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![7H-PYRROLO[2,3-H]QUINAZOLINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS](/abs-image/US/2009/09/10/US20090227575A1/abs.jpg.150x150.jpg)
1.发明申请7H-PYRROLO[2,3-H]QUINAZOLINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS 审中-公开7H-PYRROO [2,3-H]喹唑啉化合物，它们作为mTOR激酶和PI3激酶抑制剂使用，以及它们的合成公开(公告)号：US20090227575A1
公开(公告)日：2009-09-10
申请号：US12397590
申请日：2009-03-04
申请人： Aranapakam Mudumbai Venkatesan , Zecheng Chen , Osvaldo Dos Santos , Natasja Brooijmans , Ariamala Gopalsamy
发明人： Aranapakam Mudumbai Venkatesan , Zecheng Chen , Osvaldo Dos Santos , Natasja Brooijmans , Ariamala Gopalsamy
IPC分类号： A61K31/5377 , C07D487/04 , A61P35/00
CPC分类号： C07D487/04
摘要： A 7H-pyrrolo[2,3-h]quinazoline compound of the formula I wherein Ar, R1, R2, R7, R8, R9, R10, R11, R12, and n are as defined in the specification, and methods for making same.
摘要翻译： 其中Ar，R 1，R 2，R 7，R 8，R 9，R 10，R 11，R 12和n如说明书中所定义的式I的7H-吡咯并[2,3-h]喹唑啉化合物及其制备方法 。
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![3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES](/abs-image/US/2009/07/16/US20090181963A1/abs.jpg.150x150.jpg)
2.发明申请3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES 审中-公开3H- [1,2,3]三唑[4,5-D]吡嗪化合物，它们作为mTOR激酶和PI3激酶抑制剂使用，以及它们的合成公开(公告)号：US20090181963A1
公开(公告)日：2009-07-16
申请号：US12354027
申请日：2009-01-15
申请人： Christoph Martin Dehnhardt , Aranapakam Mudumbai Venkatesan , Efren Guillermo Delos Santos , Zecheng Chen , Osvaldo Dos Santos , Natasja Brooijmans , Arie Zask , Jeroen Cunera Verheijen , Semiramis Ayral-Kaloustian
发明人： Christoph Martin Dehnhardt , Aranapakam Mudumbai Venkatesan , Efren Guillermo Delos Santos , Zecheng Chen , Osvaldo Dos Santos , Natasja Brooijmans , Arie Zask , Jeroen Cunera Verheijen , Semiramis Ayral-Kaloustian
IPC分类号： A61K31/5377 , C07D413/14 , A61P35/00
CPC分类号： C07D487/04
摘要： The invention relates to 3H-[1,2,3]triazolo[4,5-d]pyrimidine compounds of the Formula 1: or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.
摘要翻译： 本发明涉及式1的3H- [1,2,3]三唑并[4,5-d]嘧啶化合物或其药学上可接受的盐，其中组分变量如本文所定义，包含该化合物的组合物和 制备和使用化合物的方法。
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3.发明申请IMIDAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS PI3 KINASE AND MTOR INHIBITORS 审中-公开咪唑吡嗪类似物及其作为PI3激酶和MT抑制剂的用途公开(公告)号：US20080233127A1
公开(公告)日：2008-09-25
申请号：US12044500
申请日：2008-03-07
申请人： Matthew Gregory Bursavich , Aranapakam Mudumbai Venkatesan , Pawel Wojciech Nowak , Sabrina Lombardi , Adam Matthew Gilbert , Christoph Martin Denhardt , Osvaldo Dos Santos , Efren Guillermo Delos Santos , Natasja Brooijmans , Semiramis Ayral-Kaloustian , Zecheng Chen , Jeroen Cunera Verheijen , Joshua Kaplan , Arie Zask
发明人： Matthew Gregory Bursavich , Aranapakam Mudumbai Venkatesan , Pawel Wojciech Nowak , Sabrina Lombardi , Adam Matthew Gilbert , Christoph Martin Denhardt , Osvaldo Dos Santos , Efren Guillermo Delos Santos , Natasja Brooijmans , Semiramis Ayral-Kaloustian , Zecheng Chen , Jeroen Cunera Verheijen , Joshua Kaplan , Arie Zask
IPC分类号： A61K39/395 , C07D473/00 , A61K31/5377 , A61P35/04 , A61P3/00 , A61P1/00 , A61P29/00 , A61P19/00 , A61K31/52
CPC分类号： C07D473/34
摘要： The present invention relates to Imidazolopyrimidine Analogs, methods of making Imidazolopyrimidine Analogs, compositions comprising an Imidazolopyrimidine Analog, and methods for treating or preventing a PI3K-related disorder comprising administering to a subject in need thereof an effective amount of an Imidazolopyrimidine Analog. The invention also relates to methods for treating or preventing mTOR-related disorders comprising administering to a subject in need thereof an effective amount of an Imidazolopyrimidine Analog.
摘要翻译： 本发明涉及咪唑并嘧啶类似物，制备咪唑并嘧啶类似物的方法，包含咪唑并嘧啶类似物的组合物，以及用于治疗或预防PI3K相关病症的方法，其包括向有需要的受试者施用有效量的咪唑并嘧啶类似物。 本发明还涉及治疗或预防mTOR相关病症的方法，包括向有需要的受试者施用有效量的咪唑并嘧啶类似物。
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4.发明申请3-SUBSTITUTED-1H-INDOLE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES 审中-公开3-取代的1H-吲哚化合物，它们作为MTOR激酶和PI3激酶抑制剂使用，以及它们的合成公开(公告)号：US20090311217A1
公开(公告)日：2009-12-17
申请号：US12473605
申请日：2009-05-28
申请人： Matthew Gregory Bursavich , Nan Zhang , Semiramis Ayral-Kaloustian , James Thomas Anderson , Thai Hiep Nguyen , Sabrina Lombardi , David Malwitz , Natasja Brooijmans , Derek Cecil Cole , Adam Matthew Gilbert , Pawel Wojciech Nowak , Kaapjoo Park , Sasmita Das , Hwei-Ru Tsou , Aranapakam Mudumbai Venkatesan , Mercy Adufa Otteng , Gary Harold Birnberg , Gloria Jean MacEwan
发明人： Matthew Gregory Bursavich , Nan Zhang , Semiramis Ayral-Kaloustian , James Thomas Anderson , Thai Hiep Nguyen , Sabrina Lombardi , David Malwitz , Natasja Brooijmans , Derek Cecil Cole , Adam Matthew Gilbert , Pawel Wojciech Nowak , Kaapjoo Park , Sasmita Das , Hwei-Ru Tsou , Aranapakam Mudumbai Venkatesan , Mercy Adufa Otteng , Gary Harold Birnberg , Gloria Jean MacEwan
IPC分类号： A61K31/404 , C07D405/02 , C07D403/14 , C07D413/02 , A61K31/496 , A61K31/5377 , A61K38/21 , A61K39/395 , A61P35/00
CPC分类号： C07D405/14 , C07D405/06
摘要： The invention relates to 3-substituted-1H-indole compounds of the Formula I: or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.
摘要翻译： 本发明涉及式I的3-取代-1H-吲哚化合物或其药学上可接受的盐，其中组分变量如本文所定义，包含该化合物的组合物，以及制备和使用该化合物的方法。
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公开(公告)号：US20140088100A1
公开(公告)日：2014-03-27
申请号：US13939967
申请日：2013-07-11
申请人： Neil Bifulco, JR. , Natasja Brooijmans , Brian L. Hodous , Joseph L. Kim , Chandrasekhar V. Miduturu
发明人： Neil Bifulco, JR. , Natasja Brooijmans , Brian L. Hodous , Joseph L. Kim , Chandrasekhar V. Miduturu
IPC分类号： C07D487/04 , C07D295/155 , C07D475/00 , C07D239/84 , C07D471/04
CPC分类号： C07K14/71 , A61K31/4375 , A61K31/517 , A61K31/519 , C07D239/42 , C07D239/84 , C07D295/155 , C07D401/04 , C07D471/04 , C07D475/00 , C07D475/04 , C07D487/04
摘要： Described herein are inhibitors of FGFR, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions to inhibit the activity of tyrosine kinases.
摘要翻译： 本文描述的是FGFR的抑制剂，包括这些化合物的药物组合物，以及使用这些化合物和组合物抑制酪氨酸激酶活性的方法。
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![4-PHENOXY-6-ARYL-1H-PYRAZOLO[3,4-D]PYRIMIDINE AND N-ARYL-6-ARYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES](/abs-image/US/2010/01/21/US20100015141A1/abs.jpg.150x150.jpg)
6.发明申请4-PHENOXY-6-ARYL-1H-PYRAZOLO[3,4-D]PYRIMIDINE AND N-ARYL-6-ARYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES 审中-公开4-苯基-6-芳基-1H-吡唑并[3,4-D]吡嗪和N-芳基-6-芳基-1H-吡唑并[3,4-D]嘧啶-4-胺化合物，它们作为MTOR KINASE 和PI3激酶抑制剂及其合成公开(公告)号：US20100015141A1
公开(公告)日：2010-01-21
申请号：US12506291
申请日：2009-07-21
申请人： Matthew Gregory Bursavich , Pawel Wojciech Nowak , David Malwitz , Sabrina Lombardi , Adam Matthew Gilbert , Nan Zhang , Semiramis Ayral-Kaloustian , James Thomas Anderson , Natasja Brooijmans
发明人： Matthew Gregory Bursavich , Pawel Wojciech Nowak , David Malwitz , Sabrina Lombardi , Adam Matthew Gilbert , Nan Zhang , Semiramis Ayral-Kaloustian , James Thomas Anderson , Natasja Brooijmans
IPC分类号： A61K31/519 , C07D487/04 , A61K39/395 , A61P35/00
CPC分类号： C07D487/04
摘要： The invention relates to 4,6-disubstituted-1H-pyrazolo[3,4-d]pyrimidin-4-amine compounds, including 4-phenoxy-6-aryl-1H-pyrazolo[3,4-d]pyrimidine and N-aryl-6-aryl-1H-pyrazolo[3,4-d]pyrimidin-4-amine compounds of the Formula I: or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.
摘要翻译： 本发明涉及4,6-二取代-1H-吡唑并[3,4-d]嘧啶-4-胺化合物，包括4-苯氧基-6-芳基-1H-吡唑并[3,4-d]嘧啶和N- 芳基-6-芳基-1H-吡唑并[3,4-d]嘧啶-4-胺化合物或其药学上可接受的盐，其中组成变量如本文所定义，包含该化合物的组合物和方法 用于制造和使用这些化合物。
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公开(公告)号：US20150210694A1
公开(公告)日：2015-07-30
申请号：US14677162
申请日：2015-04-02
申请人： Neil Bifulco, JR. , Natasja Brooijmans , Brian L. Hodous , Joseph L. Kim , Chandrasekhar V. Miduturu
发明人： Neil Bifulco, JR. , Natasja Brooijmans , Brian L. Hodous , Joseph L. Kim , Chandrasekhar V. Miduturu
IPC分类号： C07D475/00 , C07D401/04 , C07D239/42 , C07D239/84 , C07D471/04
CPC分类号： C07K14/71 , A61K31/4375 , A61K31/517 , A61K31/519 , C07D239/42 , C07D239/84 , C07D295/155 , C07D401/04 , C07D471/04 , C07D475/00 , C07D475/04 , C07D487/04
摘要： Described herein are inhibitors of FGFR, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions to inhibit the activity of tyrosine kinases.
摘要翻译： 本文描述的是FGFR的抑制剂，包括这些化合物的药物组合物，以及使用这些化合物和组合物抑制酪氨酸激酶活性的方法。
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公开(公告)号：US20140378481A1
公开(公告)日：2014-12-25
申请号：US14318149
申请日：2014-06-27
申请人： Neil Bifulco, JR. , Natasja Brooijmans , Brian L. Hodous , Joseph L. Kim , Chandrasekhar V. Miduturu
发明人： Neil Bifulco, JR. , Natasja Brooijmans , Brian L. Hodous , Joseph L. Kim , Chandrasekhar V. Miduturu
IPC分类号： C07D239/84 , A61K31/4375 , A61K31/519 , A61K31/517 , C07D471/04
CPC分类号： C07K14/71 , A61K31/4375 , A61K31/517 , A61K31/519 , C07D239/42 , C07D239/84 , C07D295/155 , C07D401/04 , C07D471/04 , C07D475/00 , C07D475/04 , C07D487/04
摘要： Described herein are inhibitors of FGFR, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions to inhibit the activity of tyrosine kinases.
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公开(公告)号：US08802697B2
公开(公告)日：2014-08-12
申请号：US13939967
申请日：2013-07-11
申请人： Neil Bifulco, Jr. , Natasja Brooijmans , Brian L. Hodous , Joseph L. Kim , Chandrasekhar V. Miduturu
发明人： Neil Bifulco, Jr. , Natasja Brooijmans , Brian L. Hodous , Joseph L. Kim , Chandrasekhar V. Miduturu
IPC分类号： A01N43/42 , A61K31/44 , C07D487/04 , C07D239/84 , C07D475/00 , C07D239/42 , C07D295/155 , C07D471/04
CPC分类号： C07K14/71 , A61K31/4375 , A61K31/517 , A61K31/519 , C07D239/42 , C07D239/84 , C07D295/155 , C07D401/04 , C07D471/04 , C07D475/00 , C07D475/04 , C07D487/04
摘要： Described herein are inhibitors of FGFR, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions to inhibit the activity of tyrosine kinases.
摘要翻译： 本文描述的是FGFR的抑制剂，包括这些化合物的药物组合物，以及使用这些化合物和组合物抑制酪氨酸激酶活性的方法。
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公开(公告)号：US09126951B2
公开(公告)日：2015-09-08
申请号：US14318149
申请日：2014-06-27
申请人： Neil Bifulco, Jr. , Natasja Brooijmans , Brian L. Hodous , Joseph L. Kim , Chandrasekhar V. Miduturu
发明人： Neil Bifulco, Jr. , Natasja Brooijmans , Brian L. Hodous , Joseph L. Kim , Chandrasekhar V. Miduturu
IPC分类号： A61K31/4375 , C07D239/84 , C07D239/42 , C07D471/04 , C07D475/00 , C07D487/04 , A61K31/517 , A61K31/519
CPC分类号： C07K14/71 , A61K31/4375 , A61K31/517 , A61K31/519 , C07D239/42 , C07D239/84 , C07D295/155 , C07D401/04 , C07D471/04 , C07D475/00 , C07D475/04 , C07D487/04
摘要： Described herein are inhibitors of FGFR, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions to inhibit the activity of tyrosine kinases.
摘要翻译： 本文描述的是FGFR的抑制剂，包括这些化合物的药物组合物，以及使用这些化合物和组合物抑制酪氨酸激酶活性的方法。
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