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公开(公告)号：US20180125986A1
公开(公告)日：2018-05-10
申请号：US15808182
申请日：2017-11-09
Applicant: Apparao Satyam
Inventor： Apparao Satyam
IPC: A61K47/54 , C07C201/04 , C07C203/04 , C07C227/18 , A61K31/621 , C07C229/42 , A61K31/21 , A61K31/216 , A61K31/60
CPC classification number: A61K47/542 , A61K31/21 , A61K31/216 , A61K31/60 , A61K47/55 , C07C201/04 , C07C203/04 , C07C227/18 , C07C229/42
Abstract: The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents wherein the drug or therapeutic agents contain at least one carboxylic acid group. The invention also relates to processes for the preparation of these nitric oxide releasing prodrugs, to pharmaceutical compositions containing them and to methods of using these prodrugs.
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公开(公告)号：US08105568B2
公开(公告)日：2012-01-31
申请号：US12501283
申请日：2009-07-10
Applicant: Iontcho R. Vlahov , Christopher P. Leamon , Matthew A. Parker , Stephen J. Howard , Hari Krishna R. Santhapuram , Apparao Satyam , Joseph A. Reddy
Inventor： Iontcho R. Vlahov , Christopher P. Leamon , Matthew A. Parker , Stephen J. Howard , Hari Krishna R. Santhapuram , Apparao Satyam , Joseph A. Reddy
CPC classification number: A61K47/48569 , A61K47/48384 , A61K47/484 , A61K47/48715 , A61K47/551 , A61K47/65 , A61K47/6803 , A61K47/6807 , A61K47/6851 , A61K47/6889 , C07K16/30 , C07K2317/55
Abstract: The invention describes a vitamin receptor binding drug delivery conjugate, and preparations therefor. The drug delivery conjugate consists of a vitamin receptor binding moiety, a bivalent linker (L), and a drug. The vitamin receptor binding moiety includes vitamins, and vitamin receptor binding analogs and derivatives thereof, and the drug includes analogs and derivatives thereof. The vitamin receptor binding moiety is covalently linked to the bivalent linker, and the drug, or the analog or the derivative thereof, is covalently linked to the bivalent linker, wherein the bivalent linker (L) includes components such as spacer linkers, releasable linkers, and heteroatom linkers, and combinations thereof. Methods and pharmaceutical compositions for eliminating pathogenic cell populations using the drug delivery conjugate are also described.
Abstract translation: 本发明描述了维生素受体结合药物递送缀合物及其制备方法。 药物递送缀合物由维生素受体结合部分，二价连接体（L）和药物组成。 维生素受体结合部分包括维生素和维生素受体结合类似物及其衍生物，并且该药物包括其类似物及其衍生物。 维生素受体结合部分与二价连接体共价连接，药物或其类似物或衍生物与二价连接体共价连接，其中二价连接体（L）包括组分如间隔连接子，可释放接头， 和杂原子接头，及其组合。 还描述了使用药物递送缀合物消除致病细胞群的方法和药物组合物。
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公开(公告)号：US09090563B2
公开(公告)日：2015-07-28
申请号：US13609995
申请日：2012-09-11
Applicant: Iontcho Radoslavov Vlahov , Christopher Paul Leamon , Apparao Satyam , Stephen J. Howard
IPC: C07D213/62 , C07D401/12 , C07D213/71 , A61K47/48 , A61K49/00 , C07D475/04
CPC classification number: C07D213/71 , A61K47/551 , A61K47/6803 , A61K49/0002 , C07D401/12 , C07D475/04
Abstract: Bivalent linkers to be included in or for preparing vitamin, drug, diagnostic agent, and/or imaging agent conjugates are described.
Abstract translation: 描述了包含在或用于制备维生素，药物，诊断剂和/或成像剂缀合物的二价连接体。
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公开(公告)号：US20120065149A1
公开(公告)日：2012-03-15
申请号：US13199654
申请日：2011-09-07
Applicant: Iontcho R. Vlahov , Christopher P. Leamon , Matthew A. Parker , Stephen J. Howard , Hari Krishna Santhapuram , Apparao Satyam , Joseph Anand Reddy
Inventor： Iontcho R. Vlahov , Christopher P. Leamon , Matthew A. Parker , Stephen J. Howard , Hari Krishna Santhapuram , Apparao Satyam , Joseph Anand Reddy
IPC: A61K31/519 , C07D519/00 , C07H15/26 , A61K31/7068 , A61P35/00 , C07K5/083 , A61K38/06 , C07K5/103 , A61K38/07 , C07K9/00 , A61K38/14 , C07K7/06 , A61K38/08 , C07F7/10 , A61K31/695 , C07D475/04
CPC classification number: A61K47/55 , A61K47/551 , A61K47/65 , A61K47/6803 , A61K47/6807 , A61K47/6851 , A61K47/6889 , C07K16/30 , C07K2317/55
Abstract: The invention describes a vitamin receptor binding drug delivery conjugate, and preparations therefor. The drug delivery conjugate consists of a vitamin receptor binding moiety, a bivalent linker (L), and a drug. The vitamin receptor binding moiety includes vitamins, and vitamin receptor binding analogs and derivatives thereof, and the drug includes analogs and derivatives thereof. The vitamin receptor binding moiety is covalently linked to the bivalent linker, and the drug, or the analog or the derivative thereof, is covalently linked to the bivalent linker, wherein the bivalent linker (L) includes components such as spacer linkers, releasable linkers, and heteroatom linkers, and combinations thereof. Methods and pharmaceutical compositions for eliminating pathogenic cell populations using the drug delivery conjugate are also described.
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公开(公告)号：US20090203889A1
公开(公告)日：2009-08-13
申请号：US11632895
申请日：2005-07-22
Applicant: Iontcho Radoslavov Vlahov , Christopher Paul Leamon , Apparao Satyam , Stephen J. Howard
IPC: C07D401/12 , C07D213/71 , C07H15/24
CPC classification number: C07D213/71 , A61K47/551 , A61K47/6803 , A61K49/0002 , C07D401/12 , C07D475/04
Abstract: Bivalent linkers derived from compounds of formulae (V), (VI), and (VII), where X1 and X2 are leaving groups and the other variables are as defined in the claims, to be included in or for preparing vitamin, drug, diagnostic agent, and/or imaging agent conjugates are described.
Abstract translation: 衍生自式（V），（VI）和（VII）的化合物的二价连接体，其中X1和X2是离去基团，其它变量如权利要求中所定义，被包括在维生素，药物，诊断中 试剂和/或成像剂共轭物。
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Patent Agency Ranking
公开(公告)号：US20060205674A2
公开(公告)日：2006-09-14
申请号：US11213396
申请日：2005-08-26
Applicant: Apparao Satyam
Inventor： Apparao Satyam
IPC: A61K38/04 , A61K31/7072 , A61K31/455 , A61K31/53 , A61K31/4172 , A61K31/4178 , A61K31/337 , A61K31/21
CPC classification number: C07D305/14 , A61K47/55 , A61K47/551 , A61K47/555 , A61K47/60 , A61K47/61 , C07C323/12 , C07C323/25 , C07C323/41 , C07C323/42 , C07C2601/14 , C07D207/26 , C07D211/22 , C07D211/90 , C07D213/82 , C07D233/91 , C07D253/075 , C07D261/08 , C07D295/088 , C07D401/12 , C07D401/14 , C07D405/12 , C07D411/14 , C07D413/12 , C07D495/04
Abstract: Abstract of the DisclosureThe invention provides the compounds of formula (I) or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutical compositions comprising one or more compounds of formula I or intermediates thereof and one or more of pharmaceutically acceptable carriers, vehicles or diluents. The invention further provides methods of preparation and methods of use of prodrugs including NO-releasing prodrugs, double prodrugs and mutual prodrugs comprising the compounds of formula I.
Abstract translation: 发明摘要本发明提供式（I）化合物或其药学上可接受的盐。 本发明还提供包含一种或多种式I化合物或其中间体以及一种或多种药学上可接受的载体，载体或稀释剂的药物组合物。 本发明还提供了制备方法和使用前药的方法，包括释放NO的前药，双前药和包含式I化合物的共价前药。
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公开(公告)号：US09844599B2
公开(公告)日：2017-12-19
申请号：US14761887
申请日：2014-01-17
Applicant: Apparao Satyam
Inventor： Apparao Satyam
IPC: A61K31/21 , A61K31/60 , C07D201/04 , A61K47/48 , C07C229/42 , C07C201/04 , C07C227/18 , A61K31/216 , A61K31/621 , C07C203/04
CPC classification number: A61K47/542 , A61K31/21 , A61K31/216 , A61K31/60 , A61K47/55 , C07C201/04 , C07C203/04 , C07C227/18 , C07C229/42
Abstract: The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents wherein the drug or therapeutic agents contain at least one carboxylic acid group. The invention also relates to processes for the preparation of these nitric oxide releasing prodrugs, to pharmaceutical compositions containing them and to methods of using these produgs.
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公开(公告)号：US20150328323A1
公开(公告)日：2015-11-19
申请号：US14761887
申请日：2014-01-17
Applicant: Apparao SATYAM
Inventor： Apparao Satyam
IPC: A61K47/48 , C07C229/42 , C07C227/18 , A61K31/621 , A61K31/216 , C07C201/04 , C07C203/04 , A61K45/06
CPC classification number: A61K47/542 , A61K31/21 , A61K31/216 , A61K31/60 , A61K47/55 , C07C201/04 , C07C203/04 , C07C227/18 , C07C229/42
Abstract: The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents wherein the drug or therapeutic agents contain at least one carboxylic acid group. The invention also relates to processes for the preparation of these nitric oxide releasing prodrugs, to pharmaceutical compositions containing them and to methods of using these produgs.
Abstract translation: 本发明涉及已知药物或治疗剂的一氧化氮释放前药，其中药物或治疗剂含有至少一个羧酸基团。 本发明还涉及制备这些一氧化氮释放前体药物的方法，含有它们的药物组合物以及使用这些产品的方法。
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公开(公告)号：US08357723B2
公开(公告)日：2013-01-22
申请号：US12977929
申请日：2010-12-23
Applicant: Apparao Satyam
Inventor： Apparao Satyam
IPC: A61K31/105 , C07C323/12
CPC classification number: C07D305/14 , A61K47/55 , A61K47/551 , A61K47/555 , A61K47/60 , A61K47/61 , C07C323/12 , C07C323/25 , C07C323/41 , C07C323/42 , C07C2601/14 , C07D207/26 , C07D211/22 , C07D211/90 , C07D213/82 , C07D233/91 , C07D253/075 , C07D261/08 , C07D295/088 , C07D401/12 , C07D401/14 , C07D405/12 , C07D411/14 , C07D413/12 , C07D495/04
Abstract: The invention provides the compounds of formula (I) or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutical compositions comprising one or more compounds of formula I or intermediates thereof and one more of pharmaceutically acceptable carriers, vehicles or diluents. The invention further provides methods of preparation and methods of use of prodrugs including NO-releasing prodrugs, double prodrugs and mutual prodrugs comprising the compounds of formula I.
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公开(公告)号：US08288557B2
公开(公告)日：2012-10-16
申请号：US11632895
申请日：2005-07-22
Applicant: Iontcho Radoslavov Vlahov , Christopher Paul Leamon , Apparao Satyam , Stephen J. Howard
IPC: C07D213/64 , C07D249/18
CPC classification number: C07D213/71 , A61K47/551 , A61K47/6803 , A61K49/0002 , C07D401/12 , C07D475/04
Abstract: Bivalent linkers derived from compounds of formulae (V), (VI), and (VII), where X1 and X2 are leaving groups and the other variables are as defined in the claims, to be included in or for preparing vitamin, drug, diagnostic agent, and/or imaging agent conjugates are described.
Abstract translation: 衍生自式（V），（VI）和（VII）的化合物的二价连接体，其中X1和X2是离去基团，其它变量如权利要求中所定义，被包括在维生素，药物，诊断中 试剂和/或成像剂共轭物。
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