公开(公告)号：US20240254076A1

公开(公告)日：2024-08-01

申请号：US18557218

申请日：2022-04-26

申请人： Ohio State Innovation Foundation

发明人： Yizhou DONG ,  Chang WANG ,  Yuebao ZHANG ,  Yonger XUE

IPC分类号： C07C237/20 ,  A61K9/16 ,  A61K9/48 ,  A61K47/18 ,  A61K47/20 ,  A61K48/00 ,  C07C211/38 ,  C07C211/49 ,  C07C237/08 ,  C07C317/30 ,  C07D209/20 ,  C07D401/04 ,  C07D487/04

CPC分类号： C07C237/20 ,  A61K9/1617 ,  A61K9/4858 ,  A61K47/18 ,  A61K47/20 ,  A61K48/0008 ,  C07C211/38 ,  C07C211/49 ,  C07C237/08 ,  C07C317/30 ,  C07D209/20 ,  C07D401/04 ,  C07D487/04

摘要： Disclosed herein are lipid formulations that can be used in drug delivery and screening.

公开(公告)号：US20190136127A1

公开(公告)日：2019-05-09

申请号：US16233058

申请日：2018-12-26

申请人： Samsung Display Co., Ltd.

发明人： Toshiyuki Matsuura ,  Hiroaki Itoi ,  Naoya Sakamoto ,  Nobutaka Akashi

IPC分类号： C09K11/02 ,  C07D401/14 ,  C07D403/10 ,  C07C211/44 ,  C07C211/49 ,  H01L51/50 ,  C07C211/43 ,  C07C211/61

CPC分类号： C09K11/025 ,  C07C211/43 ,  C07C211/44 ,  C07C211/49 ,  C07C211/61 ,  C07D401/14 ,  C07D403/10 ,  H01L51/0059 ,  H01L51/0073 ,  H01L51/0074 ,  H01L51/5064

摘要： An organic electroluminescent device of which emission life may be improved. The organic electroluminescent device includes an anode, an emission layer, and an anode-side hole transport layer provided between the anode and the emission layer and including an anode-side hole transport material. An electron accepting material is doped in the anode-side hole transport layer. An intermediate hole transport material layer is provided between the anode-side hole transport layer and the emission layer and includes an intermediate hole transport material, and an emission layer-side hole transport layer is provided between the intermediate hole transport material layer and the emission layer and adjacent to the emission layer. The emission layer-side hole transport layer includes an emission layer-side hole transport material represented by the following Formula 1.

公开(公告)号：US20180134693A1

公开(公告)日：2018-05-17

申请号：US15533978

申请日：2015-12-10

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education ,  The United States Government as represented by the Department of Veterans Affairs

发明人： Beibei Chen ,  Rama K. Mallampalli

IPC分类号： C07D413/12 ,  C07D239/26 ,  C07D413/14 ,  A61P11/06 ,  A61P11/00 ,  A61P17/06 ,  A61P19/02 ,  A61P27/00 ,  A61P1/00 ,  A61P13/02 ,  A61P17/00 ,  A61P37/08 ,  A61P9/10 ,  A61P3/10 ,  A61P31/00

CPC分类号： C07D413/12 ,  A61K31/495 ,  A61K31/496 ,  A61K31/497 ,  A61K31/505 ,  A61P1/00 ,  A61P3/10 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/02 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P27/00 ,  A61P31/00 ,  A61P37/08 ,  C07C211/27 ,  C07C211/49 ,  C07C211/54 ,  C07C217/08 ,  C07C217/58 ,  C07C2601/14 ,  C07D239/26 ,  C07D241/12 ,  C07D413/14

摘要： A compound of Formula II, or a salt, ester, solvate, hydrate or prodrug thereof: where: X1 is a branched or unbranched C1-10 alkyl, (CH2)s—NH—(CH2)t, (CH2)s—O—(CH2)t, or (CH2)s—C(NH2)—(CH2)v—NH—(CH2)t, where s, t and v are each, independently an integer from 1 to 5; A and B are each, independently, C6-10aryl, C6-10aryl-C1-6alkyl, C3-9 heteroaryl, or C3-9heteroaryl-C1-6alkyl, each optionally substituted with 1, 2 or 3 independently selected Rg groups; C and D are each, independently, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-6alkyl, C3-7 heterocycloalkyl, C3-7 heterocycloalkyl-C1-6 alkyl, C6-10aryl, C6-10aryl-C1-6alkyl, C3-9 heteroaryl, or C3-9heteroaryl-C1-6alkyl, each optionally substituted with 1, 2 or 3 independently selected Rg groups; each Rg is, independently, halogen, C1-6 alkyl, C1-6 haloalkyl, hydroxyl, C1-6 alkoxy, C1-6 haloalkoxy, amino, C1-6 alkylamino, or di-C1-6alkylamino; and n1 and p1 are each, independently, integers from 1 to 10.

公开(公告)号：US09893293B2

公开(公告)日：2018-02-13

申请号：US14937314

申请日：2015-11-10

申请人： SAMSUNG DISPLAY CO., LTD.

发明人： Ikuo Sasaki ,  Xiulan Jin ,  Masatsugu Ueno ,  Koushin Matsuoka

IPC分类号： C09K11/00 ,  H01L51/00 ,  C09K11/02 ,  C07D403/10 ,  C07D401/14 ,  C07C211/44 ,  C07C211/61 ,  C07C211/43 ,  C07C211/49 ,  C09K11/06 ,  H01L51/50

CPC分类号： H01L51/006 ,  C07C211/43 ,  C07C211/44 ,  C07C211/49 ,  C07C211/61 ,  C07D401/14 ,  C07D403/10 ,  C09K11/025 ,  C09K11/06 ,  C09K2211/1014 ,  C09K2211/1088 ,  H01L51/0054 ,  H01L51/0058 ,  H01L51/0061 ,  H01L51/0072 ,  H01L51/0073 ,  H01L51/0074 ,  H01L51/5012 ,  H01L51/506 ,  H01L51/5064 ,  H01L2251/308 ,  H01L2251/552

摘要： An organic EL device including an anode; an emission layer; an anode-side hole transport layer between the anode and the emission layer, the anode-side hole transport layer including an anode-side hole transport material and being doped with an electron accepting material; an intermediate hole transport layer between the anode-side hole transport layer and the emission layer, the intermediate hole transport layer including an intermediate hole transport material; and an emission layer-side hole transport layer between the intermediate hole transport layer and the emission layer, the emission layer-side hole transport layer being adjacent to the emission layer, wherein the emission layer-side hole transport layer includes an emission layer-side hole transport material represented by the following Formula 1:

公开(公告)号：US09446995B2

公开(公告)日：2016-09-20

申请号：US13896524

申请日：2013-05-17

申请人： Hyun-Soon Chong

发明人： Hyun-Soon Chong

IPC分类号： C07C253/14 ,  C07C209/08 ,  C07C209/74 ,  C07C213/00 ,  C07C209/10 ,  C07C319/04 ,  C07C247/10 ,  C07C327/06 ,  C07D221/10 ,  C07B43/00 ,  C07B43/04 ,  C07C331/28 ,  C07C227/18 ,  C07D255/02 ,  C07D217/04 ,  C07D209/16 ,  C07C209/62 ,  C07D265/32 ,  C07D207/404

CPC分类号： C07B43/04 ,  C07B43/00 ,  C07B2200/07 ,  C07C209/08 ,  C07C209/10 ,  C07C209/62 ,  C07C209/74 ,  C07C213/00 ,  C07C227/18 ,  C07C247/10 ,  C07C253/14 ,  C07C319/04 ,  C07C327/06 ,  C07C331/28 ,  C07C2102/08 ,  C07C2602/08 ,  C07D207/404 ,  C07D209/16 ,  C07D217/04 ,  C07D221/10 ,  C07D255/02 ,  C07D265/32 ,  C07C229/16 ,  C07C211/27 ,  C07C229/34 ,  C07C255/42 ,  C07C211/29 ,  C07C215/30 ,  C07C211/49 ,  C07C219/22 ,  C07C323/29

摘要： Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in stereoselective and regioselective synthesis of therapeutic and diagnostic compounds.

摘要翻译： 通过用于立体选择性和区域选择性合成治疗和诊断化合物的吖啶鎓离子的亲核开环反应的化合物的立体选择性和区域选择性合成。

公开(公告)号：US20160155943A1

公开(公告)日：2016-06-02

申请号：US14937314

申请日：2015-11-10

申请人： SAMSUNG DISPLAY CO., LTD.

发明人： Ikuo SASAKI ,  Xiulan JIN ,  Masatsugu UENO ,  Koushin MATSUOKA

IPC分类号： H01L51/00 ,  C09K11/02

CPC分类号： H01L51/006 ,  C07C211/43 ,  C07C211/44 ,  C07C211/49 ,  C07C211/61 ,  C07D401/14 ,  C07D403/10 ,  C09K11/025 ,  C09K11/06 ,  C09K2211/1014 ,  C09K2211/1088 ,  H01L51/0054 ,  H01L51/0058 ,  H01L51/0061 ,  H01L51/0072 ,  H01L51/0073 ,  H01L51/0074 ,  H01L51/5012 ,  H01L51/506 ,  H01L51/5064 ,  H01L2251/308 ,  H01L2251/552

摘要： An organic EL device including an anode; an emission layer; an anode-side hole transport layer between the anode and the emission layer, the anode-side hole transport layer including an anode-side hole transport material and being doped with an electron accepting material; an intermediate hole transport layer between the anode-side hole transport layer and the emission layer, the intermediate hole transport layer including an intermediate hole transport material; and an emission layer-side hole transport layer between the intermediate hole transport layer and the emission layer, the emission layer-side hole transport layer being adjacent to the emission layer, wherein the emission layer-side hole transport layer includes an emission layer-side hole transport material represented by the following Formula 1:

摘要翻译： 一种包括阳极的有机EL器件; 发射层; 在阳极和发射层之间的阳极侧空穴传输层，阳极侧空穴传输层包括阳极侧空穴传输材料并掺杂有电子接受材料; 阳极侧空穴传输层和发光层之间的中间空穴传输层，中间空穴传输层包括中间空穴传输材料; 以及在中间空穴传输层和发光层之间的发光层侧空穴传输层，发光层侧空穴传输层与发光层相邻，发光层侧空穴传输层包含发光层侧空穴传输层 由下式1表示的空穴输送材料：

公开(公告)号：US20150315126A1

公开(公告)日：2015-11-05

申请号：US14650292

申请日：2013-12-03

申请人： INSTITUTO EUROPEO DI ONCOLOGIA S.R.L.

发明人： Mario Varasi ,  Paola Vianello ,  Florian Thaler ,  Paolo Trifiro' ,  Ciro Mercurio ,  Giuseppe Meroni

IPC分类号： C07C211/40 ,  C07C217/74 ,  C07C233/80 ,  C07C271/28 ,  C07C233/44 ,  C07C311/21 ,  C07C211/49 ,  C07C247/16 ,  C07C215/42 ,  C07D295/195 ,  C07D207/50 ,  C07D213/61 ,  C07D311/70 ,  C07D319/16 ,  C07D211/58 ,  C07D263/04 ,  C07D249/06 ,  C07D233/02 ,  C07D239/42 ,  C07D271/113 ,  C07C209/00 ,  C07C231/12 ,  C07C269/06 ,  C07C303/36 ,  C07D215/12

CPC分类号： C07C211/40 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/4164 ,  A61K31/496 ,  C07C209/00 ,  C07C211/49 ,  C07C215/42 ,  C07C217/58 ,  C07C217/74 ,  C07C231/12 ,  C07C233/44 ,  C07C233/80 ,  C07C237/06 ,  C07C247/16 ,  C07C269/06 ,  C07C271/28 ,  C07C303/36 ,  C07C311/21 ,  C07C2601/02 ,  C07D207/50 ,  C07D211/58 ,  C07D213/61 ,  C07D213/64 ,  C07D215/12 ,  C07D233/02 ,  C07D233/32 ,  C07D239/42 ,  C07D249/06 ,  C07D263/04 ,  C07D263/22 ,  C07D271/10 ,  C07D271/113 ,  C07D295/155 ,  C07D295/195 ,  C07D307/54 ,  C07D311/70 ,  C07D319/16 ,  A61K2300/00

摘要： The present invention relates to cyclopropyl derivatives of general formula (I), wherein A, R1, and R2 are as defined in the specification. The present application also relates to pharmaceutical compositions containing such compounds and to their use in therapy.

摘要翻译： 本发明涉及通式（I）的环丙基衍生物，其中A，R 1和R 2如说明书中所定义。 本申请还涉及含有这些化合物的药物组合物及其在治疗中的用途。

公开(公告)号：US08529796B2

公开(公告)日：2013-09-10

申请号：US13617717

申请日：2012-09-14

申请人： Daniel David LeCloux ,  Eric Maurice Smith ,  Ying Wang ,  Norman Herron ,  Mark A Guidry ,  Nora Sabina Radu

发明人： Daniel David LeCloux ,  Eric Maurice Smith ,  Ying Wang ,  Norman Herron ,  Mark A Guidry ,  Nora Sabina Radu

IPC分类号： H01B1/00 ,  C07D241/36 ,  H01L29/08 ,  H01J1/62

CPC分类号： C07D241/42 ,  C07C211/49 ,  C07C211/52 ,  C07C211/54 ,  C07C215/74 ,  C07C217/80 ,  C07C255/58 ,  C07D209/86 ,  C07D213/38 ,  C07D241/38 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D409/04 ,  C07D409/14 ,  C07D471/04 ,  C07D471/14 ,  C07D475/00 ,  C07D487/04 ,  C07F7/0838 ,  C08G61/122 ,  C08G61/124 ,  C08L65/00 ,  C09B11/10 ,  C09K11/06 ,  C09K2211/1044 ,  C09K2211/185 ,  H01L51/0035 ,  H01L51/0043 ,  H01L51/005 ,  H01L51/0059 ,  H01L51/0062 ,  H01L51/0065 ,  H01L51/0067 ,  H01L51/0068 ,  H01L51/0071 ,  H01L51/0072 ,  H01L51/0081 ,  H01L51/0085 ,  H01L51/0094 ,  H01L51/50 ,  H01L51/5012 ,  H01L51/5016 ,  H01L51/5048 ,  H01L2251/308 ,  H05B33/14 ,  Y10S428/917

摘要： The present invention relates to charge transport compositions. The invention further relates to electronic devices in which there is at least one active layer comprising such charge transport compositions.

公开(公告)号：US20130102571A1

公开(公告)日：2013-04-25

申请号：US13707418

申请日：2012-12-06

申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION

发明人： Arnold E. RUOHO ,  Abdol R. HAJIPOUR ,  Uyen B. CHU ,  Dominique A. FONTANILLA

IPC分类号： C07C247/16 ,  C07C211/29 ,  C07C211/27

CPC分类号： C07C247/16 ,  C07C211/27 ,  C07C211/29 ,  C07C211/49

摘要： The invention provides compounds of the formulas described herein and compositions thereof. The invention further provides methods of using the compounds and compositions. The compounds of the invention can provide high affinity binding to sigma-1 receptors in a mammal. The compounds can exhibit selectivity for the sigma-1 receptor over the sigma-2 receptor. The compounds and compositions of the invention can also be used to treat conditions that involve the sigma-1 receptor, such as addiction, cardiovascular conditions, and cancer, for example, cancer of the breast, lung, prostate, ovarian, colorectal, or the CNS.

摘要翻译： 本发明提供了本文所述的化合物及其组合物。 本发明还提供了使用化合物和组合物的方法。 本发明的化合物可以提供与哺乳动物中σ-1受体的高亲和力结合。 该化合物可显示σ-2受体超过σ-2受体的选择性。 本发明的化合物和组合物还可用于治疗涉及σ-1受体的病症，例如成瘾，心血管病症和癌症，例如乳腺癌，肺癌，前列腺癌，卵巢癌，结肠直肠癌或 中枢神经系统

公开(公告)号：US20100113539A1

公开(公告)日：2010-05-06

申请号：US12603025

申请日：2009-10-21

申请人： Ian L. Scott ,  Vladimir Aleksandrovich Kuksa ,  Feng Hong ,  Ryo Kubota ,  Jennifer Gage

发明人： Ian L. Scott ,  Vladimir Aleksandrovich Kuksa ,  Feng Hong ,  Ryo Kubota ,  Jennifer Gage

IPC分类号： A61K31/426 ,  C07C215/00 ,  A61K31/135 ,  C07D277/20 ,  A61K31/18 ,  C07C303/00

CPC分类号： C07C233/25 ,  A61K31/167 ,  A61K31/18 ,  C07B59/001 ,  C07B2200/05 ,  C07C211/49 ,  C07C211/52 ,  C07C215/08 ,  C07C215/14 ,  C07C215/42 ,  C07C215/68 ,  C07C217/08 ,  C07C217/10 ,  C07C217/58 ,  C07C225/06 ,  C07C225/22 ,  C07C233/36 ,  C07C233/43 ,  C07C233/62 ,  C07C275/40 ,  C07C311/08 ,  C07C311/10 ,  C07C311/14 ,  C07C311/21 ,  C07C311/24 ,  C07C335/18 ,  C07C2601/08 ,  C07C2601/14 ,  C07D277/28

摘要： Provided are compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

摘要翻译： 提供了化合物，其药物组合物，以及使用所述化合物和组合物治疗眼科疾病和病症如老年性黄斑变性和Stargardt氏病的方法。