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1.发明申请Susceptibility gene for myocardial infarction, stroke, and PAOD; methods of treatment 失效心肌梗塞，中风和PAOD的易感基因; 治疗方法公开(公告)号：US20070280917A1
公开(公告)日：2007-12-06
申请号：US11270804
申请日：2005-11-09
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： Polymorphisms in the FLAP and LTA4H gene are shown by genetic association analysis to be susceptibility markers for myocardial infarction (MI) and ACS, as well as stroke and PAOD. Pathway targeting for treatment and diagnostic applications in identifying those who are at risk of developing MI, ACS, stroke or PAOD, in particular are described. The invention also provides methods of prophylaxis therapy for MI in human subjects having a race including black African ancestry by administering to the subject a composition comprising a therapeutically effective amount of MI therapeutic agent that inhibits leukotriene synthesis in vivo. The invention also provides for compositions comprising a leukotriene synthesis inhibitor and a statin and methods of using these compositions to reduce C-reactive protein in a human subject at risk of MI, ACS, stroke and/or PAOD.
摘要翻译： FLAP和LTA4H基因的多态性通过遗传关联分析显示为心肌梗死（MI）和ACS以及中风和PAOD的敏感性标志物。 描述了针对治疗和诊断应用的途径，用于鉴定那些处于发展中心，ACS，中风或PAOD风险的患者。 本发明还提供了通过向受试者施用包含治疗有效量的体内抑制白细胞三烯合成的MI治疗剂的组合物的组合，在具有包括黑非洲血统的种族的人类受试者中预防MI治疗的方法。 本发明还提供了包含白三烯合成抑制剂和他汀类的组合物以及使用这些组合物降低患有MI，ACS，中风和/或PAOD风险的人类受试者中的C-反应蛋白的方法。
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公开(公告)号：US20050272051A1
公开(公告)日：2005-12-08
申请号：US10944272
申请日：2004-09-17
IPC分类号： A61K31/00 , A61K31/198 , A61K31/381 , A61K31/445 , A61P9/10 , C12Q1/68 , G01N33/50
CPC分类号： A61K31/00 , A61K31/198 , A61K31/381 , A61K31/445 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： Linkage of myocardial infarction (MI) with a locus on chromosome 12q23 is disclosed. In particular, the LTA4H gene within this locus is shown by association analysis to be a susceptibility gene for MI. Methods for preventing and/or treating the recurrence of MI, in particular are described.
摘要翻译： 公开了心肌梗塞（MI）与染色体12q23上的位点的连锁。 特别地，通过关联分析将该基因内的LTA4H基因显示为MI的易感基因。 特别是描述了用于预防和/或治疗MI复发的方法。
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3.发明申请Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment 审中-公开心肌梗塞，中风和PAOD的易感基因，治疗方法公开(公告)号：US20060019269A1
公开(公告)日：2006-01-26
申请号：US11096191
申请日：2005-03-30
IPC分类号： C12Q1/68 , A61K31/401 , A61K31/366 , A61K31/225
CPC分类号： A61K31/225 , A61K31/366 , A61K31/401 , A61K38/00 , C07K14/4705 , C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N2800/324
摘要： Linkage of myocardial infarction (MI) and a locus on chromosome 13q12 is disclosed. In particular, the FLAP gene within this locus is shown by genetic association analysis to be a susceptibility gene for MI and ACS, as well as stroke and PAOD. Pathway targeting for treatment and diagnostic applications in identifying those who are at risk of developing MI, ACS, stroke or PAOD, in particular are described. The invention also provides for compositions comprising a leukotriene synthesis inhibitor and a stating and methods of using these compositions to reduce C-reactive protein in a human subject at risk of MI, ACS, stroke and/or PAOD.
摘要翻译： 公开了心肌梗塞（MI）和染色体13q12上的位点的连锁。 特别地，通过遗传关联分析将该基因内的FLAP基因显示为MI和ACS以及中风和PAOD的易感基因。 描述了针对治疗和诊断应用的途径，用于鉴定那些处于发展中心，ACS，中风或PAOD风险的患者。 本发明还提供包含白三烯合成抑制剂的组合物和使用这些组合物降低患有MI，ACS，中风和/或PAOD风险的人类受试者的C-反应蛋白的说明和方法。
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4.发明申请Susceptibility gene for myocardial infarction, stroke, and PAOD; methods of treatment 失效心肌梗塞，中风和PAOD的易感基因; 治疗方法公开(公告)号：US20050113408A1
公开(公告)日：2005-05-26
申请号：US10830477
申请日：2004-04-22
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/4705 , C12Q2600/156 , G01N2800/324
摘要： Linkage of myocardial infarction (MI) and a locus on chromosome 13q12 is disclosed. In particular, the FLAP gene within this locus is shown by genetic association analysis to be a susceptibility gene for MI and ACS, as well as stroke and PAOD. Pathway targeting for treatment and diagnostic applications in identifying those who are at risk of developing MI, ACS, stroke or PAOD, in particular are described.
摘要翻译： 公开了心肌梗塞（MI）和染色体13q12上的位点的连锁。 特别地，通过遗传关联分析将该基因内的FLAP基因显示为MI和ACS以及中风和PAOD的易感基因。 描述了针对治疗和诊断应用的途径，用于鉴定那些处于发展中心，ACS，中风或PAOD风险的患者。
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公开(公告)号：US20050282855A1
公开(公告)日：2005-12-22
申请号：US10769744
申请日：2004-01-30
CPC分类号： A61K31/47 , A61K38/00 , C07K14/4705 , C12Q1/6883 , C12Q2600/156 , G01N2800/324
摘要： Linkage of myocardial infarction (MI) and a locus on chromosome 13q12 is disclosed. In particular, the FLAP gene within this locus is shown by genetic association analysis to be a susceptibility gene for MI and ACS, as well as stroke and PAOD. Pathway targeting for treatment and diagnostic applications in identifying those who are at risk of developing MI, ACS, stroke or PAOD, in particular are described.
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6.发明申请Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment 审中-公开心肌梗死，脑卒中，Paod及其治疗方法的易感基因公开(公告)号：US20080293750A1
公开(公告)日：2008-11-27
申请号：US10587412
申请日：2005-01-31
IPC分类号： A61K31/505 , C12Q1/02 , A61K31/40 , A61P9/10 , C12Q1/68
CPC分类号： C07K14/4705 , A61K38/00 , C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N2800/324
摘要： Linkage of myocardial infarction (MI) and a locus on chromosome 13q12 is disclosed. In particular, the FLAP gene within this locus is shown by genetic association analysis to be a susceptibility gene for MI and ACS, as well as stroke and PAOD. Pathway targeting for treatment and diagnostic applications in identifying those who are at risk of developing MI, ACS, stroke or PAOD, in particular are described. The invention also provides for compositions comprising a leukotriene synthesis inhibitor and a stating and methods of using these compositions to reduce C-reactive protein in a human subject at risk of MI, ACS, stroke and/or PAOD.
摘要翻译： 公开了心肌梗塞（MI）和染色体13q12上的位点的连锁。 特别地，通过遗传关联分析将该基因内的FLAP基因显示为MI和ACS以及中风和PAOD的易感基因。 描述了针对治疗和诊断应用的途径，用于鉴定那些处于发展中心，ACS，中风或PAOD风险的患者。 本发明还提供包含白三烯合成抑制剂的组合物和使用这些组合物降低患有MI，ACS，中风和/或PAOD风险的人类受试者的C-反应蛋白的说明和方法。
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7.发明申请Methods of diagnosis and treatment for asthma and other respiratory diseases based on haplotype association 审中-公开基于单倍型关联的哮喘和其他呼吸系统疾病的诊断和治疗方法公开(公告)号：US20060014165A1
公开(公告)日：2006-01-19
申请号：US11043752
申请日：2005-01-26
申请人： Hakon Hakonarson , Mark Gurney , Eva Halapi
发明人： Hakon Hakonarson , Mark Gurney , Eva Halapi
CPC分类号： C12Q1/6883 , A61K31/47 , A61K31/519 , A61K31/553 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： Methods for diagnosis of asthma or a susceptibility to asthma based on detection of at-risk haplotypes associated with MAP3K9 are disclosed. Also methods for treatment of asthma or a susceptibility to asthma based on detection of at-risk haplotypes associated with MAP3K9 are disclosed. In particular, pathway targeting for treating individuals who are at-risk of developing asmtha are described. In certain aspects, MLK1 inhibitors are used in treatment methods.
摘要翻译： 公开了基于检测与MAP3K9相关的风险单倍型的哮喘诊断或哮喘易感性的方法。 公开了基于检测与MAP3K9相关的风险单倍型的哮喘治疗或哮喘易感性的方法。 特别地，描述了用于治疗处于发展asmtha风险的个体的途径靶向。 在某些方面，MLK1抑制剂用于治疗方法。
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8.发明申请Sustained release formulation and dosing schedule of leukotriene synthesis inhibitor for human therapy 审中-公开持续释放制剂和用于人类治疗的白三烯合成抑制剂的给药方案公开(公告)号：US20060257481A1
公开(公告)日：2006-11-16
申请号：US11407458
申请日：2006-04-20
申请人： Mark Gurney , Hakon Hakonarson
发明人： Mark Gurney , Hakon Hakonarson
CPC分类号： A61K31/472 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2866 , A61K31/47
摘要： The invention relates to improved materials and methods for therapy to inhibit production of leukotrienes, and all therapeutic applications thereof.
摘要翻译： 本发明涉及用于抑制白三烯生产的治疗的改进的材料和方法及其所有治疗应用。
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9.发明申请Genetic Alterations Associated with Autism and the Autistic Phenotype and Methods of Use Thereof for the Diagnosis and Treatment of Autism 审中-公开与自闭症相关的遗传改变和自闭症表型及其使用方法用于诊断和治疗自闭症公开(公告)号：US20110207124A1
公开(公告)日：2011-08-25
申请号：US12918508
申请日：2009-02-20
申请人： Hakon Hakonarson , Joseph Glessner , Jonathan Bradfield , Struan Grant , Haitao Zhang , Kai Wang
发明人： Hakon Hakonarson , Joseph Glessner , Jonathan Bradfield , Struan Grant , Haitao Zhang , Kai Wang
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16
摘要： Compositions and methods for the detection and treatment of autism and autistic spectrum disorder are provided.
摘要翻译： 提供了自闭症和自闭症谱系障碍检测和治疗的组合和方法。
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10.发明授权Methods for producing ex vivo models for inflammatory disease and uses thereof 失效用于产生炎症性疾病的离体模型的方法及其用途公开(公告)号：US07435548B2
公开(公告)日：2008-10-14
申请号：US11879066
申请日：2007-07-16
CPC分类号： G01N33/6863 , C12Q1/6883 , C12Q2600/158 , G01N33/564 , G01N33/6869 , G01N2333/525 , G01N2333/545 , G01N2500/10 , G01N2800/52
摘要： The invention relates to methods for inducing a pro-asthma/pro-inflammatory like state in a resident tissue cell, comprising contacting the cell with one or more cytokines, e.g., IL-β, TNFα or both. Methods are also disclosed for identifying genes that regulate responses to anti-inflammatory drugs, to methods for drug screening, and to methods for identifying genes that correlate with various pro-asthma/pro-inflammatory disease phenotypes.
摘要翻译： 本发明涉及在常驻组织细胞中诱导前哮喘/促炎样状态的方法，包括使细胞与一种或多种细胞因子例如IL-β，TNFα或两者接触。 还公开了用于鉴定调节对抗炎药物的反应的基因，药物筛选方法以及用于鉴定与各种前哮喘/促炎症疾病表型相关的基因的方法的方法。
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