公开(公告)号：US20240166598A1

公开(公告)日：2024-05-23

申请号：US18264109

申请日：2022-02-02

申请人： Arizona Board of Regents on Behalf of the University of Arizona ,  The Board of Trustees of the University of Illinois

发明人： Gregory R. Thatcher ,  Zhengnan Shen ,  Rui Xiong ,  Kiira Ratia ,  Lijun Rong ,  Laura Cooper

IPC分类号： C07D205/04 ,  A61K39/215 ,  A61K39/39 ,  A61K45/06 ,  A61P31/14 ,  C07C211/49 ,  C07C237/30 ,  C07D209/08 ,  C07D209/14 ,  C07D211/58 ,  C07D211/62 ,  C07D213/81 ,  C07D215/12 ,  C07D333/20 ,  C07D333/58 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12 ,  C07H19/067

CPC分类号： C07D205/04 ,  A61K39/215 ,  A61K39/39 ,  A61K45/06 ,  A61P31/14 ,  C07C211/49 ,  C07C237/30 ,  C07D209/08 ,  C07D209/14 ,  C07D211/58 ,  C07D211/62 ,  C07D213/81 ,  C07D215/12 ,  C07D333/20 ,  C07D333/58 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12 ,  C07H19/067

摘要： Provided herein are PLpro inhibitors and methods of treating and/or preventing an infection caused by a coronavirus by administration of one or more of said PLpro inhibitors to a subject in need thereof, as well as pharmaceutical formulations and kits for use in these methods.

公开(公告)号：US11787769B2

公开(公告)日：2023-10-17

申请号：US17735235

申请日：2022-05-03

申请人： Chicago Biosolutions, Inc. ,  The Board of Trustees of the University of Illinois

发明人： Lijun Rong ,  Irina Gaisina ,  Gregory R. Thatcher ,  Norton Peet

IPC分类号： C07D215/58 ,  A61P31/16 ,  A61K31/47 ,  A61K45/06

CPC分类号： C07D215/58 ,  A61K31/47 ,  A61K45/06 ,  A61P31/16

摘要： Vaccination is the most prevalent prophylactic means for controlling seasonal influenza infections. However, an effective vaccine usually takes at least 6 months to develop for the circulating strains. Therefore, new therapeutic options are needed for acute treatment of influenza infections to control this virus and prevent epidemic/pandemic situations from developing. Described herein are fast-acting, orally active acylated amino-substituted heterocyclyl compounds effective to control this virus. In one aspect, described herein is a method of treating an influenza infection in a subject comprising administering to the subject the compounds described herein.

公开(公告)号：US20220267275A1

公开(公告)日：2022-08-25

申请号：US17735235

申请日：2022-05-03

申请人： Chicago Biosolutions, Inc. ,  The Board of Trustees of the University of Illinois

发明人： Lijun Rong ,  Irina Gaisina ,  Gregory R. Thatcher ,  Norton Peet

IPC分类号： C07D215/58 ,  A61K31/47 ,  A61K45/06 ,  A61P31/16

摘要： Vaccination is the most prevalent prophylactic means for controlling seasonal influenza infections. However, an effective vaccine usually takes at least 6 months to develop for the circulating strains. Therefore, new therapeutic options are needed for acute treatment of influenza infections to control this virus and prevent epidemic/pandemic situations from developing. Described herein are fast-acting, orally active acylated amino-substituted heterocyclyl compounds effective to control this virus. In one aspect, described herein is a method of treating an influenza infection in a subject comprising administering to the subject the compounds described herein.

公开(公告)号：US20140357584A1

公开(公告)日：2014-12-04

申请号：US14235870

申请日：2012-07-27

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： Hongjie Zhang ,  Djaja Soejarto ,  Lijun Rong ,  Harry H.S. Fong ,  Emily Rumschlag-Booms

IPC分类号： C07H17/04

CPC分类号： C07H17/04 ,  C07D407/04

摘要： Provided herein are glycosidic aryl naphthalide lignans compounds, such as justiprocumin A isolated from the plant Justicia gendarussa Burm f. (Acanthaceae), which are effective in the treatment of AIDS and HIV infections.

摘要翻译： 本文提供糖苷芳基萘酚木酚素化合物，例如从植物Justicia gendarussa Burm f分离的justiprocumin A。 （Acanthaceae），其有效治疗艾滋病和艾滋病毒感染。