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9 条记录 (耗时 0.022 秒)

    Intranasal codeine for the rapid suppression of cough and rapid relief of pain
    1.
    发明授权
    Intranasal codeine for the rapid suppression of cough and rapid relief of pain 失效
    鼻内可待因可快速抑制咳嗽和快速缓解疼痛

    公开(公告)号：US06608073B1

    公开(公告)日：2003-08-19

    申请号：US09410033

    申请日：1999-10-01

    申请人： Anwar A. Hussain ,  Lewis W. Dittert ,  Abeer M. Al-Ghananeem

    发明人： Anwar A. Hussain ,  Lewis W. Dittert ,  Abeer M. Al-Ghananeem

    IPC分类号： A61K31435

    CPC分类号： A61K31/60 ,  A61K31/435 ,  A61K31/485 ,  A61K45/06 ,  A61K2300/00

    摘要： This invention provides a method of rapidly and reliably delivering codeine, alone or in combination with other compounds, to the systemic circulation by administration via the nasal route to produce rapid onset of beneficial effects in the treatment of pain or cough. The present invention further provides pharmaceutical compositions comprising codeine, and/or pharmaceutically acceptable salts thereof in a variety of unique pharmaceutical dosage forms, with and without other analgesic and/or antitussive compounds.

    摘要翻译： 本发明提供了一种通过经鼻途径给药可快速可靠地将可待因单独或与其它化合物组合输送至全身循环的方法，从而在治疗疼痛或咳嗽方面产生快速的有益效果。 本发明进一步提供包含可待因和/或其药学上可接受的盐的药物组合物，其具有多种独特的药物剂型，具有和不具有其它镇痛药和/或镇咳药物。

    Method of administration of sildenafil to produce instantaneous response for the treatment of erectile dysfunction
    2.
    发明授权
    Method of administration of sildenafil to produce instantaneous response for the treatment of erectile dysfunction 失效
    施用西地那非以治疗勃起功能障碍的瞬间反应的方法

    公开(公告)号：US06200591B1

    公开(公告)日：2001-03-13

    申请号：US09208439

    申请日：1998-12-10

    申请人： Anwar A. Hussain ,  Lewis W. Dittert

    发明人： Anwar A. Hussain ,  Lewis W. Dittert

    IPC分类号： A61F1302

    CPC分类号： A61K9/0043

    摘要： This invention provides a method of rapidly and reliably delivering sildenafil, or derivatives thereof, alone or in combination with other compounds, to the systemic circulation by administration via the nasal route so as to produce virtually instantaneous onset of beneficial effects in the treatment of erectile dysfunction. The present invention further provides pharmaceutical compositions comprising sildenafil, or derivatives thereof, and/or pharmaceutically acceptable salts thereof in a variety of unique pharmaceutical dosage forms, with and without apomorphine.

    摘要翻译： 本发明提供了一种通过经鼻途径给药而将西地那非或其衍生物单独或与其它化合物组合快速可靠地递送至全身循环的方法，从而在勃起功能障碍的治疗中产生几乎瞬间的有益效果 。 本发明进一步提供药物组合物，其包含西地那非或其衍生物，和/或其药学上可接受的盐，其具有和不含阿扑吗啡的各种独特的药物剂型。

    Novel method of administering aspirin and dosage forms containing same
    4.
    发明授权
    Novel method of administering aspirin and dosage forms containing same 失效
    施用阿司匹林和含有其的剂型的新方法

    公开(公告)号：US4885287A

    公开(公告)日：1989-12-05

    申请号：US229963

    申请日：1988-08-09

    申请人： Anwar A. Hussain ,  Lewis W. Dittert ,  Thomas S. Foster

    发明人： Anwar A. Hussain ,  Lewis W. Dittert ,  Thomas S. Foster

    IPC分类号： A61K9/00 ,  A61K9/06 ,  A61K9/08 ,  A61K9/107 ,  A61K31/60 ,  A61P7/02 ,  A61P43/00

    CPC分类号： A61K9/0043 ,  A61K31/60

    摘要： The invention relates to a novel method of administering aspirin to achieve improved delivery thereof. The invention further relates to novel dosage forms of neutralized aspirin adapted for nasal administration, such as solutions, suspensions, gels and ointments. These dosage forms find utility in the treatment of conditions known to respond to the administration of aspirin, particularly in the treatment of migraine and in the mitigation of cardiovascular damage resulting from heart attack.

    摘要翻译： 本发明涉及一种给予阿斯匹林以改善其递送的新方法。 本发明还涉及适于鼻腔给药的中和阿司匹林的新型剂型，例如溶液，悬浮液，凝胶和软膏。 这些剂型可用于治疗已知对阿司匹林施用有反应的病症，特别是在治疗偏头痛和缓解由心脏病发作引起的心血管损伤中。

    Brain delivery of folic acid for the prevention of alzheimer's disease and stroke
    6.
    发明授权
    Brain delivery of folic acid for the prevention of alzheimer's disease and stroke 失效
    脑输送叶酸用于预防阿尔茨海默病和中风

    公开(公告)号：US06369058B1

    公开(公告)日：2002-04-09

    申请号：US09482910

    申请日：2000-01-14

    申请人： Anwar A. Hussain ,  Lewis W. Dittert ,  Ashraf Traboulsi

    发明人： Anwar A. Hussain ,  Lewis W. Dittert ,  Ashraf Traboulsi

    IPC分类号： A61K31495

    CPC分类号： A61K31/00 ,  A61K31/505 ,  A61K31/519 ,  A61K31/44 ,  A61K31/40 ,  A61K31/27 ,  A61K31/165 ,  A61K31/155 ,  A61K2300/00

    摘要： This invention provides a method of rapidly and reliably delivering folic acid, alone or in combination with other compounds, to the systemic circulation by administration via the nasal route to produce rapid onset of beneficial effects in the treatment or prevention of Alzheimer's Disease and stroke. The present invention further provides intranasal pharmaceutical compositions comprising folic acid, and/or pharmaceutically acceptable salts thereof in a variety of unique pharmaceutical dosage forms, with and without other anti-Alzheimer's or anti-stroke compounds.

    摘要翻译： 本发明提供了一种通过经由鼻道途径给药而快速且可靠地将叶酸单独或与其它化合物组合递送至全身循环的方法，以便在治疗或预防阿尔茨海默病和中风方面产生快速的有益效果。 本发明进一步提供包含叶酸的鼻内药物组合物和/或其药学上可接受的盐，其具有和不含其它抗阿尔茨海默氏病或​​抗中风化合物的各种独特的药物剂型。

    Non-destructive method for radiolabelling biomolecules by halogenation
    8.
    发明授权
    Non-destructive method for radiolabelling biomolecules by halogenation 失效
    通过卤化放射性标记生物分子的非破坏性方法

    公开(公告)号：US5424402A

    公开(公告)日：1995-06-13

    申请号：US136849

    申请日：1993-10-18

    申请人： Anwar A. Hussain ,  Lewis W. Dittert

    发明人： Anwar A. Hussain ,  Lewis W. Dittert

    IPC分类号： A61K51/04 ,  C07K1/107 ,  C07K1/13 ,  C07K1/00 ,  A61K51/00

    CPC分类号： C07K1/13 ,  A61K51/0406 ,  C07K1/1077

    摘要： A kit and method of non-destructively radiolabelling a biomolecule substrate by halogenation, including the steps of: a) reacting a secondary amine with a chlorinating agent to produce an N-chloro secondary amine, (b) reacting the N-chloro secondary amine with a salt of a radiolabelled halogen to produce a radiolabelled halogenating agent, (c) reacting a solution of the biomolecule substrate with the radiolabelled halogenating agent, and (d) recovering a radiohalogenated biomolecule from the reaction of step (c). The kit and method allow for more complete iodination with a lessening of side reactions such as decomposition of the biomolecule substrate to be labelled.

    摘要翻译： 一种通过卤化非破坏性地放射性标记生物分子底物的试剂盒和方法，包括以下步骤：a）使仲胺与氯化剂反应以产生N-氯仲胺，（b）使N-氯仲胺与 （d）从步骤（c）的反应中回收放射性卤代生物分子。（c）将生物分子底物的溶液与放射性标记的卤化剂反应，和（d）从步骤（c）的反应中回收放射性卤代生物分子。 试剂盒和方法允许更加完全的碘化，同时减少副反应，例如待标记的生物分子底物的分解。

    Novel polymer coated bleaching composition
    9.
    发明授权
    Novel polymer coated bleaching composition 失效
    新型聚合物涂层漂白组合物

    公开(公告)号：US5000869A

    公开(公告)日：1991-03-19

    申请号：US480124

    申请日：1990-02-14

    申请人： Lewis W. Dittert

    发明人： Lewis W. Dittert

    IPC分类号： C11D3/395 ,  C11D17/00

    CPC分类号： C11D3/3955 ,  C11D17/0039

    摘要： A fabric-safe bleaching and cleaning detergent composition comprising a bleach stable surfactant and a polymer coated halogenated glycoluril compound having the formula ##STR1## wherein each R is independently selected from hydrogen, C.sub.1 -C.sub.10 straight or branched chain alkyl, aryl or alkyl substituted aryl; each X is independently selected from hydrogen, fluorine, chlorine, bromine and iodine and at least one X is not hydrogen and n is 0 or 1. 1,3,4,6-tetrachloroglycoluril is the preferred bleaching agent. The polymer coating is capable of hydrating and dissolving at a pH of greater than 6.0, preferably 7.2 to 11.0, and more preferably 9.5 to 11.0. Polymeric pharmaceutical enteric coating materials are particularly suitable as a coating material for the present invention.

    摘要翻译： 一种织物安全的漂白和清洁洗涤剂组合物，其包含漂白稳定的表面活性剂和具有式“IMAGE”的聚合物涂覆的卤代甘脲化合物，其中每个R独立地选自氢，C1-C10直链或支链烷基，芳基或烷基取代的芳基 ; 每个X独立地选自氢，氟，氯，溴和碘，并且至少一个X不是氢，n是0或1. 1,3,4,6-四氯甘露脲是优选的漂白剂。 聚合物涂层能够在大于6.0，优选7.2-11.0，更优选9.5-11.0的pH下进行水合和溶解。 聚合药物肠溶衣材料特别适合作为本发明的涂料。