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公开(公告)号:US20080214455A1
公开(公告)日:2008-09-04
申请号:US11912969
申请日:2006-05-03
申请人: Kevin Duffy , Deping Chai , Mirela Colon , Duke M. Fitch , Sarah Rae King , Antony N. Shaw , Rosanna Tedesco , Kenneth Wiggall , Michael N. Zimmerman , Neil W. Johnson , Jiri Kasparec
发明人: Kevin Duffy , Deping Chai , Mirela Colon , Duke M. Fitch , Sarah Rae King , Antony N. Shaw , Rosanna Tedesco , Kenneth Wiggall , Michael N. Zimmerman , Neil W. Johnson , Jiri Kasparec
IPC分类号: C07D417/02 , C07D417/14 , A61K31/5377 , A61K31/498 , A61K31/496 , A61K31/4709 , A61K38/22 , A61P7/00
CPC分类号: C07D417/06
摘要: This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with hYAK3 activity.
摘要翻译: 本发明涉及新鉴定的用于抑制hYAK3蛋白的化合物和用于治疗与hYAK3活性相关的疾病的方法。
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公开(公告)号:US20090203692A1
公开(公告)日:2009-08-13
申请号:US11912965
申请日:2006-05-18
申请人: Kevin Duffy , Deping Chai , Mirela Colon , Duke M. Fitch , Sarah Rae King , Antony N. Shaw , Rosanna Tedesco , Kenneth Wiggall , Neil W. Johnson , Michael N. Zimmerman
发明人: Kevin Duffy , Deping Chai , Mirela Colon , Duke M. Fitch , Sarah Rae King , Antony N. Shaw , Rosanna Tedesco , Kenneth Wiggall , Neil W. Johnson , Michael N. Zimmerman
IPC分类号: A61K31/4709 , C07D417/14 , C07D417/06 , A61K31/5377 , A61K31/498 , A61P7/06 , A61P7/00
CPC分类号: C07D417/12 , C07D417/14
摘要: This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with hYAK3 activity.
摘要翻译: 本发明涉及新鉴定的用于抑制hYAK3蛋白的化合物和用于治疗与hYAK3活性相关的疾病的方法。
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公开(公告)号:US08324208B2
公开(公告)日:2012-12-04
申请号:US12305675
申请日:2007-06-22
申请人: Kevin J. Duffy , Duke M. Fitch , Jian Jin , Ronggang Liu , Antony N. Shaw , Kenneth Wiggall
发明人: Kevin J. Duffy , Duke M. Fitch , Jian Jin , Ronggang Liu , Antony N. Shaw , Kenneth Wiggall
IPC分类号: C07D239/54 , A61K31/515
CPC分类号: C07D239/60 , A61K31/515 , C07D239/22 , C07D239/54 , C07D239/62 , C07D401/04 , C07D405/04 , C07D405/10 , C07D409/04 , C07D409/10 , C07D413/06 , C07D413/10 , C07D417/10
摘要: The invention described herein relates to certain pyrimidinetrione N-substituted glycine derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
摘要翻译: 本文描述的本发明涉及作为HIF脯氨酰羟化酶的拮抗剂的式(I)的某些嘧啶四酮N-取代的甘氨酸衍生物,并且可用于治疗受益于该酶的抑制的疾病,贫血是一个示例。
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公开(公告)号:US20100113444A1
公开(公告)日:2010-05-06
申请号:US12305675
申请日:2007-06-22
申请人: Kevin J. Duffy , Duke M. Fitch , Jian Jin , Ronggang Liu , Antony N. Shaw , Kenneth Wiggall
发明人: Kevin J. Duffy , Duke M. Fitch , Jian Jin , Ronggang Liu , Antony N. Shaw , Kenneth Wiggall
IPC分类号: A61K31/506 , C07D239/60 , C07D401/04 , C07D405/04 , C07D413/06 , A61K31/505 , A61K31/5377 , A61P7/06 , A61P9/00
CPC分类号: C07D239/60 , A61K31/515 , C07D239/22 , C07D239/54 , C07D239/62 , C07D401/04 , C07D405/04 , C07D405/10 , C07D409/04 , C07D409/10 , C07D413/06 , C07D413/10 , C07D417/10
摘要: The invention described herein relates to certain pyrimidinetrione N-substituted glycine derivatives of formula (I), (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
摘要翻译: 本文描述的本发明涉及作为HIF脯氨酰羟化酶的拮抗剂的式(I),(I)的某些嘧啶四酮N-取代的甘氨酸衍生物,并且可用于治疗受益于该酶的抑制的疾病,贫血是一个示例。
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公开(公告)号:US20080261974A1
公开(公告)日:2008-10-23
申请号:US12067471
申请日:2006-09-22
IPC分类号: A61K31/5377 , A61P7/06 , A61P7/00 , C07D417/02 , C07D417/14 , A61K31/502 , A61K31/4985 , A61K31/4725 , A61K31/498 , C07D487/04 , C07D417/06 , A61K31/53 , A61K31/517
CPC分类号: C07D417/06 , C07D487/04
摘要: This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with the imbalance or inappropriate activity of hYAK3 proteins.
摘要翻译: 本发明涉及新鉴定的用于抑制hYAK3蛋白的化合物和用于治疗与hYAK3蛋白的不平衡或不适当活性相关的疾病的方法。
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公开(公告)号:US20110039895A1
公开(公告)日:2011-02-17
申请号:US12989487
申请日:2009-04-29
申请人: Deping Chai , Duke M. Fitch
发明人: Deping Chai , Duke M. Fitch
IPC分类号: A61K31/4439 , C07D235/06 , C07D235/18 , C07D235/08 , C07D401/10 , C07D235/24 , A61K31/4184 , A61P7/06
CPC分类号: A61K31/445 , C07D235/04 , C07D235/06 , C07D235/08 , C07D235/18 , C07D401/10
摘要: The invention described herein relates to certain benzimidazol-4-ylcarboxamide derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
摘要翻译: 本文描述的本发明涉及作为HIF脯氨酰羟化酶的拮抗剂的式(I)的某些苯并咪唑-4-基甲酰胺衍生物,并且可用于治疗受益于该酶的抑制的疾病,贫血是一个示例。
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公开(公告)号:US20080262027A1
公开(公告)日:2008-10-23
申请号:US12092993
申请日:2006-11-03
申请人: Kevin J. Duffy , Duke M. Fitch , Antony N. Shaw
发明人: Kevin J. Duffy , Duke M. Fitch , Antony N. Shaw
IPC分类号: A61K31/437 , A61P7/06 , A61P7/00 , C07D471/04
CPC分类号: C07D471/04
摘要: This invention relates to newly identified compounds for inhibiting YAK3 proteins and methods for treating diseases associated with the imbalance or inappropriate activity of YAK3 proteins.
摘要翻译: 本发明涉及新鉴定的用于抑制YAK3蛋白的化合物和用于治疗与YAK3蛋白的不平衡或不适当活性相关的疾病的方法。
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公开(公告)号:US20080176830A1
公开(公告)日:2008-07-24
申请号:US11910731
申请日:2006-04-13
申请人: Nicholas D. Adams , Michael Gerard Darcy , Dashyant Dhanak , Kevin J. Duffy , Duke M. Fitch , Steven David Knight , Kenneth Allen Newlander , Antony N. Shaw
发明人: Nicholas D. Adams , Michael Gerard Darcy , Dashyant Dhanak , Kevin J. Duffy , Duke M. Fitch , Steven David Knight , Kenneth Allen Newlander , Antony N. Shaw
IPC分类号: A61K31/551 , C07D285/16 , A61K31/549 , C07D311/76 , A61K31/352 , A61K31/498 , A61P35/04 , A61P37/00 , A61P29/00 , A61P9/00 , C07D281/10 , C07D239/80 , C07D215/00 , A61K31/47 , C07D243/10
CPC分类号: C07D285/16 , C07C35/52 , C07D215/227 , C07D223/16 , C07D239/80 , C07D243/14 , C07D265/36 , C07D311/18 , C07D413/04 , C07D417/04
摘要: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
摘要翻译: 公开了通过调节KSP活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号:US20090176825A1
公开(公告)日:2009-07-09
申请号:US12299835
申请日:2007-05-08
申请人: Duke M. Fitch , Deping Chai
发明人: Duke M. Fitch , Deping Chai
IPC分类号: A61K31/4365 , C07D495/04 , C07D471/04 , A61K31/437 , A61P7/06
CPC分类号: C07D495/04 , C07D471/04
摘要: The invention described herein relates to certain bicyclic heteroaromatic N-substituted glycine derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
摘要翻译: 本文描述的本发明涉及作为HIF脯氨酰羟化酶的拮抗剂的式(I)的某些双环杂芳基N-取代的甘氨酸衍生物,并且可用于治疗受益于该酶的抑制的疾病,贫血是一个示例。
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公开(公告)号:US20090082357A1
公开(公告)日:2009-03-26
申请号:US12281677
申请日:2007-03-06
申请人: Duke M. Fitch , Mariela Colon
发明人: Duke M. Fitch , Mariela Colon
IPC分类号: A61K31/4375 , C07D471/04 , A61P7/06 , A61K31/4985 , A61K31/519
CPC分类号: C07D471/04
摘要: The invention described herein relates to certain bicyclic heteroaromatic N-substituted glycine derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
摘要翻译: 本文描述的本发明涉及作为HIF脯氨酰羟化酶的拮抗剂的式(I)的某些双环杂芳基N-取代的甘氨酸衍生物,并且可用于治疗受益于该酶的抑制的疾病,贫血是一个示例。
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