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    pH-dependent sustained release, drug-delivery composition
    5.
    发明授权
    pH-dependent sustained release, drug-delivery composition 失效
    pH依赖性持续释放，药物递送组合物

    公开(公告)号：US06465014B1

    公开(公告)日：2002-10-15

    申请号：US09814084

    申请日：2001-03-21

    申请人： Antonio Moroni ,  William Drefko

    发明人： Antonio Moroni ,  William Drefko

    IPC分类号： A61K914

    CPC分类号： A61K9/205

    摘要： A pH-dependent sustained release, drug delivery composition capable of being formed into tablets or pellets, wherein the release is controlled by a diffusion barrier formed by the interaction of a pH-dependent gelling material and a pH-independent non-gelling material, comprising a polymer matrix comprising, by weight, (a) 10 to 50% sodium alginate, (b) 2 to 15% propylene glycol alginate and (c) 40 to 80% of a pharmaceutical medicament.

    摘要翻译： pH依赖性缓释药物递送组合物，其能够形成片剂或丸粒，其中释放由通过pH依赖性凝胶材料和pH非依赖性胶凝材料的相互作用形成的扩散屏障控制，包括 包含（a）10-50％藻酸钠，（b）2-15％丙二醇藻酸盐和（c）40-80％药物的聚合物基质。

    Implantable prostheses with improved mechanical and chemical properties
    6.
    发明授权
    Implantable prostheses with improved mechanical and chemical properties 失效
    具有改善的机械和化学性质的植入假体

    公开(公告)号：US07083644B1

    公开(公告)日：2006-08-01

    申请号：US09577790

    申请日：2000-05-24

    申请人： Antonio Moroni

    发明人： Antonio Moroni

    IPC分类号： A61F2/06

    CPC分类号： A61L27/507 ,  A61L27/18 ,  C08L67/02

    摘要： Prostheses with improved chemical and mechanical properties manufactured that includes a radiation resistant and hydrolytically stable biocompatible fabric having outer and first and second ends with a textile fabric that includes a naphthalene dicarboxylate derivative polymer having the general formula: wherein R1 and R3 are the same or different groups and are independently selected from the naphthalene dicarboxylate derivative repeating unit (I), a hydrogen radical and a methyl radical. R2 is an alkylene radical having 1 to 6 carbon atoms; n is from 10 to 200. Also contemplated are implantable prostheses that are flat constructions useful as patches and filters or tubular constructions useful as vascular grafts. A further aspect of this invention provides a method for making a radiation and thermal resistant and hydrolytically stable, steam sterilizable biocompatible prosthesis.

    摘要翻译： 制造具有改进的化学和机械性能的假肢，其包括耐辐射和水解稳定的生物相容性织物，其具有包含具有以下通式的萘二甲酸酯衍生物聚合物的纺织织物的外部和第一和第二端：其中R 1 和R 3'是相同或不同的基团，并且独立地选自萘二羧酸酯衍生物重复单元（I），氢基和甲基。 R 2是具有1至6个碳原子的亚烷基; n为10至200.还考虑可植入假体，其为可用作补片和过滤器的扁平结构或用作血管移植物的管状构造。 本发明的另一方面提供了一种制造辐射和耐热和水解稳定的蒸汽灭菌的生物相容性假体的方法。

    Synergistic filler composition
    7.
    发明授权
    Synergistic filler composition 有权
    协同填料组成

    公开(公告)号：US06524617B1

    公开(公告)日：2003-02-25

    申请号：US09915057

    申请日：2001-07-25

    申请人： Antonio Moroni ,  Nadhamuni G. Nerella ,  Gregory Du Browny

    发明人： Antonio Moroni ,  Nadhamuni G. Nerella ,  Gregory Du Browny

    IPC分类号： A61K920

    CPC分类号： A61K9/2054 ,  A61K9/2027

    摘要： A synergistic filler composition for making pharmaceutical tablets of sufficient tablet hardness at low compression force, and low friability, to preclude damage to the tablet upon further processing, and without requiring a substantial increase in the size of the tablet, comprising (a) a PVP-VA copolymer and (b) a microcrystalline cellulose.

    摘要翻译： 一种协同的填充剂组合物，用于制备在低压力下具有足够的片剂硬度和低脆性的药物片剂，以防止在进一步加工时对片剂的损害，并且不需要片剂大小的显着增加，包括（a）PVP -VA共聚物和（b）微晶纤维素。