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公开(公告)号:US08771726B2
公开(公告)日:2014-07-08
申请号:US12310167
申请日:2007-07-06
IPC分类号: A61F13/02 , A61F13/00 , A61K31/135 , A61K9/00 , A61K31/137 , A61K47/26 , A61K47/12 , A61K47/14 , A61K47/32
CPC分类号: A61K31/137 , A61K9/0014 , A61K47/12 , A61K47/14 , A61K47/26 , A61K47/32
摘要: The present subject matter provides a nail patch comprising a backing layer and a pressure-sensitive adhesive layer disposed on at least one side of the backing layer, wherein the pressure-sensitive adhesive layer comprises a pressure-sensitive adhesive base, terbinafine and/or a pharmacologically acceptable salt thereof, and sodium acetate and/or sorbitan monolaurate as a solubilizer.
摘要翻译: 本发明提供一种指甲贴,其包括背衬层和设置在背衬层的至少一侧上的压敏粘合剂层,其中该压敏粘合剂层包含压敏粘合剂基质,特比萘芬和/或 其药学上可接受的盐,和乙酸钠和/或脱水山梨糖醇单月桂酸酯作为增溶剂。
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公开(公告)号:US20090324696A1
公开(公告)日:2009-12-31
申请号:US12310167
申请日:2007-07-06
IPC分类号: A61F13/02 , A61K31/135
CPC分类号: A61K31/137 , A61K9/0014 , A61K47/12 , A61K47/14 , A61K47/26 , A61K47/32
摘要: The present subject matter provides a nail patch comprising a backing layer and a pressure-sensitive adhesive layer disposed on at least one side of the backing layer, wherein the pressure-sensitive adhesive layer comprises a pressure-sensitive adhesive base, terbinafine and/or a pharmacologically acceptable salt thereof, and sodium acetate and/or sorbitan monolaurate as a solubilizer.
摘要翻译: 本发明提供一种指甲贴,其包括背衬层和设置在背衬层的至少一侧上的压敏粘合剂层,其中该压敏粘合剂层包含压敏粘合剂基质,特比萘芬和/或 其药学上可接受的盐,和乙酸钠和/或脱水山梨糖醇单月桂酸酯作为增溶剂。
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公开(公告)号:US08574621B2
公开(公告)日:2013-11-05
申请号:US13577110
申请日:2011-02-07
申请人: Arata Toshimitsu , Naoko Fujita , Toshihiro Kogure
发明人: Arata Toshimitsu , Naoko Fujita , Toshihiro Kogure
IPC分类号: A61F13/02 , A61K31/135
CPC分类号: A61K9/70 , A61K9/0014 , A61K31/137
摘要: The present invention provides an adhesive patch for the treatment of tinea unguium intended to be applied once a day, comprising terbinafine and/or a pharmacologically acceptable salt thereof in an amount of 3 mg/cm2, wherein the adhesive patch is used so that the terbinafine concentration in nails may be 295±127 ng/mg and the terbinafine concentration in plasma may be 23 pg/mL or less, 8 weeks after the start of application, per cm2 of the patch size.
摘要翻译: 本发明提供了一种用于治疗意图每天一次施用的癣的粘合剂贴剂,其包含3mg / cm 2的特比萘芬和/或其药理学上可接受的盐,其中使用粘合剂片剂使得特比萘芬 钉子中的浓度可以为295±127ng / mg,并且在施用开始后8周,每平方厘米的贴片尺寸,血浆中特比萘芬浓度可以为23pg / mL或更少。
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公开(公告)号:US20120302644A1
公开(公告)日:2012-11-29
申请号:US13577110
申请日:2011-02-07
申请人: Arata Toshimitsu , Naoko Fujita , Toshihiro Kogure
发明人: Arata Toshimitsu , Naoko Fujita , Toshihiro Kogure
IPC分类号: A61K31/137 , A61P31/10
CPC分类号: A61K9/70 , A61K9/0014 , A61K31/137
摘要: The present invention provides an adhesive patch for the treatment of tinea unguium intended to be applied once a day, comprising terbinafine and/or a pharmacologically acceptable salt thereof in an amount of 3 mg/cm2, wherein the adhesive patch is used so that the terbinafine concentration in nails may be 295±127 ng/mg and the terbinafine concentration in plasma may be 23 pg/mL or less, 8 weeks after the start of application, per cm2 of the patch size.
摘要翻译: 本发明提供了一种用于治疗意图每天一次施用的癣的粘合剂贴剂,其包含3mg / cm 2的特比萘芬和/或其药理学上可接受的盐,其中使用粘合剂片剂使得特比萘芬 钉子中的浓度可以为295±127ng / mg,并且在施用开始后8周,每平方厘米的贴片尺寸,血浆中特比萘芬浓度可以为23pg / mL或更少。
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公开(公告)号:US08691267B2
公开(公告)日:2014-04-08
申请号:US10525646
申请日:2003-08-07
CPC分类号: A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/405 , A61K31/4422 , A61K31/48
摘要: A patch comprising a backing layer and an adhesive layer disposed on the backing layer and compounded with a drug and an adhesive base agent, wherein the adhesive base agent comprises styrene-isoprene-styrene block copolymer, 2-ethylhexyl acrylate-vinyl acetate copolymer and a basic nitrogen-including polymer including a basic nitrogen and having no adhesion property at normal temperature.
摘要翻译: 一种贴剂,包括背衬层和设置在背衬层上并与药物和粘合剂基剂复配的粘合剂层,其中所述粘合剂基剂包括苯乙烯 - 异戊二烯 - 苯乙烯嵌段共聚物,丙烯酸2-乙基己酯 - 乙酸乙烯酯共聚物和 碱性含氮聚合物,包括碱性氮,并且在常温下不具有附着性。
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公开(公告)号:US20050260255A1
公开(公告)日:2005-11-24
申请号:US10525646
申请日:2003-08-07
IPC分类号: A61K9/70 , A61K31/405 , A61K31/4422 , A61K31/48 , A61K47/06 , A61K47/12 , A61K47/32
CPC分类号: A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/405 , A61K31/4422 , A61K31/48
摘要: A patch comprising a backing layer and an adhesive layer disposed on the backing layer and compounded with a drug and an adhesive base agent, wherein the adhesive base agent comprises styrene-isoprene-styrene block copolymer, 2-ethylhexyl acrylate—vinyl acetate copolymer and a basic nitrogen-including polymer including a basic nitrogen and having no adhesion property at normal temperature.
摘要翻译: 一种贴剂,包括背衬层和设置在背衬层上并与药物和粘合剂基剂复配的粘合剂层,其中所述粘合剂基剂包括苯乙烯 - 异戊二烯 - 苯乙烯嵌段共聚物,丙烯酸2-乙基己酯 - 乙酸乙烯酯共聚物和 碱性含氮聚合物,包括碱性氮,并且在常温下不具有附着性。
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公开(公告)号:US09370495B2
公开(公告)日:2016-06-21
申请号:US13580332
申请日:2011-02-24
申请人: Arata Toshimitsu , Naoko Fujita
发明人: Arata Toshimitsu , Naoko Fujita
CPC分类号: A61K9/7053 , A61K31/18
摘要: The present invention provides a patch having a backing and a pressure-sensitive adhesive layer on the backing, wherein the pressure-sensitive adhesive layer contains a pressure-sensitive adhesive base composed of a polymer having a hydroxyl group, a drug, polyvinylpyrrolidone and a multivalent metal chloride.
摘要翻译: 本发明提供了一种在背衬上具有背衬和压敏粘合剂层的贴片,其中压敏粘合剂层包含由具有羟基的聚合物,药物,聚乙烯吡咯烷酮和多价的聚合物组成的压敏粘合剂基底 金属氯化物。
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公开(公告)号:US20070190123A1
公开(公告)日:2007-08-16
申请号:US10587832
申请日:2005-01-31
IPC分类号: A61F13/02
CPC分类号: A61K9/7084 , A61F2013/00646 , A61L15/44 , A61L2300/40 , A61L2300/608
摘要: The present invention provides a cover material 10, adapted to be attached to skin in a manner covering over the entirety of a patch 20, comprising a pressure-sensitive adhesive layer 12 on one side of a support 11, wherein said patch 20 comprises a drug-containing layer 22 for contacting with the skin, said layer being provided on a support film 21 with a thickness of 12-30 μm, and wherein the cover material 10 is adapted to be attached to said support film 21 and a region of the skin around said patch 20 in such a manner that the pressure-sensitive adhesive layer 12 contacts with the edges of the drug-containing layer 22, and the pressure-sensitive adhesive layer 12 comprises a pressure-sensitive adhesive obtained by polymerizing vinyl acetate or N-vinyl-2-pyrrolidone and a (meth)acrylic acid alkyl ester with a C8 alkyl group as essential monomer components. According to the invention, it is possible to provide a cover material capable of reducing irritation to an affected area such as skin when a patch employing a drug such as pergolide mesylate is covered and affixed to the affected area.
摘要翻译: 本发明提供了一种覆盖材料10,其适于以覆盖整个贴片20的方式附着到皮肤上,其包括在支撑体11的一侧上的压敏粘合剂层12,其中所述贴片20包括药物 容纳层22,用于与皮肤接触,所述层设置在厚度为12-30μm的支撑膜21上,并且其中覆盖材料10适于附着到所述支撑膜21和皮肤区域 围绕所述贴片20,使得压敏粘合剂层12与药物含有层22的边缘接触,并且压敏粘合剂层12包含通过聚合乙酸乙烯酯或N-乙烯基缩水甘油酯获得的压敏粘合剂, 乙烯基-2-吡咯烷酮和具有C8烷基作为必需单体成分的(甲基)丙烯酸烷基酯。 根据本发明,可以提供一种覆盖材料,其能够在使用药物例如甲磺酸格列德里特的贴剂覆盖并固定在受影响的区域时能够减少对患部的皮肤的刺激。
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公开(公告)号:US20060110433A1
公开(公告)日:2006-05-25
申请号:US10526065
申请日:2003-08-07
CPC分类号: A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/48
摘要: A patch comprising a backing layer and an adhesive layer disposed on the backing layer and compounded with an adhesive base agent and pergolide and/or a pharmaceutically acceptable salt thereof, wherein the adhesive base agent comprises an acrylic polymer including no substantial carboxyl group and hydroxyl group and having self-adhesion properties and a rubber polymer, and the weight ratio of the content of the acrylic polymer to the content of the rubber polymer is from 1:1 to 1:9.
摘要翻译: 一种贴剂,其包括背衬层和设置在背衬层上并与粘合剂基剂和高氯代内酯和/或其药学上可接受的盐复合的粘合剂层,其中所述粘合剂基剂包含不含实质性羧基和羟基的丙烯酸聚合物 并且具有自粘性和橡胶聚合物,并且丙烯酸类聚合物的含量与橡胶聚合物的含量的重量比为1:1至1:9。
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公开(公告)号:US20130211353A1
公开(公告)日:2013-08-15
申请号:US13881829
申请日:2011-10-26
申请人: Arata Toshimitsu , Hisakazu Kurita
发明人: Arata Toshimitsu , Hisakazu Kurita
CPC分类号: A61K47/18 , A61K9/7038 , A61K31/4045 , A61K31/4174 , A61K47/14 , A61M35/00
摘要: Provided is a percutaneous absorption type formulation of a drug such as imidafenacin and silodosin, wherein stable absorption through the skin is realized. The percutaneous absorption type formulation containing a drug such as imidafenacin and silodosin further contains a transdermal absorption promoting agent, and fatty acid ester and/or fatty acid amide that further improve(s) the function of the transdermal absorption promoting agent.
摘要翻译: 本发明提供了药物如咪达那新和西洛多辛的经皮吸收型制剂,其中实现了通过皮肤的稳定吸收。 含有药物如咪达那新和西洛多辛的经皮吸收型制剂还含有透皮吸收促进剂,以及进一步改善透皮吸收促进剂功能的脂肪酸酯和/或脂肪酸酰胺。
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