公开(公告)号：US20080167549A1

公开(公告)日：2008-07-10

申请号：US12002553

申请日：2007-12-17

申请人： Robert S. Balaban ,  Kathleen M. Ward ,  Anthony H. Aletras

发明人： Robert S. Balaban ,  Kathleen M. Ward ,  Anthony H. Aletras

IPC分类号： A61B5/055

CPC分类号： A61B5/055 ,  A61B5/416 ,  A61K49/06 ,  A61K49/10 ,  G01R33/5601

摘要： A method for obtaining an image by MRI, comprising: administering at least one contrast agent to a subject in amounts effective to perform CEDST MRI analysis; and performing CEDST MRI analysis to produce an image of the subject. A number of different contrast agents can be used to practice the present method including, without limitation, sugars, amino acids, nitrogen-containing heterocycles, purines and pyrimidines, nucleosides; imidazole and derivatives thereof, imino acids, barbituric acid and analogs thereof, and miscellaneous materials, such as guanidine hydantoin, parabanic acid, and biologically active salts thereof.

摘要翻译： 一种用于通过MRI获得图像的方法，包括：以有效执行CEDST MRI分析的量向对象施用至少一种造影剂; 并进行CEDST MRI分析以产生受试者的图像。 可以使用许多不同的造影剂来实施本发明的方法，包括但不限于糖，氨基酸，含氮杂环，嘌呤和嘧啶，核苷; 咪唑及其衍生物，亚氨基酸，巴比妥酸及其类似物，以及其它各种材料，例如胍乙内酰脲，对乙酰苯胺和其生物活性盐。

公开(公告)号：US07330748B2

公开(公告)日：2008-02-12

申请号：US10948942

申请日：2004-09-24

申请人： Robert S. Balaban ,  Kathleen M. Ward ,  Anthony H. Aletras

发明人： Robert S. Balaban ,  Kathleen M. Ward ,  Anthony H. Aletras

IPC分类号： A61B5/055

CPC分类号： A61B5/055 ,  A61B5/416 ,  A61K49/06 ,  A61K49/10 ,  G01R33/5601

摘要： Method for determining in vivo concentration of a metabolite that includes administering a contrast agent to a subject, allowing the contrast agent to disperse to tissue of interest, performing CEDST MRI analysis of the subject, and comparing the results to known in vitro results to determine metabolite concentration.

摘要翻译： 用于确定代谢物的体内浓度的方法，其包括对受试者施用造影剂，允许造影剂分散到感兴趣的组织，进行受试者的CEDST MRI分析，并将结果与​​已知的体外结果进行比较以确定代谢物 浓度。

公开(公告)号：US07835783B1

公开(公告)日：2010-11-16

申请号：US10421535

申请日：2003-04-21

申请人： Anthony H. Aletras

发明人： Anthony H. Aletras

IPC分类号： A61B5/05

CPC分类号： G01R33/56333

摘要： Image contributions produced by an untagged specimen magnetization component in magnetic resonance imaging are controlled by applying one or more radiofrequency (RF) pulses that invert at least a portion of the untagged specimen magnetization. In an example, a specimen is tagged with a spatially modulated magnetization that is used to produce an image signal that includes a contribution associated with the tagged magnetization and an untagged magnetization. The untagged magnetization is substantially along an axial direction defined by an applied axial magnetic field. The untagged magnetization increases in magnitude because of so-called T1 relaxation. A contribution to the image signal increases for a predetermined time or to a predetermined magnitude, and a 180-degree pulse is applied to invert at least a portion of the untagged magnetization. The untagged magnetization is then antiparallel with respect to the applied axial magnetic field. Additional inversion recovery causes the untagged magnetization to increase from a negative value to zero and then becomes positive. As a result, signal contributions associated with the untagged magnetization are reduced. Additional 180-degree pulses can be applied whenever the untagged magnetization becomes larger than a predetermined value so that image contrast can be maintained. When the tagged magnetization decreases to a predetermined level, an initial specimen magnetization is reestablished for subsequent imaging.

摘要翻译： 通过应用一个或多个射频（RF）脉冲来控制在磁共振成像中由未标记的样本磁化分量产生的图像贡献，其反转至少一部分未标记的样本磁化。 在一个示例中，样本被标记有空间调制的磁化，其用于产生包括与标记的磁化和未标记磁化相关联的贡献的图像信号。 未标记的磁化基本上沿着由施加的轴向磁场限定的轴向方向。 由于所谓的T1弛豫，未标记的磁化强度增加。 对图像信号的贡献在预定时间或预定幅度增加，并且施加180度脉冲以反转至少一部分未标记磁化。 然后，无标记磁化相对于施加的轴向磁场反平行。 额外的反转恢复使得未标记的磁化从负值增加到零然后变为正。 结果，与未标记磁化相关联的信号贡献减小。 每当无标记磁化变得大于预定值时，可以施加额外的180度脉冲，从而可以保持图像对比度。 当标记的磁化强度降低到预定水平时，重新建立初始样品磁化强度，用于随后的成像。

公开(公告)号：US07706857B2

公开(公告)日：2010-04-27

申请号：US11800398

申请日：2007-05-03

申请人： Anthony H. Aletras ,  Han Wen

发明人： Anthony H. Aletras ,  Han Wen

IPC分类号： A61B5/05

CPC分类号： G01R33/56308 ,  G01R33/56316

摘要： Magnetic resonance imaging method and apparatus are provided for mapping the internal or bulk motion of an object by labeling the phase of a specimen magnetization with a selected spatial function and measuring changes in the phase of the magnetization. The spatial function is selectable to provide magnetization phase modulation corresponding to displacements in a selected direction, such as a radial or azimuthal direction. Methods and apparatus for producing images based on magnetization phase modulation acquire image data based on stimulated echos and stimulated anti-echos. In an embodiment, a series of 180 degree pulses produces alternating stimulated and stimulated anti-echos that are measured and assigned to respective images.

摘要翻译： 提供磁共振成像方法和装置，用于通过用选定的空间函数标记样本磁化的相位并测量磁化相位的变化来映射对象的内部或体积运动。 空间功能是可选择的，以提供对应于所选方向（例如径向或方位角方向）上的位移的磁化相位调制。 用于基于磁化相位调制产生图像的方法和装置基于受激发的回波和刺激的抗回波获取图像数据。 在一个实施例中，一系列180度脉冲产生交替的被刺激和刺激的抗回波，其被测量并分配给相应的图像。

公开(公告)号：US07233818B1

公开(公告)日：2007-06-19

申请号：US10049005

申请日：2000-08-04

申请人： Anthony H. Aletras ,  Han Wen

发明人： Anthony H. Aletras ,  Han Wen

IPC分类号： A61B5/055

CPC分类号： G01R33/56308 ,  G01R33/56316 ,  G01R33/56509 ,  G01R33/5676

摘要： Magnetic resonance imaging method and apparatus are provided for mapping the internal or bulk motion of an object by labeling the phase of a specimen magnetization with a selected spatial function and measuring changes in the phase of the magnetization. The spatial function is selectable to provide magnetization phase modulation corresponding to displacements in a selected direction, such as a radial or azimuthal direction. Methods and apparatus for producing images based on magnetization phase modulation acquire image data based on stimulated echos and stimulated anti-echos. In an embodiment, a series of 180 degree pulses produces alternating stimulated and stimulated anti-echos that are measured and assigned to respective images.

摘要翻译： 提供磁共振成像方法和装置，用于通过用选定的空间函数标记样本磁化的相位并测量磁化相位的变化来映射对象的内部或体积运动。 空间功能是可选择的，以提供对应于所选方向（例如径向或方位角方向）上的位移的磁化相位调制。 用于基于磁化相位调制产生图像的方法和装置基于受激发的回波和刺激的抗回波获取图像数据。 在一个实施例中，一系列180度脉冲产生交替的被刺激和刺激的抗回波，其被测量并分配给相应的图像。

公开(公告)号：US06963769B1

公开(公告)日：2005-11-08

申请号：US09959138

申请日：2000-04-20

申请人： Robert S. Balaban ,  Kathleen M. Ward ,  Anthony H. Aletras

发明人： Robert S. Balaban ,  Kathleen M. Ward ,  Anthony H. Aletras

IPC分类号： A61B5/055 ,  A61K49/00 ,  A61K49/06 ,  A61K49/10

CPC分类号： A61B5/055 ,  A61B5/416 ,  A61K49/06 ,  A61K49/10 ,  G01R33/5601

摘要： A method for obtaining an image by MRI, comprising: administering at least one contrast agent to a subject in amounts effective to perform CEDST MRI analysis; and performing CEDST MRI analysis to produce an image of the subject. A number of different contast agents can be used to practice the present method including, without limitation, sugars, animo acids, nitrogen-containing heterocycles, purines and pyrimidines, nucleosides; imidazole and derivatives thereof, imino acids, barbituric acid and analogs thereof, and miscellaneous materials, such as guanidine hydantoin, parabanic acid, and biologically active salts thereof.

摘要翻译： 一种用于通过MRI获得图像的方法，包括：以有效执行CEDST MRI分析的量向对象施用至少一种造影剂; 并进行CEDST MRI分析以产生受试者的图像。 许多不同的耐受剂可用于实施本发明的方法，包括但不限于糖，阿莫西酸，含氮杂环，嘌呤和嘧啶，核苷; 咪唑及其衍生物，亚氨基酸，巴比妥酸及其类似物，以及其它各种材料，例如胍乙内酰脲，对乙酰苯胺和其生物活性盐。