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公开(公告)号:US20080214455A1
公开(公告)日:2008-09-04
申请号:US11912969
申请日:2006-05-03
申请人: Kevin Duffy , Deping Chai , Mirela Colon , Duke M. Fitch , Sarah Rae King , Antony N. Shaw , Rosanna Tedesco , Kenneth Wiggall , Michael N. Zimmerman , Neil W. Johnson , Jiri Kasparec
发明人: Kevin Duffy , Deping Chai , Mirela Colon , Duke M. Fitch , Sarah Rae King , Antony N. Shaw , Rosanna Tedesco , Kenneth Wiggall , Michael N. Zimmerman , Neil W. Johnson , Jiri Kasparec
IPC分类号: C07D417/02 , C07D417/14 , A61K31/5377 , A61K31/498 , A61K31/496 , A61K31/4709 , A61K38/22 , A61P7/00
CPC分类号: C07D417/06
摘要: This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with hYAK3 activity.
摘要翻译: 本发明涉及新鉴定的用于抑制hYAK3蛋白的化合物和用于治疗与hYAK3活性相关的疾病的方法。
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公开(公告)号:US20090203692A1
公开(公告)日:2009-08-13
申请号:US11912965
申请日:2006-05-18
申请人: Kevin Duffy , Deping Chai , Mirela Colon , Duke M. Fitch , Sarah Rae King , Antony N. Shaw , Rosanna Tedesco , Kenneth Wiggall , Neil W. Johnson , Michael N. Zimmerman
发明人: Kevin Duffy , Deping Chai , Mirela Colon , Duke M. Fitch , Sarah Rae King , Antony N. Shaw , Rosanna Tedesco , Kenneth Wiggall , Neil W. Johnson , Michael N. Zimmerman
IPC分类号: A61K31/4709 , C07D417/14 , C07D417/06 , A61K31/5377 , A61K31/498 , A61P7/06 , A61P7/00
CPC分类号: C07D417/12 , C07D417/14
摘要: This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with hYAK3 activity.
摘要翻译: 本发明涉及新鉴定的用于抑制hYAK3蛋白的化合物和用于治疗与hYAK3活性相关的疾病的方法。
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公开(公告)号:US20110039895A1
公开(公告)日:2011-02-17
申请号:US12989487
申请日:2009-04-29
申请人: Deping Chai , Duke M. Fitch
发明人: Deping Chai , Duke M. Fitch
IPC分类号: A61K31/4439 , C07D235/06 , C07D235/18 , C07D235/08 , C07D401/10 , C07D235/24 , A61K31/4184 , A61P7/06
CPC分类号: A61K31/445 , C07D235/04 , C07D235/06 , C07D235/08 , C07D235/18 , C07D401/10
摘要: The invention described herein relates to certain benzimidazol-4-ylcarboxamide derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
摘要翻译: 本文描述的本发明涉及作为HIF脯氨酰羟化酶的拮抗剂的式(I)的某些苯并咪唑-4-基甲酰胺衍生物,并且可用于治疗受益于该酶的抑制的疾病,贫血是一个示例。
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公开(公告)号:US20090176825A1
公开(公告)日:2009-07-09
申请号:US12299835
申请日:2007-05-08
申请人: Duke M. Fitch , Deping Chai
发明人: Duke M. Fitch , Deping Chai
IPC分类号: A61K31/4365 , C07D495/04 , C07D471/04 , A61K31/437 , A61P7/06
CPC分类号: C07D495/04 , C07D471/04
摘要: The invention described herein relates to certain bicyclic heteroaromatic N-substituted glycine derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
摘要翻译: 本文描述的本发明涉及作为HIF脯氨酰羟化酶的拮抗剂的式(I)的某些双环杂芳基N-取代的甘氨酸衍生物,并且可用于治疗受益于该酶的抑制的疾病,贫血是一个示例。
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公开(公告)号:US20130225524A1
公开(公告)日:2013-08-29
申请号:US13883023
申请日:2011-11-03
IPC分类号: A61K31/506 , A61K31/4709 , A61K31/4706 , A61K31/496 , A61K31/513 , A61K31/69 , A61K31/517 , C07D401/10 , C07D413/10 , C07D215/54 , C07D401/14 , C07D405/14 , C07D471/04 , C07F5/02 , C07D413/14 , A61K45/06
CPC分类号: A61K31/506 , A61K31/4706 , A61K31/4709 , A61K31/496 , A61K31/513 , A61K31/517 , A61K31/69 , A61K45/06 , C07D215/44 , C07D215/54 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D407/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D471/04 , C07F5/025
摘要: The invention is directed to substituted quinoline derivatives. Specifically, the invention is directed to compounds according to Formula I: wherein R1, R2, R3, R4, and R5 are defined herein.The compounds of the invention are inhibitors of lactate dehydrogenase A and can be useful in the treatment of cancer and diseases associated with tumor cell metabolism, such as cancer, and more specifically cancers of the breast, colon, prostate and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting lactate dehydrogenase A activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
摘要翻译: 本发明涉及取代的喹啉衍生物。 具体地,本发明涉及式I化合物:其中R1,R2,R3,R4和R5如本文所定义。 本发明的化合物是乳酸脱氢酶A的抑制剂,并且可用于治疗与肿瘤细胞代谢相关的癌症和疾病,例如癌症,更具体地说,涉及乳腺癌,结肠癌,前列腺癌和肺癌。 因此,本发明进一步涉及包含本发明化合物的药物组合物。 本发明还涉及抑制乳酸脱氢酶A活性的方法以及使用本发明化合物或包含本发明化合物的药物组合物治疗与之相关的病症。
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