein, oligodendrocyte myelin glycoprotein, Nogo-A, Nogo-66, GT1b, an antibody to Nogo receptor, an antibody to GT1b, an antibody to p75 neurotrophin receptor, and an antibody to Lingo-1, etc. The invention also provides antibodies to the mimetic peptide antagonists. The present invention is further directed to novel therapeutics and therapeutic targets and to methods of screening and assessing test compounds for treatments requiring axonal regeneration, i.e., reversal of the effects of NgR1 ligand binding to the NgR1 (i.e., producing inhibition of axonal growth). The present invention also is directed to novel methods for treating disorders arising from inhibition of axonal growth mediated by the binding of NgR1 ligands to the NgR1. Further, the invention is directed to methods of treating a subject with a neurodegenerative disorder, including, but not limited to, Parkinson's disease, Alzheimer's disease, progressive supranuclear palsy, multiple sclerosis, multiple system atrophy, corticobasal degeneration, Huntington's disease, dementia with Lewy bodies, spinocerebellar ataxia, stroke, spinal cord trauma, traumatic brain injury, multiinfarct dementia, epilepsy, and senile dementia, comprising, e.g., antagonizing NgR1.

    摘要翻译： 本发明提供了与Nogo受体1（NgR1）的功能基序相关的新型分离和纯化的多核苷酸和多肽（例如，NgR1侧表面的结合口袋，包含FRG的氨基酸序列的功能基序等）和 使用模仿这些功能基序的肽作为NgR1配体的拮抗剂，例如髓鞘相关糖蛋白，少突胶质细胞髓鞘糖蛋白，Nogo-A，Nogo-66，GT1b，Nogo受体的抗体，GT1b的抗体，p75神经营养蛋白的抗体 受体和针对Lingo-1的抗体等。本发明还提供了针对模拟肽拮抗剂的抗体。 本发明还涉及新的治疗学和治疗靶标，以及筛选和评估需要轴突再生的治疗的试验化合物的方法，即逆转NgR1配体结合NgR1的作用（即产生轴突生长的抑制）。 本发明还涉及用于治疗由NgR1配体与NgR1结合介导的轴突生长抑制引起的疾病的新方法。 此外，本发明涉及用神经退行性疾病治疗受试者的方法，包括但不限于帕金森病，阿尔茨海默病，进行性核上性麻痹，多发性硬化，多系统萎缩，皮质基底变性，亨廷顿病，路易氏痴呆 身体，脊髓小脑性共济失调，中风，脊髓创伤，创伤性脑损伤，多发性痴呆，癫痫和老年性痴呆，包括例如拮抗NgR1。

    Interactive system and method for boxing and martial arts
    5.
    发明授权
    Interactive system and method for boxing and martial arts 有权
    拳击和武术的交互系统和方法

    公开(公告)号：US08337366B2

    公开(公告)日：2012-12-25

    申请号：US13234110

    申请日：2011-09-15

    申请人： Terry G. Jones ,  Redza Shah ,  Jeffrey Eversmann ,  Nathan Sewell ,  Brian Bates ,  Joshua Eversmann

    发明人： Terry G. Jones ,  Redza Shah ,  Jeffrey Eversmann ,  Nathan Sewell ,  Brian Bates ,  Joshua Eversmann

    IPC分类号： A63B71/00 ,  A63B69/34

    CPC分类号： A63B69/201 ,  A63B24/0062 ,  A63B69/004 ,  A63B69/32 ,  A63B2024/0037 ,  A63B2220/53 ,  A63B2244/10 ,  A63B2244/102 ,  G09B19/0038

    摘要： A boxing or martial arts training and exercise device may include punching pads locationally displaced on a frame. Respective pads may be positioned in support on the frame for punching and kicking. Each pad can communicatively connect to one or more impact sensor. Each impact sensor can communicatively connect to a control unit. The control unit may be communicatively connected to a display. The impact sensor detects strikes to the pad. The impact sensor includes an accelerometer and a signal processor. The control unit includes an aggregator for receiving and logging strike metrics. The control unit directs sequences in the display according to a routine, and delivers indicators of strike metrics. The control unit includes a user interface for selection among sequences, as well as for selection of various menu items. A video of a human instructor or an animated avatar is viewable in a display.

    摘要翻译： 拳击或武术训练和锻炼装置可以包括位于框架上位置的冲压垫。 相应的垫可以被定位在框架上用于冲压和踢脚。 每个垫可以通信地连接到一个或多个冲击传感器。 每个冲击传感器可以通信地连接到控制单元。 控制单元可以通信地连接到显示器。 撞击传感器检测到撞击垫。 冲击传感器包括加速度计和信号处理器。 控制单元包括用于接收和记录打击度量的聚合器。 控制单元根据例程指示显示中的序列，并提供罢工指标的指标。 控制单元包括用于在序列之间进行选择的用户界面，以及用于选择各种菜单项。 人类教练或动画头像的视频可在显示器中观看。

    Coated implantable medical device
    8.
    发明申请
    Coated implantable medical device 有权
    涂层可植入医疗器械

    公开(公告)号：US20070050010A1

    公开(公告)日：2007-03-01

    申请号：US11515395

    申请日：2006-09-01

    申请人： Brian Bates ,  Anthony Ragheb ,  Neal Fearnot ,  William Voorhees ,  Thomas Kozma ,  David Grewe ,  Darin Schaeffer

    发明人： Brian Bates ,  Anthony Ragheb ,  Neal Fearnot ,  William Voorhees ,  Thomas Kozma ,  David Grewe ,  Darin Schaeffer

    IPC分类号： A61F2/86 ,  A61F2/06

    CPC分类号： A61F2/91 ,  A61F2/24 ,  A61F2/82 ,  A61F2/885 ,  A61F2250/0068 ,  A61K51/1282 ,  A61L27/306 ,  A61L27/54 ,  A61L29/085 ,  A61L29/106 ,  A61L29/16 ,  A61L31/088 ,  A61L31/10 ,  A61L31/16 ,  A61L33/022 ,  A61L2300/256 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61N5/1002 ,  C08L65/04

    摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.

    摘要翻译： 涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 和至少一层生物活性物质的层18位于涂层16的至少一部分上，其中涂层16提供生物活性材料从涂层的受控释放。 此外，至少一个多孔层20可以放置在生物活性材料层18上方，其中多孔层包括聚合物并提供生物活性材料通过其控制释放。 优选地，结构12是冠状动脉支架。 多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物，并提供生物活性材料的受控释放。 特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不经溶剂，热或催化剂沉积，并且仅通过单体蒸气的冷凝而沉积。