公开(公告)号：US20130129634A1

公开(公告)日：2013-05-23

申请号：US13812741

申请日：2011-07-28

申请人： Anna Tampieri ,  Elena Landi ,  Monica Sandri ,  Daniele Pressato ,  José Rivas Rey ,  Manuel Banobre Lopez ,  Maurilio Marcacci

发明人： Anna Tampieri ,  Elena Landi ,  Monica Sandri ,  Daniele Pressato ,  José Rivas Rey ,  Manuel Banobre Lopez ,  Maurilio Marcacci

IPC分类号： A61K47/02 ,  A61K49/08 ,  A61L27/12

CPC分类号： A61K47/02 ,  A61K49/0002 ,  A61K49/08 ,  A61L27/12 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/64 ,  A61L2400/12 ,  A61L2430/02 ,  A61L2430/06 ,  C01B25/32 ,  C01B25/322 ,  C01B25/45 ,  C01P2004/62 ,  C01P2006/62 ,  C01P2006/64

摘要： The present invention relates to hydroxyapatite doped with Fe2+ ions and Fe3+ ions which partially substitute the calcium ions in the crystal lattice. The hydroxyapatite is characterized by an intrinsic magnetism of 0.05 to 8 emu/g, measured by applying a magnetic field of 34 Oe, due to the presence of magnetic nano-domains in the crystal lattice of HA, given the limited amount of magnetic secondary phases present, less than about 3% by volume.The intrinsically magnetic hydroxyapatite can be loaded with biological substances selected in the group consisting of proteins, genes, stem cells, growth factors, vascularization factors, active substances and drugs, under the control of an external magnetic field, as a carrier and release agent for biological substances or drugs, as a contrast agent in diagnostics or for bone or osteocartilage regeneration.

摘要翻译： 本发明涉及掺杂有Fe2 +离子的羟基磷灰石和部分代替晶格中的钙离子的Fe 3+离子。 由于在HA的晶格中存在磁性纳米域，所以羟基磷灰石的特征在于通过施加34Oe的磁场测量的0.05至8emu / g的固有磁性，给定有限量的磁性次级 目前，少于约3％（体积）。 本征磁性羟基磷灰石可以在外部磁场的控制下装载由蛋白质，基因，干细胞，生长因子，血管形成因子，活性物质和药物组成的组中选择的生物物质作为载体和脱模剂 生物物质或药物，作为诊断或骨或骨软骨再生的造影剂。