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公开(公告)号：US07834138B2
公开(公告)日：2010-11-16
申请号：US11402350
申请日：2006-04-11
IPC分类号： C08F6/00
CPC分类号： C08G65/329 , A61K47/56 , A61K47/60 , Y10S530/815
摘要： Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation.
摘要翻译： 描述了含有与较低分子量链段连接的较高分子量链段的分段水溶性聚合物。 在一个实施方案中，聚合物链段是聚（乙二醇）链段。 分段的聚合物被官能化并且可用于与各种部分缀合，例如药理学活性物质。 还描述了这些聚合物的共轭物及其制备方法。
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公开(公告)号：US07053150B2
公开(公告)日：2006-05-30
申请号：US10734858
申请日：2003-12-11
CPC分类号： C08G65/329 , A61K47/56 , A61K47/60 , Y10S530/815
摘要： Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation.
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公开(公告)号：US08084572B2
公开(公告)日：2011-12-27
申请号：US12898687
申请日：2010-10-05
IPC分类号： C08G6/00
CPC分类号： C08G65/329 , A61K47/56 , A61K47/60 , Y10S530/815
摘要： Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation.
摘要翻译： 描述了含有与较低分子量链段连接的较高分子量链段的分段水溶性聚合物。 在一个实施方案中，聚合物链段是聚（乙二醇）链段。 分段的聚合物被官能化并且可用于与各种部分缀合，例如药理学活性物质。 还描述了这些聚合物的共轭物及其制备方法。
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公开(公告)号：US20110021761A1
公开(公告)日：2011-01-27
申请号：US12898687
申请日：2010-10-05
IPC分类号： C07K14/00 , C07C309/64 , C07C271/06 , C07D207/40 , C07C223/02 , C07C229/02
CPC分类号： C08G65/329 , A61K47/56 , A61K47/60 , Y10S530/815
摘要： Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation.
摘要翻译： 描述了含有与较低分子量链段连接的较高分子量链段的分段水溶性聚合物。 在一个实施方案中，聚合物链段是聚（乙二醇）链段。 分段的聚合物被官能化并且可用于与各种部分缀合，例如药理学活性物质。 还描述了这些聚合物的共轭物及其制备方法。
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公开(公告)号：US08383380B2
公开(公告)日：2013-02-26
申请号：US13267619
申请日：2011-10-06
IPC分类号： C12N9/96
CPC分类号： C08G65/329 , A61K47/56 , A61K47/60 , Y10S530/815
摘要： Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation.
摘要翻译： 描述了含有与较低分子量链段连接的较高分子量链段的分段水溶性聚合物。 在一个实施方案中，聚合物链段是聚（乙二醇）链段。 分段的聚合物被官能化并且可用于与各种部分缀合，例如药理学活性物质。 还描述了这些聚合物的共轭物及其制备方法。
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公开(公告)号：US20120027714A1
公开(公告)日：2012-02-02
申请号：US13267619
申请日：2011-10-06
IPC分类号： A61K31/765 , A61P11/00
CPC分类号： C08G65/329 , A61K47/56 , A61K47/60 , Y10S530/815
摘要： Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation.
摘要翻译： 描述了含有与较低分子量链段连接的较高分子量链段的分段水溶性聚合物。 在一个实施方案中，聚合物链段是聚（乙二醇）链段。 分段的聚合物被官能化并且可用于与各种部分缀合，例如药理学活性物质。 还描述了这些聚合物的共轭物及其制备方法。
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公开(公告)号：US20060183855A1
公开(公告)日：2006-08-17
申请号：US11402350
申请日：2006-04-11
申请人： Antoni Kozlowski , Xiaoming Shen , Michael Bentley , Zhihao Fang , Tony Sander
发明人： Antoni Kozlowski , Xiaoming Shen , Michael Bentley , Zhihao Fang , Tony Sander
IPC分类号： A61K47/48
CPC分类号： C08G65/329 , A61K47/56 , A61K47/60 , Y10S530/815
摘要： Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation.
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公开(公告)号：US06774180B2
公开(公告)日：2004-08-10
申请号：US10024357
申请日：2001-12-18
IPC分类号： C08G6350
CPC分类号： C08G65/329 , A61K47/56
摘要： High molecular weight derivatives of activated poly(ethylene glycol) and the like polymers are prepared in high purity by conjugating a large PEG molecule to a small PEG molecule. Most of the reaction steps can be accomplished on the more readily purified small molecule to avoid laborious purification of the high molecular weight derivatives.
摘要翻译： 活性聚（乙二醇）等高分子量衍生物通过将大PEG分子与小PEG分子结合而制备成高纯度。 大多数反应步骤可以在更容易纯化的小分子上完成，以避免对高分子量衍生物的费时的纯化。
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公开(公告)号：US08058385B2
公开(公告)日：2011-11-15
申请号：US12940009
申请日：2010-11-04
申请人： Antoni Kozlowski , John Handley , Anthony G. Schaefer , Brian Bray , Ryan Odom , Tony L. Sander
发明人： Antoni Kozlowski , John Handley , Anthony G. Schaefer , Brian Bray , Ryan Odom , Tony L. Sander
IPC分类号： C08G69/08
CPC分类号： C08G73/121 , A61K47/60 , C07D207/452 , C08G65/329 , C08G65/33331
摘要： Methods for preparing conjugates using polymeric reagents bearing a maleimide are provided. Also provided are compositions comprising the conjugates.
摘要翻译： 提供了使用含有马来酰亚胺的聚合物制备共轭物的方法。 还提供了包含缀合物的组合物。
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公开(公告)号：US20110046315A1
公开(公告)日：2011-02-24
申请号：US12940009
申请日：2010-11-04
申请人： Antoni Kozlowski , John Handley , Anthony G. Schaefer , Brian Bray , Ryan Odom , Tony L. Sander
发明人： Antoni Kozlowski , John Handley , Anthony G. Schaefer , Brian Bray , Ryan Odom , Tony L. Sander
IPC分类号： C08G65/00
CPC分类号： C08G73/121 , A61K47/60 , C07D207/452 , C08G65/329 , C08G65/33331
摘要： Methods for preparing conjugates using polymeric reagents bearing a maleimide are provided. Also provided are compositions comprising the conjugates.
摘要翻译： 提供了使用含有马来酰亚胺的聚合物制备共轭物的方法。 还提供了包含缀合物的组合物。
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