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1.发明申请Genetic Alterations Associated with Autism and the Autistic Phenotype and Methods of Use Thereof for the Diagnosis and Treatment of Autism 审中-公开与自闭症相关的遗传改变和自闭症表型及其使用方法用于诊断和治疗自闭症公开(公告)号：US20110207124A1
公开(公告)日：2011-08-25
申请号：US12918508
申请日：2009-02-20
申请人： Hakon Hakonarson , Joseph Glessner , Jonathan Bradfield , Struan Grant , Haitao Zhang , Kai Wang
发明人： Hakon Hakonarson , Joseph Glessner , Jonathan Bradfield , Struan Grant , Haitao Zhang , Kai Wang
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16
摘要： Compositions and methods for the detection and treatment of autism and autistic spectrum disorder are provided.
摘要翻译： 提供了自闭症和自闭症谱系障碍检测和治疗的组合和方法。
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2.发明授权Methods for producing ex vivo models for inflammatory disease and uses thereof 失效用于产生炎症性疾病的离体模型的方法及其用途公开(公告)号：US07435548B2
公开(公告)日：2008-10-14
申请号：US11879066
申请日：2007-07-16
CPC分类号： G01N33/6863 , C12Q1/6883 , C12Q2600/158 , G01N33/564 , G01N33/6869 , G01N2333/525 , G01N2333/545 , G01N2500/10 , G01N2800/52
摘要： The invention relates to methods for inducing a pro-asthma/pro-inflammatory like state in a resident tissue cell, comprising contacting the cell with one or more cytokines, e.g., IL-β, TNFα or both. Methods are also disclosed for identifying genes that regulate responses to anti-inflammatory drugs, to methods for drug screening, and to methods for identifying genes that correlate with various pro-asthma/pro-inflammatory disease phenotypes.
摘要翻译： 本发明涉及在常驻组织细胞中诱导前哮喘/促炎样状态的方法，包括使细胞与一种或多种细胞因子例如IL-β，TNFα或两者接触。 还公开了用于鉴定调节对抗炎药物的反应的基因，药物筛选方法以及用于鉴定与各种前哮喘/促炎症疾病表型相关的基因的方法的方法。
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3.发明申请Methods for producing ex vivo models for inflammatory disease and uses thereof 失效用于产生炎症性疾病的离体模型的方法及其用途公开(公告)号：US20070275406A1
公开(公告)日：2007-11-29
申请号：US11879066
申请日：2007-07-16
CPC分类号： G01N33/6863 , C12Q1/6883 , C12Q2600/158 , G01N33/564 , G01N33/6869 , G01N2333/525 , G01N2333/545 , G01N2500/10 , G01N2800/52
摘要： The invention relates to methods for inducing a pro-asthma/pro-inflammatory like state in a resident tissue cell, comprising contacting the cell with one or more cytokines, e.g., IL-β, TNFα or both. Methods are also disclosed for identifying genes that regulate responses to anti-inflammatory drugs, to methods for drug screening, and to methods for identifying genes that correlate with various pro-asthma/pro-inflammatory disease phenotypes.
摘要翻译： 本发明涉及在常驻组织细胞中诱导前哮喘/促炎样状态的方法，包括使细胞与一种或多种细胞因子例如IL-β，TNFα或两者接触。 还公开了用于鉴定调节对抗炎药物的反应的基因，药物筛选方法以及用于鉴定与各种前哮喘/促炎症疾病表型相关的基因的方法的方法。
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4.发明授权公开(公告)号：US07148008B2
公开(公告)日：2006-12-12
申请号：US10234652
申请日：2002-09-03
申请人： Hakon Hakonarson
发明人： Hakon Hakonarson
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6809 , G01N33/5047 , G01N2800/52
摘要： Methods are disclosed for predicting the efficacy of a drug for treating an inflammatory disease in a human patient, including: obtaining a sample of cells from the patient; obtaining a gene expression profile of the sample in the absence and presence of in vitro modulation of the cells with specific cytokines and/or mediators; and comparing the gene expression profile of the sample with a reference gene expression profile, wherein similarities between the sample expression profile and the reference expression profile predicts the efficacy of the drug for treating the inflammatory disease in the patient.
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公开(公告)号：US20050272051A1
公开(公告)日：2005-12-08
申请号：US10944272
申请日：2004-09-17
IPC分类号： A61K31/00 , A61K31/198 , A61K31/381 , A61K31/445 , A61P9/10 , C12Q1/68 , G01N33/50
CPC分类号： A61K31/00 , A61K31/198 , A61K31/381 , A61K31/445 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： Linkage of myocardial infarction (MI) with a locus on chromosome 12q23 is disclosed. In particular, the LTA4H gene within this locus is shown by association analysis to be a susceptibility gene for MI. Methods for preventing and/or treating the recurrence of MI, in particular are described.
摘要翻译： 公开了心肌梗塞（MI）与染色体12q23上的位点的连锁。 特别地，通过关联分析将该基因内的LTA4H基因显示为MI的易感基因。 特别是描述了用于预防和/或治疗MI复发的方法。
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公开(公告)号：US06630140B1
公开(公告)日：2003-10-07
申请号：US09261104
申请日：1999-03-03
IPC分类号： A61K39395
CPC分类号： C07K14/7056 , A61K38/00 , A61K2039/505 , A61K2039/54 , C07K14/70535 , C07K16/2851
摘要： Methods of treating or preventing induction of asthma in a human patient are provided. The methods comprise administering to the human an anti-Fc&egr;RII receptor protein ligand suspended in a pharmaceutically acceptable carrier in an amount sufficient to inhibit binding of IgE to an anti-Fc&egr;RII receptor protein thereby treating or preventing induction of asthma in the human.
摘要翻译： 提供了治疗或预防人类患者哮喘诱导的方法。 所述方法包括以足以抑制IgE与抗FcepsilRII受体蛋白结合从而治疗或预防人类诱发哮喘的量向悬浮在药学上可接受的载体中的人施用抗FcepsilRII受体蛋白质配体。
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公开(公告)号：US09783851B2
公开(公告)日：2017-10-10
申请号：US12918508
申请日：2009-02-20
申请人： Hakon Hakonarson , Joseph Glessner , Jonathan Bradfield , Struan Grant , Haitao Zhang , Kai Wang
发明人： Hakon Hakonarson , Joseph Glessner , Jonathan Bradfield , Struan Grant , Haitao Zhang , Kai Wang
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16
摘要： Compositions and methods for the detection and treatment of autism and autistic spectrum disorder are provided.
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公开(公告)号：US20140315992A1
公开(公告)日：2014-10-23
申请号：US14131359
申请日：2012-07-09
申请人： Hakon Hakonarson , Dexter Hadley , Zhi-Liang Wu , Joseph Glessner
发明人： Hakon Hakonarson , Dexter Hadley , Zhi-Liang Wu , Joseph Glessner
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/156
摘要： Compositions and methods for the detection and treatment of autism and autistic spectrum disorder are provided.
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9.发明申请Compositions and Methods for Diagnosing Genome Related Diseases and Disorders 审中-公开用于诊断基因组相关疾病和疾病的组合物和方法公开(公告)号：US20120309639A1
公开(公告)日：2012-12-06
申请号：US13499515
申请日：2010-10-08
申请人： Hakon Hakonarson , Kai Wang , Zhi Wei
发明人： Hakon Hakonarson , Kai Wang , Zhi Wei
CPC分类号： C12Q1/6883 , C12Q2600/156 , G16B20/00 , G16B40/00
摘要： Compositions, methods, and kits for diagnosing genetic disorders such as type I diabetes are disclosed.
摘要翻译： 公开了用于诊断遗传性疾病如I型糖尿病的组合物，方法和试剂盒。
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10.发明申请Genetic Alterations on Chromosome 16 and Methods of Use Thereof for the Diagnosis and Treatment of Type 1 Diabetes 审中-公开第16号染色体上的遗传改变及其使用方法用于诊断和治疗1型糖尿病公开(公告)号：US20110286997A1
公开(公告)日：2011-11-24
申请号：US12531272
申请日：2008-03-13
IPC分类号： A61K39/395 , C12Q1/68 , C40B40/06 , A61P3/10 , C07H21/00 , A61K31/713 , A61K31/7088 , A61K38/02 , G01N33/566 , C40B30/04
CPC分类号： C12Q1/6883 , C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12Q2600/136 , C12Q2600/156 , C12Y207/11022
摘要： Compositions and methods for the detection and treatment of T1D are provided.
摘要翻译： 提供了T1D检测和处理的组成和方法。
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