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公开(公告)号:US20130005805A1
公开(公告)日:2013-01-03
申请号:US13495049
申请日:2012-06-13
申请人: Annabelle Gallois-Bernos , Frank F. Molock, JR. , Carrie L. Davis , Kathrine Osborn Lorenz , James K. Young , Kristy L. Canavan , Fang Lu
发明人: Annabelle Gallois-Bernos , Frank F. Molock, JR. , Carrie L. Davis , Kathrine Osborn Lorenz , James K. Young , Kristy L. Canavan , Fang Lu
IPC分类号: A61K31/232 , A61P27/04 , A61P27/02 , A61P29/00 , A61K31/215 , A61K31/164
CPC分类号: A61K31/232 , A61K9/0048 , A61K9/08 , A61K31/16 , A61K31/201 , A61K31/202 , A61K31/203 , A61K31/215 , A61K31/557 , A61K31/5575 , A61K31/661 , A61K31/683
摘要: The present invention relates to ophthalmic compositions and methods for the treatment of dry eye and other inflammatory ocular conditions. In particular, the present invention relates to a composition comprising an esterified anti-inflammatory lipid mediator, which is an ester of an anti-inflammatory lipid mediator that is a reaction product of the anti-inflammatory lipid mediator and a monohydric alcohol or an amide wherein the majority of the anti-inflammatory lipid mediator is present in an ester form. In this way, the compositions are substantially free of an acid form of the anti-inflammatory lipid mediators. This composition can be topically delivered to the ocular surface via a preparation, solution, gel, ointment, and/or strip and/or a contact lens.
摘要翻译: 本发明涉及用于治疗干眼症和其它炎性眼部病症的眼用组合物和方法。 特别地,本发明涉及包含酯化抗炎脂质介体的组合物,其是作为抗炎脂质介体和一元醇或酰胺的反应产物的抗炎脂质介体的酯,其中 大多数抗炎脂质介体以酯形式存在。 以这种方式,组合物基本上不含酸形式的抗炎脂质介质。 该组合物可以通过制剂,溶液,凝胶,软膏和/或条带和/或隐形眼镜被局部递送到眼表面。
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公开(公告)号:US10383839B2
公开(公告)日:2019-08-20
申请号:US13495049
申请日:2012-06-13
申请人: Annabelle Gallois-Bernos , Frank F. Molock, Jr. , Carrie L. Davis , Kathrine Osborn Lorenz , James K. Young , Kristy L. Canavan , Fang Lu
发明人: Annabelle Gallois-Bernos , Frank F. Molock, Jr. , Carrie L. Davis , Kathrine Osborn Lorenz , James K. Young , Kristy L. Canavan , Fang Lu
IPC分类号: A61K31/232 , A61K9/00 , A61K31/557 , A61K31/215 , A61K31/5575 , A61K31/661 , A61K31/16 , A61K31/201 , A61K31/202 , A61K31/203 , A61K31/683 , A61K9/08
摘要: The present invention relates to ophthalmic compositions and methods for the treatment of dry eye and other inflammatory ocular conditions. In particular, the present invention relates to a composition comprising an esterified anti-inflammatory lipid mediator, which is an ester of an anti-inflammatory lipid mediator that is a reaction product of the anti-inflammatory lipid mediator and a monohydric alcohol or an amide wherein the majority of the anti-inflammatory lipid mediator is present in an ester form. In this way, the compositions are substantially free of an acid form of the anti-inflammatory lipid mediators. This composition can be topically delivered to the ocular surface via a preparation, solution, gel, ointment, and/or strip and/or a contact lens.
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公开(公告)号:US08696115B2
公开(公告)日:2014-04-15
申请号:US12896930
申请日:2010-10-04
申请人: Kevin P. McCabe , Robert B. Steffen , Helene Aguilar , W. Anthony Martin , Susan W. Neadle , Ann-Marie W. Meyers , Dominic P. Gourd , Kristy L. Canavan , Gregory A. Hill , Douglas G. Vanderlaan
发明人: Kevin P. McCabe , Robert B. Steffen , Helene Aguilar , W. Anthony Martin , Susan W. Neadle , Ann-Marie W. Meyers , Dominic P. Gourd , Kristy L. Canavan , Gregory A. Hill , Douglas G. Vanderlaan
CPC分类号: G02B1/043 , A61L12/04 , A61L12/08 , A61L27/34 , A61L27/50 , A61L27/54 , A61L2300/452 , B29D11/00067 , B29K2039/06 , G02C7/049 , G02C13/00
摘要: This invention relates to comfortable ophthalmic devices and methods of producing such devices by treating said ophthalmic lens with a wetting agent and packaging solution.
摘要翻译: 本发明涉及舒适的眼科装置和通过用润湿剂和包装溶液处理所述眼科镜片来生产这种装置的方法。
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公开(公告)号:US20110021656A1
公开(公告)日:2011-01-27
申请号:US12896930
申请日:2010-10-04
申请人: Kevin P. McCabe , Robert B. Steffen , Helene Aguilar , W. Anthony Martin , Susan W. Neadle , Ann-Marie W. Meyers , Dominic P. Gourd , Kristy L. Canavan , Gregory A. Hill , Douglas G. Vanderlaan
发明人: Kevin P. McCabe , Robert B. Steffen , Helene Aguilar , W. Anthony Martin , Susan W. Neadle , Ann-Marie W. Meyers , Dominic P. Gourd , Kristy L. Canavan , Gregory A. Hill , Douglas G. Vanderlaan
IPC分类号: B29D11/00
CPC分类号: G02B1/043 , A61L12/04 , A61L12/08 , A61L27/34 , A61L27/50 , A61L27/54 , A61L2300/452 , B29D11/00067 , B29K2039/06 , G02C7/049 , G02C13/00
摘要: This invention relates to comfortable ophthalmic devices and methods of producing such devices.
摘要翻译: 本发明涉及舒适的眼科装置及其制造方法。
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公开(公告)号:US07841716B2
公开(公告)日:2010-11-30
申请号:US11351907
申请日:2006-02-10
申请人: Kevin P. McCabe , Robert B. Steffen , Helene Aguilar , W. Anthony Martin , Susan W. Neadle , Ann-Marie W. Meyers , Douglas G. Vanderlaan , Dominic P. Gourd , Kristy L. Canavan , Gregory A. Hill
发明人: Kevin P. McCabe , Robert B. Steffen , Helene Aguilar , W. Anthony Martin , Susan W. Neadle , Ann-Marie W. Meyers , Douglas G. Vanderlaan , Dominic P. Gourd , Kristy L. Canavan , Gregory A. Hill
CPC分类号: G02B1/043 , A61L12/04 , A61L12/08 , A61L27/34 , A61L27/50 , A61L27/54 , A61L2300/452 , B29D11/00067 , B29K2039/06 , G02C7/049 , G02C13/00
摘要: A method of providing a polymerized ophthalmic lens in which a polymerized ophthalmic lens is heated with a packaging solution comprising about 100 ppm to about 3,000 ppm of a wetting agent after its polymerization, and the ophthalmic lens formulation not having the wetting agent prior to its polymerization.
摘要翻译: 提供聚合眼科镜片的方法,其中聚合的眼科镜片在其聚合之后用包含约100ppm至约3,000ppm的润湿剂的包装溶液加热,以及在其聚合之前不具有润湿剂的眼用镜片制剂 。
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