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    METHOD OF MANAGING OR TREATING PAIN
    3.
    发明申请
    METHOD OF MANAGING OR TREATING PAIN 有权
    管理或治疗疼痛的方法

    公开(公告)号：US20120277267A1

    公开(公告)日：2012-11-01

    申请号：US13541314

    申请日：2012-07-03

    申请人： Peter James WATTS ,  Jonathan David CASTILE ,  William Columbus Ian LAFFERTY ,  Alan SMITH

    发明人： Peter James WATTS ,  Jonathan David CASTILE ,  William Columbus Ian LAFFERTY ,  Alan SMITH

    IPC分类号： A61K31/445 ,  A61P29/00

    CPC分类号： A61K31/4468 ,  A61K9/0043 ,  A61K47/26 ,  A61K47/36 ,  A61M11/00 ,  A61M15/08

    摘要： A composition for the intranasal delivery of fentanyl or a pharmaceutically acceptable salt thereof to an animal includes an aqueous solution of fentanyl or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable additive selected from (i) a pectin and (ii) a poloxamer and chitosan or a salt or derivative thereof; provided that when the composition comprises a pectin it is substantially free of divalent metal ions; and which, in comparison to a simple aqueous solution of fentanyl administered intranasally at the same dose, provides a peak plasma concentration of fentanyl (Cmax) that is from 10 to 80% of that achieved using a simple aqueous solution of fentanyl administered intranasally at an identical fentanyl dose. A method for treating or managing pain by intranasally administering the composition is also disclosed.

    摘要翻译： 用于向动物鼻内递送芬太尼或其药学上可接受的盐的组合物包括芬太尼或其药学上可接受的盐的水溶液和选自以下的药学上可接受的添加剂：（i）果胶和（ii）泊洛沙姆和壳聚糖或 其盐或衍生物; 条件是当组合物包含果胶时，其基本上不含二价金属离子; 并且与以相同剂量鼻内施用的芬太尼的简单水溶液相比，提供了芬太尼（C max）的峰值血浆浓度，其为使用芬太尼简单的水溶液在10％至80％ 芬太尼剂量相同。 还公开了通过鼻内施用组合物治疗或治疗疼痛的方法。

    INTRANASAL SPRAY DEVICE CONTAINING PHARMACEUTICAL COMPOSITION
    4.
    发明申请
    INTRANASAL SPRAY DEVICE CONTAINING PHARMACEUTICAL COMPOSITION 有权
    包含药物组合物的内窥镜喷雾装置

    公开(公告)号：US20120270903A1

    公开(公告)日：2012-10-25

    申请号：US13541325

    申请日：2012-07-03

    申请人： Peter James WATTS ,  Jonathan David CASTILE ,  William Columbus Ian LAFFERTY ,  Alan SMITH

    发明人： Peter James WATTS ,  Jonathan David CASTILE ,  William Columbus Ian LAFFERTY ,  Alan SMITH

    IPC分类号： A61K31/4468 ,  A61M11/00

    CPC分类号： A61K31/4468 ,  A61K9/0043 ,  A61K47/26 ,  A61K47/36 ,  A61M11/00 ,  A61M15/08

    摘要： An intranasnal spray device contains a composition for the intranasal delivery of fentanyl or a pharmaceutically acceptable salt thereof to an animal includes an aqueous solution of fentanyl or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable additive selected from (i) a pectin and (ii) a poloxamer and chitosan or a salt or derivative thereof; provided that when the composition comprises a pectin it is substantially free of divalent metal ions; and which, in comparison to a simple aqueous solution of fentanyl administered intranasally at the same dose, provides a peak plasma concentration of fentanyl (Cmax) that is from 10 to 80% of that achieved using a simple aqueous solution of fentanyl administered intranasally at an identical fentanyl dose. A method for treating or managing pain by intranasally administering the composition is also disclosed.

    摘要翻译： 包含芬太尼或其药学上可接受的盐向动物鼻内递送的组合物包括芬太尼或其药学上可接受的盐和可药用添加剂的水溶液，所述添加剂选自（i）果胶和（ii） 泊洛沙姆和壳聚糖或其盐或衍生物; 条件是当组合物包含果胶时，其基本上不含二价金属离子; 并且与以相同剂量鼻内施用的芬太尼的简单水溶液相比，提供了芬太尼（C max）的峰值血浆浓度，其为使用芬太尼简单的水溶液在10％至80％ 芬太尼剂量相同。 还公开了通过鼻内施用组合物治疗或治疗疼痛的方法。