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公开(公告)号：US20080176215A1
公开(公告)日：2008-07-24
申请号：US11857942
申请日：2007-09-19
申请人： Angela Hudson , Tamara Sander , Poonam Agarwal , Michelle Garsha , Hon Ip , Robert W. Kwiatkowski , Vecheslav Elagin , Marilyn Olson-Munoz , Michelle Curtis , Sarah Olson , Ilse Tyler
发明人： Angela Hudson , Tamara Sander , Poonam Agarwal , Michelle Garsha , Hon Ip , Robert W. Kwiatkowski , Vecheslav Elagin , Marilyn Olson-Munoz , Michelle Curtis , Sarah Olson , Ilse Tyler
IPC分类号： C12Q1/70
CPC分类号： C12Q1/708 , C12Q2561/109
摘要： The present invention provides compositions and methods for the detection and characterization of HPV sequences. More particularly, the present invention provides compositions, methods and kits for using invasive cleavage structure assays (e.g. the INVADER assay) to screen nucleic acid samples, e.g., from patients, for the presence of any one of a collection of HPV sequences. The present invention also provides compositions, methods and kits for screening sets of HPV sequences in a single reaction container.
摘要翻译： 本发明提供用于检测和表征HPV序列的组合物和方法。 更具体地，本发明提供了使用侵入性切割结构测定法（例如INVADER测定法）筛选核酸样品（例如来自患者）以存在HPV序列集合中的任何一个的组合物，方法和试剂盒。 本发明还提供了用于在单个反应容器中筛选HPV序列的组合物，方法和试剂盒。
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公开(公告)号：US20130149697A1
公开(公告)日：2013-06-13
申请号：US13768794
申请日：2013-02-15
申请人： Angela Hudson , Tamara Sander , Poonam Agarwal , Michelle Garsha , Hon Ip , Robert W. Kwiatkowski, JR. , Vecheslav Elagin , Marilyn Olson-Munoz , Michelle Curtis , Sarah Olson , Ilse Tyler
发明人： Angela Hudson , Tamara Sander , Poonam Agarwal , Michelle Garsha , Hon Ip , Robert W. Kwiatkowski, JR. , Vecheslav Elagin , Marilyn Olson-Munoz , Michelle Curtis , Sarah Olson , Ilse Tyler
IPC分类号： C12Q1/70
CPC分类号： C12Q1/708 , C12Q2561/109
摘要： The present invention provides compositions and methods for the detection and characterization of HPV sequences. More particularly, the present invention provides compositions, methods and kits for using invasive cleavage structure assays (e.g. the INVADER assay) to screen nucleic acid samples, e.g., from patients, for the presence of any one of a collection of HPV sequences. The present invention also provides compositions, methods and kits for screening sets of HPV sequences in a single reaction container.
摘要翻译： 本发明提供用于检测和表征HPV序列的组合物和方法。 更具体地，本发明提供了使用侵入性切割结构测定法（例如INVADER测定法）筛选核酸样品（例如来自患者）以存在HPV序列集合中的任何一个的组合物，方法和试剂盒。 本发明还提供了用于在单个反应容器中筛选HPV序列的组合物，方法和试剂盒。
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公开(公告)号：US08389245B2
公开(公告)日：2013-03-05
申请号：US11857942
申请日：2007-09-19
申请人： Angela Hudson , Tamara Sander , Poonam Agarwal , Michelle Garsha , Hon Ip , Robert W. Kwiatkowski, Jr. , Vecheslav Elagin , Marilyn Olson-Munoz , Michelle Curtis , Sarah Olson , Ilse Tyler
发明人： Angela Hudson , Tamara Sander , Poonam Agarwal , Michelle Garsha , Hon Ip , Robert W. Kwiatkowski, Jr. , Vecheslav Elagin , Marilyn Olson-Munoz , Michelle Curtis , Sarah Olson , Ilse Tyler
IPC分类号： C12P19/34
CPC分类号： C12Q1/708 , C12Q2561/109
摘要： The present invention provides compositions and methods for the detection and characterization of HPV sequences. More particularly, the present invention provides compositions, methods and kits for using invasive cleavage structure assays (e.g. the INVADER assay) to screen nucleic acid samples, e.g., from patients, for the presence of any one of a collection of HPV sequences. The present invention also provides compositions, methods and kits for screening sets of HPV sequences in a single reaction container.
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公开(公告)号：US07527948B2
公开(公告)日：2009-05-05
申请号：US10951241
申请日：2004-09-27
申请人： Angela Hudson , Tamara Sander , Poonam Agarwal , Michelle Garsha , Hon Ip , Robert W. Kwiatkowski, Jr. , Vecheslav Elagin , Marilyn Olson-Munoz , Michelle Curtis , Sarah Olson , Ilse Tyler
发明人： Angela Hudson , Tamara Sander , Poonam Agarwal , Michelle Garsha , Hon Ip , Robert W. Kwiatkowski, Jr. , Vecheslav Elagin , Marilyn Olson-Munoz , Michelle Curtis , Sarah Olson , Ilse Tyler
CPC分类号： C12Q1/708 , C12Q2561/109
摘要： The present invention provides compositions and methods for the detection and characterization of HPV sequences. More particularly, the present invention provides compositions, methods and kits for using invasive cleavage structure assays (e.g. the INVADER assay) to screen nucleic acid samples, e.g., from patients, for the presence of any one of a collection of HPV sequences. The present invention also provides compositions, methods and kits for screening sets of HPV sequences in a single reaction container.
摘要翻译： 本发明提供用于检测和表征HPV序列的组合物和方法。 更具体地，本发明提供了使用侵入性切割结构测定法（例如INVADER测定法）筛选核酸样品（例如来自患者）以存在HPV序列集合中的任何一个的组合物，方法和试剂盒。 本发明还提供了用于在单个反应容器中筛选HPV序列的组合物，方法和试剂盒。
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公开(公告)号：US20070111200A1
公开(公告)日：2007-05-17
申请号：US10951241
申请日：2004-09-27
申请人： Angela Hudson , Tamara Sander , Poonam Agarwal , Michelle Garsha , Hon Ip , Robert Kwiatkowski , Vecheslav Elagin , Marilyn Olson-Munoz , Michelle Curtis , Sarah Olson , Ilse Tyler
发明人： Angela Hudson , Tamara Sander , Poonam Agarwal , Michelle Garsha , Hon Ip , Robert Kwiatkowski , Vecheslav Elagin , Marilyn Olson-Munoz , Michelle Curtis , Sarah Olson , Ilse Tyler
CPC分类号： C12Q1/708 , C12Q2561/109
摘要： The present invention provides compositions and methods for the detection and characterization of HPV sequences. More particularly, the present invention provides compositions, methods and kits for using invasive cleavage structure assays (e.g. the INVADER assay) to screen nucleic acid samples, e.g., from patients, for the presence of any one of a collection of HPV sequences. The present invention also provides compositions, methods and kits for screening sets of HPV sequences in a single reaction container.
摘要翻译： 本发明提供用于检测和表征HPV序列的组合物和方法。 更具体地，本发明提供了使用侵入性切割结构测定法（例如INVADER测定法）筛选核酸样品（例如来自患者）以存在HPV序列集合中的任何一个的组合物，方法和试剂盒。 本发明还提供了用于在单个反应容器中筛选HPV序列的组合物，方法和试剂盒。
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公开(公告)号：US20060252032A1
公开(公告)日：2006-11-09
申请号：US11342459
申请日：2006-01-30
CPC分类号： C12Q1/705
摘要： The present invention provides methods, compositions, and kits related to nucleic acid detection assays for detecting human herpes virus. For example, the present invention provides detection assays for detecting human herpes virus subtypes HHV1- through HHV-8.
摘要翻译： 本发明提供与用于检测人疱疹病毒的核酸检测测定相关的方法，组合物和试剂盒。 例如，本发明提供用于检测人疱疹病毒亚型HHV1-至HHV-8的检测试验。
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7.发明申请Compositions and methods for increased dynamic range detection of nucleic acids 审中-公开用于增加核酸动态范围检测的组合物和方法公开(公告)号：US20060246475A1
公开(公告)日：2006-11-02
申请号：US11338244
申请日：2006-01-23
申请人： Patrick Peterson , Hatim Allawi , Victor Lyamichev , Scott Law , Vecheslav Elagin , Jeff Hall
发明人： Patrick Peterson , Hatim Allawi , Victor Lyamichev , Scott Law , Vecheslav Elagin , Jeff Hall
CPC分类号： C12Q1/6816 , C12Q1/6818 , C12Q1/6827 , C12Q2561/109 , C12Q2537/143 , C12Q2527/143 , C12Q2525/204 , C12Q2525/161 , C12Q2525/301 , C12Q2565/1015
摘要： The present invention provides systems, methods and kits for increasing the dynamic range of detection of a target nucleic acid in a sample. In particular, the present invention provides methods and kits for increasing the dynamic range of detection of a target nucleic acid in a sample through the use of one or more probe oligonucleotides (e.g., analyte-specific probe oligonucleotides).
摘要翻译： 本发明提供用于增加样品中靶核酸的动态检测范围的系统，方法和试剂盒。 特别地，本发明提供了通过使用一种或多种探针寡核苷酸（例如分析物特异性探针寡核苷酸）增加样品中靶核酸的动态检测范围的方法和试剂盒。
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公开(公告)号：US20050196750A1
公开(公告)日：2005-09-08
申请号：US11031487
申请日：2005-01-07
申请人： Vecheslav Elagin , Scott Law , Bjork Hill
发明人： Vecheslav Elagin , Scott Law , Bjork Hill
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention provides compositions and methods for the detection and characterization of HCV sequences. More particularly, the present invention provides compositions, methods and kits for using invasive cleavage structure assays (e.g. the INVADER assay) to screen nucleic acid samples, e.g., from patients, to determine HCV genotype.
摘要翻译： 本发明提供用于检测和表征HCV序列的组合物和方法。 更具体地，本发明提供了用于使用侵入性切割结构测定（例如INVADER测定）来筛选例如来自患者的核酸样品以确定HCV基因型的组合物，方法和试剂盒。
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公开(公告)号：US20070207455A1
公开(公告)日：2007-09-06
申请号：US11601551
申请日：2006-11-17
申请人： Scott Law , Vecheslav Elagin
发明人： Scott Law , Vecheslav Elagin
CPC分类号： C12Q1/707 , C12Q2561/109
摘要： The present invention provides methods and compositions for detecting hepatitis C virus (HCV). In particular, the present invention provides nucleic acid detection assays configured to detect a novel sub-type of HCV-1.
摘要翻译： 本发明提供用于检测丙型肝炎病毒（HCV）的方法和组合物。 特别地，本发明提供配置用于检测新型亚型HCV-1的核酸检测测定。
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公开(公告)号：US20060147955A1
公开(公告)日：2006-07-06
申请号：US11266723
申请日：2005-11-03
申请人： Hatim Allawi , Victor Lyamichev , Vecheslav Elagin , Scott Law , Jeff Hall
发明人： Hatim Allawi , Victor Lyamichev , Vecheslav Elagin , Scott Law , Jeff Hall
CPC分类号： C12Q1/6823 , C12Q2561/109 , C12Q2547/101 , C12Q2531/113
摘要： The present invention provides methods and routines for developing and optimizing nucleic acid detection assays for use in basic research, clinical research, and for the development of clinical detection assays. In particular, the present invention provides methods for designing oligonucleotide primers to be used in multiplex amplification reactions. The present invention also provides methods to optimize multiplex amplification reactions. The present invention also provides methods for combined target and signal generation assays.
摘要翻译： 本发明提供用于开发和优化用于基础研究，临床研究和用于开发临床检测测定的核酸检测测定的方法和程序。 特别地，本发明提供了用于多重扩增反应中使用的寡核苷酸引物的设计方法。 本发明还提供优化多重扩增反应的方法。 本发明还提供了用于组合的靶和信号产生测定的方法。
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