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公开(公告)号：US08084572B2
公开(公告)日：2011-12-27
申请号：US12898687
申请日：2010-10-05
IPC分类号： C08G6/00
CPC分类号： C08G65/329 , A61K47/56 , A61K47/60 , Y10S530/815
摘要： Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation.
摘要翻译： 描述了含有与较低分子量链段连接的较高分子量链段的分段水溶性聚合物。 在一个实施方案中，聚合物链段是聚（乙二醇）链段。 分段的聚合物被官能化并且可用于与各种部分缀合，例如药理学活性物质。 还描述了这些聚合物的共轭物及其制备方法。
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公开(公告)号：US20110021761A1
公开(公告)日：2011-01-27
申请号：US12898687
申请日：2010-10-05
IPC分类号： C07K14/00 , C07C309/64 , C07C271/06 , C07D207/40 , C07C223/02 , C07C229/02
CPC分类号： C08G65/329 , A61K47/56 , A61K47/60 , Y10S530/815
摘要： Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation.
摘要翻译： 描述了含有与较低分子量链段连接的较高分子量链段的分段水溶性聚合物。 在一个实施方案中，聚合物链段是聚（乙二醇）链段。 分段的聚合物被官能化并且可用于与各种部分缀合，例如药理学活性物质。 还描述了这些聚合物的共轭物及其制备方法。
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公开(公告)号：US07834138B2
公开(公告)日：2010-11-16
申请号：US11402350
申请日：2006-04-11
IPC分类号： C08F6/00
CPC分类号： C08G65/329 , A61K47/56 , A61K47/60 , Y10S530/815
摘要： Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation.
摘要翻译： 描述了含有与较低分子量链段连接的较高分子量链段的分段水溶性聚合物。 在一个实施方案中，聚合物链段是聚（乙二醇）链段。 分段的聚合物被官能化并且可用于与各种部分缀合，例如药理学活性物质。 还描述了这些聚合物的共轭物及其制备方法。
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公开(公告)号：US07053150B2
公开(公告)日：2006-05-30
申请号：US10734858
申请日：2003-12-11
CPC分类号： C08G65/329 , A61K47/56 , A61K47/60 , Y10S530/815
摘要： Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation.
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公开(公告)号：US08383380B2
公开(公告)日：2013-02-26
申请号：US13267619
申请日：2011-10-06
IPC分类号： C12N9/96
CPC分类号： C08G65/329 , A61K47/56 , A61K47/60 , Y10S530/815
摘要： Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation.
摘要翻译： 描述了含有与较低分子量链段连接的较高分子量链段的分段水溶性聚合物。 在一个实施方案中，聚合物链段是聚（乙二醇）链段。 分段的聚合物被官能化并且可用于与各种部分缀合，例如药理学活性物质。 还描述了这些聚合物的共轭物及其制备方法。
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公开(公告)号：US20120027714A1
公开(公告)日：2012-02-02
申请号：US13267619
申请日：2011-10-06
IPC分类号： A61K31/765 , A61P11/00
CPC分类号： C08G65/329 , A61K47/56 , A61K47/60 , Y10S530/815
摘要： Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation.
摘要翻译： 描述了含有与较低分子量链段连接的较高分子量链段的分段水溶性聚合物。 在一个实施方案中，聚合物链段是聚（乙二醇）链段。 分段的聚合物被官能化并且可用于与各种部分缀合，例如药理学活性物质。 还描述了这些聚合物的共轭物及其制备方法。
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7.发明授权Conjugates formed from polymer derivatives having particular atom arrangements 有权由具有特定原子排列的聚合物衍生物形成的共轭物公开(公告)号：US07947261B2
公开(公告)日：2011-05-24
申请号：US11389431
申请日：2006-03-23
申请人： J. Milton Harris , Antoni Kozlowski , Samuel P. McManus , Michael D. Bentley , Stephen A. Charles
发明人： J. Milton Harris , Antoni Kozlowski , Samuel P. McManus , Michael D. Bentley , Stephen A. Charles
CPC分类号： A61K47/60 , A61K31/357 , A61K31/4025 , A61K31/52 , A61K38/11 , A61K38/1816 , A61K38/193 , A61K38/212 , A61K38/215 , A61K38/24 , A61K38/27 , A61K38/37 , C08G65/329 , C08G65/33337 , C08G65/33344
摘要： Polymeric reagents are provided comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble polymer and a reactive group. The polymeric reagents are useful for, among other things, forming polymer-active agent conjugates. Related methods, compositions, preparations, and so forth are also provided.
摘要翻译： 提供聚合试剂，其包含以特定顺序排列的原子部分，其中该部分位于水溶性聚合物和反应性基团之间。 聚合物试剂尤其可用于形成聚合物 - 活性剂缀合物。 还提供了相关方法，组合物，制剂等。
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8.发明授权Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation 有权异双功能聚（乙二醇）衍生物及其制备方法公开(公告)号：US07642323B2
公开(公告)日：2010-01-05
申请号：US11016383
申请日：2004-12-17
IPC分类号： C08L71/02 , C08G65/32 , C07D207/00 , C07C211/00 , B01F17/00
CPC分类号： C08G65/3322 , C08G65/329
摘要： This invention provides a method for preparing, in high purity and high yield, heterobifunctional derivatives of poly(ethylene glycol) or related polymers. A chromatographic purification step is not necessary in the method. In accordance with the method of the invention, an intermediate polymer having a formula of W-Poly-OH is provided bearing a removable group W at one terminus. The intermediate polymer W-Poly-OH is first altered by modifying the OH group to a first functional group X, followed by the removal of W to generate a second hydroxyl group. The latter hydroxyl group may then be further converted to a second functional group Y, thus providing the desired heterobifunctional derivative.
摘要翻译： 本发明提供一种以高纯度和高收率制备聚（乙二醇）或相关聚合物的异双功能衍生物的方法。 在该方法中不需要色谱纯化步骤。 根据本发明的方法，提供具有式W-聚-OH的中间体聚合物，其在一个末端具有可除去的基团W. 首先通过将OH基团改性为第一官能团X，随后除去W以产生第二羟基来改变中间体聚合物W-Poly-OH。 然后可以将后一羟基进一步转化为第二官能团Y，从而提供所需的异双功能衍生物。
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公开(公告)号：US07887789B2
公开(公告)日：2011-02-15
申请号：US10851691
申请日：2004-05-21
申请人： J. Milton Harris , Antoni Kozlowski , Samuel P. McManus , Michael D. Bentley , Stephen A. Charles
发明人： J. Milton Harris , Antoni Kozlowski , Samuel P. McManus , Michael D. Bentley , Stephen A. Charles
IPC分类号： A61K31/74
CPC分类号： C08G65/33344 , A61K47/60 , C08G65/329 , C08G65/33337
摘要： Polymeric reagents are provided comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble polymer and a reactive group. The polymeric reagents are useful for, among other things, forming polymer-active agent conjugates. Related methods, compositions, preparations, and so forth are also provided.
摘要翻译： 提供聚合试剂，其包含以特定顺序排列的原子部分，其中该部分位于水溶性聚合物和反应性基团之间。 聚合物试剂尤其可用于形成聚合物 - 活性剂缀合物。 还提供了相关方法，组合物，制剂等。
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10.发明申请公开(公告)号：US20100063328A1
公开(公告)日：2010-03-11
申请号：US12620011
申请日：2009-11-17
IPC分类号： C07C41/01
CPC分类号： C08G65/3322 , C08G65/329
摘要： This invention provides a method related to the preparation of derivatives of poly(ethylene glycol).
摘要翻译： 本发明提供了与制备聚（乙二醇）衍生物有关的方法。
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