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![4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE DERIVATIVES AND THEIR USE AS SIGMA RECEPTOR LIGANDS](/abs-image/US/2012/09/20/US20120238567A1/abs.jpg.150x150.jpg)
1.发明申请4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE DERIVATIVES AND THEIR USE AS SIGMA RECEPTOR LIGANDS 有权4,5,6,7-四氢苯并[B]噻吩衍生物及其作为SIGMA受体配体的用途公开(公告)号：US20120238567A1
公开(公告)日：2012-09-20
申请号：US13483170
申请日：2012-05-30
IPC分类号： A61K31/381 , A61P3/04 , A61P3/06 , A61P25/06 , A61P19/02 , A61P9/12 , A61P9/06 , A61P1/04 , A61P25/28 , A61P25/00 , A61P25/36 , A61P25/34 , A61P9/10 , A61P25/08 , A61P25/24 , A61P25/18 , A61P29/00 , A61P37/06 , A61P35/00 , A61P25/32 , A61K31/4535 , A61K31/5377 , A61K31/438 , A61K31/4035 , A61K31/454 , A61K31/4725 , A61P1/12
CPC分类号： C07D471/10 , C07D333/54 , C07D409/06 , C07D409/14 , C07D491/10
摘要： The present invention relates to compounds having pharmacological activity towards the sigma (σ) receptor, and more particularly to some 4, 5, 6, 7 tetrahydrobenzo[b]thiophene derivatives, wherein n is selected from 0, 1, 2, 3 or 4; m is selected from 0, 1 or 2; the dotted line represents either a single or a double bond; to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy and prophylaxis, in particular for the treatment of psychosis.
摘要翻译： 本发明涉及对西格玛（＆amp;）受体具有药理活性的化合物，更具体地说涉及约4,5,6,7,7,8-四氢苯并[b]噻吩衍生物，其中n选自0,1,2,3或 4; m选自0,1或2; 虚线表示单键或双键; 涉及制备这些化合物的方法，包括它们的药物组合物，以及它们在治疗和预防中的用途，特别是用于治疗精神病。
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![4,5,6,7-tetrahydrobenzo[b]thiophene derivatives and their use as sigma receptor ligands](/abs-image/US/2012/07/24/US08227625B2/abs.jpg.150x150.jpg)
2.发明授权4,5,6,7-tetrahydrobenzo[b]thiophene derivatives and their use as sigma receptor ligands 有权4,5,6,7-四氢苯并[b]噻吩衍生物及其作为σ受体配体的用途公开(公告)号：US08227625B2
公开(公告)日：2012-07-24
申请号：US12281317
申请日：2007-03-02
IPC分类号： C07D333/00
CPC分类号： C07D471/10 , C07D333/54 , C07D409/06 , C07D409/14 , C07D491/10
摘要： The present invention relates to compounds having pharmacological activity towards the sigma (σ) receptor, and more particularly to some 4,5,6,7 tetrahydrobenzo[b]thiophene derivatives, wherein n is selected from 0, 1, 2, 3 or 4; m is selected from 0, 1 or 2; the dotted line represents either a single or a double bond; to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy and prophylaxis, in particular for the treatment of psychosis.
摘要翻译： 本发明涉及对σ（＆amp;）受体具有药理活性的化合物，更具体地涉及约4,5,6,7-四氢苯并[b]噻吩衍生物，其中n选自0,1,2,3或 4; m选自0,1或2; 虚线表示单键或双键; 涉及制备这些化合物的方法，包括它们的药物组合物，以及它们在治疗和预防中的用途，特别是用于治疗精神病。
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3.发明授权Derivatives of cyano-aryl (or cyanoheteroaryl)-carbonyl-piperazinyl-pyrimidines, their preparation and application as medication 失效氰基 - 芳基（或氰基杂芳基） - 羰基 - 哌嗪基 - 嘧啶的衍生物，其制备和作为药物的应用公开(公告)号：US07300937B2
公开(公告)日：2007-11-27
申请号：US10312195
申请日：2001-10-10
申请人： Jordi Corbera-Arjona , David Vano-Domenech , Maria Neus Mesquida-Estevez , Jordi Frigola-Constansa
发明人： Jordi Corbera-Arjona , David Vano-Domenech , Maria Neus Mesquida-Estevez , Jordi Frigola-Constansa
IPC分类号： A61K31/496 , C07D403/04
CPC分类号： C07D239/47 , C07D401/12 , C07D405/12 , C07D409/12
摘要： New derivatives of cyanoaryl (or cyanoheteroaryl)-carbonyl-piperazinyl-pyrimidines (I), where R1 represents an OR3 radical, where R3 represents a radical derived from a saturated hydrocarbon, with a linear or branched chain of 1 to 4 carbon atoms, and R2 represents a phenyl radical substituted at least by one cyan radical (—C≡N), or a radical of a heteroaromatic ring of 5 or 6 members substituted at least by one cyan radical (—C≡N); and their physiologically acceptable salts, are useful for application in human and/or veterinary therapeutics as sedatives, anticonvulsants, hypnotics and general anaesthetics
摘要翻译： 氰基芳基（或氰基杂芳基） - 羰基 - 哌嗪基 - 嘧啶（I）的新衍生物，其中R 1表示OR 3，其中R 3
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![4,5,6,7-tetrahydrobenzo[B]thiophene derivatives and their use as sigma receptor ligands](/abs-image/US/2013/07/23/US08492563B2/abs.jpg.150x150.jpg)
4.发明授权4,5,6,7-tetrahydrobenzo[B]thiophene derivatives and their use as sigma receptor ligands 有权4,5,6,7-四氢苯并[b]噻吩衍生物及其作为σ受体配体的用途公开(公告)号：US08492563B2
公开(公告)日：2013-07-23
申请号：US13483170
申请日：2012-05-30
IPC分类号： C07D333/00 , C07D409/00 , A61K31/397
CPC分类号： C07D471/10 , C07D333/54 , C07D409/06 , C07D409/14 , C07D491/10
摘要： The present invention relates to compounds having pharmacological activity towards the sigma (σ) receptor, and more particularly to some 4, 5, 6, 7 tetrahydrobenzo[b]thiophene derivatives, wherein n is selected from 0, 1, 2, 3 or 4; m is selected from 0, 1 or 2; the dotted line represents either a single or a double bond; to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy and prophylaxis, in particular for the treatment of psychosis.
摘要翻译： 本发明涉及对σ（sigma）受体具有药理活性的化合物，更具体地说涉及约4,5,6,7,7,8-四氢苯并[b]噻吩衍生物，其中n选自0,1,2,3或4 ; m选自0,1或2; 虚线表示单键或双键; 涉及制备这些化合物的方法，包括它们的药物组合物，以及它们在治疗和预防中的用途，特别是用于治疗精神病。
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公开(公告)号：US08481567B2
公开(公告)日：2013-07-09
申请号：US12281300
申请日：2007-03-02
IPC分类号： A61K31/445
CPC分类号： C07D209/08 , C07D401/06
摘要： The present invention relates to compounds of formula (I), methods for their preparation, medicaments comprising these compounds as well their use in the manufacture of a medicament for the treatment of humans and animals.
摘要翻译： 本发明涉及式（I）化合物，其制备方法，包含这些化合物的药物及其在制备用于治疗人和动物的药物中的用途。
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![4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE DERIVATIVES AND THEIR USE AS SIGMA RECEPTOR LIGANDS](/abs-image/US/2009/09/03/US20090221572A1/abs.jpg.150x150.jpg)
6.发明申请4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE DERIVATIVES AND THEIR USE AS SIGMA RECEPTOR LIGANDS 有权4,5,6,7-四氢苯并[B]噻吩衍生物及其作为SIGMA受体配体的用途公开(公告)号：US20090221572A1
公开(公告)日：2009-09-03
申请号：US12281317
申请日：2007-03-02
IPC分类号： A61K31/5377 , C07D409/06 , A61K31/4535 , A61K31/381 , C07D333/58 , C07D413/08 , A61P37/06
CPC分类号： C07D471/10 , C07D333/54 , C07D409/06 , C07D409/14 , C07D491/10
摘要： The present invention relates to compounds having pharmacological activity towards the sigma (σ) receptor, and more particularly to some 4, 5, 6, 7 tetrahydrobenzo[b]thiophene derivatives, wherein n is selected from 0, 1, 2, 3 or 4; m is selected from 0, 1 or 2; the dotted line represents either a single or a double bond; to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy and prophylaxis, in particular for the treatment of psychosis.
摘要翻译： 本发明涉及对σ（sigma）受体具有药理活性的化合物，更具体地说涉及约4,5,6,7,7,8-四氢苯并[b]噻吩衍生物，其中n选自0,1,2,3或4 ; m选自0,1或2; 虚线表示单键或双键; 涉及制备这些化合物的方法，包括它们的药物组合物，以及它们在治疗和预防中的用途，特别是用于治疗精神病。
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公开(公告)号：US20090197915A1
公开(公告)日：2009-08-06
申请号：US12281300
申请日：2007-03-02
IPC分类号： A61K31/454 , A61K31/403 , C07D209/02 , C07D401/08 , A61P25/00
CPC分类号： C07D209/08 , C07D401/06
摘要： The present invention relates to compounds of formula (I), methods for their preparation, medicaments comprising these compounds as well their use in the manufacture of a medicament for the treatment of humans and animals.
摘要翻译： 本发明涉及式（I）化合物，其制备方法，包含这些化合物的药物及其在制备用于治疗人和动物的药物中的用途。
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公开(公告)号：US20070232585A1
公开(公告)日：2007-10-04
申请号：US11574364
申请日：2005-08-29
申请人： Jordi Corbera Arjona , Maria Rosa Cuberes-Altisent , Joerg Holenz , Daniel Martinez-Olmo , David Vano-Domenech
发明人： Jordi Corbera Arjona , Maria Rosa Cuberes-Altisent , Joerg Holenz , Daniel Martinez-Olmo , David Vano-Domenech
IPC分类号： A61K31/416 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/55 , C07D401/06 , C07D403/06 , C07D417/06 , C07D491/10
CPC分类号： C07D491/10 , C07D231/56 , C07D401/06 , C07D403/06
摘要： The invention relates to compounds having pharmacological activity towards the sigma receptor, and more particularly to pyrazole derivatives of formula (I) and to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use therapy and prophylaxis, in particular for the treatment of psychosis or pain.
摘要翻译： 本发明涉及具有对σ受体的药理学活性的化合物，更具体地说，涉及式（I）的吡唑衍生物及其制备方法，包括它们的药物组合物，以及它们的用途治疗和预防，特别是 治疗精神病或疼痛。
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