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公开(公告)号：US10668012B2
公开(公告)日：2020-06-02
申请号：US12554361
申请日：2009-09-04
申请人： Andrew Xian Chen , Patricia D Kigin , Hai Liang Chen , Jun Fan
发明人： Andrew Xian Chen , Patricia D Kigin , Hai Liang Chen , Jun Fan
摘要： Sustained release compositions in tablet or multiparticulate forms comprising (a) an active ingredient, (b) a primary sustain release agent, (c) a wax-like agent, and (d) a bulking or spheronizing agent are provided. The compositions are chewable and/or taste masked. Oral dosage forms comprising such compositions and methods for preparing and using such compositions and dosage forms are also provided.
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公开(公告)号：US20100062988A1
公开(公告)日：2010-03-11
申请号：US12554361
申请日：2009-09-04
申请人： Andrew Xian Chen , Patricia D. Kigin , Hai Liang Chen , Jun Fan
发明人： Andrew Xian Chen , Patricia D. Kigin , Hai Liang Chen , Jun Fan
IPC分类号： A61K47/42 , A61K31/137 , A61K31/7008 , A61K31/135 , A61P1/00 , A61P25/00
摘要： Sustained release compositions in tablet or multiparticulate forms comprising (a) an active ingredient, (b) a primary sustain release agent, (c) a wax-like agent, and (d) a bulking or spheronizing agent are provided. The compositions are chewable and/or taste masked. Oral dosage forms comprising such compositions and methods for preparing and using such compositions and dosage forms are also provided.
摘要翻译： 包括片剂或多颗粒形式的缓释组合物，其包含（a）活性成分，（b）初级维持释放剂，（c）蜡状试剂和（d）膨化剂或滚圆剂。 组合物可咀嚼和/或掩味。 还提供了包含这些组合物的口服剂型和用于制备和使用这些组合物和剂型的方法。
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公开(公告)号：US10888521B2
公开(公告)日：2021-01-12
申请号：US12040443
申请日：2008-02-29
IPC分类号： A61K9/16 , A61K31/7008 , A61K9/00 , A61K31/522 , A61K31/135 , A61P3/02
摘要： Sustained release spherical or non-spherical pellets comprising (a) an active ingredient (b) a wax-like agent, and (c) a spheronizing agent are provided. Oral dosage forms comprising the pellets and methods for preparing and using such pellets and dosage forms are also provided.
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公开(公告)号：US20080220079A1
公开(公告)日：2008-09-11
申请号：US12040443
申请日：2008-02-29
IPC分类号： A61K9/14 , A61K31/167 , A61K31/135 , A61K38/02 , A61K31/351 , A61K31/52 , A61K31/662 , A61K31/522 , A61K31/472 , A61K31/427 , A61K31/7072 , A61K31/42 , A61K38/00 , A61K31/535 , A61K31/421 , A61K31/505 , A61K31/65 , A61K31/7048 , A61K31/7028 , A61K31/43 , A61K33/08 , A61K31/4184 , A61K31/196 , A61K31/485 , A61P31/04 , A61P33/00 , A61K31/4164 , A61P25/00 , A61P31/12 , A61P1/00
CPC分类号： A61K9/1617 , A61K9/0095 , A61K9/1652 , A61K9/1694 , A61K31/135 , A61K31/522 , A61K31/7008
摘要： Sustained release spherical or non-spherical pellets comprising (a) an active ingredient (b) a wax-like agent, and (c) a spheronizing agent are provided. Oral dosage forms comprising said pellets and methods for preparing and using such pellets and dosage forms are also provided.
摘要翻译： 提供包含（a）活性成分（b）蜡状试剂和（c）滚圆剂）的缓释球形或非球形颗粒。 还提供了包含所述丸粒的口服剂型以及制备和使用这种丸剂和剂型的方法。
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公开(公告)号：US08470346B2
公开(公告)日：2013-06-25
申请号：US13111873
申请日：2011-05-19
申请人： Andrew Xian Chen
发明人： Andrew Xian Chen
IPC分类号： A61K9/00
CPC分类号： A61K45/06 , A61K31/14 , A61K31/722 , A61K33/00 , A61K33/30 , A61K2300/00
摘要： The present invention provides antiviral compositions that comprise one or more of an ionic multivalent metal component, a cationic polymer, and a cationic surfactant. The present invention also provides methods for making and using such antiviral compositions.
摘要翻译： 本发明提供包含一种或多种离子多价金属组分，阳离子聚合物和阳离子表面活性剂的抗病毒组合物。 本发明还提供了制备和使用这些抗病毒组合物的方法。
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公开(公告)号：US20110223259A1
公开(公告)日：2011-09-15
申请号：US13111873
申请日：2011-05-19
申请人： Andrew Xian Chen
发明人： Andrew Xian Chen
IPC分类号： A61K33/30 , C08B37/08 , A61K31/722 , A61P31/12 , A61P31/18 , A61P31/22 , A61P31/16 , A61P31/14
CPC分类号： A61K45/06 , A61K31/14 , A61K31/722 , A61K33/00 , A61K33/30 , A61K2300/00
摘要： The present invention provides antiviral compositions that comprise one or more of an ionic multivalent metal component, a cationic polymer, and a cationic surfactant. The present invention also provides methods for making and using such antiviral compositions.
摘要翻译： 本发明提供包含一种或多种离子多价金属组分，阳离子聚合物和阳离子表面活性剂的抗病毒组合物。 本发明还提供了制备和使用这些抗病毒组合物的方法。
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公开(公告)号：US07968122B2
公开(公告)日：2011-06-28
申请号：US11003302
申请日：2004-12-03
申请人： Andrew Xian Chen
发明人： Andrew Xian Chen
IPC分类号： A61K9/14
CPC分类号： A61K45/06 , A61K31/14 , A61K31/722 , A61K33/00 , A61K33/30 , A61K2300/00
摘要： The present invention provides antiviral compositions that comprise one or more of an ionic multivalent metal component, a cationic polymer, and a cationic surfactant. The present invention also provides methods for making and using such antiviral compositions.
摘要翻译： 本发明提供包含一种或多种离子多价金属组分，阳离子聚合物和阳离子表面活性剂的抗病毒组合物。 本发明还提供了制备和使用这些抗病毒组合物的方法。
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公开(公告)号：US07871632B2
公开(公告)日：2011-01-18
申请号：US10889226
申请日：2004-07-12
申请人： Andrew Xian Chen
发明人： Andrew Xian Chen
IPC分类号： A61K9/00
CPC分类号： A61K31/475 , A61K9/0019 , A61K9/1075 , A61K9/19
摘要： The present invention provides compositions for delivering highly water-soluble drugs (such as vinca alkaloids) and methods of using such compositions.
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公开(公告)号：US09248098B2
公开(公告)日：2016-02-02
申请号：US13122771
申请日：2009-10-09
CPC分类号： A61K9/1075 , A61K31/7076
摘要： The present invention relates to a pharmaceutical composition comprising spicamycin derivatives that vary in their fatty acid side chain moieties and are useful in the treatment of pain. The invention further provides a method of using the pharmaceutical composition to treat pain, including neuropathic pain.
摘要翻译： 本发明涉及包含其脂肪酸侧链部分变化且可用于治疗疼痛的spicamycin衍生物的药物组合物。 本发明还提供使用该药物组合物治疗疼痛的方法，包括神经性疼痛。
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公开(公告)号：US09132144B2
公开(公告)日：2015-09-15
申请号：US13242778
申请日：2011-09-23
CPC分类号： A61K9/107 , A61K9/0019 , A61K9/0024 , A61K9/1075 , A61K9/145 , A61K9/16 , A61K9/1617 , A61K9/1682 , A61K31/7036 , A61K38/14 , A61K47/10 , A61K47/24 , A61K47/44
摘要： The present invention provides a clear depot comprising at least one hydrophilic water-soluble pharmaceutically active agent selected from the group consisting of vancomycin, gentamicin, a pharmaceutically acceptable salt thereof and a mixture thereof, water, a phospholipid, an oil, optionally a pH adjusting agent, and a viscosity modifying agent selected from the group consisting of ethanol, isopropanol, and a mixture thereof, wherein the water present in the depot is no more than about 4 wt % relative to the total weight of the depot and the depot has a pH of between about 3 and about 6, method of making and administering same.
摘要翻译： 本发明提供了一种清洁剂，其包含至少一种选自万古霉素，庆大霉素，其药学上可接受的盐及其混合物的亲水性水溶性药物活性剂，水，磷脂，油，任选的pH调节 试剂和选自乙醇，异丙醇及其混合物的粘度调节剂，其中存在于贮存库中的水相对于贮存库的总重量不超过约4重量％，并且贮存库具有 约3至约6的pH值，其制备和施用方法。
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