公开(公告)号：US20100256091A1

公开(公告)日：2010-10-07

申请号：US12675306

申请日：2008-08-29

Applicant: Peter James Watts ,  Yu-Hui Cheng ,  Alan Smith ,  Jonathan Castile

Inventor： Peter James Watts ,  Yu-Hui Cheng ,  Alan Smith ,  Jonathan Castile

IPC: A61K31/722 ,  A61P25/08 ,  A61P25/22 ,  A61P25/32 ,  A61P25/18

CPC classification number: A61K9/0043 ,  A61K9/146 ,  A61K9/1652 ,  A61K9/1694 ,  A61K9/19 ,  A61K31/5513 ,  A61K31/5517

Abstract: A powder composition for intranasal delivery includes a benzodiazepine drug and chitosan, a salt of chitosan, a derivative of chitosan or a salt of a derivative of chitosan.

Abstract translation: 用于鼻内递送的粉末组合物包括苯并二氮杂药物和壳聚糖，壳聚糖的盐，壳聚糖的衍生物或壳聚糖的衍生物的盐。

公开(公告)号：US20100021553A1

公开(公告)日：2010-01-28

申请号：US12570039

申请日：2009-09-30

Applicant: Ann Margaret DYER ,  Peter James WATTS ,  Yu-Hui CHENG ,  Alan SMITH

Inventor： Ann Margaret DYER ,  Peter James WATTS ,  Yu-Hui CHENG ,  Alan SMITH

IPC: A61K9/14 ,  A61K38/27

CPC classification number: A61K9/0043 ,  A61K9/1652 ,  A61K38/27 ,  A61K47/36 ,  Y10S514/951

Abstract: There is provided a powder formulation for nasal delivery including a protein having a molecular weight of 10 kDa or greater and chitosan or a derivative thereof or a salt of chitosan or a salt of a derivative of chitosan. Preferably the protein is human growth hormone.

Abstract translation: 提供了一种用于鼻腔输送的粉末制剂，其包括分子量为10kDa或更高的蛋白质和壳聚糖或其衍生物或壳聚糖的盐或壳聚糖衍生物的盐。 优选地，蛋白质是人生长激素。

公开(公告)号：US20050101688A1

公开(公告)日：2005-05-12

申请号：US10771360

申请日：2004-02-05

Applicant: Wen-Yih Liao ,  Huei-Wen Yang ,  Ching-Yu Hsieh ,  Fu-Hsi Yu ,  Yu-Hui Cheng

Inventor： Wen-Yih Liao ,  Huei-Wen Yang ,  Ching-Yu Hsieh ,  Fu-Hsi Yu ,  Yu-Hui Cheng

IPC: C08G18/67 ,  C08J3/28 ,  C08K3/00 ,  C08K3/28 ,  C08L75/06 ,  C08L75/16 ,  G11B7/24 ,  G11B7/245 ,  G11B7/256 ,  G11B7/26

CPC classification number: G11B7/263 ,  C08G18/672 ,  C08L75/16 ,  G11B7/24038 ,  G11B7/245 ,  G11B7/256 ,  C08G18/42

Abstract: A polymeric material applicable for making a data-recording layer of a multi-layer recording medium in the process using a plastic stamper is provided. In the manufacturing process of multi-layer recording media, a plastic substrate carrying data signals is used as a stamper. The stamper includes a plastic substrate formed thereon a signal-carrying layer. The polymeric material is applied on the plastic stamper to form a data-recording layer. The polymeric material has good duplicating characteristics and has different adhesion to a metallic layer and a polymeric layer so that data-recording layer made by the polymeric material is easy to be peeled off from the stamper. The stamper is also reusable for several times so as to save manufacturing cost.

Abstract translation: 提供了一种适用于在使用塑料压模的工艺中制作多层记录介质的数据记录层的聚合材料。 在多层记录介质的制造过程中，使用承载数据信号的塑料基板作为压模。 压模包括在其上形成信号承载层的塑料基板。 将聚合物材料施加在塑料压模上以形成数据记录层。 聚合物材料具有良好的复制特性，并且与金属层和聚合物层具有不同的粘合性，使得由聚合物材料制成的数据记录层易于从压模剥离。 压模也可重复使用多次，以节省制造成本。

公开(公告)号：US08946208B2

公开(公告)日：2015-02-03

申请号：US12201226

申请日：2008-08-29

Applicant: Jonathan Castile ,  Alan Smith ,  Yu-Hui Cheng ,  Peter James Watts

Inventor： Jonathan Castile ,  Alan Smith ,  Yu-Hui Cheng ,  Peter James Watts

IPC: A01N43/62 ,  A61K31/55 ,  C07D243/12 ,  A61K9/00 ,  A61K9/08 ,  A61K31/5517 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22

CPC classification number: A61K9/0043 ,  A61K9/08 ,  A61K31/55 ,  A61K31/5517 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22

Abstract: A composition for intranasal delivery of a drug comprising: includes: (i) the drug; and (ii) a non-aqueous vehicle containing (a) propylene glycol and at least one additional solvent selected from N-methylpyrrolidone, propylene carbonate, dimethyl sulfoxide and at least one propylene glycol fatty acid ester; (b) from about 40 to 100% by volume of N-methylpyrrolidone; or (c) from about 40 to 100% by volume of dimethyl sulfoxide (DMSO).

Abstract translation: 一种用于鼻内递送药物的组合物，包括：（i）药物; 和（ii）含有（a）丙二醇和至少一种另外的选自N-甲基吡咯烷酮，碳酸亚丙酯，二甲基亚砜和至少一种丙二醇脂肪酸酯的溶剂的非水性载体; （b）约40-100％（体积）的N-甲基吡咯烷酮; 或（c）约40〜100体积％的二甲基亚砜（DMSO）。

公开(公告)号：US20090233912A1

公开(公告)日：2009-09-17

申请号：US12201226

申请日：2008-08-29

Applicant: Jonathan CASTILE ,  Alan SMITH ,  Yu-Hui CHENG ,  Peter James WATTS

Inventor： Jonathan CASTILE ,  Alan SMITH ,  Yu-Hui CHENG ,  Peter James WATTS

IPC: A61K31/551 ,  A61K31/5513 ,  A61P25/00

CPC classification number: A61K9/0043 ,  A61K9/08 ,  A61K31/55 ,  A61K31/5517 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22

Abstract: A composition for intranasal delivery of a drug comprising: includes: (i) the drug; and (ii) a non-aqueous vehicle containing (a) propylene glycol and at least one additional solvent selected from N-methylpyrrolidone, propylene carbonate, dimethyl sulfoxide and at least one propylene glycol fatty acid ester; (b) from about 40 to 100% by volume of N-methylpyrrolidone; or (c) from about 40 to 100% by volume of dimethyl sulfoxide (DMSO).

Abstract translation: 一种用于鼻内递送药物的组合物，包括：（i）药物; 和（ii）含有（a）丙二醇和至少一种另外的选自N-甲基吡咯烷酮，碳酸亚丙酯，二甲基亚砜和至少一种丙二醇脂肪酸酯的溶剂的非水性载体; （b）约40-100％（体积）的N-甲基吡咯烷酮; 或（c）约40〜100体积％的二甲基亚砜（DMSO）。

公开(公告)号：US20060120973A1

公开(公告)日：2006-06-08

申请号：US11325073

申请日：2006-01-04

Applicant: Ann Dyer ,  Peter Watts ,  Yu-Hui Cheng ,  Alan Smith

Inventor： Ann Dyer ,  Peter Watts ,  Yu-Hui Cheng ,  Alan Smith

IPC: A61K38/17 ,  A61K31/722 ,  A61L9/04 ,  A61K9/14

CPC classification number: A61K9/0043 ,  A61K9/1652 ,  A61K38/27 ,  A61K47/36 ,  Y10S514/951

Abstract: There is provided a powder formulation for nasal delivery including a protein having a molecular weight of 10 kDa or greater and chitosan or a derivative thereof or a salt of chitosan or a salt of a derivative of chitosan. Preferably the protein is human growth hormone.

公开(公告)号：US08710028B2

公开(公告)日：2014-04-29

申请号：US12675306

申请日：2008-08-29

Applicant: Peter James Watts ,  Yu-Hui Cheng ,  Alan Smith ,  Jonathan Castile

Inventor： Peter James Watts ,  Yu-Hui Cheng ,  Alan Smith ,  Jonathan Castile

IPC: A61K31/55 ,  A61K31/70

CPC classification number: A61K9/0043 ,  A61K9/146 ,  A61K9/1652 ,  A61K9/1694 ,  A61K9/19 ,  A61K31/5513 ,  A61K31/5517

Abstract: A powder composition for intranasal delivery includes a benzodiazepine drug and chitosan, a salt of chitosan, a derivative of chitosan or a salt of a derivative of chitosan.

Abstract translation: 用于鼻内递送的粉末组合物包括苯并二氮杂药物和壳聚糖，壳聚糖的盐，壳聚糖的衍生物或壳聚糖的衍生物的盐。

公开(公告)号：US08481070B2

公开(公告)日：2013-07-09

申请号：US12570039

申请日：2009-09-30

Applicant: Ann Margaret Dyer ,  Peter James Watts ,  Yu-Hui Cheng ,  Alan Smith

Inventor： Ann Margaret Dyer ,  Peter James Watts ,  Yu-Hui Cheng ,  Alan Smith

IPC: A61K9/14 ,  A61K9/16 ,  A61K38/00 ,  A61K38/27

CPC classification number: A61K9/0043 ,  A61K9/1652 ,  A61K38/27 ,  A61K47/36 ,  Y10S514/951

Abstract: There is provided a powder formulation for nasal delivery including a protein having a molecular weight of 10 kDa or greater and chitosan or a derivative thereof or a salt of chitosan or a salt of a derivative of chitosan. Preferably the protein is human growth hormone.

Abstract translation: 提供了一种用于鼻腔输送的粉末制剂，其包括分子量为10kDa或更高的蛋白质和壳聚糖或其衍生物或壳聚糖的盐或壳聚糖衍生物的盐。 优选地，蛋白质是人生长激素。

公开(公告)号：US08309108B2

公开(公告)日：2012-11-13

申请号：US12741932

申请日：2008-11-10

Applicant: Peter Watts ,  Yu-Hui Cheng

Inventor： Peter Watts ,  Yu-Hui Cheng

IPC: A61K9/00 ,  A61P25/16

CPC classification number: A61K31/473 ,  A61K9/0043 ,  A61K47/10 ,  A61K47/36 ,  A61K47/40

Abstract: A liquid aqueous formulation for the intranasal administration of apomorphine includes: (a) at least about 15 mg/ml of apomorphine; and (b) a solubilising agent selected from (i) at least one polyoxyethylene-polyoxypropylene copolymer (poloxamer); (ii) at least one cyclodextrin; and (iii) at least one cyclodextrin together with chitosan. The formulations of the invention can be used in the treatment or management of Parkinson's disease and erectile dysfunction.

Abstract translation: 用于鼻内施用阿扑吗啡的液体含水制剂包括：（a）至少约15mg / ml的阿朴吗啡; 和（b）选自（i）至少一种聚氧乙烯 - 聚氧丙烯共聚物（泊洛沙姆）的增溶剂; （ii）至少一种环糊精; 和（iii）至少一种环糊精与壳聚糖一起。 本发明的制剂可用于治疗或治疗帕金森病和勃起功能障碍。

公开(公告)号：US08034371B2

公开(公告)日：2011-10-11

申请号：US10596817

申请日：2004-12-23

Applicant: Jonathan David Castile ,  Yu-Hui Cheng ,  Paul George Jenkins ,  Alan Smith ,  Peter James Watts

Inventor： Jonathan David Castile ,  Yu-Hui Cheng ,  Paul George Jenkins ,  Alan Smith ,  Peter James Watts

IPC: A61K9/08 ,  A61K9/12 ,  A61K31/44 ,  A61F13/00

CPC classification number: B82Y5/00 ,  A61K9/0043 ,  A61K9/1623 ,  A61K9/1652 ,  A61K31/4184 ,  A61K47/36 ,  A61K47/40 ,  A61K47/6951 ,  Y10S514/923

Abstract: The present invention provides compositions for the intranasal administration of zolpidem or a pharmaceutically acceptable salt thereof. Preferred compositions of the invention are in the form of aqueous solutions. Optionally the compositions of the invention comprise a cyclodextrin and/or chitosan, a salt or derivative thereof or a salt of a derivative of chitosan. The compositions can be used for the treatment or prevention insomnia or the treatment of neurological disorders such as those arising from brain trauma, stroke and spinocerebellar ataxia or in the treatment of Parkinson's disease.

Abstract translation: 本发明提供了用于鼻内施用唑吡旦或其药学上可接受的盐的组合物。 本发明的优选组合物是水溶液的形式。 任选地，本发明的组合物包含环糊精和/或壳聚糖，其盐或衍生物或壳聚糖衍生物的盐。 该组合物可用于治疗或预防失眠或治疗诸如由脑创伤，中风和脊髓小脑共济失调引起的神经障碍或治疗帕金森病。