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公开(公告)号：US4721614A
公开(公告)日：1988-01-26
申请号：US879609
申请日：1986-06-27
CPC分类号： A61Q11/00 , A61K8/19 , A61K2800/412
摘要： A toothpaste containing at least 60% sodium bicarbonate particles as the sole abrasive, at least 30% of the sodium bicarbonate having particle sizes of less than 25 microns. Humectants, thickening agents, fluoridating agents, flavors, sweeteners and other conventional adjuvants may also be included in the toothpaste.
摘要翻译： 含有至少60％碳酸氢钠颗粒作为唯一研磨剂的牙膏，至少30％的碳酸氢钠颗粒尺寸小于25微米。 润湿剂，增稠剂，氟化剂，香料，甜味剂和其它常规佐剂也可以包括在牙膏中。
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公开(公告)号：US4623536A
公开(公告)日：1986-11-18
申请号：US744497
申请日：1985-06-13
CPC分类号： A61Q11/00 , A61K8/19 , A61K2800/412
摘要： A toothpaste containing at least 60% sodium bicarbonate particles as the sole abrasive, at least 30% of the sodium bicarbonate having particle sizes of less than 25 microns. Humectants, thickening agents, fluoridating agents, flavors, sweeteners and other conventional adjuvants may also be included in the toothpaste.
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3.发明授权Remineralizing/mineralizing oral products having improved whitening and stain removal properties 有权重新矿化/矿化具有改善的美白和去污性能的口服产品公开(公告)号：US06303104B1
公开(公告)日：2001-10-16
申请号：US09249295
申请日：1999-02-12
申请人： Anthony E. Winston , Jordan Barth , Norman Usen
发明人： Anthony E. Winston , Jordan Barth , Norman Usen
IPC分类号： A61K716
CPC分类号： A61Q11/00 , A61K8/19 , A61K8/24 , A61K2800/88
摘要： An oral product, preferably a toothpaste, effective for remineralizing subsurface dental lesions, mineralizing exposed dentinal tubules and whitening teeth stained with discoloring residues containing heavy metal ions such as Fe+3, Mn+2 and Cu+2, is composed of a first discrete part composed of a water-soluble or partially water-soluble calcium salt and optionally a non-toxic, non-calcium water-soluble divalent metal salt, and a second discrete part composed of a water-soluble orthophosphate salt and preferably a water-soluble fluoride salt. Further enhanced stain-removing properties without excessive abrasivity are imparted to the oral product when part (A) further contains an effective amount of an anhydrous dicalcium phosphate abrasive and part (B) further contains an effective amount of a silica abrasive.
摘要翻译： 用于再矿化地下牙齿病变，矿化暴露的牙质小管和由含有重金属离子如Fe + 3，Mn + 2和Cu + 2的变色残渣染色的美白牙齿的口服产品，优选牙膏由第一离散 由水溶性或部分水溶性钙盐和任选的无毒非钙水溶性二价金属盐组成的部分，以及由水溶性正磷酸盐组成的第二离散部分，优选水溶性 氟化盐。 当部分（A）还含有有效量的无水磷酸二钙研磨剂时，口腔产品也能赋予进一步增强的除污性能，而不会过度磨损，部分（B）还含有有效量的二氧化硅磨料。
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公开(公告)号：US6036944A
公开(公告)日：2000-03-14
申请号：US301364
申请日：1999-04-29
申请人： Anthony E. Winston , Norman Usen
发明人： Anthony E. Winston , Norman Usen
CPC分类号： A61Q11/00 , A61K8/24 , A61K2800/88
摘要： A method for remineralizing one or more subsurface lesions in a tooth and/or mineralizing one or more exposed dentinal tubules in the tooth involves dispensing effective amounts of at least one water-soluble calcium salt, at least one water-soluble non-toxic divalent metal compound wherein the divalent metal is other than calcium, at least one water-soluble phosphate salt and, optionally, a water-soluble fluoride salt; mixing the salts and compound to form a non-carbonated mixture having a pH in water such that a non-carbonated aqueous solution containing the mixture has a pH of from 4.5 to about 7.0; and then applying the non-carbonated mixture as the non-carbonated aqueous solution to a surface of the tooth for a sufficient period of time to allow sufficient amounts of calcium, phosphate and, if present, fluoride, ions in the solution to diffuse into the subsurface of the tooth where the diffused ions then react to form an insoluble precipitate onto the lesions and/or exposed tubules, thereby remineralizing the lesions and/or mineralizing the tubules.
摘要翻译： 一种用于再牙合牙齿中的一个或多个地下损伤和/或矿化牙齿中的一个或多个暴露的牙质小管的方法包括分配有效量的至少一种水溶性钙盐，至少一种水溶性无毒二价金属 化合物，其中二价金属不是钙，至少一种水溶性磷酸盐和任选的水溶性氟化物盐; 混合盐和化合物以形成具有在水中的pH的非碳酸化混合物，使得含有该混合物的非碳酸化水溶液的pH为4.5至约7.0; 然后将非碳酸化混合物作为非碳酸化的水溶液施加到牙齿的表面足够长的时间以允许足够量的钙，磷酸盐和（如果存在的话）溶液中的氟离子扩散到 然后扩散的离子然后反应以在病变和/或暴露的小管上形成不溶性沉淀物，从而使病变再矿化和/或使小管矿化。
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5.发明授权
公开(公告)号：US5895641A
公开(公告)日：1999-04-20
申请号：US670897
申请日：1996-06-26
申请人： Norman Usen , Anthony E. Winston
发明人： Norman Usen , Anthony E. Winston
CPC分类号： A61Q11/00 , A61K8/21 , A61K8/24 , A61K2800/88
摘要： The present invention relates to the problems of remineralization without demineralization of dental enamel by applying to the teeth a composition which is present in two phases which do not react with one another until introduced into the oral cavity. One phase contains at least one water-soluble calcium compound and the other contains at least one water-soluble inorganic phosphate and at least one water-soluble fluorine compound. In this way the ions which effect remineralization can be absorbed by the dental enamel and their subsequent reaction causes rehardening of demineralized areas in the dental enamel.
摘要翻译： 本发明涉及通过向牙齿施用不同于相互反应直至引入口腔的两相中的组合物而使牙釉质没有软化的再矿化的问题。 一相含有至少一种水溶性钙化合物，另一种含有至少一种水溶性无机磷酸盐和至少一种水溶性氟化合物。 以这种方式，可以通过牙釉质吸收影响再矿化的离子，并且随后的反应引起牙釉质中软化区域的再固化。
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6.发明授权
公开(公告)号：US5571502A
公开(公告)日：1996-11-05
申请号：US512287
申请日：1995-08-08
申请人： Anthony E. Winston , Norman Usen
发明人： Anthony E. Winston , Norman Usen
摘要： This invention relates to non-aqueous compositions and methods utilizing same which are useful to remineralize subsurface dental enamel. More specifically, this invention relates to stable, single-part compositions containing calcium and phosphate salts which may be in a hydrophilic, non-aqueous vehicle and which when applied to lesions in dental enamel result in remineralization of subsurface dental enamel and/or mineralization of tubules in dentin thereby counteracting caries and/or hypersensitivity.
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公开(公告)号：US4740366A
公开(公告)日：1988-04-26
申请号：US820694
申请日：1986-01-21
摘要： An air deodorizer, and a method for deodorizing rooms therewith, utilizing an aerosol of a solution containing from 2-25% by weight of non-toxic, non-oxidizing, deodorizing agent, said solution constituting liquid droplets having a weight average droplet size of less than 50 microns, more than 90% of said droplets having a size, by count, of less than 10 microns.
摘要翻译： 空气除臭剂及其室内除臭方法，利用含有2-25％（重量）无毒非氧化性除臭剂的溶液气溶胶，所述溶液构成液滴重均粒径为 小于50微米，超过90％的所述液滴具有小于10微米的尺寸。
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8.发明授权Remineralizing-mineralizing oral products containing discrete cationic and anionic agglomerate components and method of use 有权含离子阳离子和阴离子聚集体组分的再矿化矿化口服产品及其使用方法公开(公告)号：US06482395B1
公开(公告)日：2002-11-19
申请号：US10137317
申请日：2002-05-03
申请人： Jordan Barth , Anthony E. Winston , Norman Usen
发明人： Jordan Barth , Anthony E. Winston , Norman Usen
IPC分类号： A61K968
CPC分类号： A61Q11/00 , A61K8/19 , A61K8/24 , A61K2800/88
摘要： A solid oral product, e.g., chewing gum, lozenge, an edible foodstuff, and the like, which is useful for remineralizing subsurface dental lesions and/or mineralizing exposed dentinal tubules, contains (A) a discrete cationic agglomerate component composed of at least one water-soluble or partially water-soluble calcium salt and a first inert solid carrier, and (B) a discrete anionic agglomerate component composed of at least one water-soluble orthophosphate salt and a second inert solid carrier. The agglomerate nature of the cationic and anionic components keeps these components separate from one another during storage of the product but allows the cationic and anionic salts to be simultaneously released from the product upon mixing of the product with water and/or saliva to form a mixed aqueous solution such that the solution contains both calcium cations released from the calcium salt and orthophosphate anions released by the orthophosphate salt.
摘要翻译： 可用于再矿化地下牙齿损伤和/或矿化暴露的牙质小管的固体口服产品，例如口香糖，锭剂，食用食品等，其包含（A）由至少一个 水溶性或部分水溶性钙盐和第一惰性固体载体，和（B）由至少一种水溶性正磷酸盐和第二惰性固体载体组成的离散的阴离子附聚物组分。 阳离子和阴离子组分的聚集性质使这些组分在产物储存期间彼此分离，但是当产品与水和/或唾液混合时，允许阳离子和阴离子盐同时从产物中释放，以形成混合 水溶液使得溶液含有从钙盐释放的钙阳离子和由正磷酸盐释放的正磷酸盐阴离子。
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9.发明授权公开(公告)号：US06451290B2
公开(公告)日：2002-09-17
申请号：US09884354
申请日：2001-06-20
申请人： Anthony E. Winston , Norman Usen
发明人： Anthony E. Winston , Norman Usen
IPC分类号： A61K968
CPC分类号： A61Q11/00 , A61K8/19 , A61K8/24 , A61K2800/88
摘要： Improved solid products for remineralizing subsurface lesions and/or mineralizing exposed tubules in dentin contain an anionic component, a cationic component and a separating component for separating the anionic and cationic components in the product. The anionic component contains at least one water-soluble phosphate salt and the cationic component contains at least one partially water-soluble calcium salt. To remineralize subsurface lesions and/or mineralize exposed dentin tubules in a tooth, the anionic and cationic components are mixed with water and/or saliva to form a mixed aqueous composition having a pH of from greater than about 4.0 to about 10.0, which is then applied to the tooth. Because of the partial water-solubility of the calcium salt, the calcium cations and the phosphate anions in the mixed aqueous composition remain soluble for a period of time sufficient to allow the cations and anions to diffuse through the surface of the tooth to the subsurface and/or dentin, where the diffused cations and anions react to form an insoluble precipitate on the lesion for remineralization thereof and/or on the exposed tubule for mineralization thereof. The products may be in the form of chewing gums, lozenges, candies, edible food products, and the like.
摘要翻译： 用于再矿化地下病变和/或矿化牙本质中暴露的小管的改进的固体产品含有阴离子组分，阳离子组分和用于分离产物中阴离子和阳离子组分的分离组分。 阴离子组分含有至少一种水溶性磷酸盐，阳离子组分含有至少一种部分水溶性钙盐。 为了再次矿化地下损伤和/或使牙齿中暴露的牙质小管矿化，将阴离子和阳离子组分与水和/或唾液混合以形成具有大于约4.0至约10.0的pH的混合水性组合物 适用于牙齿。 由于钙盐的部分水溶性，混合水性组合物中的钙阳离子和磷酸盐阴离子保持溶解一段时间，足以允许阳离子和阴离子通过牙齿的表面扩散到地下， /或牙本质，其中扩散的阳离子和阴离子反应以在病变上形成不溶性沉淀物，用于再矿化和/或暴露的小管以使其矿化。 产品可以是口香糖，锭剂，糖果，食用食品等的形式。
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公开(公告)号：US06440394B2
公开(公告)日：2002-08-27
申请号：US09893019
申请日：2001-06-26
申请人： Jordan Barth , Anthony E. Winston , Norman Usen
发明人： Jordan Barth , Anthony E. Winston , Norman Usen
IPC分类号： A61K916
CPC分类号： A61Q11/00 , A61K8/19 , A61K8/24 , A61K2800/88
摘要： A solid oral product, e.g., chewing gum, lozenge, an edible foodstuff, and the like, which is useful for remineralizing subsurface dental lesions and/or mineralizing exposed dentinal tubules, contains (A) a discrete cationic agglomerate component composed of at least one water-soluble or partially water-soluble calcium salt and a first inert solid carrier, and (B) a discrete anionic agglomerate component composed of at least one water-soluble orthophosphate salt and a second inert solid carrier. The agglomerate nature of the cationic and anionic components keeps these components separate from one another during storage of the product but allows the cationic and anionic salts to be simultaneously released from the product upon mixing of the product with water and/or saliva to form a mixed aqueous solution such that the solution contains both calcium cations released from the calcium salt and orthophosphate anions released by the orthophosphate salt.
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