公开(公告)号：US20230389855A1

公开(公告)日：2023-12-07

申请号：US18451100

申请日：2023-08-17

申请人： Applied Cognition, Inc.

发明人： Paul Dagum ,  Gregory T.A. Kovacs ,  Laurent B. Giovangrandi ,  Carl J. Weber ,  Joerg C. Student ,  Nathan Whipple ,  Jonathan I. Kaplan

IPC分类号： A61B5/00 ,  A61B5/372 ,  A61B5/0205

CPC分类号： A61B5/4088 ,  A61B5/372 ,  A61B5/0006 ,  A61B5/6817 ,  A61B5/0205 ,  A61B5/418 ,  A61B5/7275 ,  A61B2562/166

摘要： A computer-implemented method and system includes accessing neurophysiological and neurovascular data recorded during sleep. A function mapping is executed from said neurophysiological and neurovascular data to a target that is one of a glymphatic flow marker, a molecular analysis marker of neurodegeneration, or a neuroimaging marker of neurodegeneration. A target prediction model is output based on the function mapping. The target prediction model can receive new neurophysiological and neurovascular data and output a predicted marker of neurodegeneration.

公开(公告)号：US20240268748A1

公开(公告)日：2024-08-15

申请号：US18636234

申请日：2024-04-15

申请人： Applied Cognition, Inc.

发明人： Paul Dagum ,  Gregory T.A. Kovacs ,  Laurent B. Giovangrandi ,  Carl J. Weber ,  Joerg C. Student ,  Nathan Whipple ,  Jonathan I. Kaplan

IPC分类号： A61B5/00 ,  A61B5/0205 ,  A61B5/372

CPC分类号： A61B5/4088 ,  A61B5/0006 ,  A61B5/0205 ,  A61B5/372 ,  A61B5/418 ,  A61B5/6817 ,  A61B5/7275 ,  A61B2562/166

摘要： A computer-implemented method and system includes accessing neurophysiological and neurovascular data recorded during sleep. A function mapping is executed from said neurophysiological and neurovascular data to a target that is one of a glymphatic flow marker, a molecular analysis marker of neurodegeneration, or a neuroimaging marker of neurodegeneration. A target prediction model is output based on the function mapping. The target prediction model can receive new neurophysiological and neurovascular data and output a predicted marker of neurodegeneration.

公开(公告)号：US20240225522A9

公开(公告)日：2024-07-11

申请号：US18185365

申请日：2023-03-16

申请人： Applied Cognition, Inc.

发明人： Paul Dagum ,  Laurent B. Giovangrandi

IPC分类号： A61B5/00 ,  A61M21/02 ,  A61N1/05

CPC分类号： A61B5/6817 ,  A61B5/4088 ,  A61M21/02 ,  A61N1/0541

摘要： A computer-implemented method and system includes a head-mounted wearable device with two current electrodes that provide input alternating currents over a range of frequencies to a subject during at least one intervention. The head-mounted wearable device includes at least two sense electrodes that collect voltage difference measurements in response to the input alternating currents. A measurement validation module applies a Hilbert transform or a Kramer-Kronig test to the voltage difference measurements to generate validated time-series impedance spectra. A cranial fluid dynamics module fits the validated time-series impedance spectra to an electrical circuit model to determine a glymphatic flow response to the at least one intervention.

公开(公告)号：US20240130664A1

公开(公告)日：2024-04-25

申请号：US18492775

申请日：2023-10-22

申请人： Applied Cognition, Inc.

发明人： Paul Dagum ,  Laurent B. Giovangrandi

IPC分类号： A61B5/00 ,  A61B5/0536 ,  A61B5/256

CPC分类号： A61B5/4064 ,  A61B5/0536 ,  A61B5/256 ,  A61B5/4088 ,  A61B5/6814

摘要： A computer-implemented method and system includes accessing neurophysiological and neurovascular data recorded during sleep. A device mounted on a subject's head during sleep can gather neurovascular data by measuring transcranial impedance. The device can be in the form of a single band, multiple bands, or a headcap that are worn on the subject's head. Electrodes located along an inner surface of the wearable device contact the subject's head and measure transcranial impedance. Transcranial impedance measurements are gathered from multiple locations on the subject's head and over multiple frequencies to obtain a more complete assessment of glymphatic flow.

公开(公告)号：US20240285224A1

公开(公告)日：2024-08-29

申请号：US18654877

申请日：2024-05-03

申请人： Applied Cognition, Inc.

发明人： Paul Dagum ,  Laurent B. Giovangrandi

IPC分类号： A61B5/00 ,  A61B5/0536 ,  A61B5/256 ,  A61M21/02 ,  A61N1/05

CPC分类号： A61B5/4064 ,  A61B5/0536 ,  A61B5/256 ,  A61B5/4088 ,  A61B5/6814 ,  A61B5/6817 ,  A61M21/02 ,  A61N1/0541

摘要： A computer-implemented method and system includes a head-mounted wearable device with two current electrodes that provide input alternating currents over a range of frequencies to a subject during at least one intervention. The head-mounted wearable device includes at least two sense electrodes that collect voltage difference measurements in response to the input alternating currents. A measurement validation module applies a Hilbert transform or a Kramer-Kronig test to the voltage difference measurements to generate validated time-series impedance spectra. A cranial fluid dynamics module fits the validated time-series impedance spectra to an electrical circuit model to determine a glymphatic flow response to the at least one intervention.

公开(公告)号：US12004874B2

公开(公告)日：2024-06-11

申请号：US18185365

申请日：2023-03-16

申请人： Applied Cognition, Inc.

发明人： Paul Dagum ,  Laurent B. Giovangrandi

IPC分类号： A61M21/02 ,  A61B5/00 ,  A61N1/05

CPC分类号： A61B5/6817 ,  A61B5/4088 ,  A61M21/02 ,  A61N1/0541

摘要： A computer-implemented method and system includes a head-mounted wearable device with two current electrodes that provide input alternating currents over a range of frequencies to a subject during at least one intervention. The head-mounted wearable device includes at least two sense electrodes that collect voltage difference measurements in response to the input alternating currents. A measurement validation module applies a Hilbert transform or a Kramer-Kronig test to the voltage difference measurements to generate validated time-series impedance spectra. A cranial fluid dynamics module fits the validated time-series impedance spectra to an electrical circuit model to determine a glymphatic flow response to the at least one intervention.

公开(公告)号：US11759142B2

公开(公告)日：2023-09-19

申请号：US17937952

申请日：2022-10-04

申请人： Applied Cognition, Inc.

发明人： Paul Dagum ,  Gregory T. A. Kovacs ,  Laurent B. Giovangrandi ,  Carl J. Weber ,  Joerg C. Student ,  Nathan Whipple ,  Jonathan I. Kaplan

IPC分类号： A61B5/00 ,  A61B5/372 ,  A61B5/0205

CPC分类号： A61B5/4088 ,  A61B5/0006 ,  A61B5/0205 ,  A61B5/372 ,  A61B5/418 ,  A61B5/6817 ,  A61B5/7275 ,  A61B2562/166

摘要： A computer-implemented method and system includes accessing neurophysiological and neurovascular data recorded during sleep. A function mapping is executed from said neurophysiological and neurovascular data to a target that is one of a glymphatic flow marker, a molecular analysis marker of neurodegeneration, or a neuroimaging marker of neurodegeneration. A target prediction model is output based on the function mapping. The target prediction model can receive new neurophysiological and neurovascular data and output a predicted marker of neurodegeneration.

公开(公告)号：US20240225523A9

公开(公告)日：2024-07-11

申请号：US18492775

申请日：2023-10-23

申请人： Applied Cognition, Inc.

发明人： Paul Dagum ,  Laurent B. Giovangrandi

IPC分类号： A61B5/00 ,  A61B5/0536 ,  A61B5/256

CPC分类号： A61B5/4064 ,  A61B5/0536 ,  A61B5/256 ,  A61B5/4088 ,  A61B5/6814

摘要： A computer-implemented method and system includes accessing neurophysiological and neurovascular data recorded during sleep. A device mounted on a subject's head during sleep can gather neurovascular data by measuring transcranial impedance. The device can be in the form of a single band, multiple bands, or a headcap that are worn on the subject's head. Electrodes located along an inner surface of the wearable device contact the subject's head and measure transcranial impedance. Transcranial impedance measurements are gathered from multiple locations on the subject's head and over multiple frequencies to obtain a more complete assessment of glymphatic flow.

公开(公告)号：US20240130680A1

公开(公告)日：2024-04-25

申请号：US18185365

申请日：2023-03-15

申请人： Applied Cognition, Inc.

发明人： Paul Dagum ,  Laurent B. Giovangrandi

IPC分类号： A61B5/00 ,  A61M21/02 ,  A61N1/05

CPC分类号： A61B5/6817 ,  A61B5/4088 ,  A61M21/02 ,  A61N1/0541

摘要： A computer-implemented method and system includes a head-mounted wearable device with two current electrodes that provide input alternating currents over a range of frequencies to a subject during at least one intervention. The head-mounted wearable device includes at least two sense electrodes that collect voltage difference measurements in response to the input alternating currents. A measurement validation module applies a Hilbert transform or a Kramer-Kronig test to the voltage difference measurements to generate validated time-series impedance spectra. A cranial fluid dynamics module fits the validated time-series impedance spectra to an electrical circuit model to determine a glymphatic flow response to the at least one intervention.

公开(公告)号：US20230080140A1

公开(公告)日：2023-03-16

申请号：US17937952

申请日：2022-10-04

申请人： Applied Cognition, Inc.

发明人： Paul Dagum ,  Gregory T.A. Kovacs ,  Laurent B. Giovangrandi ,  Carl J. Weber ,  Joerg C. Student ,  Nathan Whipple ,  Jonathan I. Kaplan

IPC分类号： A61B5/00 ,  A61B5/0205 ,  A61B5/372

摘要： A computer-implemented method and system includes accessing neurophysiological and neurovascular data recorded during sleep. A function mapping is executed from said neurophysiological and neurovascular data to a target that is one of a glymphatic flow marker, a molecular analysis marker of neurodegeneration, or a neuroimaging marker of neurodegeneration. A target prediction model is output based on the function mapping. The target prediction model can receive new neurophysiological and neurovascular data and output a predicted marker of neurodegeneration.