公开(公告)号：US08940493B2

公开(公告)日：2015-01-27

申请号：US12303243

申请日：2007-05-29

申请人： Antonio Gualberto ,  Maria Luisa Paccagnella ,  Carrie L. Melvin ,  Madeline I. Repollet ,  David Chianese ,  Mark Carle Connelly ,  Leonardus Wendelinus Mathias Marie Terstappen

发明人： Antonio Gualberto ,  Maria Luisa Paccagnella ,  Carrie L. Melvin ,  Madeline I. Repollet ,  David Chianese ,  Mark Carle Connelly ,  Leonardus Wendelinus Mathias Marie Terstappen

IPC分类号： G01N33/574 ,  G01N33/50 ,  G01N30/02

CPC分类号： G01N33/57496 ,  G01N30/02 ,  G01N33/5023 ,  G01N33/5064 ,  G01N33/574 ,  G01N33/57492 ,  G01N2333/4742 ,  G01N2333/4745 ,  G01N2333/71 ,  G01N2333/91205 ,  G01N2458/00 ,  G01N2800/52 ,  B01D15/3804

摘要： Methods for the detection, enumeration and analysis of circulating tumor cells expressing insulin-like growth factor-1 receptors (IGF-1R) are disclosed. These methods are useful for cancer screening and staging, development of treatment regimens, and for monitoring for treatment responses, cancer recurrence or the like. Test kits that facilitate the detection, enumeration and analysis of such circulating tumor cells are also provided.

摘要翻译： 公开了用于检测，计数和分析表达胰岛素样生长因子-1受体（IGF-1R）的循环肿瘤细胞的方法。 这些方法可用于癌症筛查和分期，治疗方案的开发，以及用于治疗反应，癌症复发等的监测。 还提供了促进这种循环肿瘤细胞的检测，计数和分析的测试试剂盒。

公开(公告)号：US20100028915A1

公开(公告)日：2010-02-04

申请号：US12303243

申请日：2007-05-29

申请人： Antonio Gualberto ,  Maria Luisa Paccagnella ,  Carrie L. Melvin ,  Madeline I. Repollet ,  David Chianese ,  Mark Carle Connelly ,  Leonardus Wendelinus Mathias Marie Terstappen

发明人： Antonio Gualberto ,  Maria Luisa Paccagnella ,  Carrie L. Melvin ,  Madeline I. Repollet ,  David Chianese ,  Mark Carle Connelly ,  Leonardus Wendelinus Mathias Marie Terstappen

IPC分类号： G01N33/574

CPC分类号： G01N33/57496 ,  G01N30/02 ,  G01N33/5023 ,  G01N33/5064 ,  G01N33/574 ,  G01N33/57492 ,  G01N2333/4742 ,  G01N2333/4745 ,  G01N2333/71 ,  G01N2333/91205 ,  G01N2458/00 ,  G01N2800/52 ,  B01D15/3804

摘要： Methods for the detection, enumeration and analysis of circulating tumor cells expressing insulin-like growth factor-1 receptors (IGF-1R) are disclosed. These methods are useful for cancer screening and staging, development of treatment regimens, and for monitoring for treatment responses, cancer recurrence or the like. Test kits that facilitate the detection, enumeration and analysis of such circulating tumor cells are also provided.

摘要翻译： 公开了用于检测，计数和分析表达胰岛素样生长因子-1受体（IGF-1R）的循环肿瘤细胞的方法。 这些方法可用于癌症筛查和分期，治疗方案的开发，以及用于治疗反应，癌症复发等的监测。 还提供了促进这种循环肿瘤细胞的检测，计数和分析的测试试剂盒。

公开(公告)号：US5804141A

公开(公告)日：1998-09-08

申请号：US720979

申请日：1996-10-15

申请人： David Chianese

发明人： David Chianese

IPC分类号： G01N1/31 ,  G01N33/52 ,  G01N35/10

CPC分类号： G01N33/52 ,  G01N1/312 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/25 ,  Y10T436/2575

摘要： A reagent strip slide treating apparatus includes a reagent strip comprised of a plurality of chambers. A reagent passageway on the strip connects to each of the chambers and connects to a common passageway. The chambers are arranged at variable predetermined distances along the strip. A double slide is provided which is comprised of a first and a second slide spaced apart by a predetermined distance and adapted to have therebetween biological material to be treated sequentially by a plurality of reagents. A tube connects the common passageway of the reagent strip to the space between the space slides. The capsules containing reagents are provided within the chambers on the strip. The capsules are provided with thin walls which are adapted to burst upon the application of pressure. A press moving at a constant speed is provided to press the reagent strip and capsules in the chambers causing the capsules to burst. The spacing between the chambers determines the timing of the application of the reagents. The strip may preferably be straight, although it may be curved such as an arc or a roller may be mounted on a radial arm.

摘要翻译： 试剂条滑动处理装置包括由多个室组成的试剂条。 条上的试剂通道连接到每个室，并连接到公共通道。 这些腔室沿条带以可变的预定距离布置。 提供双滑块，其由间隔开预定距离的第一和第二滑动件组成，并且适于在其间通过多个试剂依次处理生物材料。 管将试剂条的公共通道连接到空间幻灯片之间的空间。 含有试剂的胶囊设置在条带上的室内。 胶囊设置有薄壁，其适于在施加压力时爆裂。 提供以恒定速度移动的压力机以将试剂条和胶囊压在腔室中，导致胶囊爆裂。 室之间的间距决定了试剂的施用时间。 带可以优选地是直的，尽管它可以是弯曲的，例如电弧或辊可以安装在径向臂上。