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1.发明申请ACTIVE SUBSTANCE COMBINATION COMPRISING A COMPOUND WITH NPY RECEPTOR AFFINITY AND A COMPOUND WITH 5-HT6 RECEPTOR AFFINITY 审中-公开具有NPY受体亲和性的化合物的活性物质组合和具有5-HT6受体亲和性的化合物公开(公告)号：US20120128768A1
公开(公告)日：2012-05-24
申请号：US13361625
申请日：2012-01-30
申请人： Antoni Torrens Jover , Josep Mas Prio , Alberto Dordal Zueras , Xavier Codony Soler , Ramon Merce Vidal , Jose-Aurelio Castrillo Perez , Jordi Frigola Constansa , Helmut-Heinrich Buschmann
发明人： Antoni Torrens Jover , Josep Mas Prio , Alberto Dordal Zueras , Xavier Codony Soler , Ramon Merce Vidal , Jose-Aurelio Castrillo Perez , Jordi Frigola Constansa , Helmut-Heinrich Buschmann
IPC分类号： A61K31/536 , A61K9/14 , A61P9/00 , A61P3/04 , A61P3/10 , A61P1/00 , A61P25/00 , A61P19/02 , A61P25/08 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/16 , A61P25/18 , A61P9/12 , A61P25/04 , A61P37/00 , A61P29/00 , A61K9/48
CPC分类号： A61K31/404 , A61K31/4045 , A61K31/536 , A61K2300/00
摘要： The present invention relates to an active substance combination comprising at least one compound with neuropeptide Y-receptor affinity and at least one compound with 5-HT6 receptor affinity, a medicament comprising said active substance combination, and the use of said active substance combination for the manufacture of a medicament.
摘要翻译： 本发明涉及包含至少一种具有神经肽Y受体亲和力的化合物和至少一种具有5-HT 6受体亲和力的化合物的活性物质组合物，包含所述活性物质组合的药物，以及所述活性物质组合物用于 制造药物。
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2.发明申请Active substance combination comprising a compound with npy receptor affinity and a compound with 5-ht6 receptor affinity 审中-公开包含具有npy受体亲和力的化合物和具有5-ht6受体亲和力的化合物的活性物质组合公开(公告)号：US20070059364A1
公开(公告)日：2007-03-15
申请号：US10566100
申请日：2004-07-29
申请人： Antoni Torrens Jover , Josep Mas Prio , Alberto Dordal Zueras , Xavier Codony Soler , Ramon Merce Vidal , Jose-Aurello Castrillo Perez , Jordi Frigola Constansa , Helmut-Heinrich Buschmann
发明人： Antoni Torrens Jover , Josep Mas Prio , Alberto Dordal Zueras , Xavier Codony Soler , Ramon Merce Vidal , Jose-Aurello Castrillo Perez , Jordi Frigola Constansa , Helmut-Heinrich Buschmann
IPC分类号： A61K31/538 , A61K31/404 , A61K9/22
CPC分类号： A61K31/404 , A61K31/4045 , A61K31/536 , A61K2300/00
摘要： The present invention relates to an active substance combination comprising at least one compound with neuropeptide Y-receptor affinity and at least one compound with 5-HT6 receptor affinity, a medicament comprising said active substance combination, and the use of said active substance combination for the manufacture of a medicament.
摘要翻译： 本发明涉及包含至少一种具有神经肽Y受体亲和力的化合物和至少一种具有5-HT 6受体亲和力的化合物的活性物质组合物，包含所述活性物质组合的药物，以及所述活性物质组合物用于 制造药物。
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3.发明申请Active substance combination comprising a compound with npy receptor affinity and a compound with 5-ht6 receptor affinity 审中-公开包含具有npy受体亲和力的化合物和具有5-ht6受体亲和力的化合物的活性物质组合公开(公告)号：US20070009597A1
公开(公告)日：2007-01-11
申请号：US10566402
申请日：2004-07-29
申请人： Antoni Torrens Jover , Josep Mas Prio , Albert Dordal Zueras , Xavier Codony Soler , Ramon Merce Vidal , Jose-Aurello Castillo Perez , Jordi Frigola Constansa , Helmut-Heinrich Buschmann
发明人： Antoni Torrens Jover , Josep Mas Prio , Albert Dordal Zueras , Xavier Codony Soler , Ramon Merce Vidal , Jose-Aurello Castillo Perez , Jordi Frigola Constansa , Helmut-Heinrich Buschmann
IPC分类号： A61K39/395 , A61K31/538 , A61K31/445 , A61K31/405 , A61K9/22
CPC分类号： A61K45/06
摘要： The present invention relates to an active substance combination comprising at least one compound with neuropeptide Y-receptor affinity, preferably neuropeptide Y5-receptor affinity, and at least one compound with 5-HT6 receptor affinity, a medicament comprising said active substance combination, and the use of said active substance combination for the manufacture of a medicament.
摘要翻译： 本发明涉及包含至少一种具有神经肽Y受体亲和力的化合物，优选神经肽Y5-受体亲和力的活性物质组合物和至少一种具有5-HT 6受体亲和力的化合物，药物 包括所述活性物质组合，以及所述活性物质组合用于制备药物的用途。
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4.发明授权公开(公告)号：US07514429B2
公开(公告)日：2009-04-07
申请号：US11338363
申请日：2006-01-24
申请人： Antoni Torrens Jover , Jose Aurelio Castrillo Perez , Jordi Frigola Constansa , Josep Mas Prió , Alberto Dordal Zueras , Maria Angeles Fisas Escasany
发明人： Antoni Torrens Jover , Jose Aurelio Castrillo Perez , Jordi Frigola Constansa , Josep Mas Prió , Alberto Dordal Zueras , Maria Angeles Fisas Escasany
IPC分类号： C07D405/04 , C07D405/14 , A61K31/536 , A61P3/04
CPC分类号： C07D413/04 , C07D413/14 , C07D417/14
摘要： The present invention relates to Benzoxazinone-derived compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans or animals.
摘要翻译： 本发明涉及通式（I）的苯并恶嗪酮衍生化合物，其制备方法，包含这些化合物的药物及其制备用于治疗人或动物的药物的用途。
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公开(公告)号：US07056914B2
公开(公告)日：2006-06-06
申请号：US10407343
申请日：2003-04-04
申请人： Antoni Torrens Jover , Jose Aurelio Castrillo Perez , Jordi Frigola Constansa , Josep Mas Prió , Alberto Dordal Zueras , Maria Angeles Fisas Escasany
发明人： Antoni Torrens Jover , Jose Aurelio Castrillo Perez , Jordi Frigola Constansa , Josep Mas Prió , Alberto Dordal Zueras , Maria Angeles Fisas Escasany
IPC分类号： C07D405/04 , C07D405/14 , A61K31/536 , A61P3/04
CPC分类号： C07D413/04 , C07D413/14 , C07D417/14
摘要： The present invention relates to Benzoxazinone-derived compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans or animals.
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公开(公告)号：US20070066651A1
公开(公告)日：2007-03-22
申请号：US11504584
申请日：2006-08-16
申请人： Rosa Cuberes Altisen , Jordi Frigola Constansa , Ramon Mangues Bafalluy , Isolda Casanova Rigal
发明人： Rosa Cuberes Altisen , Jordi Frigola Constansa , Ramon Mangues Bafalluy , Isolda Casanova Rigal
IPC分类号： A61K31/4709 , A61K31/4439 , A61K31/427 , A61K31/422 , A61K31/416 , A61K31/4178 , A61K31/4152 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D231/06
摘要： Compounds of formula (I) wherein: X is selected from the group consisting of trihalomethyl, C1-C6 alkyl, and a group of formula (II) wherein: R3 and R4 are independently selected from the group consisting of hydrogen; halogen; hydroxyl; nitro; C1-C6 alkyl; C1-C6 alkoxy; carboxy; C1-C6 trihaloalkyl; and cyano; Z is selected from the group consisting of substituted and unsubstituted aryl; or a pharmaceutically acceptable salt thereof. The compounds are inhibitors of cyclooxygenase-2 activity. They are useful for treating cyclooxygenase-mediated disorders, including, for example, inflamation, neoplastic disorders and angiogenesis-mediated disorders.
摘要翻译： 式（I）的化合物，其中：X选自三卤代甲基，C 1 -C 6烷基和式（II）的基团，其中：R 3个和R 4个独立地选自氢; 卤素; 羟; 硝基 C 1 -C 6烷基; C 1 -C 6烷基; C 1 -C 6烷氧基; 羧基; C 1 -C 6 - 三卤代烷基; 和氰基; Z选自取代和未取代的芳基; 或其药学上可接受的盐。 化合物是环氧合酶-2活性的抑制剂。 它们可用于治疗环氧合酶介导的病症，包括例如炎症，肿瘤性疾病和血管发生介导的病症。
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7.发明申请Substituted Azetidine compounds, their preparation and use as medicaments 审中-公开取代的氮杂环丁烷化合物，其制备和用作药物公开(公告)号：US20050187208A1
公开(公告)日：2005-08-25
申请号：US10804558
申请日：2004-03-19
IPC分类号： C07D205/04 , C07D409/12 , C07D417/12 , C07D513/04 , C07D491/02 , A61K31/397 , A61K31/416 , A61K31/433 , A61K31/4745
CPC分类号： C07D409/12 , C07D205/04 , C07D417/12 , C07D513/04
摘要： The present invention relates to substituted Azetidine compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.
摘要翻译： 本发明涉及通式（I）的取代氮杂环丁烷化合物，其制备方法，包含这些化合物的药物及其用于制备治疗人和动物的药物的用途。
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公开(公告)号：US20060189658A1
公开(公告)日：2006-08-24
申请号：US11410943
申请日：2006-04-26
IPC分类号： A61K31/454 , C07D403/02
CPC分类号： C07D231/06 , C07D231/14
摘要： The present invention relates to substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.
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9.发明申请Substituted azetidine compounds, their preparation and use as medicaments 审中-公开取代的氮杂环丁烷化合物，其制备和用作药物公开(公告)号：US20070066587A1
公开(公告)日：2007-03-22
申请号：US11505463
申请日：2006-08-17
IPC分类号： A61K31/397 , A61K31/433 , A61K31/4188 , C07D409/02 , C07D405/02 , C07D417/02
CPC分类号： C07D409/12 , C07D205/04 , C07D417/12 , C07D513/04
摘要： The present invention relates to substituted Azetidine compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.
摘要翻译： 本发明涉及通式（I）的取代氮杂环丁烷化合物，其制备方法，包含这些化合物的药物及其用于制备治疗人和动物的药物的用途。
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10.发明授权Process for obtaining 4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide 失效获得4-羟基-2-甲基-N-（2-吡啶基）-2H-1,2-苯并噻嗪-3-甲酰胺1,1-二氧化物的方法
公开(公告)号：US4797483A
公开(公告)日：1989-01-10
申请号：US66711
申请日：1987-06-24
IPC分类号： C07D275/06 , C07D417/12 , C07D279/16
CPC分类号： C07D275/06 , C07D417/12
摘要： A process for obtaining 4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide, which may be used as a non-steroidal analgesic and anti-inflammatory drug. The process comprises reacting saccharin sodium with isopropyl chloroacetate in dimethylformamide, reacting the resultant isopropyl 3-oxo-1,2-benzoisothiazoline-2-acetate 1,1-dioxide with sodium isopropylate in isopropanol to produce an intermediate which, when methylated in an aqueous-alcoholic basic medium with dimethyl sulfate, gives an intermediate compound which when condensed with 2-aminopyridine in xylene, yields 4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazone-3-carboxamide 1,1-dioxide.
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