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公开(公告)号：US07834138B2
公开(公告)日：2010-11-16
申请号：US11402350
申请日：2006-04-11
IPC分类号： C08F6/00
CPC分类号： C08G65/329 , A61K47/56 , A61K47/60 , Y10S530/815
摘要： Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation.
摘要翻译： 描述了含有与较低分子量链段连接的较高分子量链段的分段水溶性聚合物。 在一个实施方案中，聚合物链段是聚（乙二醇）链段。 分段的聚合物被官能化并且可用于与各种部分缀合，例如药理学活性物质。 还描述了这些聚合物的共轭物及其制备方法。
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公开(公告)号：US07053150B2
公开(公告)日：2006-05-30
申请号：US10734858
申请日：2003-12-11
CPC分类号： C08G65/329 , A61K47/56 , A61K47/60 , Y10S530/815
摘要： Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation.
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公开(公告)号：US08084572B2
公开(公告)日：2011-12-27
申请号：US12898687
申请日：2010-10-05
IPC分类号： C08G6/00
CPC分类号： C08G65/329 , A61K47/56 , A61K47/60 , Y10S530/815
摘要： Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation.
摘要翻译： 描述了含有与较低分子量链段连接的较高分子量链段的分段水溶性聚合物。 在一个实施方案中，聚合物链段是聚（乙二醇）链段。 分段的聚合物被官能化并且可用于与各种部分缀合，例如药理学活性物质。 还描述了这些聚合物的共轭物及其制备方法。
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公开(公告)号：US20110021761A1
公开(公告)日：2011-01-27
申请号：US12898687
申请日：2010-10-05
IPC分类号： C07K14/00 , C07C309/64 , C07C271/06 , C07D207/40 , C07C223/02 , C07C229/02
CPC分类号： C08G65/329 , A61K47/56 , A61K47/60 , Y10S530/815
摘要： Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation.
摘要翻译： 描述了含有与较低分子量链段连接的较高分子量链段的分段水溶性聚合物。 在一个实施方案中，聚合物链段是聚（乙二醇）链段。 分段的聚合物被官能化并且可用于与各种部分缀合，例如药理学活性物质。 还描述了这些聚合物的共轭物及其制备方法。
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公开(公告)号：US08383380B2
公开(公告)日：2013-02-26
申请号：US13267619
申请日：2011-10-06
IPC分类号： C12N9/96
CPC分类号： C08G65/329 , A61K47/56 , A61K47/60 , Y10S530/815
摘要： Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation.
摘要翻译： 描述了含有与较低分子量链段连接的较高分子量链段的分段水溶性聚合物。 在一个实施方案中，聚合物链段是聚（乙二醇）链段。 分段的聚合物被官能化并且可用于与各种部分缀合，例如药理学活性物质。 还描述了这些聚合物的共轭物及其制备方法。
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公开(公告)号：US20120027714A1
公开(公告)日：2012-02-02
申请号：US13267619
申请日：2011-10-06
IPC分类号： A61K31/765 , A61P11/00
CPC分类号： C08G65/329 , A61K47/56 , A61K47/60 , Y10S530/815
摘要： Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation.
摘要翻译： 描述了含有与较低分子量链段连接的较高分子量链段的分段水溶性聚合物。 在一个实施方案中，聚合物链段是聚（乙二醇）链段。 分段的聚合物被官能化并且可用于与各种部分缀合，例如药理学活性物质。 还描述了这些聚合物的共轭物及其制备方法。
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公开(公告)号：US08058385B2
公开(公告)日：2011-11-15
申请号：US12940009
申请日：2010-11-04
申请人： Antoni Kozlowski , John Handley , Anthony G. Schaefer , Brian Bray , Ryan Odom , Tony L. Sander
发明人： Antoni Kozlowski , John Handley , Anthony G. Schaefer , Brian Bray , Ryan Odom , Tony L. Sander
IPC分类号： C08G69/08
CPC分类号： C08G73/121 , A61K47/60 , C07D207/452 , C08G65/329 , C08G65/33331
摘要： Methods for preparing conjugates using polymeric reagents bearing a maleimide are provided. Also provided are compositions comprising the conjugates.
摘要翻译： 提供了使用含有马来酰亚胺的聚合物制备共轭物的方法。 还提供了包含缀合物的组合物。
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公开(公告)号：US20110046315A1
公开(公告)日：2011-02-24
申请号：US12940009
申请日：2010-11-04
申请人： Antoni Kozlowski , John Handley , Anthony G. Schaefer , Brian Bray , Ryan Odom , Tony L. Sander
发明人： Antoni Kozlowski , John Handley , Anthony G. Schaefer , Brian Bray , Ryan Odom , Tony L. Sander
IPC分类号： C08G65/00
CPC分类号： C08G73/121 , A61K47/60 , C07D207/452 , C08G65/329 , C08G65/33331
摘要： Methods for preparing conjugates using polymeric reagents bearing a maleimide are provided. Also provided are compositions comprising the conjugates.
摘要翻译： 提供了使用含有马来酰亚胺的聚合物制备共轭物的方法。 还提供了包含缀合物的组合物。
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公开(公告)号：US07872082B2
公开(公告)日：2011-01-18
申请号：US11490268
申请日：2006-07-19
申请人： Antoni Kozlowski , John Handley , Anthony G. Schaefer , Brian Bray , Ryan Odom , Tony L. Sander
发明人： Antoni Kozlowski , John Handley , Anthony G. Schaefer , Brian Bray , Ryan Odom , Tony L. Sander
IPC分类号： C08F22/40
CPC分类号： C08G73/121 , A61K47/60 , C07D207/452 , C08G65/329 , C08G65/33331
摘要： Methods for preparing polymeric reagents bearing a maleimide are provided. Also provided are compositions comprising the polymeric reagents, and conjugates prepared by polymeric reagents obtained by the described methods.
摘要翻译： 提供了制备含有马来酰亚胺的聚合物的方法。 还提供了包含聚合物试剂的组合物和通过所述方法获得的聚合物试剂制备的共轭物。
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公开(公告)号：US20120022220A1
公开(公告)日：2012-01-26
申请号：US13252761
申请日：2011-10-04
申请人： Antoni Kozlowski , John Handley , Anthony G. Schaefer , Brian Bray , Ryan Odom , Tony L. Sander
发明人： Antoni Kozlowski , John Handley , Anthony G. Schaefer , Brian Bray , Ryan Odom , Tony L. Sander
IPC分类号： C08G65/333
CPC分类号： C08G73/121 , A61K47/60 , C07D207/452 , C08G65/329 , C08G65/33331
摘要： Methods for preparing polymeric reagents bearing a maleimide are provided. Also provided are related compositions.
摘要翻译： 提供了制备含有马来酰亚胺的聚合物的方法。 还提供了相关组合物。
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