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公开(公告)号：US20100305092A1
公开(公告)日：2010-12-02
申请号：US12809816
申请日：2008-12-17
IPC分类号： A61K31/397 , C07D413/04 , A61K31/4245 , C07D413/14 , A61K31/4439 , A61K31/5377 , C07D401/14 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/497 , A61P19/02 , A61P3/10 , A61P9/10 , A61P1/04 , A61P17/06 , A61P11/06 , A61P29/00
CPC分类号： C07D413/04 , C07D413/14
摘要： The invention relates to compounds of formula I: wherein R1, R2, Ra, Rb, X have the meanings given in claim 16. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis.
摘要翻译： 本发明涉及式I化合物：其中R1，R2，Ra，Rb，X具有权利要求1中给出的含义。 治疗自身免疫性疾病，如多发性硬化症。
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公开(公告)号：US08202856B2
公开(公告)日：2012-06-19
申请号：US12809816
申请日：2008-12-17
申请人： Anna Quattropani , Christophe Cleva , Eric Sebille , Matthias Schwarz , Delphine Marin , Agnes Bombrun , Wesley Blackaby , Charles Baker-Glenn , Chris Knight , Craig Rouse
发明人： Anna Quattropani , Christophe Cleva , Eric Sebille , Matthias Schwarz , Delphine Marin , Agnes Bombrun , Wesley Blackaby , Charles Baker-Glenn , Chris Knight , Craig Rouse
IPC分类号： A61K31/397 , A61K31/4545 , A61K31/444 , A61K31/5377 , A61K31/4245 , A61K31/4439 , A61K31/4725 , A61K31/497 , C07D413/04 , C07D413/14 , C07D401/14 , A61P19/02 , A61P3/10 , A61P9/10 , A61P29/00 , A61P1/04 , A61P17/06 , A61P11/06
CPC分类号： C07D413/04 , C07D413/14
摘要： The invention relates to compounds of formula I: wherein R1, R2,Ra, Rb, X have the meanings given in claim 16. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis.
摘要翻译： 本发明涉及式I化合物：其中R1，R2，Ra，Rb，X具有权利要求1中给出的含义。 治疗自身免疫性疾病，如多发性硬化症。
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公开(公告)号：US08796280B2
公开(公告)日：2014-08-05
申请号：US11918294
申请日：2006-04-20
申请人： Patrick Page , Matthias Schwarz , Eric Sebille , Christophe Cleva , Cedric Merlot , Maurizio Maio
发明人： Patrick Page , Matthias Schwarz , Eric Sebille , Christophe Cleva , Cedric Merlot , Maurizio Maio
IPC分类号： A61K31/4965 , C07D409/12 , C07D401/10 , C07D241/22 , C07D413/10 , C07D405/12 , C07D403/10 , C07D401/12
CPC分类号： C07D241/22 , C07D241/20 , C07D401/10 , C07D401/12 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D411/14 , C07D413/10 , C07D413/12 , C07D417/10 , C07D417/12
摘要： The present invention is related to the use of 2,3 substituted pyrazine sulfonamides of formula (I) for the treatment and/or prevention of allergic diseases, inflammatory dermatoses and other diseases with an inflammatory component. Specifically, the present invention is related to the use of 2,3 substituted pyrazine sulfonamides for the modulation, notably the inhibition, of CRTH2 activity.
摘要翻译： 本发明涉及式（I）的2,3-取代吡嗪磺酰胺在治疗和/或预防过敏性疾病，炎性皮肤病和其它具有炎性成分的疾病中的应用。 具体地说，本发明涉及2,3取代吡嗪磺酰胺用于调节，特别是抑制CRTH2活性的用途。
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公开(公告)号：US08236963B2
公开(公告)日：2012-08-07
申请号：US11919471
申请日：2006-05-23
申请人： Matthias Schwarz , Eric Sebille , Christophe Cleva , Cedric Merlot , Dennis Church , Patrick Page , Jacqueline A. Macritchie , John Frederick Atherall , Stefano Crosignani , Doris Pupowicz
发明人： Matthias Schwarz , Eric Sebille , Christophe Cleva , Cedric Merlot , Dennis Church , Patrick Page , Jacqueline A. Macritchie , John Frederick Atherall , Stefano Crosignani , Doris Pupowicz
IPC分类号： C07D277/20 , C07D271/06 , C07D417/14 , C07D487/10 , C07D261/06 , A61K31/44 , A61K31/431 , A61K31/4184 , A61K31/4196 , A61K31/41
CPC分类号： C07D487/10
摘要： The present invention is related to the use of spiro derivatives of Formula (I) for the treatment and/or prevention of allergic diseases, inflammatory dermatoses and other diseases with an inflammatory component. Specifically, the present invention is related to the use of spiro derivatives for the modulation of CRTH2 activity.
摘要翻译： 本发明涉及式（I）的螺衍生物用于治疗和/或预防具有炎性成分的过敏性疾病，炎性皮肤病和其它疾病的用途。 具体地说，本发明涉及螺衍生物用于调节CRTH2活性的用途。
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公开(公告)号：US20090054447A1
公开(公告)日：2009-02-26
申请号：US11918294
申请日：2006-04-20
申请人： Patrick Page , Matthias Schwarz , Eric Sebille , Christophe Cleva , Cedric Merlot , Maurizio Maio
发明人： Patrick Page , Matthias Schwarz , Eric Sebille , Christophe Cleva , Cedric Merlot , Maurizio Maio
IPC分类号： A61K31/497 , C07D403/08 , A61K31/4965 , C07D241/20 , C07D401/14
CPC分类号： C07D241/22 , C07D241/20 , C07D401/10 , C07D401/12 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D411/14 , C07D413/10 , C07D413/12 , C07D417/10 , C07D417/12
摘要： The present invention is related to the use of 2,3 substituted pyrazine sulfonamides of formula (I) for the treatment and/or prevention of allergic diseases, inflammatory dermatoses and other diseases with an inflammatory component. Specifically, the present invention is related to the use of 2,3 substituted pyrazine sulfonamides for the modulation, notably the inhibition, of CRTH2 activity.
摘要翻译： 本发明涉及式（I）的2,3-取代吡嗪磺酰胺在治疗和/或预防过敏性疾病，炎性皮肤病和其它具有炎性成分的疾病中的应用。 具体地说，本发明涉及2,3取代吡嗪磺酰胺用于调节，特别是抑制CRTH2活性的用途。
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公开(公告)号：US20090318486A1
公开(公告)日：2009-12-24
申请号：US11919471
申请日：2006-05-23
申请人： Matthias Schwarz , Eric Sebille , Christophe Cleva , Cedric Merlot , Dennis Church , Patrick Page , Jacqueline A. Macritchie , John Frederick Atherall , Stefano Crosignani , Doris Pupowicz
发明人： Matthias Schwarz , Eric Sebille , Christophe Cleva , Cedric Merlot , Dennis Church , Patrick Page , Jacqueline A. Macritchie , John Frederick Atherall , Stefano Crosignani , Doris Pupowicz
IPC分类号： A61K31/437 , C07D487/10 , A61K31/427 , C07D471/04 , A61P25/00
CPC分类号： C07D487/10
摘要： The present invention is related to the use of spiro derivatives of Formula (I) for the treatment and/or prevention of allergic diseases, inflammatory dermatoses and other diseases with an inflammatory component. Specifically, the present invention is related to the use of spiro derivatives for the modulation of CRTH2 activity.
摘要翻译： 本发明涉及式（I）的螺衍生物用于治疗和/或预防具有炎性成分的过敏性疾病，炎性皮肤病和其它疾病的用途。 具体地说，本发明涉及螺衍生物用于调节CRTH2活性的用途。
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公开(公告)号：US09073940B2
公开(公告)日：2015-07-07
申请号：US13509291
申请日：2010-11-12
申请人： Pascale Gaillard , Isabelle Jeanclaude-Etter , Vincent Pomel , Eric Sebille , Seenisamy Jeyaprakashnarayanan , Mathilde Muzerelle
发明人： Pascale Gaillard , Isabelle Jeanclaude-Etter , Vincent Pomel , Eric Sebille , Seenisamy Jeyaprakashnarayanan , Mathilde Muzerelle
IPC分类号： C07D495/04 , C07D495/14
CPC分类号： C07D495/04 , C07D495/14
摘要： This invention relates to compounds of Formula (I*) as Pi3k inhibitors for treating autoimmune diseases, inflammatory disorders, multiple sclerosis and other diseases like cancers.
摘要翻译： 本发明涉及作为用于治疗自身免疫性疾病，炎症性疾病，多发性硬化和其它疾病如癌症的Pi3k抑制剂的式（I *）化合物。
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公开(公告)号：US20120238545A1
公开(公告)日：2012-09-20
申请号：US13509291
申请日：2010-11-12
申请人： Pascale Gaillard , Isabelle Jeanclaude-Etter , Vincent Pomel , Eric Sebille , Seenisamy Jeyaprakashnarayanan , Mathilde Muzerelle
发明人： Pascale Gaillard , Isabelle Jeanclaude-Etter , Vincent Pomel , Eric Sebille , Seenisamy Jeyaprakashnarayanan , Mathilde Muzerelle
IPC分类号： A61K31/5377 , A61K31/553 , A61P29/00 , A61P37/00 , A61P35/00 , A61P25/00 , A61P11/06 , A61P17/14 , A61P7/06 , A61P31/14 , A61P27/16 , A61P1/00 , A61P11/00 , A61P17/00 , A61P3/10 , A61P15/00 , A61P5/16 , A61P19/04 , A61P21/04 , A61P17/06 , A61P1/16 , A61P25/18 , A61P7/00 , A61P1/04 , C07D495/04
CPC分类号： C07D495/04 , C07D495/14
摘要： This invention relates to compounds of Formula (I*) as Pi3k inhibitors for treating autoimmune diseases, inflammatory disorders, multiple sclerosis and other diseases like cancers.
摘要翻译： 本发明涉及作为用于治疗自身免疫性疾病，炎症性疾病，多发性硬化和其它疾病如癌症的Pi3k抑制剂的式（I *）化合物。
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