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公开(公告)号:US07608621B2
公开(公告)日:2009-10-27
申请号:US11972702
申请日:2008-01-11
申请人: Antony N. Shaw , Kevin J. Duffy , William Henry Miller , Andrea K. Myers , Michael N. Zimmerman
发明人: Antony N. Shaw , Kevin J. Duffy , William Henry Miller , Andrea K. Myers , Michael N. Zimmerman
IPC分类号: A61K31/501 , C07D237/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10 , C07D409/04 , C07D409/10 , C07C229/22 , C07C229/38 , C07C229/40 , C07C229/46 , A61P7/06 , C07F401/04
CPC分类号: C07D237/24
摘要: The invention described herein relates to certain pyridazinedione N-substituted glycine derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
摘要翻译: 本文描述的本发明涉及作为HIF脯氨酰羟化酶的拮抗剂的式(I)的某些哒嗪二酮N-取代的甘氨酸衍生物,并且可用于治疗受益于该酶的抑制的疾病,贫血是一个示例。
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公开(公告)号:USRE44613E1
公开(公告)日:2013-11-26
申请号:US13281965
申请日:2011-10-26
申请人: Kevin J. Duffy , William Henry Miller , Andrea K. Myers , Antony N. Shaw , Michael N. Zimmerman
发明人: Kevin J. Duffy , William Henry Miller , Andrea K. Myers , Antony N. Shaw , Michael N. Zimmerman
CPC分类号: C07D237/24
摘要: The invention described herein relates to certain pyridazinedione N-substituted glycine derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
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公开(公告)号:US20080214549A1
公开(公告)日:2008-09-04
申请号:US11972702
申请日:2008-01-11
申请人: Antony N. SHAW , Kevin J. Duffy , William Henry Miller , Andrea K. Myers , Michael N. Zimmerman
发明人: Antony N. SHAW , Kevin J. Duffy , William Henry Miller , Andrea K. Myers , Michael N. Zimmerman
IPC分类号: C07D237/16 , A61K31/50 , A61P7/06
CPC分类号: C07D237/24
摘要: The invention described herein relates to certain pyridazinedione N-substituted glycine derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
摘要翻译: 本文描述的本发明涉及作为HIF脯氨酰羟化酶的拮抗剂的式(I)的某些哒嗪二酮N-取代的甘氨酸衍生物,并且可用于治疗受益于该酶的抑制的疾病,贫血是一个示例。
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公开(公告)号:US20080214455A1
公开(公告)日:2008-09-04
申请号:US11912969
申请日:2006-05-03
申请人: Kevin Duffy , Deping Chai , Mirela Colon , Duke M. Fitch , Sarah Rae King , Antony N. Shaw , Rosanna Tedesco , Kenneth Wiggall , Michael N. Zimmerman , Neil W. Johnson , Jiri Kasparec
发明人: Kevin Duffy , Deping Chai , Mirela Colon , Duke M. Fitch , Sarah Rae King , Antony N. Shaw , Rosanna Tedesco , Kenneth Wiggall , Michael N. Zimmerman , Neil W. Johnson , Jiri Kasparec
IPC分类号: C07D417/02 , C07D417/14 , A61K31/5377 , A61K31/498 , A61K31/496 , A61K31/4709 , A61K38/22 , A61P7/00
CPC分类号: C07D417/06
摘要: This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with hYAK3 activity.
摘要翻译: 本发明涉及新鉴定的用于抑制hYAK3蛋白的化合物和用于治疗与hYAK3活性相关的疾病的方法。
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公开(公告)号:US20090203692A1
公开(公告)日:2009-08-13
申请号:US11912965
申请日:2006-05-18
申请人: Kevin Duffy , Deping Chai , Mirela Colon , Duke M. Fitch , Sarah Rae King , Antony N. Shaw , Rosanna Tedesco , Kenneth Wiggall , Neil W. Johnson , Michael N. Zimmerman
发明人: Kevin Duffy , Deping Chai , Mirela Colon , Duke M. Fitch , Sarah Rae King , Antony N. Shaw , Rosanna Tedesco , Kenneth Wiggall , Neil W. Johnson , Michael N. Zimmerman
IPC分类号: A61K31/4709 , C07D417/14 , C07D417/06 , A61K31/5377 , A61K31/498 , A61P7/06 , A61P7/00
CPC分类号: C07D417/12 , C07D417/14
摘要: This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with hYAK3 activity.
摘要翻译: 本发明涉及新鉴定的用于抑制hYAK3蛋白的化合物和用于治疗与hYAK3活性相关的疾病的方法。
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公开(公告)号:US20080261974A1
公开(公告)日:2008-10-23
申请号:US12067471
申请日:2006-09-22
IPC分类号: A61K31/5377 , A61P7/06 , A61P7/00 , C07D417/02 , C07D417/14 , A61K31/502 , A61K31/4985 , A61K31/4725 , A61K31/498 , C07D487/04 , C07D417/06 , A61K31/53 , A61K31/517
CPC分类号: C07D417/06 , C07D487/04
摘要: This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with the imbalance or inappropriate activity of hYAK3 proteins.
摘要翻译: 本发明涉及新鉴定的用于抑制hYAK3蛋白的化合物和用于治疗与hYAK3蛋白的不平衡或不适当活性相关的疾病的方法。
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